STRINGSTRING
ENG ENG NF1 NF1 ZMIZ1 ZMIZ1 PKD2 PKD2 APOB APOB SHH SHH LEP LEP NKX3-1 NKX3-1 SMAD6 SMAD6 JAG1 JAG1 NOG NOG LOC114236675 LOC114236675 LDLR LDLR ANGPTL3 ANGPTL3 CHD7 CHD7 SRF SRF APLNR APLNR NOTCH1 NOTCH1 TBX2 TBX2 LOXL1 LOXL1 STRA6 STRA6 SMAD7 SMAD7 TGFBR1 TGFBR1 COL3A1 COL3A1 COMP COMP HES1 HES1 WNT11 WNT11 ADGRF5 ADGRF5 TFAP2B TFAP2B SIX1 SIX1 BMP4 BMP4 HAND2 HAND2 HPGD HPGD PLXND1 PLXND1 SEC24B SEC24B PRDM1 PRDM1 HEY2 HEY2 BMPR2 BMPR2 EDNRA EDNRA TAB1 TAB1 NDST1 NDST1 LOX LOX GLI3 GLI3 FGF8 FGF8 SUFU SUFU DCTN5 DCTN5 FOXH1 FOXH1 SLC2A10 SLC2A10 EYA1 EYA1 LRP2 LRP2 NPRL3 NPRL3 HECTD1 HECTD1 DLL4 DLL4 DDIT3 DDIT3 ACVRL1 ACVRL1 ARID2 ARID2 LOC103008251 LOC103008251 NGFR NGFR ADAMTS6 ADAMTS6 PROX1 PROX1 MYOCD MYOCD LUZP1 LUZP1 BMPR1A BMPR1A EDN1 EDN1 PRRX1 PRRX1 FOXF1 FOXF1 HOXA13 HOXA13 EGR2 EGR2 PRICKLE1 PRICKLE1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ENGEndoglin isoform X1. (652 aa)
NF1Neurofibromin. (2821 aa)
ZMIZ1Zinc finger MIZ domain-containing protein 1 isoform X1. (1071 aa)
PKD2Polycystin-2. (763 aa)
APOBApolipoprotein B-100. (4585 aa)
SHHLOW QUALITY PROTEIN: sonic hedgehog protein. (271 aa)
LEPLeptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] (167 aa)
NKX3-1Homeobox protein Nkx-3.1. (153 aa)
SMAD6Mothers against decapentaplegic homolog. (321 aa)
JAG1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1218 aa)
NOGNoggin. (154 aa)
LOC114236675LOW QUALITY PROTEIN: folate receptor alpha-like. (249 aa)
LDLRLow-density lipoprotein receptor. (842 aa)
ANGPTL3LOW QUALITY PROTEIN: angiopoietin-related protein 3. (465 aa)
CHD7chromodomain-helicase-DNA-binding protein 7. (2829 aa)
SRFSerum response factor. (464 aa)
APLNRApelin receptor; Belongs to the G-protein coupled receptor 1 family. (400 aa)
NOTCH1LOW QUALITY PROTEIN: neurogenic locus notch homolog protein 1. (2379 aa)
TBX2LOW QUALITY PROTEIN: T-box transcription factor TBX2. (592 aa)
LOXL1Lysyl oxidase homolog 1. (268 aa)
STRA6Receptor for retinol uptake STRA6 isoform X1. (685 aa)
SMAD7Mothers against decapentaplegic homolog. (426 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (434 aa)
COL3A1Collagen alpha-1(III) chain. (1464 aa)
COMPCartilage oligomeric matrix protein. (658 aa)
HES1Transcription factor HES-1. (280 aa)
WNT11Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
ADGRF5Adhesion G protein-coupled receptor F5 isoform X1; Belongs to the G-protein coupled receptor 2 family. (1383 aa)
TFAP2BTranscription factor AP-2-beta isoform X1. (467 aa)
SIX1Homeobox protein SIX1. (284 aa)
BMP4Bone morphogenetic protein 4 isoform X1. (420 aa)
HAND2Heart- and neural crest derivatives-expressed protein 2. (130 aa)
HPGD15-hydroxyprostaglandin dehydrogenase [NAD(+)]. (145 aa)
PLXND1plexin-D1. (1747 aa)
SEC24BProtein transport protein Sec24B isoform X1. (1173 aa)
PRDM1PR domain zinc finger protein 1. (672 aa)
HEY2Hairy/enhancer-of-split related with YRPW motif protein 2 isoform X1. (337 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1038 aa)
EDNRAEndothelin-1 receptor; Belongs to the G-protein coupled receptor 1 family. (427 aa)
TAB1TGF-beta-activated kinase 1 and MAP3K7-binding protein 1. (506 aa)
NDST1Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 1 isoform X1. (882 aa)
LOXProtein-lysine 6-oxidase. (284 aa)
GLI3Transcriptional activator GLI3 isoform X1. (1591 aa)
FGF8Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (244 aa)
SUFUSuppressor of fused homolog; Negative regulator in the hedgehog signaling pathway. Down- regulates GLI1-mediated transactivation of target genes. Part of a corepressor complex that acts on DNA-bound GLI1. May also act by linking GLI1 to BTRC and thereby targeting GLI1 to degradation by the proteasome. Sequesters GLI1, GLI2 and GLI3 in the cytoplasm, this effect is overcome by binding of STK36 to both SUFU and a GLI protein. Negative regulator of beta-catenin signaling. Regulates the formation of either the repressor form (GLI3R) or the activator form (GLI3A) of the full-length form of [...] (485 aa)
DCTN5Dynactin subunit 5. (182 aa)
FOXH1Forkhead box protein H1. (360 aa)
SLC2A10Solute carrier family 2, facilitated glucose transporter member 10 isoform X1; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (554 aa)
EYA1Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (584 aa)
LRP2Low-density lipoprotein receptor-related protein 2. (4651 aa)
NPRL3GATOR complex protein NPRL3 isoform X1. (569 aa)
HECTD1LOW QUALITY PROTEIN: E3 ubiquitin-protein ligase HECTD1. (2609 aa)
DLL4Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (685 aa)
DDIT3DNA damage-inducible transcript 3 protein; Multifunctional transcription factor in ER stress response. Plays an essential role in the response to a wide variety of cell stresses and induces cell cycle arrest and apoptosis in response to ER stress. Plays a dual role both as an inhibitor of CCAAT/enhancer- binding protein (C/EBP) function and as an activator of other genes. Acts as a dominant-negative regulator of C/EBP-induced transcription: dimerizes with members of the C/EBP family, impairs their association with C/EBP binding sites in the promoter regions, and inhibits the expression [...] (168 aa)
ACVRL1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (515 aa)
ARID2AT-rich interactive domain-containing protein 2. (1687 aa)
LOC103008251Peptidylprolyl isomerase. (583 aa)
NGFRTumor necrosis factor receptor superfamily member 16. (427 aa)
ADAMTS6A disintegrin and metalloproteinase with thrombospondin motifs 6. (1117 aa)
PROX1Prospero homeobox protein 1 isoform X1. (738 aa)
MYOCDMyocardin isoform X1. (985 aa)
LUZP1Leucine zipper protein 1. (1071 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
EDN1Endothelin-1. (202 aa)
PRRX1Paired mesoderm homeobox protein 1 isoform X1. (245 aa)
FOXF1Forkhead box protein F1. (354 aa)
HOXA13Homeobox protein Hox-A13. (294 aa)
EGR2E3 SUMO-protein ligase EGR2. (472 aa)
PRICKLE1Prickle-like protein 1. (834 aa)
Your Current Organism:
Balaenoptera acutorostrata
NCBI taxonomy Id: 310752
Other names: B. acutorostrata scammoni, Balaenoptera acutorostrata scammoni
Server load: low (34%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.