STRINGSTRING
MMP2 MMP2 LOC103014668 LOC103014668 PRKAA2 PRKAA2 PRDX1 PRDX1 LOC103001311 LOC103001311 TP53INP1 TP53INP1 NOS3 NOS3 SLC2A4 SLC2A4 PTGS2 PTGS2 PARP1 PARP1 PYCR2 PYCR2 LOC103004066 LOC103004066 NET1 NET1 STOX1 STOX1 SIRT1 SIRT1 LRRK2 LRRK2 SOD3 SOD3 PDGFRA PDGFRA KEAP1 KEAP1 LRRC8E LRRC8E TREX1 TREX1 LONP1 LONP1 MAPK9 MAPK9 ERRFI1 ERRFI1 BRF2 BRF2 PARK7 PARK7 SESN2 SESN2 RELA RELA CCS CCS PRDX2 PRDX2 SLC7A11 SLC7A11 ADNP2 ADNP2 RCSD1 RCSD1 TRPM2 TRPM2 ATM ATM LOC103001267 LOC103001267 LOC103018270 LOC103018270 GSR GSR CAPN9 CAPN9 EDN1 EDN1 PRDX5 PRDX5 RNF112 RNF112 PRKCD PRKCD ATP13A2 ATP13A2 PINK1 PINK1 AQP1 AQP1 ZNF580 ZNF580 MPO MPO LRRC8D LRRC8D PDK2 PDK2 SIGMAR1 SIGMAR1 DAPK1 DAPK1 FANCC FANCC WNT16 WNT16 PCGF2 PCGF2 ARNT ARNT GSKIP GSKIP BDKRB2 BDKRB2 AQP5 AQP5 FAS FAS DDIT3 DDIT3 SIRT2 SIRT2 TRPV4 TRPV4 SLC12A6 SLC12A6 PRKD1 PRKD1 RIPK3 RIPK3 PRR5L PRR5L CAT CAT NOX1 NOX1 TBC1D24 TBC1D24 FXN FXN ANXA1 ANXA1 ADPRHL2 ADPRHL2 ZC3H12A ZC3H12A NR4A2 NR4A2 PLA2R1 PLA2R1 PDK1 PDK1 NFE2L1 NFE2L1 SOD1 SOD1 HTRA2 HTRA2 PPIF PPIF EIF2S1 EIF2S1 ZFP36L1 ZFP36L1 G6PD G6PD EZH2 EZH2 STK25 STK25 TRPA1 TRPA1 MMP9 MMP9 SPHK1 SPHK1 LOC103012704 LOC103012704 SOD2 SOD2 WNK3 WNK3 MAPK3 MAPK3 EPO EPO NCF1 NCF1 VKORC1L1 VKORC1L1 LOC102997446 LOC102997446 CHUK CHUK PPARGC1A PPARGC1A EGFR EGFR LOC103018156 LOC103018156 ANKZF1 ANKZF1 ZNF622 ZNF622 PPARGC1B PPARGC1B OXR1 OXR1 MGAT3 MGAT3 ATF4 ATF4 EDNRA EDNRA DIABLO DIABLO STX2 STX2 VRK2 VRK2 PNPT1 PNPT1 EPAS1 EPAS1 ATF2 ATF2 PRKRA PRKRA NFE2L2 NFE2L2 ATG5 ATG5 PTPRK PTPRK MAP3K5 MAP3K5 TNFAIP3 TNFAIP3 BCL2 BCL2 FER FER PRKAA1 PRKAA1 MSRA MSRA FANCD2 FANCD2 HIF1A HIF1A OSER1 OSER1 CHD6 CHD6 SRC SRC ROMO1 ROMO1 SRXN1 SRXN1 FOXO1 FOXO1 AIF1 AIF1 SETX SETX ABL1 ABL1 MGST1 MGST1 ZNF277 ZNF277 CAV1 CAV1 ETV5 ETV5 TMEM161A TMEM161A SLC4A11 SLC4A11 MAPK1 MAPK1 MELK MELK ECT2 ECT2 PDCD10 PDCD10 PML PML IMPACT IMPACT NQO1 NQO1 SELENON SELENON PRDX3 PRDX3 SMPD3 SMPD3 PIK3CA PIK3CA RPS3 RPS3 PYROXD1 PYROXD1 LOC103008148 LOC103008148 MAPK13 MAPK13 RELB RELB RAD52 RAD52 RIPK1 RIPK1 MAPK7 MAPK7 SELENOS SELENOS HDAC6 HDAC6 STK39 STK39 PKD2 PKD2 RBM11 RBM11 ATP2A2 ATP2A2 FOXO3 FOXO3 PJVK PJVK PLEC PLEC
Nodes:
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
MMP272 kDa type IV collagenase. (584 aa)
LOC103014668Transcription factor AP-1; Belongs to the bZIP family. (253 aa)
PRKAA2Non-specific serine/threonine protein kinase. (524 aa)
PRDX1Peroxiredoxin-1 isoform X1. (199 aa)
LOC103001311Transcription factor AP-1-like. (199 aa)
TP53INP1Tumor protein p53-inducible nuclear protein 1 isoform X1. (240 aa)
NOS3Nitric oxide synthase; Produces nitric oxide (NO). (1206 aa)
SLC2A4Solute carrier family 2, facilitated glucose transporter member 4 isoform X1; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (550 aa)
PTGS2Prostaglandin G/H synthase 2. (604 aa)
PARP1Poly [ADP-ribose] polymerase. (1021 aa)
PYCR2Pyrroline-5-carboxylate reductase; Belongs to the pyrroline-5-carboxylate reductase family. (320 aa)
LOC103004066Cytochrome P450 1B1; Belongs to the cytochrome P450 family. (543 aa)
NET1Neuroepithelial cell-transforming gene 1 protein. (542 aa)
STOX1Storkhead-box protein 1. (879 aa)
SIRT1NAD-dependent protein deacetylase sirtuin-1 isoform X1. (557 aa)
LRRK2Leucine-rich repeat serine/threonine-protein kinase 2 isoform X1. (2527 aa)
SOD3Superoxide dismutase [Cu-Zn]; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the Cu-Zn superoxide dismutase family. (244 aa)
PDGFRAPlatelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1089 aa)
KEAP1Kelch-like ECH-associated protein 1. (624 aa)
LRRC8EVolume-regulated anion channel subunit LRRC8E. (795 aa)
TREX1Three-prime repair exonuclease 1. (314 aa)
LONP1Lon protease homolog, mitochondrial; ATP-dependent serine protease that mediates the selective degradation of misfolded, unassembled or oxidatively damaged polypeptides as well as certain short-lived regulatory proteins in the mitochondrial matrix. May also have a chaperone function in the assembly of inner membrane protein complexes. Participates in the regulation of mitochondrial gene expression and in the maintenance of the integrity of the mitochondrial genome. Binds to mitochondrial promoters and RNA in a single-stranded, site-specific, and strand- specific manner. May regulate mi [...] (966 aa)
MAPK9Mitogen-activated protein kinase. (424 aa)
ERRFI1ERBB receptor feedback inhibitor 1 isoform X1. (466 aa)
BRF2Transcription factor IIIB 50 kDa subunit. (424 aa)
PARK7Protein/nucleic acid deglycase DJ-1. (189 aa)
SESN2Sestrin-2. (471 aa)
RELATranscription factor p65 isoform X1. (520 aa)
CCSCopper chaperone for superoxide dismutase. (274 aa)
PRDX2Peroxiredoxin-2. (198 aa)
SLC7A11Cystine/glutamate transporter. (503 aa)
ADNP2Activity-dependent neuroprotector homeobox protein 2. (1163 aa)
RCSD1capZ-interacting protein. (410 aa)
TRPM2Transient receptor potential cation channel subfamily M member 2. (1502 aa)
ATMSerine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3057 aa)
LOC103001267Peroxiredoxin-1-like. (205 aa)
LOC10301827040S ribosomal protein S3. (194 aa)
GSRGlutathione reductase, mitochondrial. (410 aa)
CAPN9Calpain-9; Belongs to the peptidase C2 family. (526 aa)
EDN1Endothelin-1. (202 aa)
PRDX5Peroxiredoxin; Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides; Belongs to the peroxiredoxin family. Prx5 subfamily. (219 aa)
RNF112RING finger protein 112. (421 aa)
PRKCDProtein kinase C delta type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti- apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (675 aa)
ATP13A2Cation-transporting ATPase; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily. (892 aa)
PINK1Serine/threonine-protein kinase PINK1, mitochondrial. (405 aa)
AQP1Aquaporin-1; Belongs to the MIP/aquaporin (TC 1.A.8) family. (271 aa)
ZNF580Zinc finger protein 580. (126 aa)
MPOMyeloperoxidase. (719 aa)
LRRC8DVolume-regulated anion channel subunit LRRC8D. (858 aa)
PDK2Protein-serine/threonine kinase. (407 aa)
SIGMAR1Sigma non-opioid intracellular receptor 1. (223 aa)
DAPK1Death-associated protein kinase 1 isoform X1. (1472 aa)
FANCCFanconi anemia group C protein homolog; DNA repair protein that may operate in a postreplication repair or a cell cycle checkpoint function. May be implicated in interstrand DNA cross-link repair and in the maintenance of normal chromosome stability. Upon IFNG induction, may facilitate STAT1 activation by recruiting STAT1 to IFNGR1. (562 aa)
WNT16Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (361 aa)
PCGF2Polycomb group RING finger protein 2 isoform X1. (345 aa)
ARNTAryl hydrocarbon receptor nuclear translocator isoform X1. (790 aa)
GSKIPGSK3B-interacting protein. (139 aa)
BDKRB2B2 bradykinin receptor; Belongs to the G-protein coupled receptor 1 family. (379 aa)
AQP5Aquaporin-5; Belongs to the MIP/aquaporin (TC 1.A.8) family. (265 aa)
FASTumor necrosis factor receptor superfamily member 6 isoform X1. (334 aa)
DDIT3DNA damage-inducible transcript 3 protein; Multifunctional transcription factor in ER stress response. Plays an essential role in the response to a wide variety of cell stresses and induces cell cycle arrest and apoptosis in response to ER stress. Plays a dual role both as an inhibitor of CCAAT/enhancer- binding protein (C/EBP) function and as an activator of other genes. Acts as a dominant-negative regulator of C/EBP-induced transcription: dimerizes with members of the C/EBP family, impairs their association with C/EBP binding sites in the promoter regions, and inhibits the expression [...] (168 aa)
SIRT2NAD-dependent protein deacetylase; NAD-dependent protein deacetylase. (389 aa)
TRPV4Transient receptor potential cation channel subfamily V member 4; Belongs to the transient receptor (TC 1.A.4) family. (871 aa)
SLC12A6Solute carrier family 12 member 6 isoform X1. (1150 aa)
PRKD1Serine/threonine-protein kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. (840 aa)
RIPK3LOW QUALITY PROTEIN: receptor-interacting serine/threonine-protein kinase 3. (564 aa)
PRR5LLOW QUALITY PROTEIN: proline-rich protein 5-like. (365 aa)
CATCatalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. (527 aa)
NOX1LOW QUALITY PROTEIN: NADPH oxidase 1. (562 aa)
TBC1D24TBC1 domain family member 24. (559 aa)
FXNFrataxin, mitochondrial. (239 aa)
ANXA1Annexin. (346 aa)
ADPRHL2ADP-ribose glycohydrolase ARH3. (284 aa)
ZC3H12AEndoribonuclease ZC3H12A. (583 aa)
NR4A2Nuclear receptor subfamily 4 group A member 2 isoform X1. (598 aa)
PLA2R1Secretory phospholipase A2 receptor isoform X1. (1454 aa)
PDK1Protein-serine/threonine kinase. (378 aa)
NFE2L1Endoplasmic reticulum membrane sensor NFE2L1 isoform X1. (778 aa)
SOD1Superoxide dismutase [Cu-Zn]; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the Cu-Zn superoxide dismutase family. (153 aa)
HTRA2Serine protease HTRA2, mitochondrial. (458 aa)
PPIFPeptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family. (205 aa)
EIF2S1Eukaryotic translation initiation factor 2 subunit 1. (315 aa)
ZFP36L1mRNA decay activator protein ZFP36L1. (323 aa)
G6PDGlucose-6-phosphate 1-dehydrogenase; Catalyzes the rate-limiting step of the oxidative pentose- phosphate pathway, which represents a route for the dissimilation of carbohydrates besides glycolysis. (631 aa)
EZH2Histone-lysine N-methyltransferase EZH2. (746 aa)
STK25LOW QUALITY PROTEIN: serine/threonine-protein kinase 25. (433 aa)
TRPA1Transient receptor potential cation channel subfamily A member 1; Belongs to the transient receptor (TC 1.A.4) family. (1314 aa)
MMP9LOW QUALITY PROTEIN: matrix metalloproteinase-9. (706 aa)
SPHK1Sphingosine kinase 1. (476 aa)
LOC103012704Pyrroline-5-carboxylate reductase; Belongs to the pyrroline-5-carboxylate reductase family. (596 aa)
SOD2Superoxide dismutase; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the iron/manganese superoxide dismutase family. (176 aa)
WNK3Serine/threonine-protein kinase WNK3. (1569 aa)
MAPK3Mitogen-activated protein kinase 3. (265 aa)
EPOErythropoietin; Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors, including STAT1 and STAT3. Belongs to the EPO/TPO family. (193 aa)
NCF1Neutrophil cytosol factor 1. (392 aa)
VKORC1L1Vitamin K epoxide reductase complex subunit 1-like protein 1. (138 aa)
LOC102997446ATP-dependent RNA helicase DDX3X isoform X1; Belongs to the DEAD box helicase family. (662 aa)
CHUKInhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1. (744 aa)
PPARGC1APeroxisome proliferator-activated receptor gamma coactivator 1-alpha isoform X1. (803 aa)
EGFRReceptor protein-tyrosine kinase. (1156 aa)
LOC103018156Gamma-crystallin D; Belongs to the beta/gamma-crystallin family. (174 aa)
ANKZF1LOW QUALITY PROTEIN: ankyrin repeat and zinc finger domain-containing protein 1. (714 aa)
ZNF622Zinc finger protein 622 isoform X1. (473 aa)
PPARGC1BPeroxisome proliferator-activated receptor gamma coactivator 1-beta. (1021 aa)
OXR1Oxidation resistance protein 1 isoform X1. (895 aa)
MGAT3Beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase. (533 aa)
ATF4Cyclic AMP-dependent transcription factor ATF-4. (352 aa)
EDNRAEndothelin-1 receptor; Belongs to the G-protein coupled receptor 1 family. (427 aa)
DIABLODiablo homolog, mitochondrial isoform X1. (237 aa)
STX2Syntaxin-2; Belongs to the syntaxin family. (290 aa)
VRK2Serine/threonine-protein kinase VRK2. (512 aa)
PNPT1Polyribonucleotide nucleotidyltransferase 1, mitochondrial. (776 aa)
EPAS1Endothelial PAS domain-containing protein 1 isoform X1. (884 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2 isoform X1. (505 aa)
PRKRAInterferon-inducible double-stranded RNA-dependent protein kinase activator A. (313 aa)
NFE2L2Nuclear factor erythroid 2-related factor 2 isoform X1. (617 aa)
ATG5Autophagy protein 5; Involved in autophagic vesicle formation. (275 aa)
PTPRKReceptor-type tyrosine-protein phosphatase kappa isoform X1. (1461 aa)
MAP3K5Mitogen-activated protein kinase kinase kinase 5 isoform X3. (1219 aa)
TNFAIP3Tumor necrosis factor alpha-induced protein 3. (785 aa)
BCL2Apoptosis regulator Bcl-2 isoform X1. (233 aa)
FERTyrosine-protein kinase; Belongs to the protein kinase superfamily. Tyr protein kinase family. Fes/fps subfamily. (822 aa)
PRKAA1Non-specific serine/threonine protein kinase. (458 aa)
MSRAMitochondrial peptide methionine sulfoxide reductase isoform X1. (294 aa)
FANCD2Fanconi anemia group D2 protein. (1456 aa)
HIF1AHypoxia-inducible factor 1-alpha isoform X1. (823 aa)
OSER1Oxidative stress-responsive serine-rich protein 1. (292 aa)
CHD6chromodomain-helicase-DNA-binding protein 6 isoform X1. (2717 aa)
SRCTyrosine-protein kinase. (557 aa)
ROMO1Reactive oxygen species modulator 1. (79 aa)
SRXN1Sulfiredoxin. (137 aa)
FOXO1Forkhead box protein O1. (518 aa)
AIF1Allograft inflammatory factor 1. (147 aa)
SETXProbable helicase senataxin isoform X1. (2680 aa)
ABL1Tyrosine-protein kinase. (1149 aa)
MGST1Microsomal glutathione S-transferase 1. (155 aa)
ZNF277Zinc finger protein 277 isoform X1. (456 aa)
CAV1Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (178 aa)
ETV5ETS translocation variant 5. (510 aa)
TMEM161ATransmembrane protein 161A isoform X1. (479 aa)
SLC4A11Sodium bicarbonate transporter-like protein 11 isoform X1. (875 aa)
MAPK1Mitogen-activated protein kinase 1. (263 aa)
MELKNon-specific serine/threonine protein kinase. (665 aa)
ECT2Protein ECT2 isoform X1. (914 aa)
PDCD10Programmed cell death protein 10. (212 aa)
PMLProtein PML isoform X1. (871 aa)
IMPACTProtein IMPACT isoform X1. (334 aa)
NQO1NAD(P)H dehydrogenase [quinone] 1. (237 aa)
SELENONSelenoprotein N. (524 aa)
PRDX3LOW QUALITY PROTEIN: thioredoxin-dependent peroxide reductase, mitochondrial. (257 aa)
SMPD3Sphingomyelin phosphodiesterase 3. (656 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
RPS3LOW QUALITY PROTEIN: 40S ribosomal protein S3; Belongs to the universal ribosomal protein uS3 family. (243 aa)
PYROXD1Pyridine nucleotide-disulfide oxidoreductase domain-containing protein 1. (488 aa)
LOC103008148Y-box-binding protein 3. (342 aa)
MAPK13Mitogen-activated protein kinase. (288 aa)
RELBLOW QUALITY PROTEIN: transcription factor RelB. (626 aa)
RAD52DNA repair protein RAD52 homolog isoform X1. (439 aa)
RIPK1Receptor-interacting serine/threonine-protein kinase 1. (674 aa)
MAPK7Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (779 aa)
SELENOSSelenoprotein S isoform X1. (203 aa)
HDAC6Histone deacetylase 6. (1143 aa)
STK39STE20/SPS1-related proline-alanine-rich protein kinase. (566 aa)
PKD2Polycystin-2. (763 aa)
RBM11Splicing regulator RBM11 isoform X2. (246 aa)
ATP2A2Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1008 aa)
FOXO3LOW QUALITY PROTEIN: forkhead box protein O3. (467 aa)
PJVKPejvakin isoform X2. (355 aa)
PLECPlectin. (4277 aa)
Your Current Organism:
Balaenoptera acutorostrata
NCBI taxonomy Id: 310752
Other names: B. acutorostrata scammoni, Balaenoptera acutorostrata scammoni
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