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IDH2 IDH2 ATP8 ATP8 ATP6 ATP6 ATP5PF ATP5PF GABPA GABPA DNAJC11 DNAJC11 ATP5F1C ATP5F1C MICOS13 MICOS13 ATP5PB ATP5PB GABPB1 GABPB1 SIRT3 SIRT3 LOC103003361 LOC103003361 SIRT5 SIRT5 TMEM11 TMEM11 GLUD1 GLUD1 MICOS10 MICOS10 IMMT IMMT POLG2 POLG2 ATP5MC1 ATP5MC1 ATP5F1D ATP5F1D SSBP1 SSBP1 CHCHD3 CHCHD3 NRF1 NRF1 GABPB2 GABPB2 CRTC2 CRTC2 LOC103003117 LOC103003117 ATP5MC2 ATP5MC2 ATP5F1B ATP5F1B CHCHD6 CHCHD6 ATP5PO ATP5PO SIRT4 SIRT4 APOO APOO ATP5F1E ATP5F1E CUNH17orf80 CUNH17orf80 ATP5PD ATP5PD SOD2 SOD2 TWNK TWNK PPARGC1A PPARGC1A PPARGC1B PPARGC1B LOC103012265 LOC103012265 LOC103016559 LOC103016559 LOC103017780 LOC103017780 LOC102999215 LOC102999215 MTX2 MTX2 ATP5MC3 ATP5MC3 LOC102999969 LOC102999969 DMAC2L DMAC2L ACSS2 ACSS2 CRTC1 CRTC1 ATP5MG ATP5MG ATP5F1A ATP5F1A CRTC3 CRTC3 LOC103014355 LOC103014355 LOC103001729 LOC103001729 LOC103017251 LOC103017251 LOC114236024 LOC114236024 LOC103007402 LOC103007402 LOC114236798 LOC114236798 LOC103010657 LOC103010657 LOC102998244 LOC102998244 LOC103007678 LOC103007678 ATP5ME ATP5ME LOC103006898 LOC103006898 TFB1M TFB1M ATP5MF ATP5MF LOC103002409 LOC103002409
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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
IDH2Isocitrate dehydrogenase [NADP]; Belongs to the isocitrate and isopropylmalate dehydrogenases family. (400 aa)
ATP8ATP synthase protein 8; Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subuni [...] (63 aa)
ATP6ATP synthase subunit a. (226 aa)
ATP5PFATP synthase-coupling factor 6, mitochondrial; Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain; Belongs to the eukaryotic ATPase subunit F6 family. (108 aa)
GABPAGA-binding protein alpha chain. (454 aa)
DNAJC11dnaJ homolog subfamily C member 11. (559 aa)
ATP5F1CATP synthase subunit gamma. (298 aa)
MICOS13MICOS complex subunit MIC13; Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. (118 aa)
ATP5PBATP synthase F(0) complex subunit B1, mitochondrial. (277 aa)
GABPB1GA-binding protein subunit beta-1 isoform X1. (395 aa)
SIRT3NAD-dependent protein deacetylase; NAD-dependent protein deacetylase. (260 aa)
LOC103003361Cytochrome c; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
SIRT5NAD-dependent protein deacylase sirtuin-5, mitochondrial; NAD-dependent lysine demalonylase, desuccinylase and deglutarylase that specifically removes malonyl, succinyl and glutaryl groups on target proteins. Activates CPS1 and contributes to the regulation of blood ammonia levels during prolonged fasting: acts by mediating desuccinylation and deglutarylation of CPS1, thereby increasing CPS1 activity in response to elevated NAD levels during fasting. Activates SOD1 by mediating its desuccinylation, leading to reduced reactive oxygen species. Modulates ketogenesis through the desuccinyl [...] (358 aa)
TMEM11Transmembrane protein 11, mitochondrial. (191 aa)
GLUD1Glutamate dehydrogenase 1, mitochondrial; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. (558 aa)
MICOS10MICOS complex subunit MIC10; Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. (78 aa)
IMMTMICOS complex subunit MIC60; Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. (751 aa)
POLG2DNA polymerase subunit gamma-2, mitochondrial isoform X1. (508 aa)
ATP5MC1ATP synthase F(0) complex subunit C1, mitochondrial; Belongs to the ATPase C chain family. (136 aa)
ATP5F1DATP synthase subunit delta, mitochondrial. (131 aa)
SSBP1Single-stranded DNA-binding protein, mitochondrial. (148 aa)
CHCHD3MICOS complex subunit; Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. (227 aa)
NRF1LOW QUALITY PROTEIN: nuclear respiratory factor 1. (501 aa)
GABPB2GA-binding protein subunit beta-2 isoform X1. (447 aa)
CRTC2CREB-regulated transcription coactivator 2 isoform X1. (693 aa)
LOC103003117ATP synthase subunit g, mitochondrial-like. (196 aa)
ATP5MC2ATP synthase F(0) complex subunit C2, mitochondrial; Belongs to the ATPase C chain family. (142 aa)
ATP5F1BATP synthase subunit beta; Produces ATP from ADP in the presence of a proton gradient across the membrane. (528 aa)
CHCHD6MICOS complex subunit; Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. (114 aa)
ATP5POATP synthase subunit O, mitochondrial. (213 aa)
SIRT4NAD-dependent protein lipoamidase sirtuin-4, mitochondrial; Acts as NAD-dependent protein lipoamidase, ADP-ribosyl transferase and deacetylase. Catalyzes more efficiently removal of lipoyl- and biotinyl- than acetyl-lysine modifications. Inhibits the pyruvate dehydrogenase complex (PDH) activity via the enzymatic hydrolysis of the lipoamide cofactor from the E2 component, DLAT, in a phosphorylation-independent manner. Catalyzes the transfer of ADP- ribosyl groups onto target proteins, including mitochondrial GLUD1, inhibiting GLUD1 enzyme activity. Acts as a negative regulator of mitoc [...] (314 aa)
APOOMICOS complex subunit; Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. (198 aa)
ATP5F1EATP synthase subunit epsilon, mitochondrial. (51 aa)
CUNH17orf80Uncharacterized protein C17orf80 homolog isoform X1. (572 aa)
ATP5PDATP synthase subunit d, mitochondrial; Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the cent [...] (161 aa)
SOD2Superoxide dismutase; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the iron/manganese superoxide dismutase family. (176 aa)
TWNKTwinkle protein, mitochondrial isoform X1. (684 aa)
PPARGC1APeroxisome proliferator-activated receptor gamma coactivator 1-alpha isoform X1. (803 aa)
PPARGC1BPeroxisome proliferator-activated receptor gamma coactivator 1-beta. (1021 aa)
LOC103012265Serum response factor-binding protein 1. (428 aa)
LOC103016559ATP synthase F(0) complex subunit B1, mitochondrial-like. (187 aa)
LOC103017780Cytochrome c 2; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
LOC102999215Cytochrome c-like; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
MTX2Metaxin-2 isoform X1. (264 aa)
ATP5MC3ATP synthase F(0) complex subunit C3, mitochondrial; Belongs to the ATPase C chain family. (141 aa)
LOC102999969Transmembrane protein 11, mitochondrial-like. (153 aa)
DMAC2LATP synthase subunit s, mitochondrial isoform X1. (199 aa)
ACSS2Acetyl-coenzyme A synthetase, cytoplasmic isoform X1. (714 aa)
CRTC1LOW QUALITY PROTEIN: CREB-regulated transcription coactivator 1. (622 aa)
ATP5MGATP synthase subunit; Mitochondrial membrane ATP synthase (F1F0 ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F1 - containing the extramembraneous catalytic core, and F0 - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F1 is coupled via a rotary mechanism of the central stalk subunits to proto [...] (103 aa)
ATP5F1AATP synthase subunit alpha; Produces ATP from ADP in the presence of a proton gradient across the membrane. (553 aa)
CRTC3CREB-regulated transcription coactivator 3 isoform X1. (449 aa)
LOC103014355Single-stranded DNA-binding protein, mitochondrial. (148 aa)
LOC103001729Cytochrome c-like; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
LOC103017251LOW QUALITY PROTEIN: glutamate dehydrogenase 1, mitochondrial-like; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. (578 aa)
LOC114236024Cytochrome c-like; Belongs to the cytochrome c family. (59 aa)
LOC103007402ATP synthase subunit; Mitochondrial membrane ATP synthase (F1F0 ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F1 - containing the extramembraneous catalytic core, and F0 - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F1 is coupled via a rotary mechanism of the central stalk subunits to proto [...] (103 aa)
LOC114236798ATP synthase subunit epsilon, mitochondrial-like. (65 aa)
LOC103010657ATP synthase subunit f, mitochondrial-like isoform X1. (87 aa)
LOC102998244Cytochrome c-like; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
LOC103007678Glutamate dehydrogenase; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. (488 aa)
ATP5MEATP synthase subunit e, mitochondrial. (71 aa)
LOC103006898LOW QUALITY PROTEIN: ATP synthase subunit beta, mitochondrial-like. (213 aa)
TFB1MrRNA adenine N(6)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. (334 aa)
ATP5MFATP synthase subunit f, mitochondrial. (88 aa)
LOC103002409Cytochrome c-like. (69 aa)
Your Current Organism:
Balaenoptera acutorostrata
NCBI taxonomy Id: 310752
Other names: B. acutorostrata scammoni, Balaenoptera acutorostrata scammoni
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