STRINGSTRING
CCN1 CCN1 ILK ILK SCUBE2 SCUBE2 PPP3CA PPP3CA NOCT NOCT SMAD5 SMAD5 TCIRG1 TCIRG1 FGF23 FGF23 CTNNBIP1 CTNNBIP1 TWIST1 TWIST1 JAG1 JAG1 LRP3 LRP3 SUCO SUCO TNN TNN IGF1 IGF1 SMAD3 SMAD3 SMAD6 SMAD6 SKI SKI TENT5A TENT5A SNAI2 SNAI2 LTF LTF LIMD1 LIMD1 PDLIM7 PDLIM7 IL6ST IL6ST JUND JUND CDK6 CDK6 TWSG1 TWSG1 FNDC3B FNDC3B NOTCH1 NOTCH1 TP63 TP63 CHRD CHRD SCUBE3 SCUBE3 LRP5 LRP5 LRP5L LRP5L HOXA2 HOXA2 FGF2 FGF2 NOG NOG PTCH1 PTCH1 TMEM64 TMEM64 HDAC7 HDAC7 GREM1 GREM1 SOX11 SOX11 REST REST OSTN OSTN RUNX2 RUNX2 CTNNB1 CTNNB1 SEMA4D SEMA4D BMP4 BMP4 ZHX3 ZHX3 MEF2C MEF2C FERMT2 FERMT2 HAND2 HAND2 RANBP3L RANBP3L BMP2 BMP2 RASSF2 RASSF2 ACVR2B ACVR2B CRIM1 CRIM1 YAP1 YAP1 ATRAID ATRAID DDR2 DDR2 BMPR2 BMPR2 UCMA UCMA SFRP2 SFRP2 SMAD1 SMAD1 ATF4 ATF4 VEGFC VEGFC CCN4 CCN4 FBN2 FBN2 BAMBI BAMBI WWTR1 WWTR1 GLI3 GLI3 LOC103008872 LOC103008872 LOC103007708 LOC103007708 FFAR4 FFAR4 FBXO5 FBXO5 SOX9 SOX9 AXIN2 AXIN2 BMP7 BMP7 GDPD2 GDPD2 TWIST2 TWIST2 HDAC4 HDAC4 RIOX1 RIOX1 SMOC1 SMOC1 BMPR1B BMPR1B ACVR2A ACVR2A LOC103004151 LOC103004151 TNFAIP6 TNFAIP6 RORB RORB SFRP1 SFRP1 PRKACA PRKACA PRKD1 PRKD1 TMEM119 TMEM119 GLI1 GLI1 WNT10B WNT10B GDF10 GDF10 LOC103007666 LOC103007666 LOC103005722 LOC103005722 TOB1 TOB1 ID3 ID3 BMPR1A BMPR1A MEN1 MEN1 BMP6 BMP6 CTHRC1 CTHRC1 WDR63 WDR63
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CCN1Protein CYR61. (382 aa)
ILKIntegrin-linked protein kinase. (452 aa)
SCUBE2Signal peptide, CUB and EGF-like domain-containing protein 2 isoform X1. (942 aa)
PPP3CASerine/threonine-protein phosphatase. (521 aa)
NOCTNocturnin. (362 aa)
SMAD5Mothers against decapentaplegic homolog. (465 aa)
TCIRG1V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (745 aa)
FGF23Fibroblast growth factor 23; Belongs to the heparin-binding growth factors family. (231 aa)
CTNNBIP1Beta-catenin-interacting protein 1. (81 aa)
TWIST1Twist-related protein 1. (153 aa)
JAG1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1218 aa)
LRP3Low-density lipoprotein receptor-related protein 3. (645 aa)
SUCOSUN domain-containing ossification factor isoform X1. (1252 aa)
TNNtenascin-N. (1266 aa)
IGF1Insulin-like growth factor I isoform X1. (187 aa)
SMAD3Mothers against decapentaplegic homolog. (425 aa)
SMAD6Mothers against decapentaplegic homolog. (321 aa)
SKISki oncogene. (772 aa)
TENT5ATerminal nucleotidyltransferase 5A. (424 aa)
SNAI2Zinc finger protein SNAI2. (268 aa)
LTFLactotransferrin; Belongs to the transferrin family. (725 aa)
LIMD1LIM domain-containing protein 1. (188 aa)
PDLIM7PDZ and LIM domain protein 7 isoform X1. (458 aa)
IL6STInterleukin-6 receptor subunit beta. (918 aa)
JUNDTranscription factor jun-D. (262 aa)
CDK6Cyclin-dependent kinase 6; Belongs to the protein kinase superfamily. (326 aa)
TWSG1Twisted gastrulation protein homolog 1 isoform X1. (223 aa)
FNDC3BFibronectin type III domain-containing protein 3B isoform X1. (1206 aa)
NOTCH1LOW QUALITY PROTEIN: neurogenic locus notch homolog protein 1. (2379 aa)
TP63Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. (680 aa)
CHRDChordin; Dorsalizing factor. Key developmental protein that dorsalizes early vertebrate embryonic tissues by binding to ventralizing TGF-beta family bone morphogenetic proteins (BMPs) and sequestering them in latent complexes. (943 aa)
SCUBE3Signal peptide, CUB and EGF-like domain-containing protein 3 isoform X1. (1004 aa)
LRP5Low-density lipoprotein receptor-related protein 5. (1080 aa)
LRP5LLOW QUALITY PROTEIN: low-density lipoprotein receptor-related protein 5-like protein. (469 aa)
HOXA2LOW QUALITY PROTEIN: homeobox protein Hox-A2. (369 aa)
FGF2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (155 aa)
NOGNoggin. (154 aa)
PTCH1LOW QUALITY PROTEIN: protein patched homolog 1. (1304 aa)
TMEM64Transmembrane protein 64. (334 aa)
HDAC7Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (992 aa)
GREM1Gremlin. (184 aa)
SOX11Transcription factor SOX-11. (200 aa)
RESTRE1-silencing transcription factor isoform X1. (1068 aa)
OSTNOsteocrin isoform X1. (138 aa)
RUNX2Runt-related transcription factor 2. (343 aa)
CTNNB1Catenin beta-1. (767 aa)
SEMA4Dsemaphorin-4D; Belongs to the semaphorin family. (863 aa)
BMP4Bone morphogenetic protein 4 isoform X1. (420 aa)
ZHX3Zinc fingers and homeoboxes protein 3. (952 aa)
MEF2CMyocyte-specific enhancer factor 2C isoform X5. (483 aa)
FERMT2Fermitin family homolog 2 isoform X1. (706 aa)
HAND2Heart- and neural crest derivatives-expressed protein 2. (130 aa)
RANBP3LRan-binding protein 3-like isoform X1. (491 aa)
BMP2Bone morphogenetic protein 2. (395 aa)
RASSF2Ras association domain-containing protein 2. (326 aa)
ACVR2BSerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (354 aa)
CRIM1Cysteine-rich motor neuron 1 protein isoform X2. (1037 aa)
YAP1Transcriptional coactivator YAP1. (332 aa)
ATRAIDAll-trans retinoic acid-induced differentiation factor isoform X1. (271 aa)
DDR2Discoidin domain-containing receptor 2. (855 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1038 aa)
UCMAUnique cartilage matrix-associated protein isoform X1. (138 aa)
SFRP2Secreted frizzled-related protein 2. (294 aa)
SMAD1Mothers against decapentaplegic homolog. (465 aa)
ATF4Cyclic AMP-dependent transcription factor ATF-4. (352 aa)
VEGFCVascular endothelial growth factor C; Belongs to the PDGF/VEGF growth factor family. (453 aa)
CCN4WNT1-inducible-signaling pathway protein 1. (323 aa)
FBN2Fibrillin-2. (2784 aa)
BAMBIBMP and activin membrane-bound inhibitor homolog; Negatively regulates TGF-beta signaling. Belongs to the BAMBI family. (247 aa)
WWTR1WW domain-containing transcription regulator protein 1. (400 aa)
GLI3Transcriptional activator GLI3 isoform X1. (1591 aa)
LOC103008872RE1-silencing transcription factor-like. (326 aa)
LOC103007708RE1-silencing transcription factor-like. (871 aa)
FFAR4LOW QUALITY PROTEIN: free fatty acid receptor 4. (361 aa)
FBXO5F-box only protein 5. (448 aa)
SOX9Transcription factor SOX-9. (432 aa)
AXIN2Axin-2. (543 aa)
BMP7Bone morphogenetic protein 7. (431 aa)
GDPD2LOW QUALITY PROTEIN: glycerophosphoinositol inositolphosphodiesterase GDPD2. (539 aa)
TWIST2Twist-related protein 2 isoform X1. (160 aa)
HDAC4Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1149 aa)
RIOX1Bifunctional lysine-specific demethylase and histidyl-hydroxylase; Oxygenase that can act as both a histone lysine demethylase and a ribosomal histidine hydroxylase. (578 aa)
SMOC1SPARC-related modular calcium-binding protein 1. (420 aa)
BMPR1BSerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (502 aa)
ACVR2ASerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (513 aa)
LOC103004151LIM domain-containing protein 1-like. (279 aa)
TNFAIP6Tumor necrosis factor-inducible gene 6 protein. (277 aa)
RORBNuclear receptor ROR-beta. (459 aa)
SFRP1Secreted frizzled-related protein 1. (295 aa)
PRKACAcAMP-dependent protein kinase catalytic subunit alpha. (293 aa)
PRKD1Serine/threonine-protein kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. (840 aa)
TMEM119Transmembrane protein 119. (304 aa)
GLI1Zinc finger protein GLI1. (1106 aa)
WNT10BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (389 aa)
GDF10Growth/differentiation factor 10. (544 aa)
LOC103007666Next to BRCA1 gene 1 protein isoform X1. (985 aa)
LOC103005722Next to BRCA1 gene 1 protein isoform X1. (985 aa)
TOB1Protein Tob1. (344 aa)
ID3DNA-binding protein inhibitor ID-3. (119 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
MEN1Menin. (517 aa)
BMP6Bone morphogenetic protein 6. (388 aa)
CTHRC1Collagen triple helix repeat-containing protein 1. (244 aa)
WDR63WD repeat-containing protein 63 isoform X1. (892 aa)
Your Current Organism:
Balaenoptera acutorostrata
NCBI taxonomy Id: 310752
Other names: B. acutorostrata scammoni, Balaenoptera acutorostrata scammoni
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