(95 nodes) Lipoprotein biosynthetic process network (Balaenoptera acutorostrata)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ZDHHC4	Palmitoyltransferase; Belongs to the DHHC palmitoyltransferase family. (365 aa)
	WIPI2	WD repeat domain phosphoinositide-interacting protein 2. (441 aa)
	GOLGA7B	Golgin subfamily A member 7B isoform X1. (164 aa)
	ZDHHC16	Palmitoyltransferase; Belongs to the DHHC palmitoyltransferase family. (377 aa)
	ZDHHC15	Palmitoyltransferase; Belongs to the DHHC palmitoyltransferase family. (232 aa)
	LOC103015520	Palmitoyltransferase ZDHHC15. (86 aa)
	PIGF	Phosphatidylinositol-glycan biosynthesis class F protein isoform X1. (219 aa)
	PIGW	Phosphatidylinositol-glycan biosynthesis class W protein; Probable acetyltransferase, which acetylates the inositol ring of phosphatidylinositol during biosynthesis of GPI-anchor. (503 aa)
	ATG5	Autophagy protein 5; Involved in autophagic vesicle formation. (275 aa)
	CUNH2orf66	Uncharacterized protein C2orf66 homolog. (118 aa)
	HHAT	Protein-cysteine N-palmitoyltransferase HHAT; Belongs to the membrane-bound acyltransferase family. (493 aa)
	ZDHHC20	Palmitoyltransferase; Belongs to the DHHC palmitoyltransferase family. (302 aa)
	CLIP3	CAP-Gly domain-containing linker protein 3. (547 aa)
	PIGC	Phosphatidylinositol N-acetylglucosaminyltransferase subunit C. (297 aa)
	GPAA1	Glycosylphosphatidylinositol anchor attachment 1 protein. (621 aa)
	ZDHHC3	Palmitoyltransferase; Belongs to the DHHC palmitoyltransferase family. (364 aa)
	ZDHHC18	Palmitoyltransferase; Belongs to the DHHC palmitoyltransferase family. (344 aa)
	PIGV	GPI mannosyltransferase 2; Mannosyltransferase involved in glycosylphosphatidylinositol- anchor biosynthesis. (493 aa)
	ZDHHC24	Palmitoyltransferase; Belongs to the DHHC palmitoyltransferase family. (284 aa)
	PIGX	Phosphatidylinositol-glycan biosynthesis class X protein. (352 aa)
	ZDHHC7	Palmitoyltransferase; Belongs to the DHHC palmitoyltransferase family. (308 aa)
	PIK3C3	Phosphatidylinositol 3-kinase catalytic subunit type 3. (887 aa)
	MTTP	Microsomal triglyceride transfer protein large subunit isoform X1. (900 aa)
	PGAP2	post-GPI attachment to proteins factor 2 isoform X1. (260 aa)
	ATG16L2	Autophagy-related protein 16-2 isoform X1. (618 aa)
	ZDHHC2	Palmitoyltransferase; Belongs to the DHHC palmitoyltransferase family. (322 aa)
	MBOAT4	Ghrelin O-acyltransferase; Belongs to the membrane-bound acyltransferase family. (439 aa)
	PIGL	N-acetylglucosaminyl-phosphatidylinositol de-N-acetylase. (253 aa)
	PIGA	Phosphatidylinositol N-acetylglucosaminyltransferase subunit A. (488 aa)
	NUDT22	Uridine diphosphate glucose pyrophosphatase. (290 aa)
	ZDHHC13	Palmitoyltransferase; Belongs to the DHHC palmitoyltransferase family. (622 aa)
	SELENOK	Selenoprotein K isoform X1. (94 aa)
	RGSL1	LOW QUALITY PROTEIN: regulator of G-protein signaling protein-like. (1076 aa)
	ZDHHC21	Palmitoyltransferase; Belongs to the DHHC palmitoyltransferase family. (265 aa)
	PGAP3	Post-GPI attachment to proteins factor 3; Involved in the lipid remodeling steps of GPI-anchor maturation; Belongs to the PGAP3 family. (320 aa)
	UGCG	Ceramide glucosyltransferase isoform X1. (394 aa)
	DPM3	Dolichol-phosphate mannosyltransferase subunit 3; Stabilizer subunit of the dolichol-phosphate mannose (DPM) synthase complex; tethers catalytic subunit to the ER. Belongs to the DPM3 family. (92 aa)
	NMT1	Glycylpeptide N-tetradecanoyltransferase; Adds a myristoyl group to the N-terminal glycine residue of certain cellular proteins; Belongs to the NMT family. (496 aa)
	PORCN	Protein-serine O-palmitoleoyltransferase porcupine isoform X1; Belongs to the membrane-bound acyltransferase family. (461 aa)
	WDR45	WD repeat domain phosphoinositide-interacting protein 4 isoform X1. (385 aa)
	CWH43	LOW QUALITY PROTEIN: PGAP2-interacting protein. (699 aa)
	ZDHHC9	Palmitoyltransferase; Belongs to the DHHC palmitoyltransferase family. (364 aa)
	PIGG	GPI ethanolamine phosphate transferase 2 isoform X1. (998 aa)
	PIGQ	Phosphatidylinositol N-acetylglucosaminyltransferase subunit Q isoform X1. (581 aa)
	ZDHHC23	Palmitoyltransferase; Belongs to the DHHC palmitoyltransferase family. (435 aa)
	GOLGA7	Golgin subfamily A member 7 isoform X2. (137 aa)
	LOC103020332	Phosphatidylinositol N-acetylglucosaminyltransferase subunit Y-like. (71 aa)
	LOC103020621	Protein preY, mitochondrial-like. (114 aa)
	PIGP	Phosphatidylinositol N-acetylglucosaminyltransferase subunit P; Part of the complex catalyzing the transfer of N- acetylglucosamine from UDP-N-acetylglucosamine to phosphatidylinositol, the first step of GPI biosynthesis. (146 aa)
	LOC102997806	GPI transamidase component PIG-S isoform X1. (656 aa)
	PIGY	Phosphatidylinositol N-acetylglucosaminyltransferase subunit Y. (71 aa)
	PIGH	Phosphatidylinositol N-acetylglucosaminyltransferase subunit H isoform X2. (201 aa)
	ZDHHC22	Palmitoyltransferase; Belongs to the DHHC palmitoyltransferase family. (263 aa)
	ATG16L1	Autophagy-related protein 16-1 isoform X1. (623 aa)
	DPM1	Dolichol-phosphate mannosyltransferase subunit 1; Transfers mannose from GDP-mannose to dolichol monophosphate to form dolichol phosphate mannose (Dol-P-Man) which is the mannosyl donor in pathways leading to N-glycosylation, glycosyl phosphatidylinositol membrane anchoring, and O-mannosylation of proteins. (260 aa)
	WDR45B	WD repeat domain phosphoinositide-interacting protein 3 isoform X1. (344 aa)
	ZDHHC14	Palmitoyltransferase; Belongs to the DHHC palmitoyltransferase family. (488 aa)
	LOC103005753	Protein preY, mitochondrial-like. (114 aa)
	PIGU	Phosphatidylinositol glycan anchor biosynthesis class U protein isoform X1. (435 aa)
	DPM2	Dolichol phosphate-mannose biosynthesis regulatory protein; Regulatory subunit of the dolichol-phosphate mannose (DPM) synthase complex; essential for the ER localization. Belongs to the DPM2 family. (84 aa)
	PIGB	Mannosyltransferase. (541 aa)
	ZDHHC17	Palmitoyltransferase; Belongs to the DHHC palmitoyltransferase family. (632 aa)
	MAP6D1	MAP6 domain-containing protein 1. (324 aa)
	MPPE1	Metallophosphoesterase 1 isoform X1. (486 aa)
	APOBEC1	C->U-editing enzyme APOBEC-1. (236 aa)
	NMT2	Glycylpeptide N-tetradecanoyltransferase; Adds a myristoyl group to the N-terminal glycine residue of certain cellular proteins; Belongs to the NMT family. (411 aa)
	ZDHHC5	Palmitoyltransferase; Belongs to the DHHC palmitoyltransferase family. (715 aa)
	ZDHHC8	Palmitoyltransferase; Belongs to the DHHC palmitoyltransferase family. (615 aa)
	PIGO	GPI ethanolamine phosphate transferase 3 isoform X1. (1131 aa)
	TMEM246	Transmembrane protein 246. (403 aa)
	LOC102998881	Phosphatidylinositol N-acetylglucosaminyltransferase subunit Y. (71 aa)
	LOC102998605	Protein preY, mitochondrial-like. (114 aa)
	LOC102998798	Protein preY, mitochondrial-like. (114 aa)
	LOC102998526	Phosphatidylinositol N-acetylglucosaminyltransferase subunit Y-like. (71 aa)
	LCAT	Phosphatidylcholine-sterol acyltransferase. (440 aa)
	PIGM	GPI mannosyltransferase 1; Mannosyltransferase involved in glycosylphosphatidylinositol- anchor biosynthesis. Transfers the first alpha-1,4-mannose to GlcN- acyl-PI during GPI precursor assembly. (432 aa)
	ZDHHC1	Palmitoyltransferase; Belongs to the DHHC palmitoyltransferase family. (505 aa)
	ZDHHC19	Palmitoyltransferase; Belongs to the DHHC palmitoyltransferase family. (437 aa)
	PIGZ	Mannosyltransferase. (563 aa)
	ZDHHC6	Palmitoyltransferase; Belongs to the DHHC palmitoyltransferase family. (413 aa)
	LOC102998510	LOW QUALITY PROTEIN: regulator of G-protein signaling protein-like. (660 aa)
	GLUL	Glutamine synthetase. (386 aa)
	LOC103004809	LOW QUALITY PROTEIN: phosphatidylinositol N-acetylglucosaminyltransferase subunit C-like. (297 aa)
	APOB	Apolipoprotein B-100. (4585 aa)
	WIPI1	WD repeat domain phosphoinositide-interacting protein 1 isoform X1. (398 aa)
	PPM1B	Protein phosphatase 1B isoform X1. (477 aa)
	APOE	Apolipoprotein E; APOE is an apolipoprotein, a protein associating with lipid particles, that mainly functions in lipoprotein-mediated lipid transport between organs via the plasma and interstitial fluids. APOE is a core component of plasma lipoproteins and is involved in their production, conversion and clearance. Apoliproteins are amphipathic molecules that interact both with lipids of the lipoprotein particle core and the aqueous environment of the plasma. As such, APOE associates with chylomicrons, chylomicron remnants, very low density lipoproteins (VLDL) and intermediate density [...] (313 aa)
	LOC103012739	Palmitoyltransferase; Belongs to the DHHC palmitoyltransferase family. (564 aa)
	PIGK	GPI-anchor transamidase; Mediates GPI anchoring in the endoplasmic reticulum, by replacing a protein's C-terminal GPI attachment signal peptide with a pre-assembled GPI. During this transamidation reaction, the GPI transamidase forms a carbonyl intermediate with the substrate protein. Belongs to the peptidase C13 family. (395 aa)
	PIGN	LOW QUALITY PROTEIN: GPI ethanolamine phosphate transferase 1. (932 aa)
	ATG12	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family. (140 aa)
	ATG7	Ubiquitin-like modifier-activating enzyme ATG7; E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 as well as the ATG8 family proteins for their conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Required for autophagic death induced by caspase-8 inhibition. Required for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria [...] (707 aa)
	PPM1A	Protein phosphatase 1A isoform X1. (382 aa)
	ATG10	Ubiquitin-like-conjugating enzyme ATG10 isoform X1. (234 aa)
	PIGT	GPI transamidase component PIG-T isoform X1. (578 aa)

Your Current Organism:

Balaenoptera acutorostrata

NCBI taxonomy Id: 310752
Other names: B. acutorostrata scammoni, Balaenoptera acutorostrata scammoni

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
APOB	APOBEC1	A0A452CHV5	A0A384B9H5	Apolipoprotein B-100.	C->U-editing enzyme APOBEC-1.	0.691
APOB	APOE	A0A452CHV5	P0DML7	Apolipoprotein B-100.	Apolipoprotein E; APOE is an apolipoprotein, a protein associating with lipid particles, that mainly functions in lipoprotein-mediated lipid transport between organs via the plasma and interstitial fluids. APOE is a core component of plasma lipoproteins and is involved in their production, conversion and clearance. Apoliproteins are amphipathic molecules that interact both with lipids of the lipoprotein particle core and the aqueous environment of the plasma. As such, APOE associates with chylomicrons, chylomicron remnants, very low density lipoproteins (VLDL) and intermediate density [...]	0.797
APOB	LCAT	A0A452CHV5	A0A384BFK1	Apolipoprotein B-100.	Phosphatidylcholine-sterol acyltransferase.	0.545
APOB	MTTP	A0A452CHV5	A0A383ZD13	Apolipoprotein B-100.	Microsomal triglyceride transfer protein large subunit isoform X1.	0.984
APOBEC1	APOB	A0A384B9H5	A0A452CHV5	C->U-editing enzyme APOBEC-1.	Apolipoprotein B-100.	0.691
APOE	APOB	P0DML7	A0A452CHV5	Apolipoprotein E; APOE is an apolipoprotein, a protein associating with lipid particles, that mainly functions in lipoprotein-mediated lipid transport between organs via the plasma and interstitial fluids. APOE is a core component of plasma lipoproteins and is involved in their production, conversion and clearance. Apoliproteins are amphipathic molecules that interact both with lipids of the lipoprotein particle core and the aqueous environment of the plasma. As such, APOE associates with chylomicrons, chylomicron remnants, very low density lipoproteins (VLDL) and intermediate density [...]	Apolipoprotein B-100.	0.797
ATG10	ATG12	A0A384B0D0	A0A384AY09	Ubiquitin-like-conjugating enzyme ATG10 isoform X1.	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family.	0.998
ATG10	ATG16L1	A0A384B0D0	A0A384ABS1	Ubiquitin-like-conjugating enzyme ATG10 isoform X1.	Autophagy-related protein 16-1 isoform X1.	0.735
ATG10	ATG16L2	A0A384B0D0	A0A383ZF99	Ubiquitin-like-conjugating enzyme ATG10 isoform X1.	Autophagy-related protein 16-2 isoform X1.	0.484
ATG10	ATG5	A0A384B0D0	A0A384ATS6	Ubiquitin-like-conjugating enzyme ATG10 isoform X1.	Autophagy protein 5; Involved in autophagic vesicle formation.	0.860
ATG10	ATG7	A0A384B0D0	A0A384AZ29	Ubiquitin-like-conjugating enzyme ATG10 isoform X1.	Ubiquitin-like modifier-activating enzyme ATG7; E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 as well as the ATG8 family proteins for their conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Required for autophagic death induced by caspase-8 inhibition. Required for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria [...]	0.956
ATG10	PIK3C3	A0A384B0D0	A0A383ZCD5	Ubiquitin-like-conjugating enzyme ATG10 isoform X1.	Phosphatidylinositol 3-kinase catalytic subunit type 3.	0.424
ATG10	WIPI1	A0A384B0D0	A0A452CJD4	Ubiquitin-like-conjugating enzyme ATG10 isoform X1.	WD repeat domain phosphoinositide-interacting protein 1 isoform X1.	0.446
ATG12	ATG10	A0A384AY09	A0A384B0D0	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family.	Ubiquitin-like-conjugating enzyme ATG10 isoform X1.	0.998
ATG12	ATG16L1	A0A384AY09	A0A384ABS1	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family.	Autophagy-related protein 16-1 isoform X1.	0.999
ATG12	ATG16L2	A0A384AY09	A0A383ZF99	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family.	Autophagy-related protein 16-2 isoform X1.	0.993
ATG12	ATG5	A0A384AY09	A0A384ATS6	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family.	Autophagy protein 5; Involved in autophagic vesicle formation.	0.999
ATG12	ATG7	A0A384AY09	A0A384AZ29	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family.	Ubiquitin-like modifier-activating enzyme ATG7; E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 as well as the ATG8 family proteins for their conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Required for autophagic death induced by caspase-8 inhibition. Required for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria [...]	0.999
ATG12	PIK3C3	A0A384AY09	A0A383ZCD5	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family.	Phosphatidylinositol 3-kinase catalytic subunit type 3.	0.821
ATG12	WIPI1	A0A384AY09	A0A452CJD4	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family.	WD repeat domain phosphoinositide-interacting protein 1 isoform X1.	0.872