(81 nodes) Response to interleukin-1 network (Balaenoptera acutorostrata)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	RC3H1	Roquin-1. (1134 aa)
	PLCB1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1115 aa)
	CCL20	C-C motif chemokine. (97 aa)
	CCL17	C-C motif chemokine. (95 aa)
	CCL22	C-C motif chemokine. (93 aa)
	MYLK3	Myosin light chain kinase 3 isoform X1. (800 aa)
	NKX3-1	Homeobox protein Nkx-3.1. (153 aa)
	HYAL1	Hyaluronidase. (467 aa)
	HYAL3	Hyaluronidase. (517 aa)
	HYAL2	Hyaluronidase. (476 aa)
	CCL25	C-C motif chemokine 25. (151 aa)
	RELA	Transcription factor p65 isoform X1. (520 aa)
	TOLLIP	Toll-interacting protein isoform X1. (273 aa)
	IL1RL2	Interleukin-1 receptor-like 2. (569 aa)
	LOC103007128	Lymphotactin-like. (112 aa)
	EGR1	Early growth response protein; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Belongs to the EGR C2H2-type zinc-finger protein family. (539 aa)
	USP10	Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (849 aa)
	LOC103007438	Lymphotactin-like. (112 aa)
	NFKB1	Nuclear factor NF-kappa-B p105 subunit isoform X1. (974 aa)
	SMPD1	Sphingomyelin phosphodiesterase; Converts sphingomyelin to ceramide. (625 aa)
	ADAMTS7	A disintegrin and metalloproteinase with thrombospondin motifs 7. (1593 aa)
	RPS6KA4	Non-specific serine/threonine protein kinase. (601 aa)
	TAF9	Transcription initiation factor TFIID subunit 9. (265 aa)
	CACTIN	Cactin isoform X1. (755 aa)
	CCL21	C-C motif chemokine 21. (118 aa)
	CCL19	C-C motif chemokine. (100 aa)
	NR1D1	Nuclear receptor subfamily 1 group D member 1. (614 aa)
	DAB2IP	Disabled homolog 2-interacting protein. (999 aa)
	IRAK3	Interleukin-1 receptor-associated kinase 3 isoform X2. (517 aa)
	CXCL8	Multifunctional fusion protein; Belongs to the intercrine alpha (chemokine CxC) family. (101 aa)
	RPS6KA5	Ribosomal protein S6 kinase. (800 aa)
	TRAF6	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (561 aa)
	SFRP1	Secreted frizzled-related protein 1. (295 aa)
	RIPK2	Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. (536 aa)
	ANXA1	Annexin. (346 aa)
	ZC3H12A	Endoribonuclease ZC3H12A. (583 aa)
	LOC103007083	Early growth response protein 1-like. (215 aa)
	TANK	TRAF family member-associated NF-kappa-B activator isoform X1. (426 aa)
	LOC103014608	C-C motif chemokine. (99 aa)
	CCL16	C-C motif chemokine. (137 aa)
	LOC114238844	C-C motif chemokine 13-like. (106 aa)
	LOC103004078	LOW QUALITY PROTEIN: hyaluronan synthase 2-like. (552 aa)
	CCL26	C-C motif chemokine 26. (86 aa)
	IKBKB	Inhibitor of nuclear factor kappa-B kinase subunit beta. (765 aa)
	RORA	Nuclear receptor ROR-alpha. (386 aa)
	MAPK13	Mitogen-activated protein kinase. (288 aa)
	IL1R1	Interleukin-1 receptor type 1 isoform X1. (585 aa)
	IL1B	Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (266 aa)
	UPF1	Regulator of nonsense transcripts 1 isoform X1. (1127 aa)
	PTGES	Prostaglandin E synthase. (153 aa)
	IL17A	interleukin-17A. (153 aa)
	SRC	Tyrosine-protein kinase. (557 aa)
	HIF1A	Hypoxia-inducible factor 1-alpha isoform X1. (823 aa)
	IRAK2	Interleukin-1 receptor-associated kinase-like 2 isoform X1. (623 aa)
	YTHDC2	3'-5' RNA helicase YTHDC2. (1430 aa)
	ADAMTS12	A disintegrin and metalloproteinase with thrombospondin motifs 12. (1549 aa)
	TNFRSF11A	Tumor necrosis factor receptor superfamily member 11A. (781 aa)
	MYD88	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (296 aa)
	LOC103001618	C-C motif chemokine. (92 aa)
	CCL5	C-C motif chemokine. (91 aa)
	LOC103014886	C-C motif chemokine. (97 aa)
	CCL1	C-C motif chemokine 1. (93 aa)
	LOC103001344	C-C motif chemokine. (90 aa)
	RBMX	RNA-binding motif protein, X chromosome. (391 aa)
	CD40	Tumor necrosis factor receptor superfamily member 5 isoform X1. (280 aa)
	PTGIS	Prostacyclin synthase. (516 aa)
	PRKCA	Non-specific serine/threonine protein kinase. (559 aa)
	IRAK1	Interleukin-1 receptor-associated kinase 1. (340 aa)
	CHI3L1	Chitinase-3-like protein 1; Belongs to the glycosyl hydrolase 18 family. (400 aa)
	SOX9	Transcription factor SOX-9. (432 aa)
	MAPK3	Mitogen-activated protein kinase 3. (265 aa)
	LOC103001880	C-C motif chemokine. (93 aa)
	CCL24	C-C motif chemokine 24. (119 aa)
	LOC103004444	Apoptosis-associated speck-like protein containing a CARD. (195 aa)
	ANKRD1	LOW QUALITY PROTEIN: ankyrin repeat domain-containing protein 1. (319 aa)
	LOC103007512	RNA-binding motif protein, X chromosome-like. (384 aa)
	MAPK11	Mitogen-activated protein kinase. (281 aa)
	LOC102999038	Apoptosis-associated speck-like protein containing a CARD isoform X3. (194 aa)
	LOC103015160	C-C motif chemokine. (99 aa)
	CCL14	C-C motif chemokine 14. (100 aa)
	LOC103001061	C-C motif chemokine. (137 aa)

Your Current Organism:

Balaenoptera acutorostrata

NCBI taxonomy Id: 310752
Other names: B. acutorostrata scammoni, Balaenoptera acutorostrata scammoni

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CCL1	CCL16	A0A384ASN4	A0A452CMY9	C-C motif chemokine 1.	C-C motif chemokine.	0.615
CCL1	CCL17	A0A384ASN4	A0A383YXL1	C-C motif chemokine 1.	C-C motif chemokine.	0.726
CCL1	CCL19	A0A384ASN4	A0A383ZPY1	C-C motif chemokine 1.	C-C motif chemokine.	0.539
CCL1	CCL20	A0A384ASN4	A0A383YVP1	C-C motif chemokine 1.	C-C motif chemokine.	0.668
CCL1	CCL21	A0A384ASN4	A0A383ZPN7	C-C motif chemokine 1.	C-C motif chemokine 21.	0.619
CCL1	CCL22	A0A384ASN4	A0A383YXL6	C-C motif chemokine 1.	C-C motif chemokine.	0.627
CCL1	CCL24	A0A384ASN4	A0A384AGY8	C-C motif chemokine 1.	C-C motif chemokine 24.	0.585
CCL1	CCL25	A0A384ASN4	A0A383Z2A6	C-C motif chemokine 1.	C-C motif chemokine 25.	0.665
CCL1	CCL26	A0A384ASN4	A0A452CJX0	C-C motif chemokine 1.	C-C motif chemokine 26.	0.531
CCL1	CCL5	A0A384ASN4	A0A384ASZ8	C-C motif chemokine 1.	C-C motif chemokine.	0.671
CCL1	IL17A	A0A384ASN4	A0A384B3P7	C-C motif chemokine 1.	interleukin-17A.	0.411
CCL1	IL1B	A0A384ASN4	A0A384BCN2	C-C motif chemokine 1.	Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family.	0.503
CCL1	LOC103001618	A0A384ASN4	A0A384AT06	C-C motif chemokine 1.	C-C motif chemokine.	0.614
CCL1	LOC103001880	A0A384ASN4	A0A384ASC3	C-C motif chemokine 1.	C-C motif chemokine.	0.600
CCL1	LOC103014608	A0A384ASN4	A0A384ASB2	C-C motif chemokine 1.	C-C motif chemokine.	0.627
CCL1	LOC103014886	A0A384ASN4	A0A384ASW5	C-C motif chemokine 1.	C-C motif chemokine.	0.629
CCL1	LOC103015160	A0A384ASN4	A0A384AS84	C-C motif chemokine 1.	C-C motif chemokine.	0.471
CCL14	CCL21	A0A384AS91	A0A383ZPN7	C-C motif chemokine 14.	C-C motif chemokine 21.	0.681
CCL14	CCL22	A0A384AS91	A0A383YXL6	C-C motif chemokine 14.	C-C motif chemokine.	0.919
CCL14	CCL24	A0A384AS91	A0A384AGY8	C-C motif chemokine 14.	C-C motif chemokine 24.	0.543