STRINGSTRING
WDR43 WDR43 CDC73 CDC73 CDK13 CDK13 LDB1 LDB1 RECQL5 RECQL5 EZH2 EZH2 SUPT6H SUPT6H NELFB NELFB AXIN1 AXIN1 NELFA NELFA EAPP EAPP SUPT16H SUPT16H CCNT1 CCNT1 CDK12 CDK12 SUPT4H1 SUPT4H1 EAF2 EAF2 USP10 USP10 RNF168 RNF168 GTF2F1 GTF2F1 ZMYND11 ZMYND11 HNRNPU HNRNPU EAF1 EAF1 MED8 MED8 PWWP2B PWWP2B NELFCD NELFCD SHH SHH CCNK CCNK BRD4 BRD4 PWWP2A PWWP2A RNF8 RNF8 ELL2 ELL2 BTBD18 BTBD18 ELL3 ELL3 ELL ELL LEO1 LEO1 CDK9 CDK9 NELFE NELFE CTNNB1 CTNNB1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
WDR43WD repeat-containing protein 43. (497 aa)
CDC73Parafibromin. (531 aa)
CDK13Cyclin-dependent kinase 13. (1280 aa)
LDB1LIM domain-binding protein 1 isoform X2. (375 aa)
RECQL5ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily. (984 aa)
EZH2Histone-lysine N-methyltransferase EZH2. (746 aa)
SUPT6HTranscription elongation factor spt6; Transcription elongation factor that enhances transcription elongation by RNA polymerase II (RNAPII). Belongs to the SPT6 family. (1726 aa)
NELFBLOW QUALITY PROTEIN: negative elongation factor B. (761 aa)
AXIN1Axin-1 isoform X1. (866 aa)
NELFANegative elongation factor A. (451 aa)
EAPPE2F-associated phosphoprotein isoform X2. (286 aa)
SUPT16HFACT complex subunit SPT16. (1047 aa)
CCNT1cyclin-T1 isoform X1; Belongs to the cyclin family. (727 aa)
CDK12Cyclin-dependent kinase 12 isoform X1. (1490 aa)
SUPT4H1Transcription elongation factor SPT4; Component of the DRB sensitivity-inducing factor complex (DSIF complex), which regulates transcription elongation by RNA polymerase II; Belongs to the SPT4 family. (117 aa)
EAF2ELL-associated factor 2. (264 aa)
USP10Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (849 aa)
RNF168E3 ubiquitin-protein ligase RNF168; E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage. Acts with UBE2N/UBC13 to amplify the RNF8-dependent histone ubiquitination. Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and H2AX and amplifies the RNF8-dependent H2A ubiquitination, promoting the formation of 'Lys-63'-linked ubiquitin conjugates. This leads to concentrate ubiquitinated histones H2A and H2AX at DNA lesions to the threshold required for recruitment of TP53BP1 and BRCA1. Also recrui [...] (592 aa)
GTF2F1Transcription initiation factor IIF subunit alpha; TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation. Belongs to the TFIIF alpha subunit family. (518 aa)
ZMYND11Zinc finger MYND domain-containing protein 11 isoform X1. (617 aa)
HNRNPUHeterogeneous nuclear ribonucleoprotein U. (798 aa)
EAF1ELL-associated factor 1. (268 aa)
MED8Mediator of RNA polymerase II transcription subunit 8; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (271 aa)
PWWP2BPWWP domain-containing protein 2B. (366 aa)
NELFCDNegative elongation factor C/D. (533 aa)
SHHLOW QUALITY PROTEIN: sonic hedgehog protein. (271 aa)
CCNKcyclin-K; Belongs to the cyclin family. (410 aa)
BRD4Bromodomain-containing protein 4. (1299 aa)
PWWP2APWWP domain-containing protein 2A isoform X1. (538 aa)
RNF8E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...] (495 aa)
ELL2RNA polymerase II elongation factor ELL2. (640 aa)
BTBD18BTB/POZ domain-containing protein 18. (728 aa)
ELL3RNA polymerase II elongation factor ELL3. (400 aa)
ELLRNA polymerase II elongation factor ELL. (612 aa)
LEO1RNA polymerase-associated protein LEO1. (666 aa)
CDK9Cyclin-dependent kinase 9; Belongs to the protein kinase superfamily. (372 aa)
NELFENegative elongation factor E isoform X4. (419 aa)
CTNNB1Catenin beta-1. (767 aa)
Your Current Organism:
Balaenoptera acutorostrata
NCBI taxonomy Id: 310752
Other names: B. acutorostrata scammoni, Balaenoptera acutorostrata scammoni
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