STRINGSTRING
porcn porcn LOC101066871 LOC101066871 dvl3 dvl3 LOC101068730 LOC101068730 LOC101073562 LOC101073562 frat2 frat2 cacybp cacybp LOC101077303 LOC101077303 lrp6 lrp6 ctnnb1 ctnnb1 VANGL1 VANGL1 LOC101074163 LOC101074163 LOC101073257 LOC101073257 cxxc4 cxxc4 gpc4 gpc4 LOC101070067 LOC101070067 sfrp1 sfrp1 serpinf1 serpinf1 charon charon AXIN2 AXIN2 map3k7 map3k7 LOC101066969 LOC101066969 fzd4 fzd4 nfatc2 nfatc2 nlk nlk CHD8 CHD8 wnt8 wnt8 sox17 sox17 csnk2a2 csnk2a2 skp1 skp1 nkd1 nkd1 LOC101073059 LOC101073059 prickle2 prickle2 myc myc LOC101063905 LOC101063905 PLCB4 PLCB4 LOC101065234 LOC101065234 LOC101064242 LOC101064242 vangl2 vangl2 ruvbl1 ruvbl1 apc apc ccn4 ccn4 LOC105416356 LOC105416356 LOC101080220 LOC101080220 LOC101076147 LOC101076147 LOC101070874 LOC101070874 wnt10b wnt10b LGR6 LGR6 wnt1 wnt1 daam1 daam1 wnt16 wnt16 LOC101061589 LOC101061589 LOC101079595 LOC101079595 LOC101071292 LOC101071292 ror2 ror2 LOC101062420 LOC101062420 WNT2B WNT2B LOC101073984 LOC101073984 axin1 axin1 dvl2 dvl2 LOC101069649 LOC101069649 wnt9b wnt9b LOC101069583 LOC101069583 fzd2 fzd2 LOC101075840 LOC101075840 ccnd1 ccnd1 ppard ppard H2UXJ7_TAKRU H2UXJ7_TAKRU LOC101067574 LOC101067574 ryk ryk RAC1 RAC1 PRICKLE1 PRICKLE1 cby1 cby1 wnt2 wnt2 LOC101069468 LOC101069468 NFATC1 NFATC1 LOC101067715 LOC101067715 LOC101068861 LOC101068861 LOC101074632 LOC101074632 wnt5a wnt5a LOC101071385 LOC101071385 LOC101077059 LOC101077059 SMAD4 SMAD4 fzd8 fzd8 sfrp5 sfrp5 dkk2 dkk2 LOC101067160 LOC101067160 wnt6 wnt6 Fzd10 Fzd10 LOC101070117 LOC101070117 LOC105416636 LOC105416636 LOC101068466 LOC101068466 c-JunL c-JunL LOC101064504 LOC101064504 FZD7 FZD7 rspo2 rspo2 LOC101078823 LOC101078823 ENSTRUP00000056046 ENSTRUP00000056046 LOC101062949 LOC101062949 LOC101070452 LOC101070452 LOC101073575 LOC101073575 wnt4 wnt4 tcf7l1 tcf7l1 LOC101069591 LOC101069591 LOC101073266 LOC101073266 TBL1XR1 TBL1XR1 LOC101071995 LOC101071995 ENSTRUP00000060126 ENSTRUP00000060126 LOC101069214 LOC101069214 LOC101070190 LOC101070190 sfrp2 sfrp2 LOC101064815 LOC101064815 LOC115248454 LOC115248454 LOC101064166 LOC101064166 LOC115249167 LOC115249167 LOC101062197 LOC101062197 ror1 ror1 PRKCB PRKCB LOC101066292 LOC101066292 ENSTRUP00000064457 ENSTRUP00000064457 rock2 rock2 nfatc4 nfatc4 znrf3 znrf3 LOC101071438 LOC101071438 LOC101068343 LOC101068343 LOC101072650 LOC101072650 LOC101068125 LOC101068125 LOC101077861 LOC101077861 LOC101066137 LOC101066137 LOC105419947 LOC105419947 LOC101063201 LOC101063201 LOC115248448 LOC115248448 LOC101079814 LOC101079814 LOC101071806 LOC101071806 LOC101069822 LOC101069822 LOC101062383 LOC101062383 LOC101074783 LOC101074783 rspo3 rspo3 lgr4 lgr4 CTBP2 CTBP2 LOC101072742 LOC101072742 nfatc3 nfatc3 tcf7l2 tcf7l2 lef1 lef1 rnf43 rnf43 PLCB1 PLCB1 LOC101067113 LOC101067113 LOC101062616 LOC101062616 LOC101067856 LOC101067856 LOC115251054 LOC115251054 H2S4D3_TAKRU H2S4D3_TAKRU fzd6 fzd6 LOC101063195 LOC101063195 LOC101078548 LOC101078548 bambi bambi lgr5 lgr5 LOC101067916 LOC101067916 gsk3b gsk3b LOC101063351 LOC101063351 LOC101071463 LOC101071463 dvl1 dvl1 wnt3a wnt3a LOC101079823 LOC101079823 ENSTRUP00000086447 ENSTRUP00000086447 rac2 rac2 mapk10 mapk10 CSNK2B CSNK2B CTBP1 CTBP1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
porcnPorcupine O-acyltransferase. (462 aa)
LOC101066871Cyclin Dx; Belongs to the cyclin family. (300 aa)
dvl3Dishevelled segment polarity protein 3a. (685 aa)
LOC101068730VANGL planar cell polarity protein 2. (525 aa)
LOC101073562Cyclin D2, a; Belongs to the cyclin family. (296 aa)
frat2Glycogen synthase kinase binding protein. (170 aa)
cacybpCalcyclin binding protein. (228 aa)
LOC101077303Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (470 aa)
lrp6Low density lipoprotein receptor-related protein 6. (1697 aa)
ctnnb1Catenin (cadherin-associated protein), beta 1. (781 aa)
VANGL1Vang-like protein. (536 aa)
LOC101074163E3 ubiquitin-protein ligase; E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. (282 aa)
LOC101073257Prickle homolog 2a. (893 aa)
cxxc4CXXC finger 4. (289 aa)
gpc4Glypican 4; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. (558 aa)
LOC101070067Frizzled class receptor 3b; Belongs to the G-protein coupled receptor Fz/Smo family. (710 aa)
sfrp1Secreted frizzled-related protein 1a. (307 aa)
serpinf1SERPIN domain-containing protein; Belongs to the serpin family. (435 aa)
charonDAN related protein. (255 aa)
AXIN2Axin 2. (790 aa)
map3k7Mitogen-activated protein kinase kinase kinase 7. (604 aa)
LOC101066969F-box-like/WD repeat-containing protein TBL1XR1. (549 aa)
fzd4Frizzled class receptor 4; Belongs to the G-protein coupled receptor Fz/Smo family. (529 aa)
nfatc2Nuclear factor of activated T cells 2a. (884 aa)
nlkMitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (441 aa)
CHD8Chromodomain-helicase-DNA-binding protein 8; DNA helicase that acts as a chromatin remodeling factor and regulates transcription. Acts as a transcription repressor by remodeling chromatin structure and recruiting histone H1 to target genes. Suppresses p53/TP53-mediated apoptosis by recruiting histone H1 and preventing p53/TP53 transactivation activity. Acts as a negative regulator of Wnt signaling pathway by regulating beta-catenin (CTNNB1) activity. Negatively regulates CTNNB1-targeted gene expression by being recruited specifically to the promoter regions of several CTNNB1 responsive [...] (2507 aa)
wnt8Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (363 aa)
sox17SRY-box transcription factor 17. (399 aa)
csnk2a2Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (351 aa)
skp1S-phase kinase-associated protein 1; Belongs to the SKP1 family. (163 aa)
nkd1NKD inhibitor of WNT signaling pathway 1. (445 aa)
LOC101073059Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (360 aa)
prickle2Prickle homolog 2b. (925 aa)
mycTranscriptional regulator; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (418 aa)
LOC101063905Cyclin D3; Belongs to the cyclin family. (300 aa)
PLCB41-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1232 aa)
LOC101065234Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (671 aa)
LOC101064242R-spondin 1. (377 aa)
vangl2Vang-like protein. (525 aa)
ruvbl1RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. (456 aa)
apcAPC regulator of WNT signaling pathway. (2226 aa)
ccn4Cellular communication network factor 4a. (364 aa)
LOC105416356Dickkopf WNT signaling pathway inhibitor 1a. (348 aa)
LOC101080220Cyclin D2, b; Belongs to the cyclin family. (294 aa)
LOC101076147Uncharacterized protein. (193 aa)
LOC101070874Vang-like protein. (539 aa)
wnt10bProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (429 aa)
LGR6Leucine rich repeat containing G protein-coupled receptor 6. (950 aa)
wnt1Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa)
daam1Dishevelled associated activator of morphogenesis 1b. (1080 aa)
wnt16Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (333 aa)
LOC101061589Notum pectinacetylesterase 2. (484 aa)
LOC101079595Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (391 aa)
LOC101071292Protein phosphatase 3 (formerly 2B), regulatory s1ubunit B, alpha isoform, b. (178 aa)
ror2Receptor tyrosine kinase-like orphan receptor 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. (925 aa)
LOC101062420Notum, palmitoleoyl-protein carboxylesterase. (462 aa)
WNT2BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (378 aa)
LOC101073984CREB binding protein a. (3609 aa)
axin1Axin 1. (833 aa)
dvl2Dishevelled segment polarity protein 2. (765 aa)
LOC101069649Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (355 aa)
wnt9bProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (355 aa)
LOC101069583Frizzled class receptor 5; Belongs to the G-protein coupled receptor Fz/Smo family. (572 aa)
fzd2Frizzled class receptor 2; Belongs to the G-protein coupled receptor Fz/Smo family. (542 aa)
LOC101075840Uncharacterized protein. (882 aa)
ccnd1Cyclin D1. (292 aa)
ppardUncharacterized protein. (491 aa)
H2UXJ7_TAKRUAxin 2 (conductin, axil). (336 aa)
LOC101067574Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (391 aa)
rykReceptor like tyrosine kinase. (624 aa)
RAC1Uncharacterized protein. (214 aa)
PRICKLE1Prickle homolog 1a. (851 aa)
cby1Chibby homolog 1 (Drosophila). (130 aa)
wnt2Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (350 aa)
LOC101069468Low density lipoprotein receptor-related protein 5. (1645 aa)
NFATC1Nuclear factor of activated T cells 1. (928 aa)
LOC101067715Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1498 aa)
LOC101068861RHD domain-containing protein. (875 aa)
LOC101074632HMG box domain-containing protein. (585 aa)
wnt5aProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (381 aa)
LOC101071385Uncharacterized protein. (929 aa)
LOC101077059Jun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family. (327 aa)
SMAD4Mothers against decapentaplegic homolog. (521 aa)
fzd8Frizzled class receptor 8a; Belongs to the G-protein coupled receptor Fz/Smo family. (581 aa)
sfrp5Secreted frizzled-related protein 5. (321 aa)
dkk2Dickkopf WNT signaling pathway inhibitor 2. (245 aa)
LOC101067160Rac family small GTPase 1b. (192 aa)
wnt6Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (355 aa)
Fzd10Frizzled class receptor 10; Belongs to the G-protein coupled receptor Fz/Smo family. (575 aa)
LOC101070117Ras homolog gene family, member Aa. (193 aa)
LOC105416636Uncharacterized protein. (671 aa)
LOC101068466Mothers against decapentaplegic homolog 4-like. (557 aa)
c-JunLC-JunL protein; Belongs to the bZIP family. (293 aa)
LOC101064504Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family. (580 aa)
FZD7Frizzled class receptor 7; Belongs to the G-protein coupled receptor Fz/Smo family. (558 aa)
rspo2R-spondin 2. (245 aa)
LOC101078823Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (350 aa)
ENSTRUP00000056046Nuclear factor of activated T cells 1. (813 aa)
LOC101062949Adenomatous polyposis coli protein 2-like isoform X1. (2486 aa)
LOC101070452Serine/threonine-protein phosphatase. (531 aa)
LOC101073575Mitogen-activated protein kinase. (427 aa)
wnt4Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (352 aa)
tcf7l1Transcription factor 7 like 1b. (592 aa)
LOC101069591PH_14 domain-containing protein. (1160 aa)
LOC101073266Uncharacterized protein. (485 aa)
TBL1XR1Uncharacterized protein. (554 aa)
LOC101071995Calcium/calmodulin-dependent protein kinase (CaM kinase) II delta 2; Belongs to the protein kinase superfamily. (520 aa)
ENSTRUP00000060126Transcription factor 7-like 1-C isoform X1. (320 aa)
LOC101069214Uncharacterized protein. (768 aa)
LOC101070190Mitogen-activated protein kinase. (462 aa)
sfrp2Secreted frizzled-related protein 2. (295 aa)
LOC101064815Protein kinase C. (687 aa)
LOC115248454RING-box protein 1. (126 aa)
LOC101064166Uncharacterized protein. (193 aa)
LOC115249167Protein-serine O-palmitoleoyltransferase porcupine-like isoform X1. (450 aa)
LOC101062197Uncharacterized protein. (491 aa)
ror1Receptor tyrosine kinase-like orphan receptor 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. ROR subfamily. (950 aa)
PRKCBNon-specific serine/threonine protein kinase. (682 aa)
LOC101066292Uncharacterized protein; Belongs to the protein kinase superfamily. (372 aa)
ENSTRUP00000064457Ras-related C3 botulinum toxin substrate 3 isoform X1. (218 aa)
rock2Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1398 aa)
nfatc4Uncharacterized protein. (893 aa)
znrf3Zinc and ring finger 3. (919 aa)
LOC101071438Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (353 aa)
LOC101068343Uncharacterized protein; Belongs to the membrane-bound acyltransferase family. (450 aa)
LOC101072650Serine/threonine-protein phosphatase. (520 aa)
LOC101068125TPTEP2-CSNK1E readthrough; Belongs to the protein kinase superfamily. (459 aa)
LOC101077861Catenin (cadherin-associated protein), delta 2a. (1260 aa)
LOC101066137C-terminal-binding protein 1-like isoform X1. (492 aa)
LOC105419947DNA N6-methyl adenine demethylase-like isoform X1. (402 aa)
LOC101063201Zgc:86598; Belongs to the protein kinase superfamily. (449 aa)
LOC115248448E1A binding protein p300 b. (2795 aa)
LOC101079814Ring-box 1, E3 ubiquitin protein ligase. (108 aa)
LOC101071806FZ domain-containing protein. (570 aa)
LOC101069822Protein kinase, cAMP-dependent, catalytic, alpha, genome duplicate a; Belongs to the protein kinase superfamily. (384 aa)
LOC101062383Transducin beta like 1 X-linked. (548 aa)
LOC101074783Serine/threonine-protein phosphatase. (532 aa)
rspo3R-spondin 3. (327 aa)
lgr4Leucine-rich repeat containing G protein-coupled receptor 4. (976 aa)
CTBP2C-terminal binding protein 2; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (483 aa)
LOC101072742Myelocytomatosis oncogene homolog. (367 aa)
nfatc3Nuclear factor of activated T cells 3a. (1109 aa)
tcf7l2Transcription factor 7 like 2. (632 aa)
lef1Lymphoid enhancer-binding factor 1. (377 aa)
rnf43RING-type domain-containing protein. (739 aa)
PLCB11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1247 aa)
LOC101067113Casein kinase 2, alpha prime polypeptide a; Belongs to the protein kinase superfamily. (426 aa)
LOC101062616Casein kinase II subunit beta; Plays a complex role in regulating the basal catalytic activity of the alpha subunit; Belongs to the casein kinase 2 subunit beta family. (240 aa)
LOC101067856Protein kinase, cAMP-dependent, catalytic, alpha, genome duplicate b; Belongs to the protein kinase superfamily. (353 aa)
LOC115251054Lymphoid enhancer-binding factor 1-like isoform X1. (315 aa)
H2S4D3_TAKRUCasein kinase 2, alpha 4 polypeptide; Belongs to the protein kinase superfamily. (398 aa)
fzd6Frizzled class receptor 6; Belongs to the G-protein coupled receptor Fz/Smo family. (718 aa)
LOC101063195Uncharacterized protein. (1174 aa)
LOC101078548Mitogen-activated protein kinase. (456 aa)
bambiBMP and activin membrane-bound inhibitor (Xenopus laevis) homolog a. (260 aa)
lgr5Leucine-rich repeat-containing G protein-coupled receptor 5. (964 aa)
LOC101067916Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (408 aa)
gsk3bGlycogen synthase kinase 3 beta, genome duplicate b; Belongs to the protein kinase superfamily. (459 aa)
LOC101063351Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (496 aa)
LOC101071463Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (378 aa)
dvl1Dishevelled segment polarity protein 1a. (729 aa)
wnt3aProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (352 aa)
LOC101079823Classical protein kinase C gamma type. (700 aa)
ENSTRUP00000086447Frizzled class receptor 9b; Belongs to the G-protein coupled receptor Fz/Smo family. (560 aa)
rac2Rac family small GTPase 2. (218 aa)
mapk10Mitogen-activated protein kinase. (537 aa)
CSNK2BCasein kinase II subunit beta; Plays a complex role in regulating the basal catalytic activity of the alpha subunit; Belongs to the casein kinase 2 subunit beta family. (215 aa)
CTBP1C-terminal binding protein 1; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (462 aa)
Your Current Organism:
Takifugu rubripes
NCBI taxonomy Id: 31033
Other names: Fugu rubripes, Sphaeroides rubripes, T. rubripes, Tetraodon rubripes, tiger puffer, torafugu
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