STRINGSTRING
VPS4B VPS4B GHRL GHRL BLK BLK TRH TRH ARF6 ARF6 HIF1A HIF1A SYK SYK GHRH GHRH CD2AP CD2AP APBB3 APBB3 LAMP1 LAMP1 PTGES PTGES LRRC8A LRRC8A STXBP1 STXBP1 TM7SF3 TM7SF3 RAB27A RAB27A SYT1 SYT1 CFTR CFTR RAB3A RAB3A CNR1 CNR1 CACNB2 CACNB2 STAM STAM NNAT NNAT LOC103014437 LOC103014437 LOC103003549 LOC103003549 CADPS CADPS LOC103018366 LOC103018366 MYOM1 MYOM1 MYH10 MYH10 LOC103018329 LOC103018329 CACNA1I CACNA1I IL13 IL13 SELENOT SELENOT STX1B STX1B LOC103007889 LOC103007889 RPH3AL RPH3AL CACNA1B CACNA1B CD160 CD160 CACNA1A CACNA1A BAIAP3 BAIAP3 EXOC1 EXOC1 CADPS2 CADPS2 ILDR1 ILDR1 GPER1 GPER1 LOC114235402 LOC114235402 PTPN11 PTPN11 LOC103015712 LOC103015712 CD177 CD177 TGFB1 TGFB1 ARHGEF7 ARHGEF7 FRMD4A FRMD4A C2CD2L C2CD2L CREB1 CREB1 NMB NMB AP1G1 AP1G1 PARD6A PARD6A VPS4A VPS4A SCAMP5 SCAMP5 TREM2 TREM2 IL1A IL1A SMAD4 SMAD4 SOX4 SOX4 GPLD1 GPLD1 STXBP5 STXBP5 IRS2 IRS2 PDX1 PDX1 FFAR1 FFAR1 CDK5 CDK5 C1QTNF6 C1QTNF6 IGF1 IGF1 NR1H4 NR1H4 C1QTNF12 C1QTNF12 NLGN2 NLGN2 LOC103018878 LOC103018878 LOC103019157 LOC103019157 PPP3CB PPP3CB MCU MCU NKX3-1 NKX3-1 SPHK2 SPHK2 LOC103002333 LOC103002333 HYAL3 HYAL3 RAB3D RAB3D PTPN23 PTPN23 LOC102999676 LOC102999676 FGR FGR PLA2G3 PLA2G3 ANO1 ANO1 SRI SRI HMMR HMMR DRD2 DRD2 MPC2 MPC2 GALR1 GALR1 ABCG1 ABCG1 TCF7L2 TCF7L2 EXPH5 EXPH5 NLGN1 NLGN1 TGFB2 TGFB2 ADORA2B ADORA2B DTNBP1 DTNBP1 EDN1 EDN1 BAD BAD TSG101 TSG101 ATP13A2 ATP13A2 PINK1 PINK1 GHRHR GHRHR CHMP2A CHMP2A VAMP8 VAMP8 DNM1L DNM1L SYT10 SYT10 F2RL1 F2RL1 CARTPT CARTPT SNF8 SNF8 FGB FGB FGG FGG HFE HFE GOLPH3L GOLPH3L ADAM9 ADAM9 RAB7A RAB7A SLC4A8 SLC4A8 NR1H2 NR1H2 RAB2B RAB2B RNASE4 RNASE4 LOC103004320 LOC103004320 GPR68 GPR68 SYTL4 SYTL4 RAB9A RAB9A CACNA1H CACNA1H SYT2 SYT2 SNX4 SNX4 WLS WLS RAB5A RAB5A CACNB4 CACNB4 GCG GCG VSNL1 VSNL1 SDC1 SDC1 DOC2B DOC2B KIAA0100 KIAA0100 SPP1 SPP1 PPID PPID RAB15 RAB15 TGFB3 TGFB3 TMED10 TMED10 CAPN10 CAPN10 CRH CRH UNC13D UNC13D C1QTNF1 C1QTNF1 HGS HGS EZR EZR VIP VIP ITGAM ITGAM STX1A STX1A TFR2 TFR2 ZP3 ZP3 TNFSF11 TNFSF11 RBP4 RBP4 FFAR4 FFAR4 ANKRD1 ANKRD1 GCK GCK CDK5R2 CDK5R2 LOC103014960 LOC103014960 LOC103017310 LOC103017310 ADCY8 ADCY8 PLA2G6 PLA2G6 AACS AACS TLR2 TLR2 LOC103003817 LOC103003817 P2RX7 P2RX7 PRKCE PRKCE RASL10B RASL10B RFX6 RFX6 UCN UCN ADCYAP1 ADCYAP1 BMP2 BMP2 RAB27B RAB27B TNFRSF11A TNFRSF11A C1QTNF3 C1QTNF3 GOLPH3 GOLPH3 TMF1 TMF1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
VPS4BVacuolar protein sorting-associated protein 4B; Belongs to the AAA ATPase family. (444 aa)
GHRLAppetite-regulating hormone. (141 aa)
BLKTyrosine-protein kinase. (501 aa)
TRHPro-thyrotropin-releasing hormone; Functions as a regulator of the biosynthesis of TSH in the anterior pituitary gland and as a neurotransmitter/ neuromodulator in the central and peripheral nervous systems. (206 aa)
ARF6ADP-ribosylation factor 6; Belongs to the small GTPase superfamily. Arf family. (175 aa)
HIF1AHypoxia-inducible factor 1-alpha isoform X1. (823 aa)
SYKTyrosine-protein kinase. (626 aa)
GHRHSomatoliberin. (106 aa)
CD2APCD2-associated protein. (714 aa)
APBB3Amyloid-beta A4 precursor protein-binding family B member 3 isoform X1. (515 aa)
LAMP1Lysosome-associated membrane glycoprotein 1. (438 aa)
PTGESProstaglandin E synthase. (153 aa)
LRRC8AVolume-regulated anion channel subunit LRRC8A isoform X1. (810 aa)
STXBP1Syntaxin-binding protein 1 isoform X1; Belongs to the STXBP/unc-18/SEC1 family. (589 aa)
TM7SF3Transmembrane 7 superfamily member 3. (570 aa)
RAB27ARas-related protein Rab-27A. (221 aa)
SYT1Synaptotagmin-1 isoform X1. (422 aa)
CFTRCystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane. Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelial fluid layer. (1480 aa)
RAB3ARas-related protein Rab-3A. (220 aa)
CNR1Cannabinoid receptor 1; G-protein coupled receptor for cannabinoids (eCBs), including N-arachidonoylethanolamide (also called anandamide or AEA) and 2- arachidonoylglycerol (2-AG). Mediates many cannabinoid-induced effects, acting, among others, on food intake, memory loss, gastrointestinal motility, catalepsy, ambulatory activity, anxiety, chronic pain. Signaling typically involves reduction in cyclic AMP. In the hypothalamus, may have a dual effect on mitochondrial respiration depending upon the agonist dose and possibly upon the cell type. Increases respiration at low doses, while d [...] (472 aa)
CACNB2Voltage-dependent L-type calcium channel subunit beta-2 isoform X1. (604 aa)
STAMSignal transducing adapter molecule 1. (529 aa)
NNATNeuronatin isoform X3. (125 aa)
LOC103014437LOW QUALITY PROTEIN: signal transducing adapter molecule 1-like. (520 aa)
LOC103003549LOW QUALITY PROTEIN: Golgi phosphoprotein 3-like. (154 aa)
CADPSCalcium-dependent secretion activator 1 isoform X7. (1361 aa)
LOC103018366Golgi phosphoprotein 3. (86 aa)
MYOM1Myomesin-1 isoform X2. (1644 aa)
MYH10Myosin-10; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1886 aa)
LOC103018329Neuroligin-2. (597 aa)
CACNA1IVoltage-dependent T-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. This channel gives rise to T-type calcium currents. T-type calcium channels belong to the "low-voltage activated (LVA)" group and are strongly blocked by nickel and mibefradil. A particularity of this type of channels is an opening at quite ne [...] (2076 aa)
IL13Interleukin-13. (146 aa)
SELENOTSelenoprotein T; Belongs to the SelWTH family. Selenoprotein T subfamily. (195 aa)
STX1Bsyntaxin-1B; Belongs to the syntaxin family. (288 aa)
LOC103007889LOW QUALITY PROTEIN: peptidyl-prolyl cis-trans isomerase D-like. (358 aa)
RPH3ALLOW QUALITY PROTEIN: rab effector Noc2. (296 aa)
CACNA1BVoltage-dependent N-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1B gives rise to N-type calcium currents. (2153 aa)
CD160LOW QUALITY PROTEIN: CD160 antigen. (386 aa)
CACNA1AVoltage-dependent P/Q-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1A gives rise to P and/or Q- type calcium currents. (2185 aa)
BAIAP3BAI1-associated protein 3 isoform X1. (1152 aa)
EXOC1Exocyst complex component 1 isoform X1. (503 aa)
CADPS2Calcium-dependent secretion activator 2 isoform X8. (1203 aa)
ILDR1Immunoglobulin-like domain-containing receptor 1. (547 aa)
GPER1G-protein coupled estrogen receptor 1; Belongs to the G-protein coupled receptor 1 family. (363 aa)
LOC114235402Olfactory receptor. (320 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (623 aa)
LOC103015712Insulin-like. (117 aa)
CD177CD177 antigen. (439 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (407 aa)
ARHGEF7Rho guanine nucleotide exchange factor 7. (794 aa)
FRMD4AFERM domain-containing protein 4A. (958 aa)
C2CD2LPhospholipid transfer protein C2CD2L. (713 aa)
CREB1Cyclic AMP-responsive element-binding protein 1 isoform X1. (341 aa)
NMBneuromedin-B isoform X1. (128 aa)
AP1G1AP-1 complex subunit gamma. (825 aa)
PARD6APartitioning defective 6 homolog alpha. (345 aa)
VPS4AVacuolar protein sorting-associated protein 4A; Belongs to the AAA ATPase family. (526 aa)
SCAMP5Secretory carrier-associated membrane protein. (235 aa)
TREM2Triggering receptor expressed on myeloid cells 2. (230 aa)
IL1AInterleukin-1; Belongs to the IL-1 family. (270 aa)
SMAD4Mothers against decapentaplegic homolog. (553 aa)
SOX4Transcription factor SOX-4. (197 aa)
GPLD1Phosphatidylinositol-glycan-specific phospholipase D. (843 aa)
STXBP5Syntaxin-binding protein 5 isoform X1. (1156 aa)
IRS2Insulin receptor substrate 2. (507 aa)
PDX1LOW QUALITY PROTEIN: pancreas/duodenum homeobox protein 1. (280 aa)
FFAR1Free fatty acid receptor 1. (300 aa)
CDK5Cyclin-dependent-like kinase 5 isoform X1; Belongs to the protein kinase superfamily. (292 aa)
C1QTNF6Complement C1q tumor necrosis factor-related protein 6. (266 aa)
IGF1Insulin-like growth factor I isoform X1. (187 aa)
NR1H4Bile acid receptor isoform X1. (486 aa)
C1QTNF12Adipolin. (308 aa)
NLGN2Neuroligin-2. (662 aa)
LOC103018878Neuroligin-2. (585 aa)
LOC103019157Neuroligin-2-like. (646 aa)
PPP3CBSerine/threonine-protein phosphatase. (528 aa)
MCUCalcium uniporter protein, mitochondrial. (348 aa)
NKX3-1Homeobox protein Nkx-3.1. (153 aa)
SPHK2Sphingosine kinase 2 isoform X1. (665 aa)
LOC103002333Exocyst complex component 1-like isoform X1. (416 aa)
HYAL3Hyaluronidase. (517 aa)
RAB3DRas-related protein Rab-3D. (219 aa)
PTPN23Tyrosine-protein phosphatase non-receptor type 23. (1628 aa)
LOC102999676Neuroligin-2-like. (688 aa)
FGRTyrosine-protein kinase. (537 aa)
PLA2G3Group 3 secretory phospholipase A2. (516 aa)
ANO1Anoctamin. (973 aa)
SRISorcin. (199 aa)
HMMRHyaluronan mediated motility receptor. (715 aa)
DRD2D(2) dopamine receptor; Belongs to the G-protein coupled receptor 1 family. (443 aa)
MPC2Mitochondrial pyruvate carrier; Mediates the uptake of pyruvate into mitochondria. Belongs to the mitochondrial pyruvate carrier (MPC) (TC 2.A.105) family. (127 aa)
GALR1Galanin receptor type 1; Belongs to the G-protein coupled receptor 1 family. (349 aa)
ABCG1ATP-binding cassette sub-family G member 1 isoform X1. (678 aa)
TCF7L2Transcription factor 7-like 2 isoform X1. (515 aa)
EXPH5LOW QUALITY PROTEIN: exophilin-5. (1925 aa)
NLGN1Neuroligin-1 isoform X1. (843 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
ADORA2BAdenosine receptor A2; Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family. (241 aa)
DTNBP1Dysbindin. (326 aa)
EDN1Endothelin-1. (202 aa)
BADBcl2-associated agonist of cell death. (168 aa)
TSG101Tumor susceptibility gene 101 protein isoform X1. (422 aa)
ATP13A2Cation-transporting ATPase; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily. (892 aa)
PINK1Serine/threonine-protein kinase PINK1, mitochondrial. (405 aa)
GHRHRGrowth hormone-releasing hormone receptor; Belongs to the G-protein coupled receptor 2 family. (423 aa)
CHMP2ACharged multivesicular body protein 2a isoform X1. (222 aa)
VAMP8Vesicle-associated membrane protein 8 isoform X1. (154 aa)
DNM1LDynamin-1-like protein isoform X2; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (749 aa)
SYT10Synaptotagmin-10. (523 aa)
F2RL1Proteinase-activated receptor 2. (397 aa)
CARTPTCocaine- and amphetamine-regulated transcript protein. (115 aa)
SNF8Vacuolar-sorting protein SNF8; Component of the endosomal sorting complex required for transport II (ESCRT-II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs. Belongs to the SNF8 family. (258 aa)
FGBFibrinogen beta chain. (488 aa)
FGGFibrinogen gamma chain isoform X1. (467 aa)
HFEHereditary hemochromatosis protein isoform X1; Belongs to the MHC class I family. (356 aa)
GOLPH3LGolgi phosphoprotein 3-like isoform X1. (285 aa)
ADAM9Disintegrin and metalloproteinase domain-containing protein 9 isoform X1. (819 aa)
RAB7ARas-related protein Rab-7a. (207 aa)
SLC4A8Anion exchange protein. (1137 aa)
NR1H2Oxysterols receptor LXR-beta isoform X1. (449 aa)
RAB2BRas-related protein Rab-2B. (216 aa)
RNASE4Ribonuclease 4; Belongs to the pancreatic ribonuclease family. (147 aa)
LOC103004320Vesicle-associated membrane protein 7; Belongs to the synaptobrevin family. (220 aa)
GPR68Ovarian cancer G-protein coupled receptor 1; Belongs to the G-protein coupled receptor 1 family. (371 aa)
SYTL4Synaptotagmin-like protein 4 isoform X1. (672 aa)
RAB9ARas-related protein Rab-9A. (201 aa)
CACNA1HLOW QUALITY PROTEIN: voltage-dependent T-type calcium channel subunit alpha-1H. (2326 aa)
SYT2Synaptotagmin-2 isoform X1. (431 aa)
SNX4Sorting nexin-4. (450 aa)
WLSProtein wntless homolog isoform X1. (555 aa)
RAB5ARas-related protein Rab-5A isoform X1. (215 aa)
CACNB4Voltage-dependent L-type calcium channel subunit beta-4 isoform X1. (502 aa)
GCGGlucagon isoform X1. (180 aa)
VSNL1Visinin-like protein 1. (191 aa)
SDC1Syndecan; Cell surface proteoglycan; Belongs to the syndecan proteoglycan family. (432 aa)
DOC2BDouble C2-like domain-containing protein beta. (257 aa)
KIAA0100Protein KIAA0100 homolog. (2092 aa)
SPP1Osteopontin. (303 aa)
PPIDPeptidyl-prolyl cis-trans isomerase D. (370 aa)
RAB15Ras-related protein Rab-15 isoform X1. (212 aa)
TGFB3Transforming growth factor beta-3 proprotein. (456 aa)
TMED10Transmembrane emp24 domain-containing protein 10. (219 aa)
CAPN10Calpain-10; Belongs to the peptidase C2 family. (645 aa)
CRHCorticoliberin. (193 aa)
UNC13DProtein unc-13 homolog D isoform X1. (1086 aa)
C1QTNF1Complement C1q tumor necrosis factor-related protein 1. (276 aa)
HGSHepatocyte growth factor-regulated tyrosine kinase substrate; Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin- coated regions. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (E [...] (773 aa)
EZREzrin. (586 aa)
VIPVIP peptides. (170 aa)
ITGAMIntegrin alpha-M; Belongs to the integrin alpha chain family. (1152 aa)
STX1Asyntaxin-1A; Belongs to the syntaxin family. (259 aa)
TFR2Transferrin receptor protein 2 isoform X1. (839 aa)
ZP3Zona pellucida sperm-binding protein 3. (421 aa)
TNFSF11Tumor necrosis factor ligand superfamily member 11; Belongs to the tumor necrosis factor family. (244 aa)
RBP4Retinol-binding protein; Retinol-binding protein that mediates retinol transport in blood plasma. (196 aa)
FFAR4LOW QUALITY PROTEIN: free fatty acid receptor 4. (361 aa)
ANKRD1LOW QUALITY PROTEIN: ankyrin repeat domain-containing protein 1. (319 aa)
GCKPhosphotransferase. (482 aa)
CDK5R2Cyclin-dependent kinase 5 activator. (310 aa)
LOC103014960Appetite-regulating hormone-like. (149 aa)
LOC103017310Phospholipase A(2). (159 aa)
ADCY8Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1248 aa)
PLA2G685/88 kDa calcium-independent phospholipase A2 isoform X1. (806 aa)
AACSacetoacetyl-CoA synthetase. (672 aa)
TLR2Toll-like receptor 2; Belongs to the Toll-like receptor family. (785 aa)
LOC103003817Toll-like receptor 2. (126 aa)
P2RX7P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. Belongs to the P2X receptor family. (595 aa)
PRKCEProtein kinase C epsilon type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays essential roles in the regulation of multiple cellular processes linked to cytoskeletal proteins, such as cell adhesion, motility, migration and cell cycle, functions in neuron growth and ion channel regulation, and is involved in immune response, cancer cell invasion and regulation of apoptosis. Mediates cell adhesion to the extracellular matrix via integrin- dependent signaling, by mediating angiotensin-2-induced activation of integrin beta- [...] (737 aa)
RASL10BRas-like protein family member 10B. (228 aa)
RFX6DNA-binding protein RFX6. (928 aa)
UCNUrocortin. (126 aa)
ADCYAP1Pituitary adenylate cyclase-activating polypeptide. (176 aa)
BMP2Bone morphogenetic protein 2. (395 aa)
RAB27BRas-related protein Rab-27B. (218 aa)
TNFRSF11ATumor necrosis factor receptor superfamily member 11A. (781 aa)
C1QTNF3Complement C1q tumor necrosis factor-related protein 3 isoform X1. (319 aa)
GOLPH3Golgi phosphoprotein 3. (272 aa)
TMF1TATA element modulatory factor isoform X1. (1093 aa)
Your Current Organism:
Balaenoptera acutorostrata
NCBI taxonomy Id: 310752
Other names: B. acutorostrata scammoni, Balaenoptera acutorostrata scammoni
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