STRINGSTRING
SIX1 SIX1 CTNNB1 CTNNB1 GCM1 GCM1 WNT11 WNT11 EHMT2 EHMT2 RUNX2 RUNX2 LHX3 LHX3 LOC103015737 LOC103015737 ONECUT1 ONECUT1 LEO1 LEO1 SOX5 SOX5 FGF10 FGF10 HES1 HES1 ISL1 ISL1 MYT1L MYT1L ID2 ID2 TBX18 TBX18 NANOG NANOG TGFBR1 TGFBR1 LATS1 LATS1 SMAD4 SMAD4 GATA6 GATA6 PML PML APC2 APC2 ATOH1 ATOH1 TBX2 TBX2 NOTCH1 NOTCH1 VWA5B2 VWA5B2 TEAD3 TEAD3 ZNF521 ZNF521 NODAL NODAL HOXA2 HOXA2 PITX1 PITX1 TAL1 TAL1 MYOD1 MYOD1 PTCH1 PTCH1 BRAF BRAF SMO SMO ETV2 ETV2 EPOP EPOP LOC103008157 LOC103008157 WNT5B WNT5B GBX1 GBX1 SHH SHH ARX ARX KDM6A KDM6A LOC103016619 LOC103016619 TBXT TBXT WNT6 WNT6 ONECUT2 ONECUT2 SOX12 SOX12 SOX13 SOX13 HOXC10 HOXC10 WNT1 WNT1 WNT10B WNT10B GATA2 GATA2 IL6R IL6R FOXA1 FOXA1 LOC102997405 LOC102997405 RARA RARA TBX21 TBX21 WNT16 WNT16 KIAA1549 KIAA1549 LOC103009986 LOC103009986 LOC103003105 LOC103003105 BARHL2 BARHL2 JAG2 JAG2 WNT3 WNT3 WNT9B WNT9B PROX1 PROX1 LOC102997198 LOC102997198 CTR9 CTR9 SOX6 SOX6 WNT4 WNT4 VWA5B1 VWA5B1 PDPN PDPN DBX1 DBX1 LOC103006469 LOC103006469 EDN1 EDN1 IRF4 IRF4 ISL2 ISL2 NKX6-2 NKX6-2 TCF7L2 TCF7L2 PRRX1 PRRX1 TBX19 TBX19 WNT8A WNT8A NEUROG1 NEUROG1 SMAD5 SMAD5 ARHGEF2 ARHGEF2 SLAMF6 SLAMF6 HOXA13 HOXA13 HOXA11 HOXA11 TLX3 TLX3 TBX10 TBX10 TBX5 TBX5 MTOR MTOR TEAD4 TEAD4 WNT9A WNT9A WNT3A WNT3A POU3F2 POU3F2 WNT2B WNT2B TBX15 TBX15 SOX17 SOX17 RHOA RHOA TOX TOX GSX2 GSX2 KDR KDR NTF4 NTF4 TM2D3 TM2D3 GATA3 GATA3 KDM6B KDM6B NEUROD4 NEUROD4 ASCL1 ASCL1 NR2F2 NR2F2 SOSTDC1 SOSTDC1 DMRTA2 DMRTA2 PTCH2 PTCH2 DOCK7 DOCK7 LATS2 LATS2 GSX1 GSX1 STAT6 STAT6 DHH DHH PAF1 PAF1 TBX3 TBX3 FOXN4 FOXN4 MGA MGA RTF1 RTF1 DLL4 DLL4 FOXG1 FOXG1 NKX2-1 NKX2-1 RAG2 RAG2 PAX6 PAX6 SOX8 SOX8 GAP43 GAP43 NKX6-3 NKX6-3 SFRP1 SFRP1 DMRT3 DMRT3 TBX20 TBX20 LOC103016910 LOC103016910 DLX1 DLX1 TBR1 TBR1 DLX2 DLX2 CDON CDON IL6 IL6 FOXN1 FOXN1 OLIG1 OLIG1 OLIG2 OLIG2 PRADC1 PRADC1 PSEN1 PSEN1 BATF BATF PRDM14 PRDM14 EYA1 EYA1 IL7 IL7 SOX9 SOX9 DLL1 DLL1 POU4F1 POU4F1 SPRY2 SPRY2 TBX6 TBX6 TGFB1I1 TGFB1I1 MYL10 MYL10 SPDEF SPDEF SUFU SUFU LBX1 LBX1 WNT8B WNT8B FGF8 FGF8 TENM4 TENM4 TBX22 TBX22 GLI3 GLI3 ERBB4 ERBB4 IHH IHH FEV FEV WNT10A WNT10A EXT1 EXT1 WNT7B WNT7B EDNRA EDNRA SMAD1 SMAD1 SFRP2 SFRP2 MYL2 MYL2 ITGB1 ITGB1 PTF1A PTF1A EPAS1 EPAS1 SIX2 SIX2 TBX4 TBX4 NEUROD1 NEUROD1 HOXD10 HOXD10 HEY2 HEY2 PRDM1 PRDM1 NR2E1 NR2E1 OLIG3 OLIG3 EOMES EOMES BMP2 BMP2 BCL2 BCL2 NKX2-2 NKX2-2 APC APC MITF MITF FEZF2 FEZF2 LOC103001360 LOC103001360 GATA4 GATA4 MEF2C MEF2C EBF2 EBF2 BMP4 BMP4
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SIX1Homeobox protein SIX1. (284 aa)
CTNNB1Catenin beta-1. (767 aa)
GCM1Chorion-specific transcription factor GCMa. (434 aa)
WNT11Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
EHMT2Histone-lysine N-methyltransferase EHMT2 isoform X1. (1268 aa)
RUNX2Runt-related transcription factor 2. (343 aa)
LHX3LIM/homeobox protein Lhx3. (493 aa)
LOC103015737Mesoderm posterior protein 1. (126 aa)
ONECUT1One cut domain family member. (470 aa)
LEO1RNA polymerase-associated protein LEO1. (666 aa)
SOX5Transcription factor SOX-5 isoform X1. (729 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (210 aa)
HES1Transcription factor HES-1. (280 aa)
ISL1Insulin gene enhancer protein ISL-1. (349 aa)
MYT1LMyelin transcription factor 1-like protein. (912 aa)
ID2DNA-binding protein inhibitor ID-2. (134 aa)
TBX18T-box transcription factor TBX18. (607 aa)
NANOGHomeobox protein NANOG isoform X1. (307 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (434 aa)
LATS1Serine/threonine-protein kinase LATS1. (1127 aa)
SMAD4Mothers against decapentaplegic homolog. (553 aa)
GATA6Transcription factor GATA-6. (357 aa)
PMLProtein PML isoform X1. (871 aa)
APC2LOW QUALITY PROTEIN: adenomatous polyposis coli protein 2. (1582 aa)
ATOH1LOW QUALITY PROTEIN: protein atonal homolog 1. (348 aa)
TBX2LOW QUALITY PROTEIN: T-box transcription factor TBX2. (592 aa)
NOTCH1LOW QUALITY PROTEIN: neurogenic locus notch homolog protein 1. (2379 aa)
VWA5B2Von Willebrand factor A domain-containing protein 5B2 isoform X1. (1295 aa)
TEAD3Transcriptional enhancer factor TEF-5; Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. (497 aa)
ZNF521Zinc finger protein 521 isoform X1. (1091 aa)
NODALNodal homolog. (280 aa)
HOXA2LOW QUALITY PROTEIN: homeobox protein Hox-A2. (369 aa)
PITX1Homeobox protein. (199 aa)
TAL1T-cell acute lymphocytic leukemia protein 1. (172 aa)
MYOD1Myogenic factor; Induces fibroblasts to differentiate into myoblasts. Acts as a transcriptional activator that promotes transcription of muscle- specific target genes and plays a role in muscle differentiation. (268 aa)
PTCH1LOW QUALITY PROTEIN: protein patched homolog 1. (1304 aa)
BRAFSerine/threonine-protein kinase B-raf. (839 aa)
SMOSmoothened homolog; Belongs to the G-protein coupled receptor Fz/Smo family. (837 aa)
ETV2ETS translocation variant 2 isoform X1. (333 aa)
EPOPElongin BC and Polycomb repressive complex 2-associated protein. (519 aa)
LOC103008157Signal transducer and activator of transcription. (793 aa)
WNT5BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (391 aa)
GBX1Homeobox protein GBX-1. (280 aa)
SHHLOW QUALITY PROTEIN: sonic hedgehog protein. (271 aa)
ARXHomeobox protein ARX. (121 aa)
KDM6ALysine-specific demethylase 6A. (1180 aa)
LOC103016619Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (253 aa)
TBXTT-box transcription factor T isoform X2. (436 aa)
WNT6Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (365 aa)
ONECUT2One cut domain family member. (433 aa)
SOX12Transcription factor SOX-12. (169 aa)
SOX13Transcription factor SOX-13 isoform X1. (618 aa)
HOXC10Homeobox protein Hox-C10 isoform X1. (368 aa)
WNT1Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa)
WNT10BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (389 aa)
GATA2LOW QUALITY PROTEIN: endothelial transcription factor GATA-2. (479 aa)
IL6RInterleukin-6 receptor subunit alpha isoform X1. (499 aa)
FOXA1Hepatocyte nuclear factor 3-alpha. (433 aa)
LOC102997405Signal transducer and activator of transcription. (783 aa)
RARARetinoic acid receptor alpha isoform X1. (462 aa)
TBX21T-box transcription factor TBX21. (379 aa)
WNT16Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (361 aa)
KIAA1549UPF0606 protein KIAA1549 homolog. (978 aa)
LOC103009986Cathepsin L1; Belongs to the peptidase C1 family. (334 aa)
LOC103003105Cathepsin L1 isoform X1; Belongs to the peptidase C1 family. (333 aa)
BARHL2barH-like 2 homeobox protein. (383 aa)
JAG2Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (894 aa)
WNT3Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (355 aa)
WNT9BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (358 aa)
PROX1Prospero homeobox protein 1 isoform X1. (738 aa)
LOC102997198Cytochrome P450 26B1 isoform X1; Belongs to the cytochrome P450 family. (512 aa)
CTR9RNA polymerase-associated protein CTR9 homolog. (1179 aa)
SOX6Transcription factor SOX-6 isoform X1. (842 aa)
WNT4Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (296 aa)
VWA5B1Von Willebrand factor A domain-containing protein 5B1. (1221 aa)
PDPNPodoplanin isoform X1. (162 aa)
DBX1Homeobox protein DBX1. (349 aa)
LOC103006469Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (152 aa)
EDN1Endothelin-1. (202 aa)
IRF4Interferon regulatory factor 4 isoform X1. (451 aa)
ISL2Insulin gene enhancer protein ISL-2. (359 aa)
NKX6-2Homeobox protein Nkx-6.2. (120 aa)
TCF7L2Transcription factor 7-like 2 isoform X1. (515 aa)
PRRX1Paired mesoderm homeobox protein 1 isoform X1. (245 aa)
TBX19T-box transcription factor TBX19. (444 aa)
WNT8AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (352 aa)
NEUROG1Neurogenin-1. (244 aa)
SMAD5Mothers against decapentaplegic homolog. (465 aa)
ARHGEF2Rho guanine nucleotide exchange factor 2 isoform X1. (1179 aa)
SLAMF6SLAM family member 6 isoform X1. (301 aa)
HOXA13Homeobox protein Hox-A13. (294 aa)
HOXA11Homeobox protein Hox-A11. (314 aa)
TLX3T-cell leukemia homeobox protein 3. (291 aa)
TBX10T-box transcription factor TBX10. (389 aa)
TBX5T-box transcription factor TBX5 isoform X1. (536 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2546 aa)
TEAD4Transcriptional enhancer factor TEF-3. (580 aa)
WNT9AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (455 aa)
WNT3AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (352 aa)
POU3F2POU domain protein. (263 aa)
WNT2BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (394 aa)
TBX15T-box transcription factor TBX15 isoform X1. (602 aa)
SOX17Transcription factor SOX-17. (296 aa)
RHOATransforming protein RhoA. (193 aa)
TOXThymocyte selection-associated high mobility group box protein TOX. (479 aa)
GSX2GS homeobox 2. (299 aa)
KDRVascular endothelial growth factor receptor 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1356 aa)
NTF4Neurotrophin-4; Belongs to the NGF-beta family. (210 aa)
TM2D3TM2 domain-containing protein 3 isoform X1. (252 aa)
GATA3Trans-acting T-cell-specific transcription factor GATA-3 isoform X1. (444 aa)
KDM6BLOW QUALITY PROTEIN: lysine-specific demethylase 6B. (1504 aa)
NEUROD4Neurogenic differentiation factor. (331 aa)
ASCL1Achaete-scute homolog 1. (169 aa)
NR2F2COUP transcription factor 2 isoform X1. (281 aa)
SOSTDC1Sclerostin domain-containing protein 1. (206 aa)
DMRTA2Doublesex- and mab-3-related transcription factor A2. (390 aa)
PTCH2Protein patched homolog 2 isoform X1. (1213 aa)
DOCK7Dedicator of cytokinesis protein 7 isoform X1; Belongs to the DOCK family. (2023 aa)
LATS2Serine/threonine-protein kinase LATS2. (795 aa)
GSX1GS homeobox 1. (256 aa)
STAT6Signal transducer and activator of transcription. (847 aa)
DHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (396 aa)
PAF1RNA polymerase II-associated factor 1 homolog. (526 aa)
TBX3T-box transcription factor TBX3. (670 aa)
FOXN4Forkhead box protein N4. (518 aa)
MGAMAX gene-associated protein isoform X1. (3115 aa)
RTF1RNA polymerase-associated protein RTF1 homolog. (710 aa)
DLL4Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (685 aa)
FOXG1Forkhead box protein G1. (352 aa)
NKX2-1Homeobox protein Nkx-2.1. (296 aa)
RAG2V(D)J recombination-activating protein 2. (527 aa)
PAX6Paired box protein Pax-6 isoform X1. (493 aa)
SOX8LOW QUALITY PROTEIN: transcription factor SOX-8. (474 aa)
GAP43Neuromodulin. (243 aa)
NKX6-3Homeobox protein Nkx-6.3. (357 aa)
SFRP1Secreted frizzled-related protein 1. (295 aa)
DMRT3Doublesex- and mab-3-related transcription factor 3. (506 aa)
TBX20T-box transcription factor TBX20. (449 aa)
LOC103016910Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (141 aa)
DLX1Homeobox protein DLX-1 isoform X1. (255 aa)
TBR1T-box brain protein 1. (798 aa)
DLX2Homeobox protein DLX-2. (251 aa)
CDONCell adhesion molecule-related/down-regulated by oncogenes. (1251 aa)
IL6Interleukin-6. (208 aa)
FOXN1Forkhead box protein N1. (645 aa)
OLIG1LOW QUALITY PROTEIN: oligodendrocyte transcription factor 1. (215 aa)
OLIG2Oligodendrocyte transcription factor 2. (254 aa)
PRADC1Protease-associated domain-containing protein 1. (188 aa)
PSEN1Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (469 aa)
BATFBasic leucine zipper transcriptional factor ATF-like. (125 aa)
PRDM14PR domain zinc finger protein 14. (571 aa)
EYA1Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (584 aa)
IL7Interleukin-7 isoform X2. (178 aa)
SOX9Transcription factor SOX-9. (432 aa)
DLL1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (719 aa)
POU4F1POU domain protein. (298 aa)
SPRY2Protein sprouty homolog 2. (315 aa)
TBX6T-box transcription factor TBX6. (436 aa)
TGFB1I1Transforming growth factor beta-1-induced transcript 1 protein isoform X1; Belongs to the paxillin family. (456 aa)
MYL10Myosin regulatory light chain 10. (167 aa)
SPDEFSAM pointed domain-containing Ets transcription factor. (337 aa)
SUFUSuppressor of fused homolog; Negative regulator in the hedgehog signaling pathway. Down- regulates GLI1-mediated transactivation of target genes. Part of a corepressor complex that acts on DNA-bound GLI1. May also act by linking GLI1 to BTRC and thereby targeting GLI1 to degradation by the proteasome. Sequesters GLI1, GLI2 and GLI3 in the cytoplasm, this effect is overcome by binding of STK36 to both SUFU and a GLI protein. Negative regulator of beta-catenin signaling. Regulates the formation of either the repressor form (GLI3R) or the activator form (GLI3A) of the full-length form of [...] (485 aa)
LBX1Transcription factor LBX1. (282 aa)
WNT8BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (336 aa)
FGF8Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (244 aa)
TENM4Teneurin-4. (2739 aa)
TBX22T-box transcription factor TBX22. (522 aa)
GLI3Transcriptional activator GLI3 isoform X1. (1591 aa)
ERBB4Receptor protein-tyrosine kinase. (1298 aa)
IHHIndian hedgehog protein. (309 aa)
FEVProtein FEV. (184 aa)
WNT10AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (417 aa)
EXT1Exostosin-1; Belongs to the glycosyltransferase 47 family. (746 aa)
WNT7BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (535 aa)
EDNRAEndothelin-1 receptor; Belongs to the G-protein coupled receptor 1 family. (427 aa)
SMAD1Mothers against decapentaplegic homolog. (465 aa)
SFRP2Secreted frizzled-related protein 2. (294 aa)
MYL2Myosin regulatory light chain 2, ventricular/cardiac muscle isoform. (166 aa)
ITGB1Integrin beta; Belongs to the integrin beta chain family. (801 aa)
PTF1APancreas transcription factor 1 subunit alpha. (300 aa)
EPAS1Endothelial PAS domain-containing protein 1 isoform X1. (884 aa)
SIX2Homeobox protein SIX2 isoform X1. (298 aa)
TBX4T-box transcription factor TBX4. (557 aa)
NEUROD1Neurogenic differentiation factor. (356 aa)
HOXD10Homeobox protein Hox-D10. (343 aa)
HEY2Hairy/enhancer-of-split related with YRPW motif protein 2 isoform X1. (337 aa)
PRDM1PR domain zinc finger protein 1. (672 aa)
NR2E1Nuclear receptor subfamily 2 group E member 1. (400 aa)
OLIG3Oligodendrocyte transcription factor 3. (281 aa)
EOMESEomesodermin homolog isoform X1. (419 aa)
BMP2Bone morphogenetic protein 2. (395 aa)
BCL2Apoptosis regulator Bcl-2 isoform X1. (233 aa)
NKX2-2Homeobox protein Nkx-2.2. (273 aa)
APCAdenomatous polyposis coli protein isoform X1. (2865 aa)
MITFMicrophthalmia-associated transcription factor isoform X1. (526 aa)
FEZF2Fez family zinc finger protein 2. (457 aa)
LOC103001360Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (204 aa)
GATA4Transcription factor GATA-4. (229 aa)
MEF2CMyocyte-specific enhancer factor 2C isoform X5. (483 aa)
EBF2Transcription factor COE2. (575 aa)
BMP4Bone morphogenetic protein 4 isoform X1. (420 aa)
Your Current Organism:
Balaenoptera acutorostrata
NCBI taxonomy Id: 310752
Other names: B. acutorostrata scammoni, Balaenoptera acutorostrata scammoni
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