STRINGSTRING
PDX1 PDX1 GSX1 GSX1 SMAD3 SMAD3 MAP2K1 MAP2K1 ASCL1 ASCL1 GATA3 GATA3 SALL1 SALL1 NEUROG3 NEUROG3 NKX6-1 NKX6-1 PDGFRA PDGFRA POU3F2 POU3F2 PROP1 PROP1 ARID5B ARID5B HOXA3 HOXA3 HOXA5 HOXA5 DRD2 DRD2 NKX6-2 NKX6-2 GCM2 GCM2 BMP6 BMP6 EDN1 EDN1 BMPR1A BMPR1A LOC103006469 LOC103006469 DKK3 DKK3 GHRHR GHRHR NR0B1 NR0B1 EIF2AK3 EIF2AK3 OTP OTP GIP GIP GLI1 GLI1 GDF11 GDF11 NKX2-1 NKX2-1 PAX6 PAX6 PDPK1 PDPK1 ANXA1 ANXA1 SOX9 SOX9 DLL1 DLL1 MAPK3 MAPK3 BHLHA15 BHLHA15 BMP5 BMP5 FGF8 FGF8 EDNRA EDNRA NEUROD1 NEUROD1 NKX2-5 NKX2-5 RFX6 RFX6 BMP2 BMP2 PAX1 PAX1 FOXA2 FOXA2 SLC6A3 SLC6A3 NKX2-2 NKX2-2 HESX1 HESX1 RAF1 RAF1 LOC103001360 LOC103001360 BMP4 BMP4 SIX1 SIX1 HNF4A HNF4A GHRH GHRH WNT11 WNT11 NR5A1 NR5A1 LHX3 LHX3 ONECUT1 ONECUT1 FGF10 FGF10 HES1 HES1 ISL1 ISL1 CDK6 CDK6 CRKL CRKL MAPK1 MAPK1 SIDT2 SIDT2 TGFBR1 TGFBR1 CDH2 CDH2 GATA6 GATA6 STRA6 STRA6 FOXE1 FOXE1 CREB1 CREB1 PAX8 PAX8 SRF SRF GIPR GIPR FGF2 FGF2 PITX1 PITX1 CRHR1 CRHR1 NOG NOG BRAF BRAF SMO SMO PAX4 PAX4 SHH SHH WT1 WT1 ARMC5 ARMC5 NF1 NF1 HOXD3 HOXD3 ONECUT2 ONECUT2 VHL VHL
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PDX1LOW QUALITY PROTEIN: pancreas/duodenum homeobox protein 1. (280 aa)
GSX1GS homeobox 1. (256 aa)
SMAD3Mothers against decapentaplegic homolog. (425 aa)
MAP2K1Dual specificity mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
ASCL1Achaete-scute homolog 1. (169 aa)
GATA3Trans-acting T-cell-specific transcription factor GATA-3 isoform X1. (444 aa)
SALL1Sal-like protein 1. (1217 aa)
NEUROG3Neurogenin-3. (215 aa)
NKX6-1Homeobox protein Nkx-6.1. (366 aa)
PDGFRAPlatelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1089 aa)
POU3F2POU domain protein. (263 aa)
PROP1Homeobox protein prophet of Pit-1 isoform X1. (226 aa)
ARID5BAT-rich interactive domain-containing protein 5B. (941 aa)
HOXA3Homeobox protein Hox-A3 isoform X1. (341 aa)
HOXA5Homeobox protein Hox-A5. (381 aa)
DRD2D(2) dopamine receptor; Belongs to the G-protein coupled receptor 1 family. (443 aa)
NKX6-2Homeobox protein Nkx-6.2. (120 aa)
GCM2Chorion-specific transcription factor GCMb. (506 aa)
BMP6Bone morphogenetic protein 6. (388 aa)
EDN1Endothelin-1. (202 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
LOC103006469Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (152 aa)
DKK3Dickkopf-related protein 3. (300 aa)
GHRHRGrowth hormone-releasing hormone receptor; Belongs to the G-protein coupled receptor 2 family. (423 aa)
NR0B1LOW QUALITY PROTEIN: nuclear receptor subfamily 0 group B member 1. (463 aa)
EIF2AK3Eukaryotic translation initiation factor 2-alpha kinase 3 isoform X1. (965 aa)
OTPLOW QUALITY PROTEIN: homeobox protein orthopedia. (324 aa)
GIPGastric inhibitory polypeptide. (144 aa)
GLI1Zinc finger protein GLI1. (1106 aa)
GDF11Growth/differentiation factor 11. (418 aa)
NKX2-1Homeobox protein Nkx-2.1. (296 aa)
PAX6Paired box protein Pax-6 isoform X1. (493 aa)
PDPK13-phosphoinositide-dependent protein kinase 1 isoform X1. (531 aa)
ANXA1Annexin. (346 aa)
SOX9Transcription factor SOX-9. (432 aa)
DLL1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (719 aa)
MAPK3Mitogen-activated protein kinase 3. (265 aa)
BHLHA15Class A basic helix-loop-helix protein 15. (138 aa)
BMP5Bone morphogenetic protein 5. (454 aa)
FGF8Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (244 aa)
EDNRAEndothelin-1 receptor; Belongs to the G-protein coupled receptor 1 family. (427 aa)
NEUROD1Neurogenic differentiation factor. (356 aa)
NKX2-5Homeobox protein Nkx-2.5. (323 aa)
RFX6DNA-binding protein RFX6. (928 aa)
BMP2Bone morphogenetic protein 2. (395 aa)
PAX1Paired box protein Pax-1. (462 aa)
FOXA2Hepatocyte nuclear factor 3-beta. (554 aa)
SLC6A3Transporter; Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. (617 aa)
NKX2-2Homeobox protein Nkx-2.2. (273 aa)
HESX1Homeobox expressed in ES cells 1 isoform X2. (187 aa)
RAF1RAF proto-oncogene serine/threonine-protein kinase isoform X1. (668 aa)
LOC103001360Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (204 aa)
BMP4Bone morphogenetic protein 4 isoform X1. (420 aa)
SIX1Homeobox protein SIX1. (284 aa)
HNF4AHepatocyte nuclear factor 4-alpha isoform X1. (474 aa)
GHRHSomatoliberin. (106 aa)
WNT11Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
NR5A1Steroidogenic factor 1. (461 aa)
LHX3LIM/homeobox protein Lhx3. (493 aa)
ONECUT1One cut domain family member. (470 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (210 aa)
HES1Transcription factor HES-1. (280 aa)
ISL1Insulin gene enhancer protein ISL-1. (349 aa)
CDK6Cyclin-dependent kinase 6; Belongs to the protein kinase superfamily. (326 aa)
CRKLCrk-like protein. (303 aa)
MAPK1Mitogen-activated protein kinase 1. (263 aa)
SIDT2SID1 transmembrane family member 2 isoform X1. (839 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (434 aa)
CDH2Cadherin-2; Cadherins are calcium-dependent cell adhesion proteins. (887 aa)
GATA6Transcription factor GATA-6. (357 aa)
STRA6Receptor for retinol uptake STRA6 isoform X1. (685 aa)
FOXE1LOW QUALITY PROTEIN: forkhead box protein E1. (331 aa)
CREB1Cyclic AMP-responsive element-binding protein 1 isoform X1. (341 aa)
PAX8Paired box protein Pax-8 isoform X1. (458 aa)
SRFSerum response factor. (464 aa)
GIPRGastric inhibitory polypeptide receptor isoform X1; Belongs to the G-protein coupled receptor 2 family. (471 aa)
FGF2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (155 aa)
PITX1Homeobox protein. (199 aa)
CRHR1Corticotropin-releasing factor receptor 1 isoform X1; Belongs to the G-protein coupled receptor 2 family. (432 aa)
NOGNoggin. (154 aa)
BRAFSerine/threonine-protein kinase B-raf. (839 aa)
SMOSmoothened homolog; Belongs to the G-protein coupled receptor Fz/Smo family. (837 aa)
PAX4LOW QUALITY PROTEIN: paired box protein Pax-4. (373 aa)
SHHLOW QUALITY PROTEIN: sonic hedgehog protein. (271 aa)
WT1Wilms tumor protein isoform X1. (323 aa)
ARMC5LOW QUALITY PROTEIN: armadillo repeat-containing protein 5. (847 aa)
NF1Neurofibromin. (2821 aa)
HOXD3LOW QUALITY PROTEIN: homeobox protein Hox-D3. (431 aa)
ONECUT2One cut domain family member. (433 aa)
VHLVon Hippel-Lindau disease tumor suppressor. (166 aa)
Your Current Organism:
Balaenoptera acutorostrata
NCBI taxonomy Id: 310752
Other names: B. acutorostrata scammoni, Balaenoptera acutorostrata scammoni
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