(28 nodes) Plasma lipoprotein particle network (Balaenoptera acutorostrata)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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Predicted Interactions

gene neighborhood

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Your Input:
	APOA2	Apolipoprotein A-II isoform X1. (103 aa)
	LIPC	Hepatic triacylglycerol lipase. (500 aa)
	APOE	Apolipoprotein E; APOE is an apolipoprotein, a protein associating with lipid particles, that mainly functions in lipoprotein-mediated lipid transport between organs via the plasma and interstitial fluids. APOE is a core component of plasma lipoproteins and is involved in their production, conversion and clearance. Apoliproteins are amphipathic molecules that interact both with lipids of the lipoprotein particle core and the aqueous environment of the plasma. As such, APOE associates with chylomicrons, chylomicron remnants, very low density lipoproteins (VLDL) and intermediate density [...] (313 aa)
	APOA1	Truncated apolipoprotein A-I; Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility (By similarity). (265 aa)
	APOBR	Apolipoprotein B receptor. (1013 aa)
	APOB	Apolipoprotein B-100. (4585 aa)
	VLDLR	Very low-density lipoprotein receptor. (920 aa)
	SELENOS	Selenoprotein S isoform X1. (203 aa)
	PCYOX1	Prenylcysteine oxidase 1. (426 aa)
	LDLR	Low-density lipoprotein receptor. (842 aa)
	APOA5	Apolipoprotein A-V isoform X1. (378 aa)
	LOC103004502	LOW QUALITY PROTEIN: serum paraoxonase/arylesterase 1. (319 aa)
	LCAT	Phosphatidylcholine-sterol acyltransferase. (440 aa)
	LIPG	Endothelial lipase. (500 aa)
	GPLD1	Phosphatidylinositol-glycan-specific phospholipase D. (843 aa)
	APOC3	Apolipoprotein C-III. (99 aa)
	APOA4	Apolipoprotein A-IV. (380 aa)
	APOM	Apolipoprotein M. (188 aa)
	PLA2G7	Platelet-activating factor acetylhydrolase. (444 aa)
	APOH	Beta-2-glycoprotein 1. (345 aa)
	PLTP	Phospholipid transfer protein. (496 aa)
	APOO	MICOS complex subunit; Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. (198 aa)
	LPL	Lipoprotein lipase; Key enzyme in triglyceride metabolism. Catalyzes the hydrolysis of triglycerides from circulating chylomicrons and very low density lipoproteins (VLDL), and thereby plays an important role in lipid clearance from the blood stream, lipid utilization and storage. Mediates margination of triglyceride-rich lipoprotein particles in capillaries. Recruited to its site of action on the luminal surface of vascular endothelium by binding to GPIHBP1 and cell surface heparan sulfate proteoglycans. (478 aa)
	LOC103021129	Serum amyloid A protein; Major acute phase reactant. Apolipoprotein of the HDL complex. (130 aa)
	LOC103020590	Serum amyloid A protein; Major acute phase reactant. Apolipoprotein of the HDL complex. (129 aa)
	MSR1	Macrophage scavenger receptor types I and II isoform X1. (454 aa)
	APOC2	Apolipoprotein C-II. (101 aa)
	APOC4	LOW QUALITY PROTEIN: apolipoprotein C-IV. (127 aa)

Your Current Organism:

Balaenoptera acutorostrata

NCBI taxonomy Id: 310752
Other names: B. acutorostrata scammoni, Balaenoptera acutorostrata scammoni

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
APOA1	APOA2	P0DMA6	A0A383Z9M2	Truncated apolipoprotein A-I; Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility (By similarity).	Apolipoprotein A-II isoform X1.	0.620
APOA1	APOA4	P0DMA6	A0A384BAA9	Truncated apolipoprotein A-I; Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility (By similarity).	Apolipoprotein A-IV.	0.790
APOA1	APOA5	P0DMA6	A0A452C5Q3	Truncated apolipoprotein A-I; Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility (By similarity).	Apolipoprotein A-V isoform X1.	0.659
APOA1	APOB	P0DMA6	A0A452CHV5	Truncated apolipoprotein A-I; Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility (By similarity).	Apolipoprotein B-100.	0.827
APOA1	APOC2	P0DMA6	A0A383YZ74	Truncated apolipoprotein A-I; Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility (By similarity).	Apolipoprotein C-II.	0.751
APOA1	APOC3	P0DMA6	A0A384BAB1	Truncated apolipoprotein A-I; Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility (By similarity).	Apolipoprotein C-III.	0.566
APOA1	APOE	P0DMA6	P0DML7	Truncated apolipoprotein A-I; Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility (By similarity).	Apolipoprotein E; APOE is an apolipoprotein, a protein associating with lipid particles, that mainly functions in lipoprotein-mediated lipid transport between organs via the plasma and interstitial fluids. APOE is a core component of plasma lipoproteins and is involved in their production, conversion and clearance. Apoliproteins are amphipathic molecules that interact both with lipids of the lipoprotein particle core and the aqueous environment of the plasma. As such, APOE associates with chylomicrons, chylomicron remnants, very low density lipoproteins (VLDL) and intermediate density [...]	0.849
APOA1	LCAT	P0DMA6	A0A384BFK1	Truncated apolipoprotein A-I; Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility (By similarity).	Phosphatidylcholine-sterol acyltransferase.	0.961
APOA1	LIPC	P0DMA6	A0A383YSZ3	Truncated apolipoprotein A-I; Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility (By similarity).	Hepatic triacylglycerol lipase.	0.567
APOA1	LIPG	P0DMA6	A0A384BCU0	Truncated apolipoprotein A-I; Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility (By similarity).	Endothelial lipase.	0.608
APOA1	LOC103020590	P0DMA6	A0A383ZID4	Truncated apolipoprotein A-I; Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility (By similarity).	Serum amyloid A protein; Major acute phase reactant. Apolipoprotein of the HDL complex.	0.400
APOA1	LOC103021129	P0DMA6	A0A383ZID7	Truncated apolipoprotein A-I; Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility (By similarity).	Serum amyloid A protein; Major acute phase reactant. Apolipoprotein of the HDL complex.	0.574
APOA1	LPL	P0DMA6	A0A384AAG0	Truncated apolipoprotein A-I; Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility (By similarity).	Lipoprotein lipase; Key enzyme in triglyceride metabolism. Catalyzes the hydrolysis of triglycerides from circulating chylomicrons and very low density lipoproteins (VLDL), and thereby plays an important role in lipid clearance from the blood stream, lipid utilization and storage. Mediates margination of triglyceride-rich lipoprotein particles in capillaries. Recruited to its site of action on the luminal surface of vascular endothelium by binding to GPIHBP1 and cell surface heparan sulfate proteoglycans.	0.617
APOA1	PLTP	P0DMA6	A0A384ADJ9	Truncated apolipoprotein A-I; Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility (By similarity).	Phospholipid transfer protein.	0.647
APOA1	VLDLR	P0DMA6	A0A452CH10	Truncated apolipoprotein A-I; Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility (By similarity).	Very low-density lipoprotein receptor.	0.558
APOA2	APOA1	A0A383Z9M2	P0DMA6	Apolipoprotein A-II isoform X1.	Truncated apolipoprotein A-I; Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility (By similarity).	0.620
APOA2	APOA4	A0A383Z9M2	A0A384BAA9	Apolipoprotein A-II isoform X1.	Apolipoprotein A-IV.	0.672
APOA2	APOA5	A0A383Z9M2	A0A452C5Q3	Apolipoprotein A-II isoform X1.	Apolipoprotein A-V isoform X1.	0.635
APOA2	APOB	A0A383Z9M2	A0A452CHV5	Apolipoprotein A-II isoform X1.	Apolipoprotein B-100.	0.925
APOA2	APOC2	A0A383Z9M2	A0A383YZ74	Apolipoprotein A-II isoform X1.	Apolipoprotein C-II.	0.980