(17 nodes) Positive regulation of lipid catabolic process network (Balaenoptera acutorostrata)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ANGPTL3	LOW QUALITY PROTEIN: angiopoietin-related protein 3. (465 aa)
	PNPLA2	Patatin-like phospholipase domain-containing protein 2. (536 aa)
	APOA5	Apolipoprotein A-V isoform X1. (378 aa)
	IRS2	Insulin receptor substrate 2. (507 aa)
	APOA4	Apolipoprotein A-IV. (380 aa)
	ABHD5	1-acylglycerol-3-phosphate O-acyltransferase ABHD5 isoform X1. (350 aa)
	PRKCE	Protein kinase C epsilon type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays essential roles in the regulation of multiple cellular processes linked to cytoskeletal proteins, such as cell adhesion, motility, migration and cell cycle, functions in neuron growth and ion channel regulation, and is involved in immune response, cancer cell invasion and regulation of apoptosis. Mediates cell adhesion to the extracellular matrix via integrin- dependent signaling, by mediating angiotensin-2-induced activation of integrin beta- [...] (737 aa)
	DAGLB	Sn1-specific diacylglycerol lipase beta isoform X1. (669 aa)
	ABCD1	ATP-binding cassette sub-family D member 1. (715 aa)
	PRKCD	Protein kinase C delta type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti- apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (675 aa)
	APOA2	Apolipoprotein A-II isoform X1. (103 aa)
	PLIN5	Perilipin; Belongs to the perilipin family. (404 aa)
	MTLN	LOW QUALITY PROTEIN: mitoregulin. (125 aa)
	RETN	Resistin. (109 aa)
	ABCD2	ATP-binding cassette sub-family D member 2. (741 aa)
	IRS1	Insulin receptor substrate 1. (1244 aa)
	TWIST1	Twist-related protein 1. (153 aa)

Your Current Organism:

Balaenoptera acutorostrata

NCBI taxonomy Id: 310752
Other names: B. acutorostrata scammoni, Balaenoptera acutorostrata scammoni

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ABCD1	ABCD2	A0A384A8F9	A0A383YWC4	ATP-binding cassette sub-family D member 1.	ATP-binding cassette sub-family D member 2.	0.913
ABCD2	ABCD1	A0A383YWC4	A0A384A8F9	ATP-binding cassette sub-family D member 2.	ATP-binding cassette sub-family D member 1.	0.913
ABHD5	PLIN5	A0A384B1I9	A0A383Z2D1	1-acylglycerol-3-phosphate O-acyltransferase ABHD5 isoform X1.	Perilipin; Belongs to the perilipin family.	0.671
ABHD5	PNPLA2	A0A384B1I9	A0A452C8M1	1-acylglycerol-3-phosphate O-acyltransferase ABHD5 isoform X1.	Patatin-like phospholipase domain-containing protein 2.	0.660
ANGPTL3	APOA5	A0A452C7H2	A0A452C5Q3	LOW QUALITY PROTEIN: angiopoietin-related protein 3.	Apolipoprotein A-V isoform X1.	0.581
APOA2	APOA4	A0A383Z9M2	A0A384BAA9	Apolipoprotein A-II isoform X1.	Apolipoprotein A-IV.	0.672
APOA2	APOA5	A0A383Z9M2	A0A452C5Q3	Apolipoprotein A-II isoform X1.	Apolipoprotein A-V isoform X1.	0.635
APOA4	APOA2	A0A384BAA9	A0A383Z9M2	Apolipoprotein A-IV.	Apolipoprotein A-II isoform X1.	0.672
APOA4	APOA5	A0A384BAA9	A0A452C5Q3	Apolipoprotein A-IV.	Apolipoprotein A-V isoform X1.	0.659
APOA5	ANGPTL3	A0A452C5Q3	A0A452C7H2	Apolipoprotein A-V isoform X1.	LOW QUALITY PROTEIN: angiopoietin-related protein 3.	0.581
APOA5	APOA2	A0A452C5Q3	A0A383Z9M2	Apolipoprotein A-V isoform X1.	Apolipoprotein A-II isoform X1.	0.635
APOA5	APOA4	A0A452C5Q3	A0A384BAA9	Apolipoprotein A-V isoform X1.	Apolipoprotein A-IV.	0.659
IRS1	IRS2	A0A383YVR7	A0A384BBC1	Insulin receptor substrate 1.	Insulin receptor substrate 2.	0.943
IRS1	PRKCD	A0A383YVR7	A0A383ZIB0	Insulin receptor substrate 1.	Protein kinase C delta type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti- apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.	0.915
IRS1	PRKCE	A0A383YVR7	A0A384ARX2	Insulin receptor substrate 1.	Protein kinase C epsilon type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays essential roles in the regulation of multiple cellular processes linked to cytoskeletal proteins, such as cell adhesion, motility, migration and cell cycle, functions in neuron growth and ion channel regulation, and is involved in immune response, cancer cell invasion and regulation of apoptosis. Mediates cell adhesion to the extracellular matrix via integrin- dependent signaling, by mediating angiotensin-2-induced activation of integrin beta- [...]	0.915
IRS1	RETN	A0A383YVR7	A0A383Z1U3	Insulin receptor substrate 1.	Resistin.	0.408
IRS2	IRS1	A0A384BBC1	A0A383YVR7	Insulin receptor substrate 2.	Insulin receptor substrate 1.	0.943
IRS2	PRKCD	A0A384BBC1	A0A383ZIB0	Insulin receptor substrate 2.	Protein kinase C delta type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti- apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.	0.914
IRS2	PRKCE	A0A384BBC1	A0A384ARX2	Insulin receptor substrate 2.	Protein kinase C epsilon type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays essential roles in the regulation of multiple cellular processes linked to cytoskeletal proteins, such as cell adhesion, motility, migration and cell cycle, functions in neuron growth and ion channel regulation, and is involved in immune response, cancer cell invasion and regulation of apoptosis. Mediates cell adhesion to the extracellular matrix via integrin- dependent signaling, by mediating angiotensin-2-induced activation of integrin beta- [...]	0.910
PLIN5	ABHD5	A0A383Z2D1	A0A384B1I9	Perilipin; Belongs to the perilipin family.	1-acylglycerol-3-phosphate O-acyltransferase ABHD5 isoform X1.	0.671