(48 nodes) Regulation of muscle adaptation network (Balaenoptera acutorostrata)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

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protein homology

Your Input:
	LOC103008965	prelamin-A/C-like; Belongs to the intermediate filament family. (103 aa)
	MLIP	Muscular LMNA-interacting protein isoform X1. (979 aa)
	GTF2IRD1	General transcription factor II-I repeat domain-containing protein 1 isoform X1. (938 aa)
	PRKCA	Non-specific serine/threonine protein kinase. (559 aa)
	HDAC4	Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1149 aa)
	SRL	Sarcalumenin; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (800 aa)
	LOC103012872	Beclin-1 isoform X1. (473 aa)
	LOC102999262	Beclin-1 isoform X3. (471 aa)
	MYOG	Myogenin. (224 aa)
	MTPN	Myotrophin. (118 aa)
	ACTN3	Alpha-actinin-3. (902 aa)
	SLC9A1	Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. (815 aa)
	TNFRSF1A	Tumor necrosis factor receptor superfamily member 1A. (343 aa)
	ERRFI1	ERBB receptor feedback inhibitor 1 isoform X1. (466 aa)
	TNFRSF1B	Tumor necrosis factor receptor superfamily member 1B. (460 aa)
	TWF1	Twinfilin-1 isoform X1. (357 aa)
	GSK3A	Glycogen synthase kinase-3 alpha; Belongs to the protein kinase superfamily. (410 aa)
	TNNI1	Troponin I, slow skeletal muscle. (221 aa)
	PARP1	Poly [ADP-ribose] polymerase. (1021 aa)
	ATP2B4	Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1243 aa)
	IGF1	Insulin-like growth factor I isoform X1. (187 aa)
	LMNA	Lamin; Belongs to the intermediate filament family. (664 aa)
	TRPC3	Short transient receptor potential channel 3 isoform X1; Belongs to the transient receptor (TC 1.A.4) family. (919 aa)
	PDE9A	Phosphodiesterase. (494 aa)
	PPP3CA	Serine/threonine-protein phosphatase. (521 aa)
	GLRX3	Glutaredoxin-3. (287 aa)
	EDN1	Endothelin-1. (202 aa)
	TNNC1	Troponin C, slow skeletal and cardiac muscles. (161 aa)
	CMYA5	Cardiomyopathy-associated protein 5. (3878 aa)
	SGCA	Alpha-sarcoglycan. (403 aa)
	NOTCH1	LOW QUALITY PROTEIN: neurogenic locus notch homolog protein 1. (2379 aa)
	SELENON	Selenoprotein N. (524 aa)
	PI16	Peptidase inhibitor 16 isoform X1; Belongs to the CRISP family. (463 aa)
	SMAD4	Mothers against decapentaplegic homolog. (553 aa)
	MYMK	Protein myomaker. (221 aa)
	HAND2	Heart- and neural crest derivatives-expressed protein 2. (130 aa)
	ADRA1A	alpha-1A adrenergic receptor isoform X1. (466 aa)
	LMCD1	LIM and cysteine-rich domains protein 1 isoform X1. (363 aa)
	CAV3	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (151 aa)
	ROCK1	Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1354 aa)
	MEF2A	Myocyte-specific enhancer factor 2A isoform X1. (503 aa)
	BMP10	Bone morphogenetic protein 10. (423 aa)
	P2RX4	P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. (388 aa)
	FBXO32	F-box only protein 32. (355 aa)
	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta isoform X1. (534 aa)
	FOXO3	LOW QUALITY PROTEIN: forkhead box protein O3. (467 aa)
	ATP2A2	Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1008 aa)
	PRKAG3	5'-AMP-activated protein kinase subunit gamma-3 isoform X1. (478 aa)

Your Current Organism:

Balaenoptera acutorostrata

NCBI taxonomy Id: 310752
Other names: B. acutorostrata scammoni, Balaenoptera acutorostrata scammoni

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACTN3	CAMK2D	A0A383Z7Q8	A0A452CNB3	Alpha-actinin-3.	Calcium/calmodulin-dependent protein kinase type II subunit delta isoform X1.	0.505
ACTN3	TNNC1	A0A383Z7Q8	A0A383ZI73	Alpha-actinin-3.	Troponin C, slow skeletal and cardiac muscles.	0.583
ACTN3	TNNI1	A0A383Z7Q8	A0A383YWS8	Alpha-actinin-3.	Troponin I, slow skeletal muscle.	0.685
ADRA1A	EDN1	A0A384AZI4	A0A383ZGM0	alpha-1A adrenergic receptor isoform X1.	Endothelin-1.	0.794
ATP2A2	ATP2B4	A0A452CMB6	A0A383YTU0	Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium.	Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium.	0.583
ATP2A2	PPP3CA	A0A452CMB6	A0A383ZCR9	Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium.	Serine/threonine-protein phosphatase.	0.421
ATP2A2	SRL	A0A452CMB6	A0A384A2L2	Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium.	Sarcalumenin; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.	0.492
ATP2A2	TNNI1	A0A452CMB6	A0A383YWS8	Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium.	Troponin I, slow skeletal muscle.	0.599
ATP2B4	ATP2A2	A0A383YTU0	A0A452CMB6	Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium.	Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium.	0.583
ATP2B4	TNNI1	A0A383YTU0	A0A383YWS8	Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium.	Troponin I, slow skeletal muscle.	0.499
BMP10	SMAD4	A0A384ARQ8	A0A384BC65	Bone morphogenetic protein 10.	Mothers against decapentaplegic homolog.	0.466
CAMK2D	ACTN3	A0A452CNB3	A0A383Z7Q8	Calcium/calmodulin-dependent protein kinase type II subunit delta isoform X1.	Alpha-actinin-3.	0.505
CAMK2D	PPP3CA	A0A452CNB3	A0A383ZCR9	Calcium/calmodulin-dependent protein kinase type II subunit delta isoform X1.	Serine/threonine-protein phosphatase.	0.532
CAV3	MYOG	A0A384AYP4	A0A384AFE6	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Myogenin.	0.538
CAV3	SGCA	A0A384AYP4	A0A383ZMY9	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Alpha-sarcoglycan.	0.600
EDN1	ADRA1A	A0A383ZGM0	A0A384AZI4	Endothelin-1.	alpha-1A adrenergic receptor isoform X1.	0.794
EDN1	HAND2	A0A383ZGM0	A0A384AZL3	Endothelin-1.	Heart- and neural crest derivatives-expressed protein 2.	0.422
EDN1	IGF1	A0A383ZGM0	A0A383YSK5	Endothelin-1.	Insulin-like growth factor I isoform X1.	0.439
FBXO32	MYOG	A0A384ANK4	A0A384AFE6	F-box only protein 32.	Myogenin.	0.428
FOXO3	IGF1	A0A452CN42	A0A383YSK5	LOW QUALITY PROTEIN: forkhead box protein O3.	Insulin-like growth factor I isoform X1.	0.431