STRINGSTRING
KCNE3 KCNE3 KCNQ1 KCNQ1 TBX5 TBX5 RYR2 RYR2 SLC9A1 SLC9A1 KCNA5 KCNA5 MTOR MTOR KCNA1 KCNA1 KCNMB4 KCNMB4 ISL1 ISL1 AKAP9 AKAP9 CACNB2 CACNB2 SCN3B SCN3B SCN4B SCN4B SCN2B SCN2B CXADR CXADR ZMPSTE24 ZMPSTE24 SCN1B SCN1B MAG MAG FFAR3 FFAR3 CACNG2 CACNG2 NFASC NFASC KCNE4 KCNE4 CTNNA3 CTNNA3 GRIK2 GRIK2 KCND3 KCND3 TRPM4 TRPM4 CAV1 CAV1 NUP155 NUP155 KCNN2 KCNN2 SCN5A SCN5A SCN10A SCN10A RGS21 RGS21 MEF2A MEF2A DRD5 DRD5 PLN PLN P2RX7 P2RX7 GLRA1 GLRA1 SLC4A3 SLC4A3 CACNG4 CACNG4 KCNJ2 KCNJ2 CACNG5 CACNG5 CLCN1 CLCN1 KCNE1 KCNE1 KCNE2 KCNE2 FKBP1B FKBP1B KCNJ5 KCNJ5 CHRNA1 CHRNA1 SCN7A SCN7A LOC102998353 LOC102998353 LOC103019313 LOC103019313 CACNB4 CACNB4 LOC103011949 LOC103011949 KCNMB2 KCNMB2 DMRT3 DMRT3 GJA5 GJA5 CACNA1H CACNA1H CACNG8 CACNG8 GJD2 GJD2 CHRM5 CHRM5 GJC1 GJC1 LOC103001476 LOC103001476 LOC103016986 LOC103016986 CACNA2D1 CACNA2D1 LOC103005437 LOC103005437 PAFAH1B1 PAFAH1B1 NTRK2 NTRK2 KCNH6 KCNH6 PKP2 PKP2 CACNA1D CACNA1D HCN4 HCN4 OTOA OTOA KCNH2 KCNH2 KCNMB3 KCNMB3 ABCC9 ABCC9 DSG2 DSG2 CHRNB4 CHRNB4 DSP DSP GPER1 GPER1 SCN4A SCN4A CACNA1C CACNA1C CACNG7 CACNG7 CACNA1A CACNA1A CACNA1B CACNA1B CACNA1I CACNA1I PLEC PLEC SPTBN4 SPTBN4
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
KCNE3Potassium voltage-gated channel subfamily E member 3. (99 aa)
KCNQ1Potassium voltage-gated channel subfamily KQT member 1; Belongs to the potassium channel family. (599 aa)
TBX5T-box transcription factor TBX5 isoform X1. (536 aa)
RYR2Ryanodine receptor 2 isoform X1. (4884 aa)
SLC9A1Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. (815 aa)
KCNA5Potassium voltage-gated channel subfamily A member 5; Belongs to the potassium channel family. (604 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2546 aa)
KCNA1Potassium voltage-gated channel subfamily A member 1; Belongs to the potassium channel family. (495 aa)
KCNMB4Calcium-activated potassium channel subunit beta-4. (210 aa)
ISL1Insulin gene enhancer protein ISL-1. (349 aa)
AKAP9A-kinase anchor protein 9. (3895 aa)
CACNB2Voltage-dependent L-type calcium channel subunit beta-2 isoform X1. (604 aa)
SCN3BSodium channel subunit beta-3 isoform X1. (255 aa)
SCN4BSodium channel subunit beta-4. (228 aa)
SCN2BSodium channel subunit beta-2. (215 aa)
CXADRCoxsackievirus and adenovirus receptor. (365 aa)
ZMPSTE24CAAX prenyl protease; Proteolytically removes the C-terminal three residues of farnesylated proteins; Belongs to the peptidase M48A family. (475 aa)
SCN1BSodium channel subunit beta-1 isoform X1. (205 aa)
MAGMyelin-associated glycoprotein. (626 aa)
FFAR3LOW QUALITY PROTEIN: free fatty acid receptor 3. (358 aa)
CACNG2Voltage-dependent calcium channel gamma-2 subunit; Regulates the trafficking and gating properties of AMPA- selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Thought to stabilize the calcium channel in an inactivated (closed) state; Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (323 aa)
NFASCNeurofascin isoform X16. (1345 aa)
KCNE4LOW QUALITY PROTEIN: potassium voltage-gated channel subfamily E member 4. (249 aa)
CTNNA3Catenin alpha-3 isoform X1. (944 aa)
GRIK2Glutamate receptor ionotropic, kainate 2 isoform X1. (908 aa)
KCND3Potassium voltage-gated channel subfamily D member 3 isoform X1; Belongs to the potassium channel family. (655 aa)
TRPM4Transient receptor potential cation channel subfamily M member 4 isoform X1. (1206 aa)
CAV1Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (178 aa)
NUP155Nuclear pore complex protein Nup155. (1391 aa)
KCNN2LOW QUALITY PROTEIN: small conductance calcium-activated potassium channel protein 2. (856 aa)
SCN5ASodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (1992 aa)
SCN10ASodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (1965 aa)
RGS21Regulator of G-protein signaling 21. (185 aa)
MEF2AMyocyte-specific enhancer factor 2A isoform X1. (503 aa)
DRD5D(1B) dopamine receptor; Belongs to the G-protein coupled receptor 1 family. (397 aa)
PLNCardiac phospholamban; Reversibly inhibits the activity of ATP2A2 in cardiac sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca(2+). Modulates the contractility of the heart muscle in response to physiological stimuli via its effects on ATP2A2. Modulates calcium re-uptake during muscle relaxation and plays an important role in calcium homeostasis in the heart muscle. The degree of ATP2A2 inhibition depends on the oligomeric state of PLN. (52 aa)
P2RX7P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. Belongs to the P2X receptor family. (595 aa)
GLRA1Glycine receptor subunit alpha-1; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (457 aa)
SLC4A3Anion exchange protein. (1228 aa)
CACNG4Voltage-dependent calcium channel gamma-4 subunit. (549 aa)
KCNJ2Inward rectifier potassium channel 2. (427 aa)
CACNG5Voltage-dependent calcium channel gamma-5 subunit. (275 aa)
CLCN1Chloride channel protein. (989 aa)
KCNE1Potassium voltage-gated channel subfamily E member 1. (129 aa)
KCNE2Potassium voltage-gated channel subfamily E member 2. (123 aa)
FKBP1BPeptidylprolyl isomerase. (108 aa)
KCNJ5G protein-activated inward rectifier potassium channel 4. (419 aa)
CHRNA1Acetylcholine receptor subunit alpha. (457 aa)
SCN7ASodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (1684 aa)
LOC102998353Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (1998 aa)
LOC103019313Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (2006 aa)
CACNB4Voltage-dependent L-type calcium channel subunit beta-4 isoform X1. (502 aa)
LOC103011949Serine/threonine-protein kinase TNNI3K isoform X1. (835 aa)
KCNMB2Calcium-activated potassium channel subunit beta-2. (235 aa)
DMRT3Doublesex- and mab-3-related transcription factor 3. (506 aa)
GJA5Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. (358 aa)
CACNA1HLOW QUALITY PROTEIN: voltage-dependent T-type calcium channel subunit alpha-1H. (2326 aa)
CACNG8Voltage-dependent calcium channel gamma-8 subunit. (228 aa)
GJD2Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. (321 aa)
CHRM5Muscarinic acetylcholine receptor; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. (532 aa)
GJC1Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. (396 aa)
LOC103001476Myosin-14. (1175 aa)
LOC103016986Potassium voltage-gated channel subfamily E member 3-like. (99 aa)
CACNA2D1Voltage-dependent calcium channel subunit alpha-2/delta-1 isoform X1. (1110 aa)
LOC103005437Junction plakoglobin. (744 aa)
PAFAH1B1Platelet-activating factor acetylhydrolase IB subunit alpha; Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the peripheral transport of microtubule fragments and the coupling of the nucleus and centrosome. Required during brain development for the proliferation of neuronal precursors and the migration of newly formed neurons from the ven [...] (410 aa)
NTRK2Tyrosine-protein kinase receptor. (838 aa)
KCNH6Potassium voltage-gated channel subfamily H member 6. (896 aa)
PKP2Plakophilin-2 isoform X1. (826 aa)
CACNA1DVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2183 aa)
HCN4Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4. (813 aa)
OTOAOtoancorin. (1139 aa)
KCNH2LOW QUALITY PROTEIN: potassium voltage-gated channel subfamily H member 2. (813 aa)
KCNMB3LOW QUALITY PROTEIN: calcium-activated potassium channel subunit beta-3. (188 aa)
ABCC9LOW QUALITY PROTEIN: ATP-binding cassette sub-family C member 9. (1549 aa)
DSG2Desmoglein-2. (1123 aa)
CHRNB4Neuronal acetylcholine receptor subunit beta-4. (495 aa)
DSPDesmoplakin isoform X1. (2867 aa)
GPER1G-protein coupled estrogen receptor 1; Belongs to the G-protein coupled receptor 1 family. (363 aa)
SCN4ASodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (1832 aa)
CACNA1CVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2273 aa)
CACNG7Voltage-dependent calcium channel gamma-7 subunit; Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit (By similarity). Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization. Shows specificity only for GRIA1 and GRIA2. Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (282 aa)
CACNA1AVoltage-dependent P/Q-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1A gives rise to P and/or Q- type calcium currents. (2185 aa)
CACNA1BVoltage-dependent N-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1B gives rise to N-type calcium currents. (2153 aa)
CACNA1IVoltage-dependent T-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. This channel gives rise to T-type calcium currents. T-type calcium channels belong to the "low-voltage activated (LVA)" group and are strongly blocked by nickel and mibefradil. A particularity of this type of channels is an opening at quite ne [...] (2076 aa)
PLECPlectin. (4277 aa)
SPTBN4Spectrin beta chain; Belongs to the spectrin family. (2447 aa)
Your Current Organism:
Balaenoptera acutorostrata
NCBI taxonomy Id: 310752
Other names: B. acutorostrata scammoni, Balaenoptera acutorostrata scammoni
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