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BMP4 BMP4 SMPD3 SMPD3 ZCCHC12 ZCCHC12 LOC103011746 LOC103011746 SMAD9 SMAD9 CHRD CHRD NOTCH2 NOTCH2 MEGF8 MEGF8 NODAL NODAL DSG4 DSG4 SMAD7 SMAD7 SMAD4 SMAD4 SMAD2 SMAD2 LOC103020685 LOC103020685 NANOG NANOG TWSG1 TWSG1 LOC102997132 LOC102997132 NOG NOG ETV2 ETV2 ZNF831 ZNF831 RGMB RGMB GDF3 GDF3 COMP COMP LOC103000722 LOC103000722 FST FST HES1 HES1 GDF15 GDF15 ABL1 ABL1 RUNX2 RUNX2 SPART SPART GDF5 GDF5 LOC103001360 LOC103001360 SLC33A1 SLC33A1 DLX5 DLX5 SOSTDC1 SOSTDC1 LOC103015222 LOC103015222 RGMA RGMA GDF6 GDF6 TMPRSS6 TMPRSS6 SMAD3 SMAD3 SMAD6 SMAD6 LOC103014954 LOC103014954 LOC103002500 LOC103002500 LOC103005758 LOC103005758 TGFBR3L TGFBR3L SMAD5 SMAD5 EGR1 EGR1 PDCD4 PDCD4 TGFB2 TGFB2 HIVEP1 HIVEP1 BMP6 BMP6 LOC103011711 LOC103011711 FAM83G FAM83G BMPR1A BMPR1A LOC103006469 LOC103006469 BMPER BMPER DDX5 DDX5 TGFBR3 TGFBR3 TMEM100 TMEM100 DLX3 DLX3 LOC103008528 LOC103008528 HFE HFE GDF2 GDF2 ACVRL1 ACVRL1 SLC39A5 SLC39A5 USP15 USP15 SOST SOST CHRDL1 CHRDL1 SFRP1 SFRP1 HJV HJV LOC103007083 LOC103007083 ACVR2A ACVR2A ACVR1 ACVR1 CCDC142 CCDC142 BMPR1B BMPR1B TGFB3 TGFB3 LOC103015599 LOC103015599 BMP7 BMP7 USP9X USP9X MAPK3 MAPK3 SMURF1 SMURF1 BMP5 BMP5 EXT1 EXT1 SMAD1 SMAD1 SFRP2 SFRP2 BMP10 BMP10 MSX2 MSX2 ATF2 ATF2 BMPR2 BMPR2 MSX1 MSX1 ACVR2B ACVR2B BMP2 BMP2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
BMP4Bone morphogenetic protein 4 isoform X1. (420 aa)
SMPD3Sphingomyelin phosphodiesterase 3. (656 aa)
ZCCHC12LOW QUALITY PROTEIN: zinc finger CCHC domain-containing protein 12. (403 aa)
LOC103011746Zinc finger CCHC domain-containing protein 18. (326 aa)
SMAD9Mothers against decapentaplegic homolog. (440 aa)
CHRDChordin; Dorsalizing factor. Key developmental protein that dorsalizes early vertebrate embryonic tissues by binding to ventralizing TGF-beta family bone morphogenetic proteins (BMPs) and sequestering them in latent complexes. (943 aa)
NOTCH2Neurogenic locus notch homolog protein 2 isoform X1. (2471 aa)
MEGF8Multiple epidermal growth factor-like domains protein 8. (2787 aa)
NODALNodal homolog. (280 aa)
DSG4LOW QUALITY PROTEIN: desmoglein-4. (679 aa)
SMAD7Mothers against decapentaplegic homolog. (426 aa)
SMAD4Mothers against decapentaplegic homolog. (553 aa)
SMAD2Mothers against decapentaplegic homolog. (467 aa)
LOC103020685Bone morphogenetic protein 8B-like. (201 aa)
NANOGHomeobox protein NANOG isoform X1. (307 aa)
TWSG1Twisted gastrulation protein homolog 1 isoform X1. (223 aa)
LOC102997132LOW QUALITY PROTEIN: probable ATP-dependent RNA helicase DDX5; Belongs to the DEAD box helicase family. (620 aa)
NOGNoggin. (154 aa)
ETV2ETS translocation variant 2 isoform X1. (333 aa)
ZNF831LOW QUALITY PROTEIN: zinc finger protein 831. (1520 aa)
RGMBRGM domain family member B. (409 aa)
GDF3Growth/differentiation factor 3. (364 aa)
COMPCartilage oligomeric matrix protein. (658 aa)
LOC103000722Bone morphogenetic protein 8A-like. (220 aa)
FSTFollistatin isoform X1. (344 aa)
HES1Transcription factor HES-1. (280 aa)
GDF15Growth/differentiation factor 15. (307 aa)
ABL1Tyrosine-protein kinase. (1149 aa)
RUNX2Runt-related transcription factor 2. (343 aa)
SPARTSpartin isoform X1. (668 aa)
GDF5Growth/differentiation factor 5. (511 aa)
LOC103001360Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (204 aa)
SLC33A1Acetyl-coenzyme A transporter 1 isoform X1. (546 aa)
DLX5Homeobox protein DLX-5. (289 aa)
SOSTDC1Sclerostin domain-containing protein 1. (206 aa)
LOC103015222Bone morphogenetic protein 8B. (390 aa)
RGMARepulsive guidance molecule A isoform X2. (345 aa)
GDF6Growth/differentiation factor 6. (375 aa)
TMPRSS6Transmembrane protease serine 6; Belongs to the peptidase S1 family. (800 aa)
SMAD3Mothers against decapentaplegic homolog. (425 aa)
SMAD6Mothers against decapentaplegic homolog. (321 aa)
LOC103014954Bone morphogenetic protein 8A-like. (279 aa)
LOC103002500Left-right determination factor. (367 aa)
LOC103005758Left-right determination factor 2. (226 aa)
TGFBR3LLOW QUALITY PROTEIN: transforming growth factor-beta receptor type 3-like protein. (478 aa)
SMAD5Mothers against decapentaplegic homolog. (465 aa)
EGR1Early growth response protein; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Belongs to the EGR C2H2-type zinc-finger protein family. (539 aa)
PDCD4Programmed cell death protein 4. (470 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
HIVEP1LOW QUALITY PROTEIN: zinc finger protein 40. (2544 aa)
BMP6Bone morphogenetic protein 6. (388 aa)
LOC103011711Bone morphogenetic protein 8A. (109 aa)
FAM83GProtein FAM83G. (556 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
LOC103006469Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (152 aa)
BMPERBMP-binding endothelial regulator protein. (685 aa)
DDX5Probable ATP-dependent RNA helicase DDX5; Belongs to the DEAD box helicase family. (614 aa)
TGFBR3Transforming growth factor beta receptor type 3 isoform X1. (863 aa)
TMEM100Transmembrane protein 100. (134 aa)
DLX3Homeobox protein DLX-3. (287 aa)
LOC103008528Bone morphogenetic protein 8A-like. (112 aa)
HFEHereditary hemochromatosis protein isoform X1; Belongs to the MHC class I family. (356 aa)
GDF2Growth/differentiation factor 2. (432 aa)
ACVRL1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (515 aa)
SLC39A5Zinc transporter ZIP5. (541 aa)
USP15Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (981 aa)
SOSTSclerostin. (212 aa)
CHRDL1Chordin-like protein 1 isoform X1. (379 aa)
SFRP1Secreted frizzled-related protein 1. (295 aa)
HJVLOW QUALITY PROTEIN: hemojuvelin. (428 aa)
LOC103007083Early growth response protein 1-like. (215 aa)
ACVR2ASerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (513 aa)
ACVR1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (509 aa)
CCDC142Coiled-coil domain-containing protein 142 isoform X1. (792 aa)
BMPR1BSerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (502 aa)
TGFB3Transforming growth factor beta-3 proprotein. (456 aa)
LOC103015599Probable ubiquitin carboxyl-terminal hydrolase FAF-X isoform X1; Belongs to the peptidase C19 family. (2559 aa)
BMP7Bone morphogenetic protein 7. (431 aa)
USP9XProbable ubiquitin carboxyl-terminal hydrolase FAF-X isoform X1; Belongs to the peptidase C19 family. (2577 aa)
MAPK3Mitogen-activated protein kinase 3. (265 aa)
SMURF1E3 ubiquitin-protein ligase SMURF1. (719 aa)
BMP5Bone morphogenetic protein 5. (454 aa)
EXT1Exostosin-1; Belongs to the glycosyltransferase 47 family. (746 aa)
SMAD1Mothers against decapentaplegic homolog. (465 aa)
SFRP2Secreted frizzled-related protein 2. (294 aa)
BMP10Bone morphogenetic protein 10. (423 aa)
MSX2Homeobox protein MSX-2. (268 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2 isoform X1. (505 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1038 aa)
MSX1Homeobox protein MSX-1. (229 aa)
ACVR2BSerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (354 aa)
BMP2Bone morphogenetic protein 2. (395 aa)
Your Current Organism:
Balaenoptera acutorostrata
NCBI taxonomy Id: 310752
Other names: B. acutorostrata scammoni, Balaenoptera acutorostrata scammoni
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