STRINGSTRING
PACRG PACRG ARRDC1 ARRDC1 UBE2T UBE2T GABARAPL2 GABARAPL2 MAP1LC3C MAP1LC3C TXNIP TXNIP MID1 MID1 PRKACA PRKACA AXIN1 AXIN1 GSK3B GSK3B HSPBP1 HSPBP1 RALB RALB PAX6 PAX6 AMBRA1 AMBRA1 TRAF6 TRAF6 PRR5L PRR5L PRKAR2B PRKAR2B NFKBIA NFKBIA NEDD8 NEDD8 RNF31 RNF31 GGN GGN PA2G4 PA2G4 ERBB3 ERBB3 PCBP2 PCBP2 UBE2K UBE2K CUL4B CUL4B LOC103005823 LOC103005823 BAG4 BAG4 TRAF1 TRAF1 LOC103008156 LOC103008156 LOC103012872 LOC103012872 LOC102999262 LOC102999262 CASC3 CASC3 UBE2G1 UBE2G1 TRIB2 TRIB2 GPR37 GPR37 SPOP SPOP NGFR NGFR UBE2D1 UBE2D1 CKB CKB TRAF3 TRAF3 ANKRA2 ANKRA2 BAG5 BAG5 TRIM28 TRIM28 DNM1L DNM1L PINK1 PINK1 MUL1 MUL1 TSG101 TSG101 SH3KBP1 SH3KBP1 OTUB1 OTUB1 UBXN1 UBXN1 UBB UBB MFHAS1 MFHAS1 ARRB1 ARRB1 YWHAZ YWHAZ FZD6 FZD6 PRKACB PRKACB CACUL1 CACUL1 BCL10 BCL10 CUL5 CUL5 APBB1 APBB1 CBS CBS WFS1 WFS1 UBASH3A UBASH3A BLZF1 BLZF1 MAP1LC3B MAP1LC3B HSPA9 HSPA9 TMEM173 TMEM173 CALR CALR UBE2B UBE2B SMAD5 SMAD5 CAMLG CAMLG FBXW9 FBXW9 SCAMP3 SCAMP3 UBXN7 UBXN7 NDUFS2 NDUFS2 SHPRH SHPRH RELA RELA SLC22A18 SLC22A18 CHEK2 CHEK2 EGR2 EGR2 PATZ1 PATZ1 LAPTM5 LAPTM5 LTBR LTBR MFN2 MFN2 ERLIN2 ERLIN2 TNFRSF1B TNFRSF1B SQSTM1 SQSTM1 GLMN GLMN FAF2 FAF2 DBT DBT ARRDC5 ARRDC5 PIAS4 PIAS4 LOC103010896 LOC103010896 PRKAR2A PRKAR2A USP19 USP19 RTN2 RTN2 PDLIM2 PDLIM2 CUL3 CUL3 WRAP53 WRAP53 GABARAP GABARAP UBE2J2 UBE2J2 PER1 PER1 ISG15 ISG15 STX8 STX8 SKI SKI SMAD6 SMAD6 PIAS1 PIAS1 SMAD3 SMAD3 CACYBP CACYBP GPI GPI LOC103001311 LOC103001311 KDM4A KDM4A LOC103014668 LOC103014668 TRAF5 TRAF5 HM13 HM13 TCP1 TCP1 PRKN PRKN RNF40 RNF40 RB1 RB1 DAXX DAXX BAG2 BAG2 WBP1L WBP1L SLF2 SLF2 ERLIN1 ERLIN1 PPARGC1A PPARGC1A PACRGL PACRGL RALA RALA EGFR EGFR XRCC5 XRCC5 HLTF HLTF USP7 USP7 SNCAIP SNCAIP DIO2 DIO2 DERL1 DERL1 TRIB1 TRIB1 FBXW7 FBXW7 RNF34 RNF34 LOC103002788 LOC103002788 CUL2 CUL2 UBC UBC FANCL FANCL RPS27A RPS27A LRPPRC LRPPRC RFFL RFFL TRIM37 TRIM37 CASP10 CASP10 CASP8 CASP8 LOC103019446 LOC103019446 SCN5A SCN5A NKD2 NKD2 BCL2 BCL2 CXCR4 CXCR4 APC APC MC4R MC4R RAD18 RAD18 FHIT FHIT PSMA3 PSMA3 HIF1A HIF1A JKAMP JKAMP MAP1LC3A MAP1LC3A SPART SPART TRIB3 TRIB3 FOXO1 FOXO1 LOC103020298 LOC103020298 LOC103004668 LOC103004668 LOC103019729 LOC103019729 BAG6 BAG6 LOC103020944 LOC103020944 LOC103020014 LOC103020014 TRAF2 TRAF2 DET1 DET1 HSPA5 HSPA5 NEK6 NEK6 CCT2 CCT2 LOC103011522 LOC103011522 IKBKE IKBKE USP13 USP13 CCDC50 CCDC50 ASB4 ASB4 UBE2J1 UBE2J1 UBOX5 UBOX5 AICDA AICDA GABARAPL1 GABARAPL1 CUL4A CUL4A USP2 USP2 RNF20 RNF20 SLF1 SLF1 SMAD7 SMAD7 PIAS2 PIAS2 PML PML CUL7 CUL7 RNF8 RNF8 NAE1 NAE1 LOC103020118 LOC103020118 CDKN1A CDKN1A FAM178B FAM178B FBXO7 FBXO7 KCNH2 KCNH2 UBE2L6 UBE2L6 ARIH1 ARIH1 FZD4 FZD4 JAK1 JAK1 SYT11 SYT11 HSPA6 HSPA6 RIPK1 RIPK1 RTN3 RTN3 MYOD1 MYOD1 DDX58 DDX58 LOC103011160 LOC103011160 HDAC6 HDAC6 ANAPC2 ANAPC2 DLG3 DLG3 LOC103012535 LOC103012535 SNX9 SNX9 LOC103017032 LOC103017032 LOC114238582 LOC114238582 LOC103016465 LOC103016465 ARRB2 ARRB2 VCL VCL RTN4 RTN4 LOC114239088 LOC114239088 USP25 USP25 SPOPL SPOPL RTN1 RTN1 HERC2 HERC2 TANK TANK LAPTM4A LAPTM4A SMC6 SMC6 CRK CRK YWHAE YWHAE NLK NLK AUP1 AUP1 GON7 GON7 CUL1 CUL1 PSMD1 PSMD1 BOK BOK ZNF746 ZNF746 UBE2W UBE2W CD40 CD40 PRKAR1A PRKAR1A ACTG1 ACTG1 NPLOC4 NPLOC4 AXIN2 AXIN2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PACRGParkin coregulated gene protein. (253 aa)
ARRDC1Arrestin domain-containing protein 1. (460 aa)
UBE2TUbiquitin-conjugating enzyme E2 T; Belongs to the ubiquitin-conjugating enzyme family. (196 aa)
GABARAPL2Gamma-aminobutyric acid receptor-associated protein-like 2. (117 aa)
MAP1LC3CMicrotubule-associated proteins 1A/1B light chain 3C. (146 aa)
TXNIPThioredoxin-interacting protein. (390 aa)
MID1E3 ubiquitin-protein ligase Midline-1 isoform X1. (677 aa)
PRKACAcAMP-dependent protein kinase catalytic subunit alpha. (293 aa)
AXIN1Axin-1 isoform X1. (866 aa)
GSK3BGlycogen synthase kinase-3 beta isoform X1; Belongs to the protein kinase superfamily. (433 aa)
HSPBP1Hsp70-binding protein 1. (357 aa)
RALBRas-related protein Ral-B isoform X1. (163 aa)
PAX6Paired box protein Pax-6 isoform X1. (493 aa)
AMBRA1Activating molecule in BECN1-regulated autophagy protein 1 isoform X1. (1310 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (561 aa)
PRR5LLOW QUALITY PROTEIN: proline-rich protein 5-like. (365 aa)
PRKAR2BcAMP-dependent protein kinase type II-beta regulatory subunit. (431 aa)
NFKBIANF-kappa-B inhibitor alpha. (280 aa)
NEDD8NEDD8. (81 aa)
RNF31E3 ubiquitin-protein ligase RNF31. (1072 aa)
GGNGametogenetin. (662 aa)
PA2G4Proliferation-associated protein 2G4. (394 aa)
ERBB3Receptor tyrosine-protein kinase erbB-3. (1338 aa)
PCBP2poly(RC)-binding protein 2 isoform X1. (471 aa)
UBE2KUbiquitin-conjugating enzyme E2 K isoform X1; Belongs to the ubiquitin-conjugating enzyme family. (219 aa)
CUL4BLOW QUALITY PROTEIN: cullin-4B; Belongs to the cullin family. (893 aa)
LOC103005823Ubiquitin-conjugating enzyme E2 A; Belongs to the ubiquitin-conjugating enzyme family. (134 aa)
BAG4BAG family molecular chaperone regulator 4 isoform X1. (539 aa)
TRAF1TNF receptor-associated factor. (415 aa)
LOC103008156Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] (765 aa)
LOC103012872Beclin-1 isoform X1. (473 aa)
LOC102999262Beclin-1 isoform X3. (471 aa)
CASC3LOW QUALITY PROTEIN: protein CASC3. (668 aa)
UBE2G1Ubiquitin-conjugating enzyme E2 G1 isoform X1; Belongs to the ubiquitin-conjugating enzyme family. (170 aa)
TRIB2Tribbles homolog 2. (343 aa)
GPR37Prosaposin receptor GPR37. (614 aa)
SPOPSpeckle-type POZ protein. (374 aa)
NGFRTumor necrosis factor receptor superfamily member 16. (427 aa)
UBE2D1Ubiquitin-conjugating enzyme E2 D1 isoform X1; Belongs to the ubiquitin-conjugating enzyme family. (148 aa)
CKBLOW QUALITY PROTEIN: creatine kinase B-type; Belongs to the ATP:guanido phosphotransferase family. (368 aa)
TRAF3TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (572 aa)
ANKRA2Ankyrin repeat family A protein 2. (313 aa)
BAG5BAG family molecular chaperone regulator 5. (447 aa)
TRIM28Transcription intermediary factor 1-beta. (700 aa)
DNM1LDynamin-1-like protein isoform X2; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (749 aa)
PINK1Serine/threonine-protein kinase PINK1, mitochondrial. (405 aa)
MUL1Mitochondrial ubiquitin ligase activator of NFKB 1 isoform X1. (370 aa)
TSG101Tumor susceptibility gene 101 protein isoform X1. (422 aa)
SH3KBP1SH3 domain-containing kinase-binding protein 1 isoform X2. (615 aa)
OTUB1Ubiquitin thioesterase. (271 aa)
UBXN1UBX domain-containing protein 1 isoform X1. (297 aa)
UBBpolyubiquitin-B. (305 aa)
MFHAS1Malignant fibrous histiocytoma-amplified sequence 1. (1094 aa)
ARRB1Beta-arrestin-1 isoform X1. (413 aa)
YWHAZ14-3-3 protein zeta/delta; Belongs to the 14-3-3 family. (245 aa)
FZD6Frizzled-6 isoform X1; Belongs to the G-protein coupled receptor Fz/Smo family. (712 aa)
PRKACBcAMP-dependent protein kinase catalytic subunit beta isoform X1; Belongs to the protein kinase superfamily. (397 aa)
CACUL1CDK2-associated and cullin domain-containing protein 1; Belongs to the cullin family. (369 aa)
BCL10B-cell lymphoma/leukemia 10. (233 aa)
CUL5Cullin-5; Belongs to the cullin family. (737 aa)
APBB1Amyloid-beta A4 precursor protein-binding family B member 1 isoform X1. (709 aa)
CBSCystathionine beta-synthase; Belongs to the cysteine synthase/cystathionine beta- synthase family. (565 aa)
WFS1Wolframin. (888 aa)
UBASH3AUbiquitin-associated and SH3 domain-containing protein A isoform X1. (624 aa)
BLZF1Golgin-45. (401 aa)
MAP1LC3BMicrotubule-associated proteins 1A/1B light chain 3B. (118 aa)
HSPA9Stress-70 protein, mitochondrial; Belongs to the heat shock protein 70 family. (679 aa)
TMEM173Stimulator of interferon genes protein isoform X1. (489 aa)
CALRCalreticulin. (417 aa)
UBE2BUbiquitin-conjugating enzyme E2 B isoform X1; Belongs to the ubiquitin-conjugating enzyme family. (152 aa)
SMAD5Mothers against decapentaplegic homolog. (465 aa)
CAMLGCalcium signal-modulating cyclophilin ligand; Likely involved in the mobilization of calcium as a result of the TCR/CD3 complex interaction. Binds to cyclophilin B. (295 aa)
FBXW9F-box/WD repeat-containing protein 9 isoform X1. (458 aa)
SCAMP3Secretory carrier-associated membrane protein. (347 aa)
UBXN7UBX domain-containing protein 7. (489 aa)
NDUFS2NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial isoform X1; Belongs to the complex I 49 kDa subunit family. (462 aa)
SHPRHE3 ubiquitin-protein ligase SHPRH isoform X1. (1684 aa)
RELATranscription factor p65 isoform X1. (520 aa)
SLC22A18Solute carrier family 22 member 18 isoform X1. (468 aa)
CHEK2Serine/threonine-protein kinase Chk2. (544 aa)
EGR2E3 SUMO-protein ligase EGR2. (472 aa)
PATZ1POZ-, AT hook-, and zinc finger-containing protein 1 isoform X1. (687 aa)
LAPTM5Lysosomal-associated transmembrane protein 5. (264 aa)
LTBRTumor necrosis factor receptor superfamily member 3. (421 aa)
MFN2Mitofusin-2 isoform X1; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (757 aa)
ERLIN2Erlin-2 isoform X1. (368 aa)
TNFRSF1BTumor necrosis factor receptor superfamily member 1B. (460 aa)
SQSTM1Sequestosome-1. (440 aa)
GLMNGlomulin isoform X1. (592 aa)
FAF2FAS-associated factor 2. (445 aa)
DBTDihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex. (482 aa)
ARRDC5Arrestin domain-containing protein 5. (329 aa)
PIAS4E3 SUMO-protein ligase PIAS4. (491 aa)
LOC103010896Cytochrome b-c1 complex subunit 1, mitochondrial isoform X1. (481 aa)
PRKAR2AcAMP-dependent protein kinase type II-alpha regulatory subunit. (365 aa)
USP19Ubiquitin carboxyl-terminal hydrolase 19 isoform X1. (1364 aa)
RTN2Reticulon. (471 aa)
PDLIM2PDZ and LIM domain protein 2. (358 aa)
CUL3Cullin-3; Belongs to the cullin family. (746 aa)
WRAP53Telomerase Cajal body protein 1 isoform X1. (543 aa)
GABARAPGamma-aminobutyric acid receptor-associated protein. (117 aa)
UBE2J2Ubiquitin-conjugating enzyme E2 J2. (259 aa)
PER1Period circadian protein homolog 1 isoform X1. (1267 aa)
ISG15Ubiquitin-like protein ISG15. (170 aa)
STX8Syntaxin-8. (236 aa)
SKISki oncogene. (772 aa)
SMAD6Mothers against decapentaplegic homolog. (321 aa)
PIAS1E3 SUMO-protein ligase PIAS1 isoform X1. (645 aa)
SMAD3Mothers against decapentaplegic homolog. (425 aa)
CACYBPCalcyclin-binding protein isoform X1. (244 aa)
GPIGlucose-6-phosphate isomerase; Belongs to the GPI family. (558 aa)
LOC103001311Transcription factor AP-1-like. (199 aa)
KDM4ALysine-specific demethylase 4A isoform X1. (1072 aa)
LOC103014668Transcription factor AP-1; Belongs to the bZIP family. (253 aa)
TRAF5TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (558 aa)
HM13Minor histocompatibility antigen H13 isoform X1. (449 aa)
TCP1T-complex protein 1 subunit alpha isoform X1. (556 aa)
PRKNE3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. (465 aa)
RNF40E3 ubiquitin protein ligase; Belongs to the BRE1 family. (1001 aa)
RB1Retinoblastoma-associated protein. (816 aa)
DAXXDeath domain-associated protein 6. (755 aa)
BAG2BAG family molecular chaperone regulator 2. (279 aa)
WBP1LWW domain binding protein 1-like isoform X1. (363 aa)
SLF2SMC5-SMC6 complex localization factor protein 2 isoform X1. (1168 aa)
ERLIN1Erlin-1 isoform X1. (352 aa)
PPARGC1APeroxisome proliferator-activated receptor gamma coactivator 1-alpha isoform X1. (803 aa)
PACRGLPACRG-like protein isoform X2. (280 aa)
RALARas-related protein Ral-A. (206 aa)
EGFRReceptor protein-tyrosine kinase. (1156 aa)
XRCC5X-ray repair cross-complementing protein 5 isoform X1. (733 aa)
HLTFHelicase-like transcription factor isoform X1. (1008 aa)
USP7Ubiquitin carboxyl-terminal hydrolase 7; Belongs to the peptidase C19 family. (1055 aa)
SNCAIPSynphilin-1 isoform X1. (969 aa)
DIO2Iodothyronine deiodinase; Responsible for the deiodination of T4 (3,5,3',5'- tetraiodothyronine). (269 aa)
DERL1Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family. (251 aa)
TRIB1Tribbles homolog 1. (372 aa)
FBXW7F-box/WD repeat-containing protein 7 isoform X1. (708 aa)
RNF34E3 ubiquitin-protein ligase RNF34. (384 aa)
LOC103002788Heat shock 70 kDa protein 1B-like. (124 aa)
CUL2Cullin-2; Belongs to the cullin family. (745 aa)
UBCpolyubiquitin-C. (609 aa)
FANCLE3 ubiquitin-protein ligase FANCL isoform X1. (375 aa)
RPS27Aubiquitin-40S ribosomal protein S27a. (156 aa)
LRPPRCLOW QUALITY PROTEIN: leucine-rich PPR motif-containing protein, mitochondrial. (1393 aa)
RFFLE3 ubiquitin-protein ligase rififylin isoform X1. (393 aa)
TRIM37E3 ubiquitin-protein ligase TRIM37. (902 aa)
CASP10Caspase-10 isoform X1; Belongs to the peptidase C14A family. (525 aa)
CASP8Caspase-8; Belongs to the peptidase C14A family. (486 aa)
LOC103019446Heat shock 70 kDa protein 1B-like. (105 aa)
SCN5ASodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (1992 aa)
NKD2Protein naked cuticle homolog 2. (542 aa)
BCL2Apoptosis regulator Bcl-2 isoform X1. (233 aa)
CXCR4C-X-C chemokine receptor type 4; Belongs to the G-protein coupled receptor 1 family. (353 aa)
APCAdenomatous polyposis coli protein isoform X1. (2865 aa)
MC4RMelanocortin receptor 4. (332 aa)
RAD18E3 ubiquitin-protein ligase RAD18 isoform X1. (499 aa)
FHITBis(5'-adenosyl)-triphosphatase. (171 aa)
PSMA3Proteasome subunit alpha type. (255 aa)
HIF1AHypoxia-inducible factor 1-alpha isoform X1. (823 aa)
JKAMPJNK1/MAPK8-associated membrane protein isoform X1. (311 aa)
MAP1LC3AMicrotubule-associated proteins 1A/1B light chain 3A. (142 aa)
SPARTSpartin isoform X1. (668 aa)
TRIB3LOW QUALITY PROTEIN: tribbles homolog 3. (411 aa)
FOXO1Forkhead box protein O1. (518 aa)
LOC103020298Heat shock 70 kDa protein 1-like; Belongs to the heat shock protein 70 family. (641 aa)
LOC103004668Heat shock 70 kDa protein 1B-like. (254 aa)
LOC103019729Heat shock 70 kDa protein 1B; Belongs to the heat shock protein 70 family. (641 aa)
BAG6Large proline-rich protein BAG6. (1128 aa)
LOC103020944Cullin-9; Belongs to the cullin family. (847 aa)
LOC103020014Heat shock 70 kDa protein 1B; Belongs to the heat shock protein 70 family. (641 aa)
TRAF2TNF receptor-associated factor. (412 aa)
DET1DET1 homolog isoform X2. (550 aa)
HSPA5Endoplasmic reticulum chaperone BiP; Belongs to the heat shock protein 70 family. (655 aa)
NEK6Serine/threonine-protein kinase Nek6 isoform X1; Belongs to the protein kinase superfamily. (365 aa)
CCT2T-complex protein 1 subunit beta. (535 aa)
LOC103011522Heat shock 70 kDa protein 1B-like. (80 aa)
IKBKEInhibitor of nuclear factor kappa-B kinase subunit epsilon isoform X1. (752 aa)
USP13Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (793 aa)
CCDC50Coiled-coil domain-containing protein 50 isoform X1. (466 aa)
ASB4Ankyrin repeat and SOCS box protein 4 isoform X1. (436 aa)
UBE2J1Ubiquitin-conjugating enzyme E2 J1. (318 aa)
UBOX5RING finger protein 37 isoform X1. (537 aa)
AICDASingle-stranded DNA cytosine deaminase. (199 aa)
GABARAPL1Gamma-aminobutyric acid receptor-associated protein-like 1. (117 aa)
CUL4Acullin-4A; Belongs to the cullin family. (637 aa)
USP2Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (603 aa)
RNF20E3 ubiquitin protein ligase; Belongs to the BRE1 family. (975 aa)
SLF1SMC5-SMC6 complex localization factor protein 1. (1057 aa)
SMAD7Mothers against decapentaplegic homolog. (426 aa)
PIAS2E3 SUMO-protein ligase PIAS2 isoform X1. (622 aa)
PMLProtein PML isoform X1. (871 aa)
CUL7Cullin-7 isoform X1; Belongs to the cullin family. (2036 aa)
RNF8E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...] (495 aa)
NAE1NEDD8-activating enzyme E1 regulatory subunit; Regulatory subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M. Belongs to the ubiquitin-activating E1 family. ULA1 subfamily. (534 aa)
LOC103020118Cullin-7; Belongs to the cullin family. (1259 aa)
CDKN1ACyclin-dependent kinase inhibitor 1. (164 aa)
FAM178BLOW QUALITY PROTEIN: protein FAM178B. (702 aa)
FBXO7F-box only protein 7. (498 aa)
KCNH2LOW QUALITY PROTEIN: potassium voltage-gated channel subfamily H member 2. (813 aa)
UBE2L6ubiquitin/ISG15-conjugating enzyme E2 L6 isoform X1; Belongs to the ubiquitin-conjugating enzyme family. (210 aa)
ARIH1RBR-type E3 ubiquitin transferase. (465 aa)
FZD4LOW QUALITY PROTEIN: frizzled-4; Belongs to the G-protein coupled receptor Fz/Smo family. (548 aa)
JAK1Tyrosine-protein kinase. (1155 aa)
SYT11Synaptotagmin-11 isoform X1. (428 aa)
HSPA6LOW QUALITY PROTEIN: heat shock 70 kDa protein 6; Belongs to the heat shock protein 70 family. (655 aa)
RIPK1Receptor-interacting serine/threonine-protein kinase 1. (674 aa)
RTN3Reticulon. (1035 aa)
MYOD1Myogenic factor; Induces fibroblasts to differentiate into myoblasts. Acts as a transcriptional activator that promotes transcription of muscle- specific target genes and plays a role in muscle differentiation. (268 aa)
DDX58LOW QUALITY PROTEIN: probable ATP-dependent RNA helicase DDX58. (912 aa)
LOC103011160Ubiquitin-like. (144 aa)
HDAC6Histone deacetylase 6. (1143 aa)
ANAPC2Anaphase-promoting complex subunit 2; Belongs to the cullin family. (780 aa)
DLG3Disks large homolog 3 isoform X1; Belongs to the MAGUK family. (625 aa)
LOC103012535LOW QUALITY PROTEIN: frizzled-5-like; Belongs to the G-protein coupled receptor Fz/Smo family. (481 aa)
SNX9Sorting nexin. (624 aa)
LOC103017032LOW QUALITY PROTEIN: frizzled-5-like; Belongs to the G-protein coupled receptor Fz/Smo family. (320 aa)
LOC114238582Frizzled-5-like. (204 aa)
LOC103016465LOW QUALITY PROTEIN: frizzled-5-like; Belongs to the G-protein coupled receptor Fz/Smo family. (523 aa)
ARRB2Beta-arrestin-2 isoform X1. (287 aa)
VCLVinculin isoform X2. (1134 aa)
RTN4Reticulon. (997 aa)
LOC114239088Heat shock 70 kDa protein-like. (100 aa)
USP25Ubiquitin carboxyl-terminal hydrolase 25 isoform X1; Belongs to the peptidase C19 family. (924 aa)
SPOPLSpeckle-type POZ protein-like isoform X1. (424 aa)
RTN1Reticulon. (701 aa)
HERC2LOW QUALITY PROTEIN: E3 ubiquitin-protein ligase HERC2. (4801 aa)
TANKTRAF family member-associated NF-kappa-B activator isoform X1. (426 aa)
LAPTM4ALysosomal-associated transmembrane protein 4A. (233 aa)
SMC6Structural maintenance of chromosomes protein 6. (1097 aa)
CRKAdapter molecule crk isoform X1. (304 aa)
YWHAE14-3-3 protein epsilon isoform X1; Belongs to the 14-3-3 family. (255 aa)
NLKMitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (527 aa)
AUP1Ancient ubiquitous protein 1 isoform X1. (466 aa)
GON7EKC/KEOPS complex subunit GON7. (100 aa)
CUL1Cullin-1; Belongs to the cullin family. (776 aa)
PSMD126S proteasome non-ATPase regulatory subunit 1; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S1 family. (953 aa)
BOKBcl-2-related ovarian killer protein. (175 aa)
ZNF746Zinc finger protein 746. (471 aa)
UBE2WUbiquitin-conjugating enzyme E2 W. (151 aa)
CD40Tumor necrosis factor receptor superfamily member 5 isoform X1. (280 aa)
PRKAR1AcAMP-dependent protein kinase type I-alpha regulatory subunit. (380 aa)
ACTG1Actin, cytoplasmic 2. (375 aa)
NPLOC4Nuclear protein localization protein 4 homolog isoform X1. (612 aa)
AXIN2Axin-2. (543 aa)
Your Current Organism:
Balaenoptera acutorostrata
NCBI taxonomy Id: 310752
Other names: B. acutorostrata scammoni, Balaenoptera acutorostrata scammoni
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