STRINGSTRING
ERCC1 ERCC1 TCEANC2 TCEANC2 PPIE PPIE RPA3 RPA3 POLR2I POLR2I POLR2B POLR2B POLR2A POLR2A POLR2C POLR2C ERCC2 ERCC2 TCEA1 TCEA1 XAB2 XAB2 SPOCD1 SPOCD1 POLD4 POLD4 UBB UBB PRPF19 PRPF19 DDB1 DDB1 POLR2G POLR2G GTF2H1 GTF2H1 TCEA3 TCEA3 POLK POLK LOC103000259 LOC103000259 CDK7 CDK7 ERCC8 ERCC8 POLR2E POLR2E RPA1 RPA1 CUL4B CUL4B ERCC6 ERCC6 RFC1 RFC1 LOC103015962 LOC103015962 PHF3 PHF3 ISY1 ISY1 POLD1 POLD1 TCEANC TCEANC AQR AQR NRDE2 NRDE2 POLE POLE UVSSA UVSSA MEIOB MEIOB LOC103006290 LOC103006290 ERCC3 ERCC3 POLR2D POLR2D POLE4 POLE4 TCEA2 TCEA2 GTF2H5 GTF2H5 RFC2 RFC2 POLR2J POLR2J RCBTB2 RCBTB2 LOC103016635 LOC103016635 POLD2 POLD2 ERCC4 ERCC4 USP7 USP7 RBX1 RBX1 RFC5 RFC5 GTF2H3 GTF2H3 UBC UBC RPS27A RPS27A ATAD5 ATAD5 ZNF830 ZNF830 LOC103008595 LOC103008595 PCNA PCNA POLE2 POLE2 MNAT1 MNAT1 CCNH CCNH RFC3 RFC3 RCBTB1 RCBTB1 GTF2H4 GTF2H4 POLR2H POLR2H KXD1 KXD1 RFC4 RFC4 UBA52 UBA52 CUL4A CUL4A BIVM BIVM ERCC5 ERCC5 XPA XPA LOC103006878 LOC103006878 POLE3 POLE3 POLR2L POLR2L LOC114235986 LOC114235986 LOC103016069 LOC103016069 LOC102999414 LOC102999414 POLR2K POLR2K POLD3 POLD3 LOC103011160 LOC103011160 HMGN1 HMGN1 USP40 USP40 LOC103007401 LOC103007401 LOC114238515 LOC114238515 POLR2F POLR2F EP300 EP300 LOC103020561 LOC103020561
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ERCC1DNA excision repair protein ERCC-1. (294 aa)
TCEANC2Transcription elongation factor A N-terminal and central domain-containing protein 2. (208 aa)
PPIEPeptidyl-prolyl cis-trans isomerase E; Catalyzes the cis-trans isomerization of proline imidic peptide bonds in proteins; Belongs to the cyclophilin-type PPIase family. PPIase E subfamily. (301 aa)
RPA3Replication protein A 14 kDa subunit isoform X1. (121 aa)
POLR2IDNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family. (125 aa)
POLR2BDNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1174 aa)
POLR2ADNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1963 aa)
POLR2CDNA-directed RNA polymerase II subunit RPB3 isoform X1. (275 aa)
ERCC2General transcription and DNA repair factor IIH helicase subunit XPD. (760 aa)
TCEA1Transcription elongation factor A protein 1. (266 aa)
XAB2pre-mRNA-splicing factor SYF1. (853 aa)
SPOCD1SPOC domain-containing protein 1 isoform X1. (899 aa)
POLD4DNA polymerase delta subunit 4 isoform X2. (107 aa)
UBBpolyubiquitin-B. (305 aa)
PRPF19pre-mRNA-processing factor 19. (504 aa)
DDB1DNA damage-binding protein 1. (1140 aa)
POLR2GDNA-directed RNA polymerase II subunit RPB7. (172 aa)
GTF2H1General transcription factor IIH subunit 1 isoform X1. (548 aa)
TCEA3Transcription elongation factor A protein 3. (346 aa)
POLKDNA polymerase kappa isoform X1. (877 aa)
LOC103000259General transcription factor IIH subunit. (395 aa)
CDK7Cyclin-dependent kinase 7 isoform X1; Belongs to the protein kinase superfamily. (346 aa)
ERCC8DNA excision repair protein ERCC-8 isoform X1. (396 aa)
POLR2EDNA-directed RNA polymerases I, II, and III subunit RPABC1. (210 aa)
RPA1Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (617 aa)
CUL4BLOW QUALITY PROTEIN: cullin-4B; Belongs to the cullin family. (893 aa)
ERCC6DNA excision repair protein ERCC-6 isoform X1. (1485 aa)
RFC1Replication factor C subunit 1. (1146 aa)
LOC103015962DNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family. (125 aa)
PHF3PHD finger protein 3 isoform X1. (2043 aa)
ISY1pre-mRNA-splicing factor ISY1 homolog isoform X1. (296 aa)
POLD1DNA polymerase. (1107 aa)
TCEANCTranscription elongation factor A N-terminal and central domain-containing protein. (352 aa)
AQRRNA helicase aquarius; Intron-binding spliceosomal protein required to link pre-mRNA splicing and snoRNP (small nucleolar ribonucleoprotein) biogenesis. Plays a key role in position-dependent assembly of intron-encoded box C/D small snoRNP, splicing being required for snoRNP assembly. May act by helping the folding of the snoRNA sequence. Binds to intron of pre- mRNAs in a sequence-independent manner, contacting the region between snoRNA and the branchpoint of introns (40 nucleotides upstream of the branchpoint) during the late stages of splicing. (1485 aa)
NRDE2Protein NRDE2 homolog. (1160 aa)
POLEDNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (2240 aa)
UVSSAUV-stimulated scaffold protein A. (679 aa)
MEIOBMeiosis-specific with OB domain-containing protein isoform X1. (471 aa)
LOC103006290Non-histone chromosomal protein HMG-14. (101 aa)
ERCC3General transcription and DNA repair factor IIH helicase subunit XPB. (782 aa)
POLR2DDNA-directed RNA polymerase II subunit RPB4. (104 aa)
POLE4DNA polymerase epsilon subunit 4. (116 aa)
TCEA2Transcription elongation factor A protein 2. (273 aa)
GTF2H5General transcription factor IIH subunit 5. (71 aa)
RFC2Replication factor C subunit 2. (352 aa)
POLR2JDNA-directed RNA polymerase II subunit RPB11-a. (117 aa)
RCBTB2RCC1 and BTB domain-containing protein 2 isoform X1. (572 aa)
LOC103016635LOW QUALITY PROTEIN: uroplakin-3b-like protein 1. (254 aa)
POLD2DNA polymerase delta subunit 2. (469 aa)
ERCC4DNA repair endonuclease XPF. (916 aa)
USP7Ubiquitin carboxyl-terminal hydrolase 7; Belongs to the peptidase C19 family. (1055 aa)
RBX1E3 ubiquitin-protein ligase RBX1. (108 aa)
RFC5Replication factor C subunit 5. (341 aa)
GTF2H3General transcription factor IIH subunit 3. (309 aa)
UBCpolyubiquitin-C. (609 aa)
RPS27Aubiquitin-40S ribosomal protein S27a. (156 aa)
ATAD5ATPase family AAA domain-containing protein 5. (1853 aa)
ZNF830Zinc finger protein 830. (380 aa)
LOC103008595Non-histone chromosomal protein HMG-17. (90 aa)
PCNAProliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (261 aa)
POLE2DNA polymerase epsilon subunit; Participates in DNA repair and in chromosomal DNA replication; Belongs to the DNA polymerase epsilon subunit B family. (527 aa)
MNAT1CDK-activating kinase assembly factor MAT1; Stabilizes the cyclin H-CDK7 complex to form a functional CDK-activating kinase (CAK) enzymatic complex. (309 aa)
CCNHcyclin-H isoform X1; Belongs to the cyclin family. (328 aa)
RFC3Replication factor C subunit 3. (356 aa)
RCBTB1RCC1 and BTB domain-containing protein 1 isoform X1. (549 aa)
GTF2H4General transcription factor IIH subunit 4; Component of the general transcription and DNA repair factor IIH (TFIIH) core complex which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA. Belongs to the TFB2 family. (463 aa)
POLR2HDNA-directed RNA polymerases I, II, and III subunit RPABC3; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non- coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively. (150 aa)
KXD1kxDL motif-containing protein 1. (176 aa)
RFC4Replication factor C subunit 4. (376 aa)
UBA52ubiquitin-60S ribosomal protein L40. (128 aa)
CUL4Acullin-4A; Belongs to the cullin family. (637 aa)
BIVMBasic immunoglobulin-like variable motif-containing protein isoform X3. (504 aa)
ERCC5DNA repair protein complementing XP-G cells isoform X1. (1201 aa)
XPADNA repair protein complementing XP-A cells. (273 aa)
LOC103006878Non-histone chromosomal protein HMG-17-like. (90 aa)
POLE3LOW QUALITY PROTEIN: DNA polymerase epsilon subunit 3. (146 aa)
POLR2LDNA-directed RNA polymerases I, II, and III subunit RPABC5. (58 aa)
LOC114235986LOW QUALITY PROTEIN: non-histone chromosomal protein HMG-14-like. (101 aa)
LOC103016069Peptidyl-prolyl cis-trans isomerase E; Catalyzes the cis-trans isomerization of proline imidic peptide bonds in proteins; Belongs to the cyclophilin-type PPIase family. PPIase E subfamily. (287 aa)
LOC102999414Peptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family. (235 aa)
POLR2KDNA-directed RNA polymerases I, II, and III subunit RPABC4. (58 aa)
POLD3DNA polymerase delta subunit 3 isoform X1. (465 aa)
LOC103011160Ubiquitin-like. (144 aa)
HMGN1Non-histone chromosomal protein HMG-14. (192 aa)
USP40Ubiquitin carboxyl-terminal hydrolase 40 isoform X1; Belongs to the peptidase C19 family. (1241 aa)
LOC103007401Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (230 aa)
LOC114238515Non-histone chromosomal protein HMG-14-like. (101 aa)
POLR2FDNA-directed RNA polymerases I, II, and III subunit RPABC2. (115 aa)
EP300Histone acetyltransferase p300. (2445 aa)
LOC103020561LOW QUALITY PROTEIN: CDK-activating kinase assembly factor MAT1-like. (454 aa)
Your Current Organism:
Balaenoptera acutorostrata
NCBI taxonomy Id: 310752
Other names: B. acutorostrata scammoni, Balaenoptera acutorostrata scammoni
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