STRINGSTRING
PTPRZ1 PTPRZ1 VSTM2L VSTM2L RASA1 RASA1 LOC103013777 LOC103013777 FOXO3 FOXO3 NF1 NF1 RILPL1 RILPL1 KDM2B KDM2B SYNGAP1 SYNGAP1 CLN3 CLN3 CTSZ CTSZ SARM1 SARM1 CDV3 CDV3 TYRO3 TYRO3 BRAF BRAF LOC103016504 LOC103016504 EGLN1 EGLN1 TIGAR TIGAR BARHL1 BARHL1 PIK3CA PIK3CA EGLN2 EGLN2 FBXO7 FBXO7 THAP11 THAP11 AARS AARS NAE1 NAE1 TREM2 TREM2 BCL2L11 BCL2L11 PRKCI PRKCI DCC DCC LIG4 LIG4 SORL1 SORL1 CNTF CNTF HYOU1 HYOU1 EFNB2 EFNB2 BACE1 BACE1 ZPR1 ZPR1 LOC103013621 LOC103013621 EPHA7 EPHA7 IL6ST IL6ST ISL1 ISL1 CRLF1 CRLF1 IFNG IFNG PAWR PAWR KRAS KRAS STXBP1 STXBP1 ABL1 ABL1 TFAP2D TFAP2D TFAP2B TFAP2B CTNNB1 CTNNB1 SIX1 SIX1 NEFL NEFL MEF2C MEF2C SIX4 SIX4 LOC103001360 LOC103001360 HIF1A HIF1A PLXND1 PLXND1 CHL1 CHL1 GDNF GDNF BCL2 BCL2 PRNP PRNP ROCK1 ROCK1 CX3CR1 CX3CR1 UCN UCN MAP3K5 MAP3K5 NCOA7 NCOA7 FYN FYN CCL5 CCL5 LOC103001880 LOC103001880 LOC103014608 LOC103014608 CDK5R1 CDK5R1 GPR75 GPR75 MSH2 MSH2 VPS54 VPS54 TRIM2 TRIM2 FBXW7 FBXW7 ATF4 ATF4 CLN8 CLN8 OXR1 OXR1 RETREG1 RETREG1 BHLHB9 BHLHB9 LANCL1 LANCL1 LOC103008872 LOC103008872 LOC103007708 LOC103007708 PPARGC1A PPARGC1A FGF8 FGF8 FZD9 FZD9 GFRAL GFRAL DAXX DAXX TMEM130 TMEM130 CORO1A CORO1A POU4F1 POU4F1 PRKN PRKN BIRC5 BIRC5 MECP2 MECP2 ALKBH1 ALKBH1 CITED1 CITED1 ADNP ADNP DNAJC5 DNAJC5 DNAJC5B DNAJC5B NENF NENF ZNF746 ZNF746 BOK BOK WNT1 WNT1 GABRA5 GABRA5 FAIM2 FAIM2 MAP3K12 MAP3K12 ERBB3 ERBB3 DDIT3 DDIT3 AGAP2 AGAP2 GRN GRN NFATC4 NFATC4 CHMP4A CHMP4A PSMC1 PSMC1 AMBRA1 AMBRA1 RAPSN RAPSN PRKCG PRKCG TBC1D24 TBC1D24 GSK3B GSK3B IL27RA IL27RA PM20D1 PM20D1 NR4A2 NR4A2 DLX1 DLX1 GRID2 GRID2 SNCA SNCA LGMN LGMN EIF2S1 EIF2S1 RACK1 RACK1 TGFB2 TGFB2 FGF20 FGF20 BAD BAD SNCG SNCG LOC103006469 LOC103006469 RRAS2 RRAS2 C1QA C1QA PINK1 PINK1 CASP9 CASP9 MAP2K4 MAP2K4 F2R F2R TMEM259 TMEM259 SIGMAR1 SIGMAR1 HIPK2 HIPK2 GBA GBA LOC103014668 LOC103014668 PCSK9 PCSK9 LOC103001311 LOC103001311 MAG MAG CDK5 CDK5 REST REST XRCC2 XRCC2 EN2 EN2 FOXB1 FOXB1 ASCL1 ASCL1 NRBP2 NRBP2 AXL AXL KIF14 KIF14 GATA3 GATA3 VPS35 VPS35 TOX3 TOX3 DDIT4 DDIT4 UNC5B UNC5B SIRT1 SIRT1 BAX BAX NTF4 NTF4 LRRK2 LRRK2 KDR KDR BBC3 BBC3 RHOA RHOA PICALM PICALM NGF NGF CSF1 CSF1 EN1 EN1 GRIK2 GRIK2 SNCB SNCB TNFRSF1B TNFRSF1B WNT3A WNT3A NMNAT1 NMNAT1 NTF3 NTF3 DRAXIN DRAXIN PARK7 PARK7 GPNMB GPNMB EPHB1 EPHB1 SEMA3E SEMA3E PLA2G3 PLA2G3 CCND1 CCND1 CLCF1 CLCF1 GABRB2 GABRB2 NES NES NTRK1 NTRK1 FBXW9 FBXW9 HDGF HDGF SLC30A10 SLC30A10 SLC7A11 SLC7A11 NDNF NDNF WFS1 WFS1 ATM ATM ADAM8 ADAM8
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PTPRZ1Receptor-type tyrosine-protein phosphatase zeta isoform X1. (2318 aa)
VSTM2LV-set and transmembrane domain-containing protein 2-like protein. (212 aa)
RASA1Ras GTPase-activating protein 1. (1041 aa)
LOC103013777LOW QUALITY PROTEIN: baculoviral IAP repeat-containing protein 5-like. (227 aa)
FOXO3LOW QUALITY PROTEIN: forkhead box protein O3. (467 aa)
NF1Neurofibromin. (2821 aa)
RILPL1RILP-like protein 1 isoform X1. (411 aa)
KDM2BLysine-specific demethylase 2B isoform X1. (1223 aa)
SYNGAP1ras/Rap GTPase-activating protein SynGAP. (1384 aa)
CLN3Battenin. (446 aa)
CTSZCathepsin Z; Belongs to the peptidase C1 family. (331 aa)
SARM1Sterile alpha and TIR motif-containing protein 1 isoform X1. (598 aa)
CDV3Protein CDV3 homolog isoform X1. (107 aa)
TYRO3Tyrosine-protein kinase receptor TYRO3 isoform X3. (845 aa)
BRAFSerine/threonine-protein kinase B-raf. (839 aa)
LOC103016504LOW QUALITY PROTEIN: ras-related protein R-Ras2-like. (260 aa)
EGLN1Egl nine homolog 1 isoform X1. (225 aa)
TIGARFructose-2,6-bisphosphatase TIGAR isoform X1. (275 aa)
BARHL1barH-like 1 homeobox protein. (354 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
EGLN2LOW QUALITY PROTEIN: egl nine homolog 2. (399 aa)
FBXO7F-box only protein 7. (498 aa)
THAP11THAP domain-containing protein 11. (397 aa)
AARSalanine--tRNA ligase, cytoplasmic; Catalyzes the attachment of alanine to tRNA(Ala) in a two- step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain. Belongs to the class-II aminoacyl-tRNA synthetase family. (968 aa)
NAE1NEDD8-activating enzyme E1 regulatory subunit; Regulatory subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M. Belongs to the ubiquitin-activating E1 family. ULA1 subfamily. (534 aa)
TREM2Triggering receptor expressed on myeloid cells 2. (230 aa)
BCL2L11Bcl-2-like protein 11; Induces apoptosis and anoikis. Belongs to the Bcl-2 family. (196 aa)
PRKCIProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (597 aa)
DCCLOW QUALITY PROTEIN: netrin receptor DCC. (1446 aa)
LIG4DNA ligase. (911 aa)
SORL1Sortilin-related receptor isoform X1. (2110 aa)
CNTFCiliary neurotrophic factor. (200 aa)
HYOU1Hypoxia up-regulated protein 1 isoform X1. (998 aa)
EFNB2ephrin-B2; Belongs to the ephrin family. (333 aa)
BACE1Beta-secretase 1; Belongs to the peptidase A1 family. (501 aa)
ZPR1Zinc finger protein ZPR1. (459 aa)
LOC103013621Protein lifeguard 2-like; Belongs to the BI1 family. (303 aa)
EPHA7Ephrin type-A receptor 7 isoform X1. (998 aa)
IL6STInterleukin-6 receptor subunit beta. (918 aa)
ISL1Insulin gene enhancer protein ISL-1. (349 aa)
CRLF1Cytokine receptor-like factor 1. (478 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (166 aa)
PAWRPRKC apoptosis WT1 regulator protein. (338 aa)
KRASGTPase KRas isoform X3. (227 aa)
STXBP1Syntaxin-binding protein 1 isoform X1; Belongs to the STXBP/unc-18/SEC1 family. (589 aa)
ABL1Tyrosine-protein kinase. (1149 aa)
TFAP2DTranscription factor AP-2-delta. (452 aa)
TFAP2BTranscription factor AP-2-beta isoform X1. (467 aa)
CTNNB1Catenin beta-1. (767 aa)
SIX1Homeobox protein SIX1. (284 aa)
NEFLNeurofilament light polypeptide; Belongs to the intermediate filament family. (547 aa)
MEF2CMyocyte-specific enhancer factor 2C isoform X5. (483 aa)
SIX4Homeobox protein SIX4. (733 aa)
LOC103001360Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (204 aa)
HIF1AHypoxia-inducible factor 1-alpha isoform X1. (823 aa)
PLXND1plexin-D1. (1747 aa)
CHL1Neural cell adhesion molecule L1-like protein isoform X1. (1225 aa)
GDNFGlial cell line-derived neurotrophic factor isoform X1. (211 aa)
BCL2Apoptosis regulator Bcl-2 isoform X1. (233 aa)
PRNPMajor prion protein; Belongs to the prion family. (257 aa)
ROCK1Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1354 aa)
CX3CR1CX3C chemokine receptor 1; Belongs to the G-protein coupled receptor 1 family. (358 aa)
UCNUrocortin. (126 aa)
MAP3K5Mitogen-activated protein kinase kinase kinase 5 isoform X3. (1219 aa)
NCOA7Nuclear receptor coactivator 7 isoform X1. (943 aa)
FYNTyrosine-protein kinase. (537 aa)
CCL5C-C motif chemokine. (91 aa)
LOC103001880C-C motif chemokine. (93 aa)
LOC103014608C-C motif chemokine. (99 aa)
CDK5R1Cyclin-dependent kinase 5 activator. (307 aa)
GPR75Probable G-protein coupled receptor 75. (540 aa)
MSH2DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (934 aa)
VPS54Vacuolar protein sorting-associated protein 54 isoform X1. (977 aa)
TRIM2Tripartite motif-containing protein 2 isoform X1. (766 aa)
FBXW7F-box/WD repeat-containing protein 7 isoform X1. (708 aa)
ATF4Cyclic AMP-dependent transcription factor ATF-4. (352 aa)
CLN8Protein CLN8. (284 aa)
OXR1Oxidation resistance protein 1 isoform X1. (895 aa)
RETREG1Reticulophagy regulator 1 isoform X1. (393 aa)
BHLHB9Protein BHLHb9. (561 aa)
LANCL1Glutathione S-transferase LANCL1. (399 aa)
LOC103008872RE1-silencing transcription factor-like. (326 aa)
LOC103007708RE1-silencing transcription factor-like. (871 aa)
PPARGC1APeroxisome proliferator-activated receptor gamma coactivator 1-alpha isoform X1. (803 aa)
FGF8Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (244 aa)
FZD9Frizzled-9; Belongs to the G-protein coupled receptor Fz/Smo family. (408 aa)
GFRALLOW QUALITY PROTEIN: GDNF family receptor alpha-like. (397 aa)
DAXXDeath domain-associated protein 6. (755 aa)
TMEM130Transmembrane protein 130 isoform X1. (435 aa)
CORO1ACoronin; Belongs to the WD repeat coronin family. (461 aa)
POU4F1POU domain protein. (298 aa)
PRKNE3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. (465 aa)
BIRC5Baculoviral IAP repeat-containing protein 5. (143 aa)
MECP2methyl-CpG-binding protein 2. (459 aa)
ALKBH1Nucleic acid dioxygenase ALKBH1 isoform X1. (390 aa)
CITED1LOW QUALITY PROTEIN: cbp/p300-interacting transactivator 1. (200 aa)
ADNPActivity-dependent neuroprotector homeobox protein. (1102 aa)
DNAJC5dnaJ homolog subfamily C member 5. (198 aa)
DNAJC5BdnaJ homolog subfamily C member 5B. (135 aa)
NENFNeudesin; Belongs to the cytochrome b5 family. (107 aa)
ZNF746Zinc finger protein 746. (471 aa)
BOKBcl-2-related ovarian killer protein. (175 aa)
WNT1Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa)
GABRA5Gamma-aminobutyric acid receptor subunit alpha-5; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (462 aa)
FAIM2Protein lifeguard 2; Belongs to the BI1 family. (316 aa)
MAP3K12Mitogen-activated protein kinase kinase kinase 12; May be an activator of the JNK/SAPK pathway. (893 aa)
ERBB3Receptor tyrosine-protein kinase erbB-3. (1338 aa)
DDIT3DNA damage-inducible transcript 3 protein; Multifunctional transcription factor in ER stress response. Plays an essential role in the response to a wide variety of cell stresses and induces cell cycle arrest and apoptosis in response to ER stress. Plays a dual role both as an inhibitor of CCAAT/enhancer- binding protein (C/EBP) function and as an activator of other genes. Acts as a dominant-negative regulator of C/EBP-induced transcription: dimerizes with members of the C/EBP family, impairs their association with C/EBP binding sites in the promoter regions, and inhibits the expression [...] (168 aa)
AGAP2arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2. (857 aa)
GRNGranulins. (587 aa)
NFATC4Nuclear factor of activated T-cells, cytoplasmic 4 isoform X1. (901 aa)
CHMP4ACharged multivesicular body protein 4a. (222 aa)
PSMC126S proteasome regulatory subunit 4; Belongs to the AAA ATPase family. (440 aa)
AMBRA1Activating molecule in BECN1-regulated autophagy protein 1 isoform X1. (1310 aa)
RAPSN43 kDa receptor-associated protein of the synapse isoform X1. (412 aa)
PRKCGProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (697 aa)
TBC1D24TBC1 domain family member 24. (559 aa)
GSK3BGlycogen synthase kinase-3 beta isoform X1; Belongs to the protein kinase superfamily. (433 aa)
IL27RAInterleukin-27 receptor subunit alpha. (656 aa)
PM20D1N-fatty-acyl-amino acid synthase/hydrolase PM20D1 isoform X1. (441 aa)
NR4A2Nuclear receptor subfamily 4 group A member 2 isoform X1. (598 aa)
DLX1Homeobox protein DLX-1 isoform X1. (255 aa)
GRID2Glutamate receptor ionotropic, delta-2. (1007 aa)
SNCAAlpha-synuclein; Belongs to the synuclein family. (139 aa)
LGMNLegumain. (433 aa)
EIF2S1Eukaryotic translation initiation factor 2 subunit 1. (315 aa)
RACK1Receptor of activated protein C kinase 1 isoform X1. (317 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
FGF20Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (211 aa)
BADBcl2-associated agonist of cell death. (168 aa)
SNCGGamma-synuclein; Belongs to the synuclein family. (127 aa)
LOC103006469Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (152 aa)
RRAS2Ras-related protein R-Ras2. (169 aa)
C1QAComplement C1q subcomponent subunit A. (245 aa)
PINK1Serine/threonine-protein kinase PINK1, mitochondrial. (405 aa)
CASP9Caspase-9 isoform X1; Belongs to the peptidase C14A family. (414 aa)
MAP2K4Dual specificity mitogen-activated protein kinase kinase 4 isoform X1; Belongs to the protein kinase superfamily. (338 aa)
F2RProteinase-activated receptor 1; Belongs to the G-protein coupled receptor 1 family. (427 aa)
TMEM259LOW QUALITY PROTEIN: membralin. (609 aa)
SIGMAR1Sigma non-opioid intracellular receptor 1. (223 aa)
HIPK2Homeodomain-interacting protein kinase 2 isoform X1. (1207 aa)
GBAGlucosylceramidase. (536 aa)
LOC103014668Transcription factor AP-1; Belongs to the bZIP family. (253 aa)
PCSK9Proprotein convertase subtilisin/kexin type 9. (723 aa)
LOC103001311Transcription factor AP-1-like. (199 aa)
MAGMyelin-associated glycoprotein. (626 aa)
CDK5Cyclin-dependent-like kinase 5 isoform X1; Belongs to the protein kinase superfamily. (292 aa)
RESTRE1-silencing transcription factor isoform X1. (1068 aa)
XRCC2DNA repair protein XRCC2. (280 aa)
EN2Homeobox protein engrailed-like. (300 aa)
FOXB1Forkhead box protein B1. (325 aa)
ASCL1Achaete-scute homolog 1. (169 aa)
NRBP2Nuclear receptor-binding protein 2 isoform X1. (480 aa)
AXLTyrosine-protein kinase receptor UFO isoform X1. (887 aa)
KIF14Kinesin-like protein KIF14; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1640 aa)
GATA3Trans-acting T-cell-specific transcription factor GATA-3 isoform X1. (444 aa)
VPS35Vacuolar protein sorting-associated protein 35; Plays a role in vesicular protein sorting. (796 aa)
TOX3TOX high mobility group box family member 3. (534 aa)
DDIT4DNA damage-inducible transcript 4 protein. (229 aa)
UNC5BNetrin receptor UNC5B isoform X1. (945 aa)
SIRT1NAD-dependent protein deacetylase sirtuin-1 isoform X1. (557 aa)
BAXApoptosis regulator BAX. (192 aa)
NTF4Neurotrophin-4; Belongs to the NGF-beta family. (210 aa)
LRRK2Leucine-rich repeat serine/threonine-protein kinase 2 isoform X1. (2527 aa)
KDRVascular endothelial growth factor receptor 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1356 aa)
BBC3Bcl-2-binding component 3. (140 aa)
RHOATransforming protein RhoA. (193 aa)
PICALMPhosphatidylinositol-binding clathrin assembly protein isoform X1. (713 aa)
NGFBeta-nerve growth factor; Belongs to the NGF-beta family. (241 aa)
CSF1Macrophage colony-stimulating factor 1. (513 aa)
EN1Homeobox protein engrailed-like. (206 aa)
GRIK2Glutamate receptor ionotropic, kainate 2 isoform X1. (908 aa)
SNCBBeta-synuclein; Belongs to the synuclein family. (134 aa)
TNFRSF1BTumor necrosis factor receptor superfamily member 1B. (460 aa)
WNT3AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (352 aa)
NMNAT1Nicotinamide-nucleotide adenylyltransferase. (281 aa)
NTF3Neurotrophin-3; Seems to promote the survival of visceral and proprioceptive sensory neurons; Belongs to the NGF-beta family. (271 aa)
DRAXINDraxin; Chemorepulsive axon guidance protein required for the development of spinal cord and forebrain commissures. Acts as a chemorepulsive guidance protein for commissural axons during development. Able to inhibit or repel neurite outgrowth from dorsal spinal cord. Inhibits the stabilization of cytosolic beta-catenin (CTNNB1) via its interaction with LRP6, thereby acting as an antagonist of Wnt signaling pathway. (349 aa)
PARK7Protein/nucleic acid deglycase DJ-1. (189 aa)
GPNMBTransmembrane glycoprotein NMB. (552 aa)
EPHB1Ephrin type-B receptor 1. (984 aa)
SEMA3Esemaphorin-3E; Belongs to the semaphorin family. (775 aa)
PLA2G3Group 3 secretory phospholipase A2. (516 aa)
CCND1G1/S-specific cyclin-D1 isoform X1; Belongs to the cyclin family. (214 aa)
CLCF1Cardiotrophin-like cytokine factor 1 isoform X1. (228 aa)
GABRB2Gamma-aminobutyric acid receptor subunit beta-2 isoform X1; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (512 aa)
NESNestin; Belongs to the intermediate filament family. (1537 aa)
NTRK1Tyrosine-protein kinase receptor. (826 aa)
FBXW9F-box/WD repeat-containing protein 9 isoform X1. (458 aa)
HDGFHepatoma-derived growth factor. (290 aa)
SLC30A10Zinc transporter 10. (483 aa)
SLC7A11Cystine/glutamate transporter. (503 aa)
NDNFProtein NDNF. (568 aa)
WFS1Wolframin. (888 aa)
ATMSerine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3057 aa)
ADAM8Disintegrin and metalloproteinase domain-containing protein 8. (771 aa)
Your Current Organism:
Balaenoptera acutorostrata
NCBI taxonomy Id: 310752
Other names: B. acutorostrata scammoni, Balaenoptera acutorostrata scammoni
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