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| | PNP | Purine nucleoside phosphorylase; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. (289 aa) |
| | SETBP1 | SET-binding protein. (1594 aa) |
| | NUDT16L1 | Tudor-interacting repair regulator protein isoform X1. (211 aa) |
| | NME4 | Nucleoside diphosphate kinase. (187 aa) |
| | NME3 | Nucleoside diphosphate kinase. (163 aa) |
| | GDA | Guanine deaminase; Catalyzes the hydrolytic deamination of guanine, producing xanthine and ammonia; Belongs to the metallo-dependent hydrolases superfamily. ATZ/TRZ family. (454 aa) |
| | CMPK1 | UMP-CMP kinase; Belongs to the adenylate kinase family. (232 aa) |
| | AK2 | Adenylate kinase 2, mitochondrial; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways. Plays a key role in hematopoiesis. (241 aa) |
| | ENTPD8 | Ectonucleoside triphosphate diphosphohydrolase 8; Belongs to the GDA1/CD39 NTPase family. (454 aa) |
| | ENTPD2 | Ectonucleoside triphosphate diphosphohydrolase 2; Belongs to the GDA1/CD39 NTPase family. (496 aa) |
| | UPP2 | Uridine phosphorylase; Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis. (320 aa) |
| | NT5C1B | Cytosolic 5'-nucleotidase 1B isoform X2. (623 aa) |
| | GART | Trifunctional purine biosynthetic protein adenosine-3; In the C-terminal section; belongs to the GART family. In the central section; belongs to the AIR synthase family. (1010 aa) |
| | NUDT9 | ADP-ribose pyrophosphatase, mitochondrial. (350 aa) |
| | NUDT16 | U8 snoRNA-decapping enzyme isoform X2. (196 aa) |
| | ENTPD5 | Ectonucleoside triphosphate diphosphohydrolase 5; Belongs to the GDA1/CD39 NTPase family. (428 aa) |
| | DTYMK | Thymidylate kinase. (186 aa) |
| | UCKL1 | Uridine-cytidine kinase; Belongs to the uridine kinase family. (467 aa) |
| | NT5C | 5'(3')-deoxyribonucleotidase, cytosolic type. (218 aa) |
| | TK1 | Thymidine kinase. (237 aa) |
| | DCTPP1 | dCTP pyrophosphatase 1; Hydrolyzes deoxynucleoside triphosphates (dNTPs) to the corresponding nucleoside monophosphates. Has a strong preference for dCTP and its analogs including 5-iodo-dCTP and 5-methyl-dCTP for which it may even have a higher efficiency. May protect DNA or RNA against the incorporation of these genotoxic nucleotide analogs through their catabolism. (169 aa) |
| | CDADC1 | Cytidine and dCMP deaminase domain-containing protein 1 isoform X1. (565 aa) |
| | NUDT15 | Nucleotide triphosphate diphosphatase NUDT15. (171 aa) |
| | SCHIP1 | Schwannomin-interacting protein 1 isoform X1. (260 aa) |
| | ENTPD1 | Ectonucleoside triphosphate diphosphohydrolase 1 isoform X2; Belongs to the GDA1/CD39 NTPase family. (526 aa) |
| | MARVELD1 | MARVEL domain-containing protein 1. (224 aa) |
| | ENTPD7 | Ectonucleoside triphosphate diphosphohydrolase 7 isoform X1; Belongs to the GDA1/CD39 NTPase family. (605 aa) |
| | ATIC | Bifunctional purine biosynthesis protein PURH. (592 aa) |
| | NME8 | Thioredoxin domain-containing protein 3. (425 aa) |
| | CTPS2 | CTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. (607 aa) |
| | ADAL | Adenosine deaminase-like protein isoform X1. (354 aa) |
| | RRM2B | Ribonucleoside-diphosphate reductase subunit M2 B. (351 aa) |
| | AMPD3 | AMP deaminase; Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. (754 aa) |
| | APRT | Adenine phosphoribosyltransferase isoform X1. (205 aa) |
| | NUDT6 | Nucleoside diphosphate-linked moiety X motif 6 isoform X1; Belongs to the Nudix hydrolase family. (316 aa) |
| | NME9 | Thioredoxin domain-containing protein 6; Belongs to the NDK family. (340 aa) |
| | GUK1 | Guanylate kinase isoform X1. (214 aa) |
| | AMPD1 | AMP deaminase; Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. (782 aa) |
| | DPYD | Dihydropyrimidine dehydrogenase [NADP(+)]; Involved in pyrimidine base degradation. Catalyzes the reduction of uracil and thymine; Belongs to the dihydropyrimidine dehydrogenase family. (1025 aa) |
| | AMPD2 | AMP deaminase; Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. (832 aa) |
| | QRICH1 | Glutamine-rich protein 1. (779 aa) |
| | IMPDH2 | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of some tumors. (538 aa) |
| | DALRD3 | DALR anticodon-binding domain-containing protein 3 isoform X1. (569 aa) |
| | NUDT18 | 8-oxo-dGDP phosphatase NUDT18. (323 aa) |
| | ENTPD4 | Ectonucleoside triphosphate diphosphohydrolase 4 isoform X1; Belongs to the GDA1/CD39 NTPase family. (616 aa) |
| | NUDT13 | Nucleoside diphosphate-linked moiety X motif 13 isoform X1. (352 aa) |
| | NUDT5 | ADP-sugar pyrophosphatase isoform X1; Belongs to the Nudix hydrolase family. (267 aa) |
| | ADK | Adenosine kinase isoform X2. (362 aa) |
| | PFAS | Phosphoribosylformylglycinamidine synthase. (1361 aa) |
| | TXNRD1 | Thioredoxin reductase 1, cytoplasmic. (497 aa) |
| | PAICS | Multifunctional protein ADE2 isoform X1. (425 aa) |
| | PPAT | Amidophosphoribosyltransferase; In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family. (540 aa) |
| | GMPS | GMP synthase [glutamine-hydrolyzing]. (733 aa) |
| | ADSS | Adenylosuccinate synthetase isozyme 2; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP. (456 aa) |
| | NT5C1A | Cytosolic 5'-nucleotidase 1A. (330 aa) |
| | CTPS1 | CTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. (591 aa) |
| | IPO13 | Importin-13 isoform X1. (963 aa) |
| | AK4 | Adenylate kinase 4, mitochondrial; Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Efficiently phosphorylates AMP and dAMP using ATP as phosphate donor, but phosphorylates only AMP when using GTP as phosphate donor. Also displays broad nucleoside diphosphate kinase activity. (223 aa) |
| | RRM1 | Ribonucleoside-diphosphate reductase; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. (791 aa) |
| | LOC103017888 | 5'-nucleotidase domain-containing protein 1-like. (236 aa) |
| | LOC103000785 | Deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial-like. (164 aa) |
| | NT5C2 | Cytosolic purine 5'-nucleotidase. (570 aa) |
| | LOC103014119 | LOW QUALITY PROTEIN: thymidylate synthase-like. (306 aa) |
| | LOC103019758 | LOW QUALITY PROTEIN: 5'-nucleotidase domain-containing protein 1-like. (453 aa) |
| | NT5M | 5'(3')-deoxyribonucleotidase, mitochondrial isoform X1. (268 aa) |
| | LOC103002621 | LOW QUALITY PROTEIN: ribonucleoside-diphosphate reductase subunit M2-like. (406 aa) |
| | UCK2 | Uridine-cytidine kinase; Belongs to the uridine kinase family. (261 aa) |
| | DUT | Deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial isoform X1. (288 aa) |
| | LOC114236184 | LOW QUALITY PROTEIN: adenylate kinase isoenzyme 1-like. (141 aa) |
| | LOC102999090 | LOW QUALITY PROTEIN: GMP synthase [glutamine-hydrolyzing]-like. (537 aa) |
| | CMPK2 | UMP-CMP kinase 2, mitochondrial. (303 aa) |
| | ENTPD3 | Ectonucleoside triphosphate diphosphohydrolase 3 isoform X1; Belongs to the GDA1/CD39 NTPase family. (527 aa) |
| | TXNRD3 | LOW QUALITY PROTEIN: thioredoxin reductase 3. (563 aa) |
| | DHODH | Dihydroorotate dehydrogenase (quinone), mitochondrial; Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily. (395 aa) |
| | TK2 | Thymidine kinase 2, mitochondrial isoform X1. (264 aa) |
| | NRSN1 | Neurensin-1. (195 aa) |
| | GLRX | Glutaredoxin-1. (106 aa) |
| | GMPR | GMP reductase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides. (345 aa) |
| | UPB1 | Beta-ureidopropionase isoform X1. (401 aa) |
| | TXNDC2 | Thioredoxin domain-containing protein 2. (335 aa) |
| | NT5E | 5'-nucleotidase isoform X1; Belongs to the 5'-nucleotidase family. (470 aa) |
| | ITPA | Inosine triphosphate pyrophosphatase; Pyrophosphatase that hydrolyzes the non-canonical purine nucleotides inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) as well as 2'-deoxy-N-6-hydroxylaminopurine triposphate (dHAPTP) and xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions; Belongs to the HAM1 NTPase family. (203 aa) |
| | RRM2 | Ribonucleoside-diphosphate reductase subunit M2 isoform X1. (393 aa) |
| | SLC25A42 | Mitochondrial coenzyme A transporter SLC25A42 isoform X1; Belongs to the mitochondrial carrier (TC 2.A.29) family. (318 aa) |
| | AK8 | Adenylate kinase 8 isoform X1; Belongs to the adenylate kinase family. (498 aa) |
| | UCK1 | Uridine-cytidine kinase; Belongs to the uridine kinase family. (277 aa) |
| | AK1 | Adenylate kinase isoenzyme 1; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Also displays broad nucleoside diphosphate kinase activity. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. (194 aa) |
| | DNPH1 | 2'-deoxynucleoside 5'-phosphate N-hydrolase 1; Catalyzes the cleavage of the N-glycosidic bond of deoxyribonucleoside 5'-monophosphates to yield deoxyribose 5-phosphate and a purine or pyrimidine base. Deoxyribonucleoside 5'-monophosphates containing purine bases are preferred to those containing pyrimidine bases. (236 aa) |
| | DCK | Deoxycytidine kinase isoform X1. (260 aa) |
| | ADA | Adenosine deaminase. (394 aa) |
| | SAMHD1 | Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 isoform X1. (628 aa) |
| | CEP44 | Centrosomal protein of 44 kDa. (385 aa) |
| | ENTPD6 | Ectonucleoside triphosphate diphosphohydrolase 6; Belongs to the GDA1/CD39 NTPase family. (456 aa) |
| | AK5 | Adenylate kinase isoenzyme 5 isoform X1; Belongs to the adenylate kinase family. (561 aa) |
| | XDH | Xanthine dehydrogenase/oxidase isoform X1. (1334 aa) |
| | TYMS | Thymidylate synthase. (303 aa) |
| | CAD | CAD protein isoform X1. (2242 aa) |
| | LOC103002524 | 5'-nucleotidase domain-containing protein 1-like. (249 aa) |
| | GLRX2 | Glutaredoxin 2 isoform X1. (132 aa) |
| | AK9 | Adenylate kinase 9. (1862 aa) |
| | ENKUR | Enkurin isoform X1. (256 aa) |
| | PRTFDC1 | Hypoxanthine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. (208 aa) |
| | PAPOLG | poly(A) polymerase gamma isoform X1. (813 aa) |
| | ADSL | Adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. (490 aa) |
| | DGUOK | Deoxyguanosine kinase, mitochondrial isoform X1. (294 aa) |
| | DCTD | Deoxycytidylate deaminase. (178 aa) |
| | DPYS | Dihydropyrimidinase. (561 aa) |
| | SMIM3 | Small integral membrane protein 3. (60 aa) |
| | GSR | Glutathione reductase, mitochondrial. (410 aa) |
| | HPRT1 | Hypoxanthine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. (254 aa) |
| | NUDT1 | 7,8-dihydro-8-oxoguanine triphosphatase; Belongs to the Nudix hydrolase family. (156 aa) |
| | CDA | Cytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis; Belongs to the cytidine and deoxycytidylate deaminase family. (146 aa) |
| | NT5C3A | 5'-nucleotidase; Belongs to the pyrimidine 5'-nucleotidase family. (331 aa) |
| | ADPRM | Manganese-dependent ADP-ribose/CDP-alcohol diphosphatase isoform X1. (342 aa) |
| | UMPS | Uridine 5'-monophosphate synthase. (480 aa) |
| | AK6 | Adenylate kinase isoenzyme 6; Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. May have a role in nuclear energy homeostasis. Has also ATPase activity. May be involved in regulation of Cajal body (CB) formation; Belongs to the adenylate kinase family. AK6 subfamily. (172 aa) |
| | ADSSL1 | Adenylosuccinate synthetase isozyme 1; Component of the purine nucleotide cycle (PNC), which interconverts IMP and AMP to regulate the nucleotide levels in various tissues, and which contributes to glycolysis and ammoniagenesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP. (441 aa) |
| | LOC103010377 | Nucleoside diphosphate kinase. (152 aa) |
| | NME2 | Nucleoside diphosphate kinase. (152 aa) |
| | IMPDH1 | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of some tumors. (551 aa) |
| | TXN | Thioredoxin; Belongs to the thioredoxin family. (105 aa) |
| | UPP1 | Uridine phosphorylase; Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis. (309 aa) |
| | TXNDC8 | Thioredoxin; Belongs to the thioredoxin family. (105 aa) |
| | AK7 | Adenylate kinase 7. (698 aa) |
| | GMPR2 | GMP reductase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides. (439 aa) |
