STRINGSTRING
FGF8 FGF8 IHH IHH EMP2 EMP2 FLRT2 FLRT2 EXT1 EXT1 ZFPM2 ZFPM2 TAB1 TAB1 EDNRA EDNRA SFRP2 SFRP2 MYL2 MYL2 BMP10 BMP10 MSX2 MSX2 ATF2 ATF2 NKX2-5 NKX2-5 BMPR2 BMPR2 NRP2 NRP2 HEY2 HEY2 AHI1 AHI1 SEC24B SEC24B MSX1 MSX1 BMP2 BMP2 ALPK2 ALPK2 NIPBL NIPBL CAV3 CAV3 PLXND1 PLXND1 HAND2 HAND2 SAV1 SAV1 HIF1A HIF1A LOC103001360 LOC103001360 GATA4 GATA4 MEF2C MEF2C BMP4 BMP4 SIX1 SIX1 ASXL1 ASXL1 IFT52 IFT52 MYLK2 MYLK2 WNT11 WNT11 ENG ENG COL5A1 COL5A1 LOC103015737 LOC103015737 WNT2 WNT2 CCDC39 CCDC39 HES1 HES1 ISL1 ISL1 CRKL CRKL ADPRHL1 ADPRHL1 TGFBR1 TGFBR1 SOX4 SOX4 SMAD4 SMAD4 SMAD7 SMAD7 GATA6 GATA6 TBX2 TBX2 NOTCH1 NOTCH1 APLNR APLNR MIB1 MIB1 SRF SRF NODAL NODAL MEGF8 MEGF8 CHD7 CHD7 TGFB1 TGFB1 NOTCH2 NOTCH2 LOC114236675 LOC114236675 C2CD3 C2CD3 SHOX2 SHOX2 EGLN1 EGLN1 DSP DSP NOG NOG MKS1 MKS1 PTCH1 PTCH1 SMO SMO SEMA3C SEMA3C SHH SHH HAND1 HAND1 MYBPC3 MYBPC3 CLUAP1 CLUAP1 DNAH11 DNAH11 PKD2 PKD2 ZMIZ1 ZMIZ1 FLNA FLNA LOC114238299 LOC114238299 TBXT TBXT ELN ELN LOC103004078 LOC103004078 RTN4 RTN4 LEMD2 LEMD2 IFT57 IFT57 SUFU SUFU LBX1 LBX1 ANKRD1 ANKRD1 SMARCD3 SMARCD3 JAG1 JAG1 TWIST1 TWIST1 LOC103001311 LOC103001311 ZMPSTE24 ZMPSTE24 HEYL HEYL LOC103014668 LOC103014668 ADAMTS1 ADAMTS1 ARL13B ARL13B TEAD2 TEAD2 GSK3A GSK3A PPP1R13L PPP1R13L GATA3 GATA3 TNNI1 TNNI1 TNNT2 TNNT2 SOS1 SOS1 SYNPO2L SYNPO2L DVL2 DVL2 SMAD6 SMAD6 SMAD3 SMAD3 ALDH1A2 ALDH1A2 MYL3 MYL3 SOX17 SOX17 TREX1 TREX1 INSR INSR TGFBR3L TGFBR3L S1PR1 S1PR1 RBM15 RBM15 WNT3A WNT3A DHRS3 DHRS3 MTOR MTOR RYR2 RYR2 TBX5 TBX5 ADGRG6 ADGRG6 SLIT3 SLIT3 FHL2 FHL2 FOXF1 FOXF1 TBX19 TBX19 ZFPM1 ZFPM1 ILK ILK DCHS1 DCHS1 CCN1 CCN1 GRHL2 GRHL2 TGFB2 TGFB2 EDN1 EDN1 BMPR1A BMPR1A TNNC1 TNNC1 LOC103006469 LOC103006469 PARVA PARVA MICALCL MICALCL MICAL2 MICAL2 PROX1 PROX1 PKP2 PKP2 PTCD2 PTCD2 COL4A3BP COL4A3BP TGFBR3 TGFBR3 TMEM100 TMEM100 ZIC3 ZIC3 CPE CPE TEK TEK NPY2R NPY2R WNT16 WNT16 MED1 MED1 TCAP TCAP EFNA1 EFNA1 ADAM15 ADAM15 ARID2 ARID2 ACVRL1 ACVRL1 COL2A1 COL2A1 TBX3 TBX3 CCDC103 CCDC103 FZD2 FZD2 DLL4 DLL4 NPHP3 NPHP3 NSD2 NSD2 ADPRH ADPRH GJA5 GJA5 TBX20 TBX20 DNAAF1 DNAAF1 HEG1 HEG1 XIRP2 XIRP2 LRP2 LRP2 NPY5R NPY5R NPY1R NPY1R ASB2 ASB2 PSEN1 PSEN1 HTR2B HTR2B EYA1 EYA1 SNAI1 SNAI1 BMP7 BMP7 FOXH1 FOXH1 GAA GAA CCDC40 CCDC40 AXIN2 AXIN2 SOX9 SOX9 DLL1 DLL1 POU4F1 POU4F1 TBX6 TBX6 MYL10 MYL10
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
FGF8Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (244 aa)
IHHIndian hedgehog protein. (309 aa)
EMP2Epithelial membrane protein 2; Functions as a key regulator of cell membrane composition by regulating proteins surface expression. Also, plays a role in regulation of processes including cell migration, cell proliferation, cell contraction and cell adhesion; Belongs to the PMP-22/EMP/MP20 family. (167 aa)
FLRT2Leucine-rich repeat transmembrane protein FLRT2. (660 aa)
EXT1Exostosin-1; Belongs to the glycosyltransferase 47 family. (746 aa)
ZFPM2Zinc finger protein ZFPM2 isoform X1. (1151 aa)
TAB1TGF-beta-activated kinase 1 and MAP3K7-binding protein 1. (506 aa)
EDNRAEndothelin-1 receptor; Belongs to the G-protein coupled receptor 1 family. (427 aa)
SFRP2Secreted frizzled-related protein 2. (294 aa)
MYL2Myosin regulatory light chain 2, ventricular/cardiac muscle isoform. (166 aa)
BMP10Bone morphogenetic protein 10. (423 aa)
MSX2Homeobox protein MSX-2. (268 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2 isoform X1. (505 aa)
NKX2-5Homeobox protein Nkx-2.5. (323 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1038 aa)
NRP2Neuropilin; Belongs to the neuropilin family. (931 aa)
HEY2Hairy/enhancer-of-split related with YRPW motif protein 2 isoform X1. (337 aa)
AHI1Jouberin isoform X1. (1197 aa)
SEC24BProtein transport protein Sec24B isoform X1. (1173 aa)
MSX1Homeobox protein MSX-1. (229 aa)
BMP2Bone morphogenetic protein 2. (395 aa)
ALPK2Alpha-protein kinase 2. (419 aa)
NIPBLNipped-B protein. (2803 aa)
CAV3Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (151 aa)
PLXND1plexin-D1. (1747 aa)
HAND2Heart- and neural crest derivatives-expressed protein 2. (130 aa)
SAV1Protein salvador homolog 1. (351 aa)
HIF1AHypoxia-inducible factor 1-alpha isoform X1. (823 aa)
LOC103001360Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (204 aa)
GATA4Transcription factor GATA-4. (229 aa)
MEF2CMyocyte-specific enhancer factor 2C isoform X5. (483 aa)
BMP4Bone morphogenetic protein 4 isoform X1. (420 aa)
SIX1Homeobox protein SIX1. (284 aa)
ASXL1Putative Polycomb group protein ASXL1 isoform X1. (1516 aa)
IFT52Intraflagellar transport protein 52 homolog isoform X1. (461 aa)
MYLK2Myosin light chain kinase 2, skeletal/cardiac muscle. (615 aa)
WNT11Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
ENGEndoglin isoform X1. (652 aa)
COL5A1LOW QUALITY PROTEIN: collagen alpha-1(V) chain. (1899 aa)
LOC103015737Mesoderm posterior protein 1. (126 aa)
WNT2Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (360 aa)
CCDC39Coiled-coil domain-containing protein 39. (941 aa)
HES1Transcription factor HES-1. (280 aa)
ISL1Insulin gene enhancer protein ISL-1. (349 aa)
CRKLCrk-like protein. (303 aa)
ADPRHL1Protein ADP-ribosylarginine hydrolase-like protein 1 isoform X1. (359 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (434 aa)
SOX4Transcription factor SOX-4. (197 aa)
SMAD4Mothers against decapentaplegic homolog. (553 aa)
SMAD7Mothers against decapentaplegic homolog. (426 aa)
GATA6Transcription factor GATA-6. (357 aa)
TBX2LOW QUALITY PROTEIN: T-box transcription factor TBX2. (592 aa)
NOTCH1LOW QUALITY PROTEIN: neurogenic locus notch homolog protein 1. (2379 aa)
APLNRApelin receptor; Belongs to the G-protein coupled receptor 1 family. (400 aa)
MIB1E3 ubiquitin-protein ligase MIB1. (923 aa)
SRFSerum response factor. (464 aa)
NODALNodal homolog. (280 aa)
MEGF8Multiple epidermal growth factor-like domains protein 8. (2787 aa)
CHD7chromodomain-helicase-DNA-binding protein 7. (2829 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (407 aa)
NOTCH2Neurogenic locus notch homolog protein 2 isoform X1. (2471 aa)
LOC114236675LOW QUALITY PROTEIN: folate receptor alpha-like. (249 aa)
C2CD3C2 domain-containing protein 3 isoform X1. (2349 aa)
SHOX2Short stature homeobox protein 2 isoform X1. (332 aa)
EGLN1Egl nine homolog 1 isoform X1. (225 aa)
DSPDesmoplakin isoform X1. (2867 aa)
NOGNoggin. (154 aa)
MKS1Meckel syndrome type 1 protein isoform X2. (608 aa)
PTCH1LOW QUALITY PROTEIN: protein patched homolog 1. (1304 aa)
SMOSmoothened homolog; Belongs to the G-protein coupled receptor Fz/Smo family. (837 aa)
SEMA3Csemaphorin-3C; Belongs to the semaphorin family. (548 aa)
SHHLOW QUALITY PROTEIN: sonic hedgehog protein. (271 aa)
HAND1Heart- and neural crest derivatives-expressed protein 1 isoform X1. (217 aa)
MYBPC3Myosin-binding protein C, cardiac-type isoform X1. (1289 aa)
CLUAP1Clusterin-associated protein 1 isoform X1. (457 aa)
DNAH11Dynein heavy chain 11, axonemal. (4188 aa)
PKD2Polycystin-2. (763 aa)
ZMIZ1Zinc finger MIZ domain-containing protein 1 isoform X1. (1071 aa)
FLNAfilamin-A. (2305 aa)
LOC114238299filamin-A-like. (174 aa)
TBXTT-box transcription factor T isoform X2. (436 aa)
ELNElastin. (857 aa)
LOC103004078LOW QUALITY PROTEIN: hyaluronan synthase 2-like. (552 aa)
RTN4Reticulon. (997 aa)
LEMD2LEM domain-containing protein 2. (358 aa)
IFT57Intraflagellar transport protein 57 homolog. (427 aa)
SUFUSuppressor of fused homolog; Negative regulator in the hedgehog signaling pathway. Down- regulates GLI1-mediated transactivation of target genes. Part of a corepressor complex that acts on DNA-bound GLI1. May also act by linking GLI1 to BTRC and thereby targeting GLI1 to degradation by the proteasome. Sequesters GLI1, GLI2 and GLI3 in the cytoplasm, this effect is overcome by binding of STK36 to both SUFU and a GLI protein. Negative regulator of beta-catenin signaling. Regulates the formation of either the repressor form (GLI3R) or the activator form (GLI3A) of the full-length form of [...] (485 aa)
LBX1Transcription factor LBX1. (282 aa)
ANKRD1LOW QUALITY PROTEIN: ankyrin repeat domain-containing protein 1. (319 aa)
SMARCD3SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 3. (483 aa)
JAG1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1218 aa)
TWIST1Twist-related protein 1. (153 aa)
LOC103001311Transcription factor AP-1-like. (199 aa)
ZMPSTE24CAAX prenyl protease; Proteolytically removes the C-terminal three residues of farnesylated proteins; Belongs to the peptidase M48A family. (475 aa)
HEYLHairy/enhancer-of-split related with YRPW motif-like protein isoform X1. (357 aa)
LOC103014668Transcription factor AP-1; Belongs to the bZIP family. (253 aa)
ADAMTS1A disintegrin and metalloproteinase with thrombospondin motifs 1. (945 aa)
ARL13BADP-ribosylation factor-like protein 13B isoform X1. (430 aa)
TEAD2Transcriptional enhancer factor TEF-4 isoform X1. (451 aa)
GSK3AGlycogen synthase kinase-3 alpha; Belongs to the protein kinase superfamily. (410 aa)
PPP1R13LrelA-associated inhibitor. (814 aa)
GATA3Trans-acting T-cell-specific transcription factor GATA-3 isoform X1. (444 aa)
TNNI1Troponin I, slow skeletal muscle. (221 aa)
TNNT2Troponin T, cardiac muscle isoform X1. (280 aa)
SOS1Son of sevenless homolog 1 isoform X1. (1001 aa)
SYNPO2LSynaptopodin 2-like protein. (1004 aa)
DVL2Segment polarity protein dishevelled homolog DVL-2. (734 aa)
SMAD6Mothers against decapentaplegic homolog. (321 aa)
SMAD3Mothers against decapentaplegic homolog. (425 aa)
ALDH1A2Retinal dehydrogenase 2 isoform X1; Belongs to the aldehyde dehydrogenase family. (518 aa)
MYL3Myosin light chain 3. (199 aa)
SOX17Transcription factor SOX-17. (296 aa)
TREX1Three-prime repair exonuclease 1. (314 aa)
INSRTyrosine-protein kinase receptor. (1343 aa)
TGFBR3LLOW QUALITY PROTEIN: transforming growth factor-beta receptor type 3-like protein. (478 aa)
S1PR1Sphingosine 1-phosphate receptor 1; Belongs to the G-protein coupled receptor 1 family. (382 aa)
RBM15RNA-binding protein 15. (962 aa)
WNT3AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (352 aa)
DHRS3Short-chain dehydrogenase/reductase 3 isoform X1; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (302 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2546 aa)
RYR2Ryanodine receptor 2 isoform X1. (4884 aa)
TBX5T-box transcription factor TBX5 isoform X1. (536 aa)
ADGRG6Adhesion G-protein coupled receptor G6 isoform X1; Belongs to the G-protein coupled receptor 2 family. (1290 aa)
SLIT3Slit homolog 3 protein isoform X1. (1523 aa)
FHL2Four and a half LIM domains protein 2. (279 aa)
FOXF1Forkhead box protein F1. (354 aa)
TBX19T-box transcription factor TBX19. (444 aa)
ZFPM1Zinc finger protein ZFPM1. (874 aa)
ILKIntegrin-linked protein kinase. (452 aa)
DCHS1Protocadherin-16. (3252 aa)
CCN1Protein CYR61. (382 aa)
GRHL2Grainyhead-like protein 2 homolog isoform X1. (625 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
EDN1Endothelin-1. (202 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
TNNC1Troponin C, slow skeletal and cardiac muscles. (161 aa)
LOC103006469Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (152 aa)
PARVAAlpha-parvin. (319 aa)
MICALCLMICAL C-terminal-like protein. (710 aa)
MICAL2F-actin-monooxygenase MICAL2 isoform X1. (1114 aa)
PROX1Prospero homeobox protein 1 isoform X1. (738 aa)
PKP2Plakophilin-2 isoform X1. (826 aa)
PTCD2Pentatricopeptide repeat-containing protein 2, mitochondrial isoform X1. (380 aa)
COL4A3BPCollagen type IV alpha-3-binding protein isoform X3. (757 aa)
TGFBR3Transforming growth factor beta receptor type 3 isoform X1. (863 aa)
TMEM100Transmembrane protein 100. (134 aa)
ZIC3Zinc finger protein ZIC 3. (163 aa)
CPECarboxypeptidase E. (397 aa)
TEKAngiopoietin-1 receptor isoform X1. (1125 aa)
NPY2RNeuropeptide Y receptor type 2; Belongs to the G-protein coupled receptor 1 family. (384 aa)
WNT16Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (361 aa)
MED1Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1578 aa)
TCAPTelethonin. (167 aa)
EFNA1ephrin-A1; Belongs to the ephrin family. (205 aa)
ADAM15Disintegrin and metalloproteinase domain-containing protein 15 isoform X1. (875 aa)
ARID2AT-rich interactive domain-containing protein 2. (1687 aa)
ACVRL1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (515 aa)
COL2A1Collagen alpha-1(II) chain. (1418 aa)
TBX3T-box transcription factor TBX3. (670 aa)
CCDC103Coiled-coil domain-containing protein 103. (235 aa)
FZD2Frizzled-2; Belongs to the G-protein coupled receptor Fz/Smo family. (565 aa)
DLL4Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (685 aa)
NPHP3Nephrocystin-3 isoform X1. (1191 aa)
NSD2Histone-lysine N-methyltransferase NSD2 isoform X4. (1358 aa)
ADPRHADP-ribosylarginine hydrolase. (362 aa)
GJA5Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. (358 aa)
TBX20T-box transcription factor TBX20. (449 aa)
DNAAF1Dynein assembly factor 1, axonemal. (648 aa)
HEG1Protein HEG homolog 1. (1339 aa)
XIRP2Xin actin-binding repeat-containing protein 2 isoform X1. (3319 aa)
LRP2Low-density lipoprotein receptor-related protein 2. (4651 aa)
NPY5RNeuropeptide Y receptor type 5. (456 aa)
NPY1RNeuropeptide Y receptor type 1; Belongs to the G-protein coupled receptor 1 family. (383 aa)
ASB2Ankyrin repeat and SOCS box protein 2. (633 aa)
PSEN1Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (469 aa)
HTR2B5-hydroxytryptamine receptor 2B isoform X1. (537 aa)
EYA1Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (584 aa)
SNAI1Zinc finger protein SNAI1. (264 aa)
BMP7Bone morphogenetic protein 7. (431 aa)
FOXH1Forkhead box protein H1. (360 aa)
GAALysosomal alpha-glucosidase isoform X1; Belongs to the glycosyl hydrolase 31 family. (940 aa)
CCDC40Coiled-coil domain-containing protein 40. (1131 aa)
AXIN2Axin-2. (543 aa)
SOX9Transcription factor SOX-9. (432 aa)
DLL1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (719 aa)
POU4F1POU domain protein. (298 aa)
TBX6T-box transcription factor TBX6. (436 aa)
MYL10Myosin regulatory light chain 10. (167 aa)
Your Current Organism:
Balaenoptera acutorostrata
NCBI taxonomy Id: 310752
Other names: B. acutorostrata scammoni, Balaenoptera acutorostrata scammoni
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