STRINGSTRING
IHH IHH GLI3 GLI3 DMRTA2 DMRTA2 ASCL1 ASCL1 KDM6B KDM6B GSX2 GSX2 SOX17 SOX17 TBX15 TBX15 POU3F2 POU3F2 TEAD4 TEAD4 TBX5 TBX5 TBX10 TBX10 TLX3 TLX3 HOXA11 HOXA11 HOXA13 HOXA13 TBX19 TBX19 ISL2 ISL2 DBX1 DBX1 TBX21 TBX21 FOXA1 FOXA1 HOXC10 HOXC10 DHH DHH TBX3 TBX3 MGA MGA PAX6 PAX6 DMRT3 DMRT3 TBX20 TBX20 TBR1 TBR1 CDON CDON OLIG2 OLIG2 PSEN1 PSEN1 PRDM14 PRDM14 EYA1 EYA1 SOX9 SOX9 DLL1 DLL1 POU4F1 POU4F1 TBX6 TBX6 MYL10 MYL10 SUFU SUFU TENM4 TENM4 TBX22 TBX22 PTCH2 PTCH2 TBXT TBXT KDM6A KDM6A SHH SHH ETV2 ETV2 SMO SMO PTCH1 PTCH1 NODAL NODAL NOTCH1 NOTCH1 TBX2 TBX2 ATOH1 ATOH1 APC2 APC2 TBX18 TBX18 MYT1L MYT1L ISL1 ISL1 LHX3 LHX3 EHMT2 EHMT2 CTNNB1 CTNNB1 SIX1 SIX1 APC APC NKX2-2 NKX2-2 EOMES EOMES OLIG3 OLIG3 HOXD10 HOXD10 TBX4 TBX4 SIX2 SIX2 ITGB1 ITGB1 MYL2 MYL2 SFRP2 SFRP2 FEV FEV
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
IHHIndian hedgehog protein. (309 aa)
GLI3Transcriptional activator GLI3 isoform X1. (1591 aa)
DMRTA2Doublesex- and mab-3-related transcription factor A2. (390 aa)
ASCL1Achaete-scute homolog 1. (169 aa)
KDM6BLOW QUALITY PROTEIN: lysine-specific demethylase 6B. (1504 aa)
GSX2GS homeobox 2. (299 aa)
SOX17Transcription factor SOX-17. (296 aa)
TBX15T-box transcription factor TBX15 isoform X1. (602 aa)
POU3F2POU domain protein. (263 aa)
TEAD4Transcriptional enhancer factor TEF-3. (580 aa)
TBX5T-box transcription factor TBX5 isoform X1. (536 aa)
TBX10T-box transcription factor TBX10. (389 aa)
TLX3T-cell leukemia homeobox protein 3. (291 aa)
HOXA11Homeobox protein Hox-A11. (314 aa)
HOXA13Homeobox protein Hox-A13. (294 aa)
TBX19T-box transcription factor TBX19. (444 aa)
ISL2Insulin gene enhancer protein ISL-2. (359 aa)
DBX1Homeobox protein DBX1. (349 aa)
TBX21T-box transcription factor TBX21. (379 aa)
FOXA1Hepatocyte nuclear factor 3-alpha. (433 aa)
HOXC10Homeobox protein Hox-C10 isoform X1. (368 aa)
DHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (396 aa)
TBX3T-box transcription factor TBX3. (670 aa)
MGAMAX gene-associated protein isoform X1. (3115 aa)
PAX6Paired box protein Pax-6 isoform X1. (493 aa)
DMRT3Doublesex- and mab-3-related transcription factor 3. (506 aa)
TBX20T-box transcription factor TBX20. (449 aa)
TBR1T-box brain protein 1. (798 aa)
CDONCell adhesion molecule-related/down-regulated by oncogenes. (1251 aa)
OLIG2Oligodendrocyte transcription factor 2. (254 aa)
PSEN1Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (469 aa)
PRDM14PR domain zinc finger protein 14. (571 aa)
EYA1Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (584 aa)
SOX9Transcription factor SOX-9. (432 aa)
DLL1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (719 aa)
POU4F1POU domain protein. (298 aa)
TBX6T-box transcription factor TBX6. (436 aa)
MYL10Myosin regulatory light chain 10. (167 aa)
SUFUSuppressor of fused homolog; Negative regulator in the hedgehog signaling pathway. Down- regulates GLI1-mediated transactivation of target genes. Part of a corepressor complex that acts on DNA-bound GLI1. May also act by linking GLI1 to BTRC and thereby targeting GLI1 to degradation by the proteasome. Sequesters GLI1, GLI2 and GLI3 in the cytoplasm, this effect is overcome by binding of STK36 to both SUFU and a GLI protein. Negative regulator of beta-catenin signaling. Regulates the formation of either the repressor form (GLI3R) or the activator form (GLI3A) of the full-length form of [...] (485 aa)
TENM4Teneurin-4. (2739 aa)
TBX22T-box transcription factor TBX22. (522 aa)
PTCH2Protein patched homolog 2 isoform X1. (1213 aa)
TBXTT-box transcription factor T isoform X2. (436 aa)
KDM6ALysine-specific demethylase 6A. (1180 aa)
SHHLOW QUALITY PROTEIN: sonic hedgehog protein. (271 aa)
ETV2ETS translocation variant 2 isoform X1. (333 aa)
SMOSmoothened homolog; Belongs to the G-protein coupled receptor Fz/Smo family. (837 aa)
PTCH1LOW QUALITY PROTEIN: protein patched homolog 1. (1304 aa)
NODALNodal homolog. (280 aa)
NOTCH1LOW QUALITY PROTEIN: neurogenic locus notch homolog protein 1. (2379 aa)
TBX2LOW QUALITY PROTEIN: T-box transcription factor TBX2. (592 aa)
ATOH1LOW QUALITY PROTEIN: protein atonal homolog 1. (348 aa)
APC2LOW QUALITY PROTEIN: adenomatous polyposis coli protein 2. (1582 aa)
TBX18T-box transcription factor TBX18. (607 aa)
MYT1LMyelin transcription factor 1-like protein. (912 aa)
ISL1Insulin gene enhancer protein ISL-1. (349 aa)
LHX3LIM/homeobox protein Lhx3. (493 aa)
EHMT2Histone-lysine N-methyltransferase EHMT2 isoform X1. (1268 aa)
CTNNB1Catenin beta-1. (767 aa)
SIX1Homeobox protein SIX1. (284 aa)
APCAdenomatous polyposis coli protein isoform X1. (2865 aa)
NKX2-2Homeobox protein Nkx-2.2. (273 aa)
EOMESEomesodermin homolog isoform X1. (419 aa)
OLIG3Oligodendrocyte transcription factor 3. (281 aa)
HOXD10Homeobox protein Hox-D10. (343 aa)
TBX4T-box transcription factor TBX4. (557 aa)
SIX2Homeobox protein SIX2 isoform X1. (298 aa)
ITGB1Integrin beta; Belongs to the integrin beta chain family. (801 aa)
MYL2Myosin regulatory light chain 2, ventricular/cardiac muscle isoform. (166 aa)
SFRP2Secreted frizzled-related protein 2. (294 aa)
FEVProtein FEV. (184 aa)
Your Current Organism:
Balaenoptera acutorostrata
NCBI taxonomy Id: 310752
Other names: B. acutorostrata scammoni, Balaenoptera acutorostrata scammoni
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