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BMP7 BMP7 NOTUM NOTUM SOX9 SOX9 MAPK3 MAPK3 FZD9 FZD9 ANKH ANKH FBN2 FBN2 ADRB2 ADRB2 TOB2 TOB2 LOC103013500 LOC103013500 P2RX7 P2RX7 SIX2 SIX2 BMPR2 BMPR2 ENPP1 ENPP1 SGMS2 SGMS2 DDR2 DDR2 ATRAID ATRAID ACVR2B ACVR2B BMP2 BMP2 BCL2 BCL2 NIPBL NIPBL PTGER4 PTGER4 HIF1A HIF1A LOC103001360 LOC103001360 MEF2C MEF2C BMP4 BMP4 KL KL RUNX2 RUNX2 AHSG AHSG SOX11 SOX11 CALCR CALCR COMP COMP MAPK1 MAPK1 MGP MGP SMAD7 SMAD7 NOTCH1 NOTCH1 TGFB1 TGFB1 LTBP3 LTBP3 PTPN11 PTPN11 GREM1 GREM1 LOC103002046 LOC103002046 LOC103002330 LOC103002330 LOC103017184 LOC103017184 PTK2B PTK2B OMD OMD SFRP1 SFRP1 GPM6B GPM6B KREMEN2 KREMEN2 LRP4 LRP4 SOST SOST BCOR BCOR TMEM119 TMEM119 LOC103001013 LOC103001013 WNT10B WNT10B ANO6 ANO6 CHSY1 CHSY1 ECM1 ECM1 LOC103007666 LOC103007666 LOC103005722 LOC103005722 PTN PTN ALOX5 ALOX5 PTH PTH LOC103006469 LOC103006469 BMPR1A BMPR1A GPR137 GPR137 TFAP2A TFAP2A BMP6 BMP6 TGFB2 TGFB2 TXLNG TXLNG CCN1 CCN1 SCUBE2 SCUBE2 INTU INTU ZBTB16 ZBTB16 BGLAP BGLAP KREMEN1 KREMEN1 ACTN3 ACTN3 EGR2 EGR2 MATN1 MATN1 FGF23 FGF23 DHRS3 DHRS3 CSF1 CSF1 S1PR1 S1PR1 LTF LTF TENT5A TENT5A SRGN SRGN PKDCC PKDCC SLC8A1 SLC8A1 ISG15 ISG15 SMAD6 SMAD6 ATP2B1 ATP2B1 BMP2K BMP2K TWIST1 TWIST1 OSR2 OSR2 ZMPSTE24 ZMPSTE24 ACVR2A ACVR2A OSR1 OSR1 RFLNB RFLNB BMPR1B BMPR1B TGFB3 TGFB3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
BMP7Bone morphogenetic protein 7. (431 aa)
NOTUMPalmitoleoyl-protein carboxylesterase NOTUM isoform X1. (356 aa)
SOX9Transcription factor SOX-9. (432 aa)
MAPK3Mitogen-activated protein kinase 3. (265 aa)
FZD9Frizzled-9; Belongs to the G-protein coupled receptor Fz/Smo family. (408 aa)
ANKHProgressive ankylosis protein homolog isoform X1. (492 aa)
FBN2Fibrillin-2. (2784 aa)
ADRB2Beta-2 adrenergic receptor isoform X1. (449 aa)
TOB2LOW QUALITY PROTEIN: protein Tob2. (344 aa)
LOC103013500refilin-A. (199 aa)
P2RX7P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. Belongs to the P2X receptor family. (595 aa)
SIX2Homeobox protein SIX2 isoform X1. (298 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1038 aa)
ENPP1Ectonucleotide pyrophosphatase/phosphodiesterase family member 1. (873 aa)
SGMS2Phosphatidylcholine:ceramide cholinephosphotransferase 2. (323 aa)
DDR2Discoidin domain-containing receptor 2. (855 aa)
ATRAIDAll-trans retinoic acid-induced differentiation factor isoform X1. (271 aa)
ACVR2BSerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (354 aa)
BMP2Bone morphogenetic protein 2. (395 aa)
BCL2Apoptosis regulator Bcl-2 isoform X1. (233 aa)
NIPBLNipped-B protein. (2803 aa)
PTGER4Prostaglandin E2 receptor EP4 subtype; Belongs to the G-protein coupled receptor 1 family. (489 aa)
HIF1AHypoxia-inducible factor 1-alpha isoform X1. (823 aa)
LOC103001360Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (204 aa)
MEF2CMyocyte-specific enhancer factor 2C isoform X5. (483 aa)
BMP4Bone morphogenetic protein 4 isoform X1. (420 aa)
KLKlotho. (959 aa)
RUNX2Runt-related transcription factor 2. (343 aa)
AHSGalpha-2-HS-glycoprotein isoform X1. (432 aa)
SOX11Transcription factor SOX-11. (200 aa)
CALCRCalcitonin receptor; Belongs to the G-protein coupled receptor 2 family. (532 aa)
COMPCartilage oligomeric matrix protein. (658 aa)
MAPK1Mitogen-activated protein kinase 1. (263 aa)
MGPMatrix Gla protein; Associates with the organic matrix of bone and cartilage. (103 aa)
SMAD7Mothers against decapentaplegic homolog. (426 aa)
NOTCH1LOW QUALITY PROTEIN: neurogenic locus notch homolog protein 1. (2379 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (407 aa)
LTBP3LOW QUALITY PROTEIN: latent-transforming growth factor beta-binding protein 3. (1209 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (623 aa)
GREM1Gremlin. (184 aa)
LOC103002046Gamma-taxilin-like. (616 aa)
LOC103002330LOW QUALITY PROTEIN: BCL-6 corepressor-like. (1668 aa)
LOC103017184Cytochrome P450 27C1; Belongs to the cytochrome P450 family. (466 aa)
PTK2BProtein-tyrosine kinase 2-beta isoform X1; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1017 aa)
OMDOsteomodulin. (422 aa)
SFRP1Secreted frizzled-related protein 1. (295 aa)
GPM6BNeuronal membrane glycoprotein M6-b isoform X1. (328 aa)
KREMEN2Kremen protein; Receptor for Dickkopf proteins. Cooperates with DKK1/2 to inhibit Wnt/beta-catenin signaling by promoting the endocytosis of Wnt receptors LRP5 and LRP6. (461 aa)
LRP4Low-density lipoprotein receptor-related protein 4. (1901 aa)
SOSTSclerostin. (212 aa)
BCORBCL-6 corepressor isoform X1. (1757 aa)
TMEM119Transmembrane protein 119. (304 aa)
LOC10300101325-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial isoform X1; Belongs to the cytochrome P450 family. (508 aa)
WNT10BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (389 aa)
ANO6Anoctamin. (897 aa)
CHSY1Hexosyltransferase. (652 aa)
ECM1Extracellular matrix protein 1 isoform X1. (543 aa)
LOC103007666Next to BRCA1 gene 1 protein isoform X1. (985 aa)
LOC103005722Next to BRCA1 gene 1 protein isoform X1. (985 aa)
PTNPleiotrophin isoform X1. (168 aa)
ALOX5Arachidonate 5-lipoxygenase isoform X1. (674 aa)
PTHParathyroid hormone; PTH elevates calcium level by dissolving the salts in bone and preventing their renal excretion; Belongs to the parathyroid hormone family. (115 aa)
LOC103006469Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (152 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
GPR137Integral membrane protein GPR137. (418 aa)
TFAP2ATranscription factor AP-2-alpha isoform X1. (439 aa)
BMP6Bone morphogenetic protein 6. (388 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
TXLNGGamma-taxilin isoform X1. (397 aa)
CCN1Protein CYR61. (382 aa)
SCUBE2Signal peptide, CUB and EGF-like domain-containing protein 2 isoform X1. (942 aa)
INTUProtein inturned. (935 aa)
ZBTB16Zinc finger and BTB domain-containing protein 16 isoform X1. (673 aa)
BGLAPOsteocalcin; Binds strongly to apatite and calcium. (100 aa)
KREMEN1Kremen protein; Receptor for Dickkopf proteins. Cooperates with DKK1/2 to inhibit Wnt/beta-catenin signaling by promoting the endocytosis of Wnt receptors LRP5 and LRP6. (453 aa)
ACTN3Alpha-actinin-3. (902 aa)
EGR2E3 SUMO-protein ligase EGR2. (472 aa)
MATN1Cartilage matrix protein. (495 aa)
FGF23Fibroblast growth factor 23; Belongs to the heparin-binding growth factors family. (231 aa)
DHRS3Short-chain dehydrogenase/reductase 3 isoform X1; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (302 aa)
CSF1Macrophage colony-stimulating factor 1. (513 aa)
S1PR1Sphingosine 1-phosphate receptor 1; Belongs to the G-protein coupled receptor 1 family. (382 aa)
LTFLactotransferrin; Belongs to the transferrin family. (725 aa)
TENT5ATerminal nucleotidyltransferase 5A. (424 aa)
SRGNSerglycin. (151 aa)
PKDCCExtracellular tyrosine-protein kinase PKDCC. (371 aa)
SLC8A1Sodium/calcium exchanger 1 isoform X1; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (991 aa)
ISG15Ubiquitin-like protein ISG15. (170 aa)
SMAD6Mothers against decapentaplegic homolog. (321 aa)
ATP2B1Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1249 aa)
BMP2KBMP-2-inducible protein kinase isoform X1. (1046 aa)
TWIST1Twist-related protein 1. (153 aa)
OSR2Protein odd-skipped-related 2 isoform X1. (312 aa)
ZMPSTE24CAAX prenyl protease; Proteolytically removes the C-terminal three residues of farnesylated proteins; Belongs to the peptidase M48A family. (475 aa)
ACVR2ASerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (513 aa)
OSR1Protein odd-skipped-related 1. (267 aa)
RFLNBrefilin-B. (175 aa)
BMPR1BSerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (502 aa)
TGFB3Transforming growth factor beta-3 proprotein. (456 aa)
Your Current Organism:
Balaenoptera acutorostrata
NCBI taxonomy Id: 310752
Other names: B. acutorostrata scammoni, Balaenoptera acutorostrata scammoni
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