STRINGSTRING
WDR19 WDR19 GLI3 GLI3 TLL2 TLL2 FGF8 FGF8 FBXL15 FBXL15 SUFU SUFU PSEN1 PSEN1 BMPR1B BMPR1B ACVR1 ACVR1 TBX20 TBX20 DMRT3 DMRT3 SFRP1 SFRP1 AXIN1 AXIN1 LRP4 LRP4 PAX6 PAX6 NKX2-1 NKX2-1 FOXG1 FOXG1 DLL4 DLL4 FOXN4 FOXN4 GLI1 GLI1 TCTN1 TCTN1 SIX3 SIX3 LHX1 LHX1 TBC1D32 TBC1D32 NKX2-2 NKX2-2 ZFR ZFR BMP4 BMP4 IFT52 IFT52 CTNNB1 CTNNB1 LHX3 LHX3 MDFI MDFI SP8 SP8 LHX2 LHX2 CHRD CHRD LOC103016245 LOC103016245 HOXA2 HOXA2 NOG NOG HOXB2 HOXB2 PTCH1 PTCH1 SMO SMO SHH SHH GREM1 GREM1 TTC21B TTC21B ACVRL1 ACVRL1 HHIP HHIP FOXA1 FOXA1 CER1 CER1 TLL1 TLL1 WNT3 WNT3 VAX2 VAX2 DBX1 DBX1 BMPR1A BMPR1A EDN1 EDN1 INTU INTU AIDA AIDA DISP1 DISP1 HOXA11 HOXA11 TULP3 TULP3 WNT3A WNT3A EN1 EN1 ZFR2 ZFR2 GSX2 GSX2 BMP1 BMP1 ASCL1 ASCL1 SMAD6 SMAD6 RFX4 RFX4 RNF220 RNF220 ARL13B ARL13B
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
WDR19WD repeat-containing protein 19 isoform X1. (1342 aa)
GLI3Transcriptional activator GLI3 isoform X1. (1591 aa)
TLL2Metalloendopeptidase. (1020 aa)
FGF8Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (244 aa)
FBXL15F-box/LRR-repeat protein 15. (300 aa)
SUFUSuppressor of fused homolog; Negative regulator in the hedgehog signaling pathway. Down- regulates GLI1-mediated transactivation of target genes. Part of a corepressor complex that acts on DNA-bound GLI1. May also act by linking GLI1 to BTRC and thereby targeting GLI1 to degradation by the proteasome. Sequesters GLI1, GLI2 and GLI3 in the cytoplasm, this effect is overcome by binding of STK36 to both SUFU and a GLI protein. Negative regulator of beta-catenin signaling. Regulates the formation of either the repressor form (GLI3R) or the activator form (GLI3A) of the full-length form of [...] (485 aa)
PSEN1Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (469 aa)
BMPR1BSerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (502 aa)
ACVR1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (509 aa)
TBX20T-box transcription factor TBX20. (449 aa)
DMRT3Doublesex- and mab-3-related transcription factor 3. (506 aa)
SFRP1Secreted frizzled-related protein 1. (295 aa)
AXIN1Axin-1 isoform X1. (866 aa)
LRP4Low-density lipoprotein receptor-related protein 4. (1901 aa)
PAX6Paired box protein Pax-6 isoform X1. (493 aa)
NKX2-1Homeobox protein Nkx-2.1. (296 aa)
FOXG1Forkhead box protein G1. (352 aa)
DLL4Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (685 aa)
FOXN4Forkhead box protein N4. (518 aa)
GLI1Zinc finger protein GLI1. (1106 aa)
TCTN1Tectonic-1 isoform X1. (588 aa)
SIX3Homeobox protein SIX3. (331 aa)
LHX1LIM/homeobox protein Lhx1. (406 aa)
TBC1D32Protein broad-minded. (1299 aa)
NKX2-2Homeobox protein Nkx-2.2. (273 aa)
ZFRZinc finger RNA-binding protein isoform X1. (1029 aa)
BMP4Bone morphogenetic protein 4 isoform X1. (420 aa)
IFT52Intraflagellar transport protein 52 homolog isoform X1. (461 aa)
CTNNB1Catenin beta-1. (767 aa)
LHX3LIM/homeobox protein Lhx3. (493 aa)
MDFImyoD family inhibitor. (246 aa)
SP8LOW QUALITY PROTEIN: transcription factor Sp8. (174 aa)
LHX2LOW QUALITY PROTEIN: LIM/homeobox protein Lhx2. (406 aa)
CHRDChordin; Dorsalizing factor. Key developmental protein that dorsalizes early vertebrate embryonic tissues by binding to ventralizing TGF-beta family bone morphogenetic proteins (BMPs) and sequestering them in latent complexes. (943 aa)
LOC103016245LOW QUALITY PROTEIN: tubby-related protein 3-like; Belongs to the TUB family. (319 aa)
HOXA2LOW QUALITY PROTEIN: homeobox protein Hox-A2. (369 aa)
NOGNoggin. (154 aa)
HOXB2LOW QUALITY PROTEIN: homeobox protein Hox-B2. (356 aa)
PTCH1LOW QUALITY PROTEIN: protein patched homolog 1. (1304 aa)
SMOSmoothened homolog; Belongs to the G-protein coupled receptor Fz/Smo family. (837 aa)
SHHLOW QUALITY PROTEIN: sonic hedgehog protein. (271 aa)
GREM1Gremlin. (184 aa)
TTC21BTetratricopeptide repeat protein 21B isoform X1. (1331 aa)
ACVRL1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (515 aa)
HHIPHedgehog-interacting protein isoform X1. (700 aa)
FOXA1Hepatocyte nuclear factor 3-alpha. (433 aa)
CER1Cerberus. (273 aa)
TLL1Metalloendopeptidase. (1013 aa)
WNT3Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (355 aa)
VAX2Ventral anterior homeobox 2. (340 aa)
DBX1Homeobox protein DBX1. (349 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
EDN1Endothelin-1. (202 aa)
INTUProtein inturned. (935 aa)
AIDAAxin interactor, dorsalization-associated protein. (306 aa)
DISP1Protein dispatched homolog 1 isoform X1. (1555 aa)
HOXA11Homeobox protein Hox-A11. (314 aa)
TULP3Tubby-like protein; Belongs to the TUB family. (456 aa)
WNT3AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (352 aa)
EN1Homeobox protein engrailed-like. (206 aa)
ZFR2Zinc finger RNA-binding protein 2 isoform X1. (949 aa)
GSX2GS homeobox 2. (299 aa)
BMP1Metalloendopeptidase. (981 aa)
ASCL1Achaete-scute homolog 1. (169 aa)
SMAD6Mothers against decapentaplegic homolog. (321 aa)
RFX4Transcription factor RFX4 isoform X1. (735 aa)
RNF220E3 ubiquitin-protein ligase RNF220. (566 aa)
ARL13BADP-ribosylation factor-like protein 13B isoform X1. (430 aa)
Your Current Organism:
Balaenoptera acutorostrata
NCBI taxonomy Id: 310752
Other names: B. acutorostrata scammoni, Balaenoptera acutorostrata scammoni
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