STRINGSTRING
TIPIN TIPIN MCM5 MCM5 GINS3 GINS3 ORC6 ORC6 DNA2 DNA2 MCM4 MCM4 DBF4 DBF4 POLA2 POLA2 POLD4 POLD4 GINS2 GINS2 CDT1 CDT1 WRN WRN FEN1 FEN1 RAD17 RAD17 CDC7 CDC7 ORC5 ORC5 CDC6 CDC6 RFC1 RFC1 MCM2 MCM2 TIMELESS TIMELESS POLD1 POLD1 POLE POLE POLA1 POLA1 GINS4 GINS4 EXO1 EXO1 ORC4 ORC4 POLE4 POLE4 MCMDC2 MCMDC2 RECQL4 RECQL4 RFC2 RFC2 MCM7 MCM7 PRIM2 PRIM2 POLD2 POLD2 RFC5 RFC5 MCM10 MCM10 ATAD5 ATAD5 ORC2 ORC2 MCM8 MCM8 GINS1 GINS1 MCM6 MCM6 POLE2 POLE2 WDHD1 WDHD1 RFC3 RFC3 RFC4 RFC4 ORC3 ORC3 CDC45 CDC45 POLE3 POLE3 PRIM1 PRIM1 MCM3 MCM3 LOC103012730 LOC103012730 ORC1 ORC1 TM4SF19 TM4SF19 LOC103006067 LOC103006067 POLD3 POLD3 LOC103007401 LOC103007401 MCM9 MCM9
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
TIPINTIMELESS-interacting protein; Plays an important role in the control of DNA replication and the maintenance of replication fork stability. Belongs to the CSM3 family. (290 aa)
MCM5DNA helicase; Belongs to the MCM family. (721 aa)
GINS3DNA replication complex GINS protein PSF3. (216 aa)
ORC6Origin recognition complex subunit 6. (252 aa)
DNA2DNA replication ATP-dependent helicase/nuclease DNA2. (1063 aa)
MCM4DNA helicase; Belongs to the MCM family. (739 aa)
DBF4Protein DBF4 homolog A. (682 aa)
POLA2DNA polymerase alpha subunit B; Accessory subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis. (598 aa)
POLD4DNA polymerase delta subunit 4 isoform X2. (107 aa)
GINS2DNA replication complex GINS protein PSF2; Belongs to the GINS2/PSF2 family. (185 aa)
CDT1DNA replication factor Cdt1. (530 aa)
WRNWerner syndrome ATP-dependent helicase isoform X1. (1447 aa)
FEN1Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (380 aa)
RAD17Cell cycle checkpoint protein RAD17 isoform X1. (766 aa)
CDC7LOW QUALITY PROTEIN: cell division cycle 7-related protein kinase. (580 aa)
ORC5Origin recognition complex subunit 5. (435 aa)
CDC6Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. (560 aa)
RFC1Replication factor C subunit 1. (1146 aa)
MCM2DNA helicase; Belongs to the MCM family. (903 aa)
TIMELESSProtein timeless homolog. (1222 aa)
POLD1DNA polymerase. (1107 aa)
POLEDNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (2240 aa)
POLA1LOW QUALITY PROTEIN: DNA polymerase alpha catalytic subunit. (1468 aa)
GINS4DNA replication complex GINS protein SLD5; The GINS complex plays an essential role in the initiation of DNA replication; Belongs to the GINS4/SLD5 family. (223 aa)
EXO1Exonuclease 1 isoform X1. (835 aa)
ORC4Origin recognition complex subunit 4; Component of the origin recognition complex (ORC) that binds origins of replication; Belongs to the ORC4 family. (436 aa)
POLE4DNA polymerase epsilon subunit 4. (116 aa)
MCMDC2Minichromosome maintenance domain-containing protein 2. (681 aa)
RECQL4LOW QUALITY PROTEIN: ATP-dependent DNA helicase Q4. (1137 aa)
RFC2Replication factor C subunit 2. (352 aa)
MCM7DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (719 aa)
PRIM2DNA primase large subunit; Regulatory subunit of the DNA primase complex and component of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which play an essential role in the initiation of DNA synthesis. The primase subunit of the polymerase alpha complex initiates DNA synthesis by oligomerising short RNA primers on both leading and lagging strands. (506 aa)
POLD2DNA polymerase delta subunit 2. (469 aa)
RFC5Replication factor C subunit 5. (341 aa)
MCM10Protein MCM10 homolog. (873 aa)
ATAD5ATPase family AAA domain-containing protein 5. (1853 aa)
ORC2Origin recognition complex subunit 2. (578 aa)
MCM8DNA helicase MCM8; Belongs to the MCM family. (837 aa)
GINS1DNA replication complex GINS protein PSF1. (196 aa)
MCM6DNA helicase; Belongs to the MCM family. (821 aa)
POLE2DNA polymerase epsilon subunit; Participates in DNA repair and in chromosomal DNA replication; Belongs to the DNA polymerase epsilon subunit B family. (527 aa)
WDHD1WD repeat and HMG-box DNA-binding protein 1. (1131 aa)
RFC3Replication factor C subunit 3. (356 aa)
RFC4Replication factor C subunit 4. (376 aa)
ORC3Origin recognition complex subunit 3 isoform X1. (714 aa)
CDC45Cell division control protein 45 homolog. (567 aa)
POLE3LOW QUALITY PROTEIN: DNA polymerase epsilon subunit 3. (146 aa)
PRIM1DNA primase; Belongs to the eukaryotic-type primase small subunit family. (416 aa)
MCM3DNA helicase; Belongs to the MCM family. (808 aa)
LOC103012730TIMELESS-interacting protein; Plays an important role in the control of DNA replication and the maintenance of replication fork stability. Belongs to the CSM3 family. (290 aa)
ORC1Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. (852 aa)
TM4SF19Transmembrane 4 L6 family member 19. (202 aa)
LOC103006067LOW QUALITY PROTEIN: protein DBF4 homolog A-like. (680 aa)
POLD3DNA polymerase delta subunit 3 isoform X1. (465 aa)
LOC103007401Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (230 aa)
MCM9LOW QUALITY PROTEIN: DNA helicase MCM9; Belongs to the MCM family. (1146 aa)
Your Current Organism:
Balaenoptera acutorostrata
NCBI taxonomy Id: 310752
Other names: B. acutorostrata scammoni, Balaenoptera acutorostrata scammoni
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