(31 nodes) Positive regulation of smoothened signaling pathway network (Balaenoptera acutorostrata)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

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textmining

co-expression

protein homology

Your Input:
	PRRX1	Paired mesoderm homeobox protein 1 isoform X1. (245 aa)
	GAS8	Dynein regulatory complex subunit 4 isoform X1. (512 aa)
	CTNNA1	Catenin alpha-1. (906 aa)
	GORAB	LOW QUALITY PROTEIN: RAB6-interacting golgin. (396 aa)
	INTU	Protein inturned. (935 aa)
	TXNDC15	Thioredoxin domain-containing protein 15. (348 aa)
	GRK2	G protein-coupled receptor kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. (647 aa)
	DLG5	Disks large homolog 5; Belongs to the MAGUK family. (1902 aa)
	FAM92A	Protein FAM92A. (434 aa)
	FGF9	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
	SHH	LOW QUALITY PROTEIN: sonic hedgehog protein. (271 aa)
	SMO	Smoothened homolog; Belongs to the G-protein coupled receptor Fz/Smo family. (837 aa)
	SHOX2	Short stature homeobox protein 2 isoform X1. (332 aa)
	ULK3	Serine/threonine-protein kinase ULK3 isoform X1; Belongs to the protein kinase superfamily. (472 aa)
	SKOR2	SKI family transcriptional corepressor 2. (586 aa)
	DCDC2	Doublecortin domain-containing protein 2. (473 aa)
	PDCL	Phosducin-like protein. (301 aa)
	UCHL5	Ubiquitin carboxyl-terminal hydrolase. (329 aa)
	TTC23	Tetratricopeptide repeat protein 23 isoform X1. (446 aa)
	EVC	Ellis-van Creveld syndrome protein. (1044 aa)
	SCUBE1	Signal peptide, CUB and EGF-like domain-containing protein 1. (1184 aa)
	NDST1	Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 1 isoform X1. (882 aa)
	STK36	Serine/threonine-protein kinase 36 isoform X1. (1316 aa)
	IHH	Indian hedgehog protein. (309 aa)
	ARMC9	lisH domain-containing protein ARMC9 isoform X1. (857 aa)
	SFRP1	Secreted frizzled-related protein 1. (295 aa)
	TEDC2	Tubulin epsilon and delta complex protein 2 isoform X1. (435 aa)
	GLI1	Zinc finger protein GLI1. (1106 aa)
	FOXA1	Hepatocyte nuclear factor 3-alpha. (433 aa)
	GPC3	Glypican-3; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. (504 aa)
	SCUBE2	Signal peptide, CUB and EGF-like domain-containing protein 2 isoform X1. (942 aa)

Your Current Organism:

Balaenoptera acutorostrata

NCBI taxonomy Id: 310752
Other names: B. acutorostrata scammoni, Balaenoptera acutorostrata scammoni

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ARMC9	TTC23	A0A384ABR5	A0A384AV81	lisH domain-containing protein ARMC9 isoform X1.	Tetratricopeptide repeat protein 23 isoform X1.	0.443
ARMC9	TXNDC15	A0A384ABR5	A0A383ZAP6	lisH domain-containing protein ARMC9 isoform X1.	Thioredoxin domain-containing protein 15.	0.439
DLG5	EVC	A0A383YUQ4	A0A384AUV5	Disks large homolog 5; Belongs to the MAGUK family.	Ellis-van Creveld syndrome protein.	0.605
EVC	DLG5	A0A384AUV5	A0A383YUQ4	Ellis-van Creveld syndrome protein.	Disks large homolog 5; Belongs to the MAGUK family.	0.605
EVC	GLI1	A0A384AUV5	A0A383ZX76	Ellis-van Creveld syndrome protein.	Zinc finger protein GLI1.	0.477
EVC	INTU	A0A384AUV5	A0A383ZB40	Ellis-van Creveld syndrome protein.	Protein inturned.	0.444
EVC	SMO	A0A384AUV5	A0A452CD94	Ellis-van Creveld syndrome protein.	Smoothened homolog; Belongs to the G-protein coupled receptor Fz/Smo family.	0.975
FGF9	GLI1	A0A383YN64	A0A383ZX76	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Zinc finger protein GLI1.	0.485
FGF9	IHH	A0A383YN64	A0A384AKW1	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Indian hedgehog protein.	0.455
FGF9	SHH	A0A383YN64	A0A452CFB9	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	LOW QUALITY PROTEIN: sonic hedgehog protein.	0.633
FOXA1	IHH	A0A383ZTB3	A0A384AKW1	Hepatocyte nuclear factor 3-alpha.	Indian hedgehog protein.	0.543
FOXA1	SHH	A0A383ZTB3	A0A452CFB9	Hepatocyte nuclear factor 3-alpha.	LOW QUALITY PROTEIN: sonic hedgehog protein.	0.543
GAS8	SMO	A0A383ZBP6	A0A452CD94	Dynein regulatory complex subunit 4 isoform X1.	Smoothened homolog; Belongs to the G-protein coupled receptor Fz/Smo family.	0.710
GLI1	EVC	A0A383ZX76	A0A384AUV5	Zinc finger protein GLI1.	Ellis-van Creveld syndrome protein.	0.477
GLI1	FGF9	A0A383ZX76	A0A383YN64	Zinc finger protein GLI1.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.485
GLI1	IHH	A0A383ZX76	A0A384AKW1	Zinc finger protein GLI1.	Indian hedgehog protein.	0.772
GLI1	SCUBE2	A0A383ZX76	A0A383ZCT3	Zinc finger protein GLI1.	Signal peptide, CUB and EGF-like domain-containing protein 2 isoform X1.	0.489
GLI1	SHH	A0A383ZX76	A0A452CFB9	Zinc finger protein GLI1.	LOW QUALITY PROTEIN: sonic hedgehog protein.	0.805
GLI1	SMO	A0A383ZX76	A0A452CD94	Zinc finger protein GLI1.	Smoothened homolog; Belongs to the G-protein coupled receptor Fz/Smo family.	0.861
GLI1	STK36	A0A383ZX76	A0A384ALB6	Zinc finger protein GLI1.	Serine/threonine-protein kinase 36 isoform X1.	0.721