STRINGSTRING
SFRP5 SFRP5 UBE2O UBE2O SKOR1 SKOR1 GREM1 GREM1 KCP KCP ITGA3 ITGA3 NOG NOG NUMA1 NUMA1 NOTCH2 NOTCH2 LOC103006152 LOC103006152 SCUBE3 SCUBE3 CHRD CHRD NOTCH1 NOTCH1 CDH5 CDH5 NEO1 NEO1 SKIL SKIL SKOR2 SKOR2 SMAD7 SMAD7 RNF165 RNF165 SMAD4 SMAD4 SORL1 SORL1 NANOG NANOG TWSG1 TWSG1 CTDSPL2 CTDSPL2 PELO PELO HES1 HES1 CRB2 CRB2 ENG ENG ABL1 ABL1 TFAP2B TFAP2B SPART SPART GDF5 GDF5 BMP4 BMP4 LOC103001360 LOC103001360 PPM1A PPM1A CRIM1 CRIM1 MSX1 MSX1 BMPR2 BMPR2 MSX2 MSX2 SFRP2 SFRP2 BAMBI BAMBI VWC2L VWC2L FBXL15 FBXL15 LEMD2 LEMD2 SMURF1 SMURF1 SMURF2 SMURF2 SULF1 SULF1 DLX1 DLX1 LRP2 LRP2 TNFAIP6 TNFAIP6 TBX20 TBX20 HJV HJV SFRP1 SFRP1 CHRDL1 CHRDL1 SOST SOST LEMD3 LEMD3 ACVRL1 ACVRL1 WNT1 WNT1 GDF2 GDF2 VWC2 VWC2 HIPK2 HIPK2 CER1 CER1 FSTL3 FSTL3 TOB1 TOB1 NBL1 NBL1 BMPER BMPER LOC103006469 LOC103006469 GPC3 GPC3 CHRDL2 CHRDL2 HTRA1 HTRA1 CCN1 CCN1 ILK ILK HTRA3 HTRA3 HOXA13 HOXA13 FBN1 FBN1 KIAA1324L KIAA1324L TRIM33 TRIM33 KDR KDR ZNF423 ZNF423 SKI SKI SMAD6 SMAD6 TMPRSS6 TMPRSS6 SOSTDC1 SOSTDC1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SFRP5Secreted frizzled-related protein 5. (247 aa)
UBE2OLOW QUALITY PROTEIN: (E3-independent) E2 ubiquitin-conjugating enzyme. (1138 aa)
SKOR1SKI family transcriptional corepressor 1. (735 aa)
GREM1Gremlin. (184 aa)
KCPLOW QUALITY PROTEIN: kielin/chordin-like protein. (1630 aa)
ITGA3Integrin alpha-3; Belongs to the integrin alpha chain family. (1048 aa)
NOGNoggin. (154 aa)
NUMA1Nuclear mitotic apparatus protein 1 isoform X1. (2153 aa)
NOTCH2Neurogenic locus notch homolog protein 2 isoform X1. (2471 aa)
LOC103006152LOW QUALITY PROTEIN: secreted frizzled-related protein 5-like. (285 aa)
SCUBE3Signal peptide, CUB and EGF-like domain-containing protein 3 isoform X1. (1004 aa)
CHRDChordin; Dorsalizing factor. Key developmental protein that dorsalizes early vertebrate embryonic tissues by binding to ventralizing TGF-beta family bone morphogenetic proteins (BMPs) and sequestering them in latent complexes. (943 aa)
NOTCH1LOW QUALITY PROTEIN: neurogenic locus notch homolog protein 1. (2379 aa)
CDH5Cadherin-5 isoform X1; Cadherins are calcium-dependent cell adhesion proteins. (782 aa)
NEO1Neogenin. (1444 aa)
SKILSki-like protein isoform X2. (684 aa)
SKOR2SKI family transcriptional corepressor 2. (586 aa)
SMAD7Mothers against decapentaplegic homolog. (426 aa)
RNF165LOW QUALITY PROTEIN: E3 ubiquitin-protein ligase RNF165. (347 aa)
SMAD4Mothers against decapentaplegic homolog. (553 aa)
SORL1Sortilin-related receptor isoform X1. (2110 aa)
NANOGHomeobox protein NANOG isoform X1. (307 aa)
TWSG1Twisted gastrulation protein homolog 1 isoform X1. (223 aa)
CTDSPL2CTD small phosphatase-like protein 2. (466 aa)
PELOProtein pelota homolog; May function in recognizing stalled ribosomes and triggering endonucleolytic cleavage of the mRNA, a mechanism to release non- functional ribosomes and degrade damaged mRNAs. (385 aa)
HES1Transcription factor HES-1. (280 aa)
CRB2Protein crumbs homolog 2. (1075 aa)
ENGEndoglin isoform X1. (652 aa)
ABL1Tyrosine-protein kinase. (1149 aa)
TFAP2BTranscription factor AP-2-beta isoform X1. (467 aa)
SPARTSpartin isoform X1. (668 aa)
GDF5Growth/differentiation factor 5. (511 aa)
BMP4Bone morphogenetic protein 4 isoform X1. (420 aa)
LOC103001360Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (204 aa)
PPM1AProtein phosphatase 1A isoform X1. (382 aa)
CRIM1Cysteine-rich motor neuron 1 protein isoform X2. (1037 aa)
MSX1Homeobox protein MSX-1. (229 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1038 aa)
MSX2Homeobox protein MSX-2. (268 aa)
SFRP2Secreted frizzled-related protein 2. (294 aa)
BAMBIBMP and activin membrane-bound inhibitor homolog; Negatively regulates TGF-beta signaling. Belongs to the BAMBI family. (247 aa)
VWC2LVon Willebrand factor C domain-containing protein 2-like. (222 aa)
FBXL15F-box/LRR-repeat protein 15. (300 aa)
LEMD2LEM domain-containing protein 2. (358 aa)
SMURF1E3 ubiquitin-protein ligase SMURF1. (719 aa)
SMURF2E3 ubiquitin-protein ligase. (735 aa)
SULF1Extracellular sulfatase Sulf-1 isoform X1. (1041 aa)
DLX1Homeobox protein DLX-1 isoform X1. (255 aa)
LRP2Low-density lipoprotein receptor-related protein 2. (4651 aa)
TNFAIP6Tumor necrosis factor-inducible gene 6 protein. (277 aa)
TBX20T-box transcription factor TBX20. (449 aa)
HJVLOW QUALITY PROTEIN: hemojuvelin. (428 aa)
SFRP1Secreted frizzled-related protein 1. (295 aa)
CHRDL1Chordin-like protein 1 isoform X1. (379 aa)
SOSTSclerostin. (212 aa)
LEMD3Inner nuclear membrane protein Man1 isoform X1. (917 aa)
ACVRL1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (515 aa)
WNT1Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa)
GDF2Growth/differentiation factor 2. (432 aa)
VWC2Brorin. (206 aa)
HIPK2Homeodomain-interacting protein kinase 2 isoform X1. (1207 aa)
CER1Cerberus. (273 aa)
FSTL3Follistatin-related protein 3. (266 aa)
TOB1Protein Tob1. (344 aa)
NBL1Neuroblastoma suppressor of tumorigenicity 1. (176 aa)
BMPERBMP-binding endothelial regulator protein. (685 aa)
LOC103006469Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (152 aa)
GPC3Glypican-3; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. (504 aa)
CHRDL2Chordin-like protein 2 isoform X1. (452 aa)
HTRA1Serine protease HTRA1. (368 aa)
CCN1Protein CYR61. (382 aa)
ILKIntegrin-linked protein kinase. (452 aa)
HTRA3LOW QUALITY PROTEIN: serine protease HTRA3. (418 aa)
HOXA13Homeobox protein Hox-A13. (294 aa)
FBN1LOW QUALITY PROTEIN: fibrillin-1. (2876 aa)
KIAA1324LUPF0577 protein KIAA1324-like homolog. (915 aa)
TRIM33E3 ubiquitin-protein ligase TRIM33. (1088 aa)
KDRVascular endothelial growth factor receptor 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1356 aa)
ZNF423Zinc finger protein 423. (1224 aa)
SKISki oncogene. (772 aa)
SMAD6Mothers against decapentaplegic homolog. (321 aa)
TMPRSS6Transmembrane protease serine 6; Belongs to the peptidase S1 family. (800 aa)
SOSTDC1Sclerostin domain-containing protein 1. (206 aa)
Your Current Organism:
Balaenoptera acutorostrata
NCBI taxonomy Id: 310752
Other names: B. acutorostrata scammoni, Balaenoptera acutorostrata scammoni
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