STRINGSTRING
FGF1 FGF1 SMAD3 SMAD3 SMAD6 SMAD6 LOC103017471 LOC103017471 GATA3 GATA3 DLG2 DLG2 CTNNBIP1 CTNNBIP1 RET RET HOXA11 HOXA11 SMAD5 SMAD5 SPRY1 SPRY1 ILK ILK DCHS1 DCHS1 HS2ST1 HS2ST1 RARB RARB GPC3 GPC3 BMPER BMPER HS3ST3A1 HS3ST3A1 WNT9B WNT9B CER1 CER1 RARA RARA WNT1 WNT1 GDF11 GDF11 FMN1 FMN1 SFRP1 SFRP1 OSR1 OSR1 HES1 HES1 CRLF1 CRLF1 TMEM59L TMEM59L GREB1 GREB1 SMAD4 SMAD4 TACSTD2 TACSTD2 SMAD7 SMAD7 PAX8 PAX8 GREB1L GREB1L KIF26B KIF26B TGFB1 TGFB1 DLG1 DLG1 FGF2 FGF2 NOG NOG PTCH1 PTCH1 SHH SHH GREM1 GREM1 WT1 WT1 CALB1 CALB1 LOC103016806 LOC103016806 PKD2 PKD2 LAMA5 LAMA5 WNT6 WNT6 LOC114239234 LOC114239234 ARG2 ARG2 EYA1 EYA1 BMP7 BMP7 FOXJ1 FOXJ1 SOX9 SOX9 LZTS2 LZTS2 PAX2 PAX2 FGF8 FGF8 SLIT2 SLIT2 GLI3 GLI3 SMAD1 SMAD1 EPCAM EPCAM LHX1 LHX1 TCF21 TCF21 ADAMTS16 ADAMTS16 BMP2 BMP2 GZF1 GZF1 BCL2 BCL2 GDNF GDNF BMP4 BMP4 SIX1 SIX1 CTNNB1 CTNNB1 WNT11 WNT11
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
FGF1Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (189 aa)
SMAD3Mothers against decapentaplegic homolog. (425 aa)
SMAD6Mothers against decapentaplegic homolog. (321 aa)
LOC103017471Kinesin-like protein KIF26B. (198 aa)
GATA3Trans-acting T-cell-specific transcription factor GATA-3 isoform X1. (444 aa)
DLG2Disks large homolog 2 isoform X8. (957 aa)
CTNNBIP1Beta-catenin-interacting protein 1. (81 aa)
RETProto-oncogene tyrosine-protein kinase receptor Ret; Receptor tyrosine-protein kinase involved in numerous cellular mechanisms including cell proliferation, neuronal navigation, cell migration, and cell differentiation upon binding with glial cell derived neurotrophic factor family ligands. (1026 aa)
HOXA11Homeobox protein Hox-A11. (314 aa)
SMAD5Mothers against decapentaplegic homolog. (465 aa)
SPRY1Protein sprouty homolog 1. (319 aa)
ILKIntegrin-linked protein kinase. (452 aa)
DCHS1Protocadherin-16. (3252 aa)
HS2ST1Heparan sulfate 2-O-sulfotransferase 1 isoform X1. (357 aa)
RARBRetinoic acid receptor beta. (584 aa)
GPC3Glypican-3; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. (504 aa)
BMPERBMP-binding endothelial regulator protein. (685 aa)
HS3ST3A1Sulfotransferase; Belongs to the sulfotransferase 1 family. (310 aa)
WNT9BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (358 aa)
CER1Cerberus. (273 aa)
RARARetinoic acid receptor alpha isoform X1. (462 aa)
WNT1Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa)
GDF11Growth/differentiation factor 11. (418 aa)
FMN1Formin-1 isoform X1. (1410 aa)
SFRP1Secreted frizzled-related protein 1. (295 aa)
OSR1Protein odd-skipped-related 1. (267 aa)
HES1Transcription factor HES-1. (280 aa)
CRLF1Cytokine receptor-like factor 1. (478 aa)
TMEM59LTransmembrane protein 59-like isoform X1. (344 aa)
GREB1Protein GREB1. (2096 aa)
SMAD4Mothers against decapentaplegic homolog. (553 aa)
TACSTD2LOW QUALITY PROTEIN: tumor-associated calcium signal transducer 2. (234 aa)
SMAD7Mothers against decapentaplegic homolog. (426 aa)
PAX8Paired box protein Pax-8 isoform X1. (458 aa)
GREB1LGREB1-like protein. (1824 aa)
KIF26BKinesin-like protein KIF26B; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1660 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (407 aa)
DLG1Disks large homolog 1 isoform X8; Belongs to the MAGUK family. (927 aa)
FGF2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (155 aa)
NOGNoggin. (154 aa)
PTCH1LOW QUALITY PROTEIN: protein patched homolog 1. (1304 aa)
SHHLOW QUALITY PROTEIN: sonic hedgehog protein. (271 aa)
GREM1Gremlin. (184 aa)
WT1Wilms tumor protein isoform X1. (323 aa)
CALB1LOW QUALITY PROTEIN: calbindin. (272 aa)
LOC103016806LOW QUALITY PROTEIN: retinoic acid receptor beta-like. (358 aa)
PKD2Polycystin-2. (763 aa)
LAMA5LOW QUALITY PROTEIN: laminin subunit alpha-5. (3531 aa)
WNT6Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (365 aa)
LOC114239234Leucine zipper putative tumor suppressor 2-like. (90 aa)
ARG2Arginase. (354 aa)
EYA1Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (584 aa)
BMP7Bone morphogenetic protein 7. (431 aa)
FOXJ1Forkhead box protein J1. (421 aa)
SOX9Transcription factor SOX-9. (432 aa)
LZTS2Leucine zipper putative tumor suppressor 2. (661 aa)
PAX2Paired box protein Pax-2 isoform X1. (463 aa)
FGF8Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (244 aa)
SLIT2Slit homolog 2 protein isoform X1. (1530 aa)
GLI3Transcriptional activator GLI3 isoform X1. (1591 aa)
SMAD1Mothers against decapentaplegic homolog. (465 aa)
EPCAMEpithelial cell adhesion molecule isoform X1. (314 aa)
LHX1LIM/homeobox protein Lhx1. (406 aa)
TCF21Transcription factor 21. (179 aa)
ADAMTS16A disintegrin and metalloproteinase with thrombospondin motifs 16. (1309 aa)
BMP2Bone morphogenetic protein 2. (395 aa)
GZF1GDNF-inducible zinc finger protein 1. (716 aa)
BCL2Apoptosis regulator Bcl-2 isoform X1. (233 aa)
GDNFGlial cell line-derived neurotrophic factor isoform X1. (211 aa)
BMP4Bone morphogenetic protein 4 isoform X1. (420 aa)
SIX1Homeobox protein SIX1. (284 aa)
CTNNB1Catenin beta-1. (767 aa)
WNT11Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
Your Current Organism:
Balaenoptera acutorostrata
NCBI taxonomy Id: 310752
Other names: B. acutorostrata scammoni, Balaenoptera acutorostrata scammoni
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