STRINGSTRING
SCN5A SCN5A SCN10A SCN10A KCNJ5 KCNJ5 CACNA2D1 CACNA2D1 PKP2 PKP2 CACNA1D CACNA1D KCNQ1 KCNQ1 TBX5 TBX5 RYR2 RYR2 SCN1B SCN1B KCNA5 KCNA5 TRPM4 TRPM4 CACNA1C CACNA1C HCN4 HCN4 SCN4B SCN4B SCN3B SCN3B CACNB2 CACNB2 NUP155 NUP155 KCNN2 KCNN2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SCN5ASodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (1992 aa)
SCN10ASodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (1965 aa)
KCNJ5G protein-activated inward rectifier potassium channel 4. (419 aa)
CACNA2D1Voltage-dependent calcium channel subunit alpha-2/delta-1 isoform X1. (1110 aa)
PKP2Plakophilin-2 isoform X1. (826 aa)
CACNA1DVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2183 aa)
KCNQ1Potassium voltage-gated channel subfamily KQT member 1; Belongs to the potassium channel family. (599 aa)
TBX5T-box transcription factor TBX5 isoform X1. (536 aa)
RYR2Ryanodine receptor 2 isoform X1. (4884 aa)
SCN1BSodium channel subunit beta-1 isoform X1. (205 aa)
KCNA5Potassium voltage-gated channel subfamily A member 5; Belongs to the potassium channel family. (604 aa)
TRPM4Transient receptor potential cation channel subfamily M member 4 isoform X1. (1206 aa)
CACNA1CVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2273 aa)
HCN4Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4. (813 aa)
SCN4BSodium channel subunit beta-4. (228 aa)
SCN3BSodium channel subunit beta-3 isoform X1. (255 aa)
CACNB2Voltage-dependent L-type calcium channel subunit beta-2 isoform X1. (604 aa)
NUP155Nuclear pore complex protein Nup155. (1391 aa)
KCNN2LOW QUALITY PROTEIN: small conductance calcium-activated potassium channel protein 2. (856 aa)
Your Current Organism:
Balaenoptera acutorostrata
NCBI taxonomy Id: 310752
Other names: B. acutorostrata scammoni, Balaenoptera acutorostrata scammoni
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