STRINGSTRING
RNF2 RNF2 RNF168 RNF168 DDB1 DDB1 PCGF2 PCGF2 CUL4B CUL4B BCOR BCOR DDB2 DDB2 PCGF3 PCGF3 PCGF1 PCGF1 RING1 RING1 PCGF5 PCGF5 BMI1 BMI1 TRIM37 TRIM37 RYBP RYBP LOC103003208 LOC103003208 PCGF6 PCGF6 LOC103002330 LOC103002330 KDM2B KDM2B
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
RNF2E3 ubiquitin-protein ligase RING2 isoform X1. (344 aa)
RNF168E3 ubiquitin-protein ligase RNF168; E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage. Acts with UBE2N/UBC13 to amplify the RNF8-dependent histone ubiquitination. Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and H2AX and amplifies the RNF8-dependent H2A ubiquitination, promoting the formation of 'Lys-63'-linked ubiquitin conjugates. This leads to concentrate ubiquitinated histones H2A and H2AX at DNA lesions to the threshold required for recruitment of TP53BP1 and BRCA1. Also recrui [...] (592 aa)
DDB1DNA damage-binding protein 1. (1140 aa)
PCGF2Polycomb group RING finger protein 2 isoform X1. (345 aa)
CUL4BLOW QUALITY PROTEIN: cullin-4B; Belongs to the cullin family. (893 aa)
BCORBCL-6 corepressor isoform X1. (1757 aa)
DDB2DNA damage-binding protein 2 isoform X1. (457 aa)
PCGF3Polycomb group RING finger protein 3 isoform X1. (242 aa)
PCGF1Polycomb group RING finger protein 1. (259 aa)
RING1E3 ubiquitin-protein ligase RING1. (406 aa)
PCGF5Polycomb group RING finger protein 5 isoform X1. (256 aa)
BMI1Polycomb complex protein BMI-1. (326 aa)
TRIM37E3 ubiquitin-protein ligase TRIM37. (902 aa)
RYBPRING1 and YY1-binding protein. (228 aa)
LOC103003208LOW QUALITY PROTEIN: E3 ubiquitin-protein ligase RING1-like. (406 aa)
PCGF6Polycomb group RING finger protein 6 isoform X1. (364 aa)
LOC103002330LOW QUALITY PROTEIN: BCL-6 corepressor-like. (1668 aa)
KDM2BLysine-specific demethylase 2B isoform X1. (1223 aa)
Your Current Organism:
Balaenoptera acutorostrata
NCBI taxonomy Id: 310752
Other names: B. acutorostrata scammoni, Balaenoptera acutorostrata scammoni
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