(35 nodes) Negative regulation of mitotic nuclear division network (Balaenoptera acutorostrata)

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Your Input:
	ZNF207	BUB3-interacting and GLEBS motif-containing protein ZNF207. (467 aa)
	ZWILCH	Protein zwilch homolog isoform X1. (589 aa)
	AURKB	Aurora kinase B isoform X1; Belongs to the protein kinase superfamily. (344 aa)
	KHDC3L	KHDC3-like protein. (203 aa)
	TPR	Nucleoprotein TPR isoform X2. (2362 aa)
	TTK	LOW QUALITY PROTEIN: dual specificity protein kinase TTK. (858 aa)
	NME6	Nucleoside diphosphate kinase. (186 aa)
	ZW10	Centromere/kinetochore protein zw10 homolog. (779 aa)
	MAD2L1	Mitotic spindle assembly checkpoint protein MAD2A. (205 aa)
	ATM	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3057 aa)
	BUB3	Mitotic checkpoint protein BUB3 isoform X1. (328 aa)
	TOM1L2	TOM1-like protein 2 isoform X1; Belongs to the TOM1 family. (488 aa)
	MAD1L1	LOW QUALITY PROTEIN: mitotic spindle assembly checkpoint protein MAD1. (719 aa)
	TOM1L1	TOM1-like protein 1 isoform X1; Belongs to the TOM1 family. (476 aa)
	HASPIN	Serine/threonine-protein kinase haspin. (781 aa)
	BUB1B	Mitotic checkpoint serine/threonine-protein kinase BUB1 beta. (1063 aa)
	CHEK1	Serine/threonine-protein kinase Chk1; Belongs to the protein kinase superfamily. (476 aa)
	BMP7	Bone morphogenetic protein 7. (431 aa)
	BIRC5	Baculoviral IAP repeat-containing protein 5. (143 aa)
	FBXO5	F-box only protein 5. (448 aa)
	PLK1	Serine/threonine-protein kinase PLK. (604 aa)
	MTBP	Mdm2-binding protein. (903 aa)
	RAD21	Double-strand-break repair protein rad21 homolog isoform X1. (630 aa)
	KNTC1	LOW QUALITY PROTEIN: kinetochore-associated protein 1. (2207 aa)
	TEX14	Inactive serine/threonine-protein kinase TEX14. (1372 aa)
	TRIP13	Pachytene checkpoint protein 2 homolog; Belongs to the AAA ATPase family. (429 aa)
	APC	Adenomatous polyposis coli protein isoform X1. (2865 aa)
	BMP4	Bone morphogenetic protein 4 isoform X1. (420 aa)
	IK	Protein Red. (553 aa)
	PSMG2	Proteasome assembly chaperone 2; Chaperone protein which promotes assembly of the 20S proteasome as part of a heterodimer with PSMG1. Belongs to the PSMG2 family. (266 aa)
	KLHL22	Kelch-like protein 22 isoform X1. (634 aa)
	BUB1	Mitotic checkpoint serine/threonine-protein kinase BUB1 isoform X1. (1081 aa)
	SPDL1	Protein Spindly; Required for the localization of dynein and dynactin to the mitotic kintochore. Dynein is believed to control the initial lateral interaction between the kinetochore and spindle microtubules and to facilitate the subsequent formation of end-on kinetochore-microtubule attachments mediated by the NDC80 complex. Also required for correct spindle orientation. Does not appear to be required for the removal of spindle assembly checkpoint (SAC) proteins from the kinetochore upon bipolar spindle attachment. (620 aa)
	LOC114237079	Uncharacterized protein LOC114237079 isoform X1. (198 aa)
	LOC103013777	LOW QUALITY PROTEIN: baculoviral IAP repeat-containing protein 5-like. (227 aa)

Your Current Organism:

Balaenoptera acutorostrata

NCBI taxonomy Id: 310752
Other names: B. acutorostrata scammoni, Balaenoptera acutorostrata scammoni

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ATM	CHEK1	A0A383ZCZ2	A0A384A831	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Serine/threonine-protein kinase Chk1; Belongs to the protein kinase superfamily.	0.971
ATM	PLK1	A0A383ZCZ2	A0A384AG87	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Serine/threonine-protein kinase PLK.	0.503
ATM	TRIP13	A0A383ZCZ2	A0A384AWU4	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Pachytene checkpoint protein 2 homolog; Belongs to the AAA ATPase family.	0.439
AURKB	BIRC5	A0A383YU69	A0A384AES1	Aurora kinase B isoform X1; Belongs to the protein kinase superfamily.	Baculoviral IAP repeat-containing protein 5.	0.992
AURKB	BUB1	A0A383YU69	A0A384BCK6	Aurora kinase B isoform X1; Belongs to the protein kinase superfamily.	Mitotic checkpoint serine/threonine-protein kinase BUB1 isoform X1.	0.941
AURKB	BUB1B	A0A383YU69	A0A383ZZD0	Aurora kinase B isoform X1; Belongs to the protein kinase superfamily.	Mitotic checkpoint serine/threonine-protein kinase BUB1 beta.	0.924
AURKB	BUB3	A0A383YU69	A0A383ZE31	Aurora kinase B isoform X1; Belongs to the protein kinase superfamily.	Mitotic checkpoint protein BUB3 isoform X1.	0.645
AURKB	HASPIN	A0A383YU69	A0A383ZQZ2	Aurora kinase B isoform X1; Belongs to the protein kinase superfamily.	Serine/threonine-protein kinase haspin.	0.480
AURKB	LOC103013777	A0A383YU69	A0A452CNA5	Aurora kinase B isoform X1; Belongs to the protein kinase superfamily.	LOW QUALITY PROTEIN: baculoviral IAP repeat-containing protein 5-like.	0.862
AURKB	MAD2L1	A0A383YU69	A0A383ZC79	Aurora kinase B isoform X1; Belongs to the protein kinase superfamily.	Mitotic spindle assembly checkpoint protein MAD2A.	0.819
AURKB	PLK1	A0A383YU69	A0A384AG87	Aurora kinase B isoform X1; Belongs to the protein kinase superfamily.	Serine/threonine-protein kinase PLK.	0.835
AURKB	TRIP13	A0A383YU69	A0A384AWU4	Aurora kinase B isoform X1; Belongs to the protein kinase superfamily.	Pachytene checkpoint protein 2 homolog; Belongs to the AAA ATPase family.	0.434
AURKB	TTK	A0A383YU69	A0A383YYS3	Aurora kinase B isoform X1; Belongs to the protein kinase superfamily.	LOW QUALITY PROTEIN: dual specificity protein kinase TTK.	0.736
BIRC5	AURKB	A0A384AES1	A0A383YU69	Baculoviral IAP repeat-containing protein 5.	Aurora kinase B isoform X1; Belongs to the protein kinase superfamily.	0.992
BIRC5	BUB1	A0A384AES1	A0A384BCK6	Baculoviral IAP repeat-containing protein 5.	Mitotic checkpoint serine/threonine-protein kinase BUB1 isoform X1.	0.938
BIRC5	BUB1B	A0A384AES1	A0A383ZZD0	Baculoviral IAP repeat-containing protein 5.	Mitotic checkpoint serine/threonine-protein kinase BUB1 beta.	0.950
BIRC5	BUB3	A0A384AES1	A0A383ZE31	Baculoviral IAP repeat-containing protein 5.	Mitotic checkpoint protein BUB3 isoform X1.	0.441
BIRC5	CHEK1	A0A384AES1	A0A384A831	Baculoviral IAP repeat-containing protein 5.	Serine/threonine-protein kinase Chk1; Belongs to the protein kinase superfamily.	0.456
BIRC5	MAD2L1	A0A384AES1	A0A383ZC79	Baculoviral IAP repeat-containing protein 5.	Mitotic spindle assembly checkpoint protein MAD2A.	0.913
BIRC5	PLK1	A0A384AES1	A0A384AG87	Baculoviral IAP repeat-containing protein 5.	Serine/threonine-protein kinase PLK.	0.887