(38 nodes) Positive regulation of Notch signaling pathway network (Balaenoptera acutorostrata)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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Known Interactions

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experimentally determined

Predicted Interactions

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Your Input:
	SRC	Tyrosine-protein kinase. (557 aa)
	AAK1	AP2-associated protein kinase 1 isoform X1. (966 aa)
	ZMIZ1	Zinc finger MIZ domain-containing protein 1 isoform X1. (1071 aa)
	LOC103008157	Signal transducer and activator of transcription. (793 aa)
	TP63	Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. (680 aa)
	NOTCH1	LOW QUALITY PROTEIN: neurogenic locus notch homolog protein 1. (2379 aa)
	PDCD10	Programmed cell death protein 10. (212 aa)
	IL6ST	Interleukin-6 receptor subunit beta. (918 aa)
	ITGB1BP1	Integrin beta-1-binding protein 1. (200 aa)
	HES1	Transcription factor HES-1. (280 aa)
	FGF10	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (210 aa)
	LOC103018834	Adropin-like. (75 aa)
	LOC103015737	Mesoderm posterior protein 1. (126 aa)
	DLL4	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (685 aa)
	POGLUT1	Protein O-glucosyltransferase 1 isoform X1. (392 aa)
	NEPRO	Nucleolus and neural progenitor protein isoform X1. (564 aa)
	TSPAN5	Tetraspanin. (268 aa)
	SLC35C2	Solute carrier family 35 member C2 isoform X1. (406 aa)
	DLL1	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (719 aa)
	RFNG	beta-1,3-N-acetylglucosaminyltransferase radical fringe. (287 aa)
	CCN3	CCN family member 3. (358 aa)
	LOC103009173	Uncharacterized protein FLJ45252. (339 aa)
	CNTN6	Contactin-6 isoform X1. (1028 aa)
	FKBP14	Peptidylprolyl isomerase. (211 aa)
	JAG1	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1218 aa)
	BMP2K	BMP-2-inducible protein kinase isoform X1. (1046 aa)
	MFNG	LOW QUALITY PROTEIN: beta-1,3-N-acetylglucosaminyltransferase manic fringe. (319 aa)
	ASCL1	Achaete-scute homolog 1. (169 aa)
	NOD2	Nucleotide-binding oligomerization domain-containing protein 2 isoform X2. (1013 aa)
	GSX2	GS homeobox 2. (299 aa)
	TGFB2	Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
	EPN2	Epsin-2. (508 aa)
	LFNG	Beta-1,3-N-acetylglucosaminyltransferase. (328 aa)
	JAG2	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (894 aa)
	ENHO	Adropin. (76 aa)
	LOC102997405	Signal transducer and activator of transcription. (783 aa)
	TM2D2	TM2 domain-containing protein 2. (214 aa)
	WNT1	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa)

Your Current Organism:

Balaenoptera acutorostrata

NCBI taxonomy Id: 310752
Other names: B. acutorostrata scammoni, Balaenoptera acutorostrata scammoni

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AAK1	LOC103009173	A0A452CMK3	A0A384AR57	AP2-associated protein kinase 1 isoform X1.	Uncharacterized protein FLJ45252.	0.840
ASCL1	DLL1	A0A383YTI0	A0A384AFJ6	Achaete-scute homolog 1.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.508
ASCL1	GSX2	A0A383YTI0	A0A383Z076	Achaete-scute homolog 1.	GS homeobox 2.	0.761
ASCL1	HES1	A0A383YTI0	A0A384B7I3	Achaete-scute homolog 1.	Transcription factor HES-1.	0.569
CCN3	NOTCH1	A0A384AND4	A0A452C441	CCN family member 3.	LOW QUALITY PROTEIN: neurogenic locus notch homolog protein 1.	0.403
DLL1	ASCL1	A0A384AFJ6	A0A383YTI0	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Achaete-scute homolog 1.	0.508
DLL1	DLL4	A0A384AFJ6	A0A383ZZS4	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.936
DLL1	HES1	A0A384AFJ6	A0A384B7I3	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Transcription factor HES-1.	0.554
DLL1	JAG1	A0A384AFJ6	A0A383YR28	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.465
DLL1	LFNG	A0A384AFJ6	A0A383ZHT4	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Beta-1,3-N-acetylglucosaminyltransferase.	0.552
DLL1	MFNG	A0A384AFJ6	A0A383YS76	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	LOW QUALITY PROTEIN: beta-1,3-N-acetylglucosaminyltransferase manic fringe.	0.551
DLL1	NOTCH1	A0A384AFJ6	A0A452C441	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	LOW QUALITY PROTEIN: neurogenic locus notch homolog protein 1.	0.996
DLL4	DLL1	A0A383ZZS4	A0A384AFJ6	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.936
DLL4	HES1	A0A383ZZS4	A0A384B7I3	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Transcription factor HES-1.	0.554
DLL4	JAG1	A0A383ZZS4	A0A383YR28	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.432
DLL4	JAG2	A0A383ZZS4	A0A383ZMK1	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.551
DLL4	LFNG	A0A383ZZS4	A0A383ZHT4	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Beta-1,3-N-acetylglucosaminyltransferase.	0.638
DLL4	MFNG	A0A383ZZS4	A0A383YS76	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	LOW QUALITY PROTEIN: beta-1,3-N-acetylglucosaminyltransferase manic fringe.	0.633
DLL4	NOTCH1	A0A383ZZS4	A0A452C441	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	LOW QUALITY PROTEIN: neurogenic locus notch homolog protein 1.	0.997
FGF10	SRC	A0A384B7G3	A0A384B0N7	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Tyrosine-protein kinase.	0.432