STRINGSTRING
SMAD3 SMAD3 TP53 TP53 PSMB6 PSMB6 TEAD2 TEAD2 PSMA5 PSMA5 MAML1 MAML1 TEAD4 TEAD4 NINJ2 NINJ2 CCND1 CCND1 PSMD13 PSMD13 TCF7 TCF7 TCF7L2 TCF7L2 PSMA4 PSMA4 UBB UBB PSMA1 PSMA1 TEAD1 TEAD1 TCF7L1 TCF7L1 PSMC5 PSMC5 PSMC2 PSMC2 PSMB3 PSMB3 PSMD3 PSMD3 LOC103001388 LOC103001388 PSMB4 PSMB4 PSMD4 PSMD4 PSMD5 PSMD5 LOC103010956 LOC103010956 MAMLD1 MAMLD1 PSMC4 PSMC4 PSMD8 PSMD8 ZFHX2 ZFHX2 PSMB5 PSMB5 PSME2 PSME2 PSME1 PSME1 PSMA6 PSMA6 PSMC1 PSMC1 PSMC3 PSMC3 CREBBP CREBBP PSMB2 PSMB2 KAT2B KAT2B PSMD14 PSMD14 SNW1 SNW1 PSMD1 PSMD1 HDAC4 HDAC4 PSMA7 PSMA7 SMURF2 SMURF2 PSMD12 PSMD12 PSMB1 PSMB1 SMURF1 SMURF1 BRD2 BRD2 PSMB8 PSMB8 FNDC3A FNDC3A EP300 EP300 PSMB9 PSMB9 PSMA2 PSMA2 PSMD9 PSMD9 UBC UBC RPS27A RPS27A PSMD11 PSMD11 LEF1 LEF1 CCN2 CCN2 MAML2 MAML2 PSMD6 PSMD6 PSMC6 PSMC6 PSMA3 PSMA3 SRC SRC RBPJL RBPJL CTNNB1 CTNNB1 PSMF1 PSMF1 PSMB7 PSMB7 MDM2 MDM2 HES1 HES1 UBA52 UBA52 PSMD10 PSMD10 SMAD2 SMAD2 SMAD4 SMAD4 FNDC3B FNDC3B PSMB10 PSMB10 TEAD3 TEAD3 ZFHX3 ZFHX3 CBFB CBFB PSMD7 PSMD7 LOC103008006 LOC103008006 TGFB1 TGFB1 MAML3 MAML3 KAT2A KAT2A LOC103012500 LOC103012500 LOC103013996 LOC103013996 LOC103011160 LOC103011160 ZFHX4 ZFHX4
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SMAD3Mothers against decapentaplegic homolog. (425 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (387 aa)
PSMB6Proteasome subunit beta. (239 aa)
TEAD2Transcriptional enhancer factor TEF-4 isoform X1. (451 aa)
PSMA5Proteasome subunit alpha type. (241 aa)
MAML1Mastermind-like protein 1. (971 aa)
TEAD4Transcriptional enhancer factor TEF-3. (580 aa)
NINJ2Ninjurin-2. (106 aa)
CCND1G1/S-specific cyclin-D1 isoform X1; Belongs to the cyclin family. (214 aa)
PSMD1326S proteasome non-ATPase regulatory subunit 13. (376 aa)
TCF7Transcription factor 7 isoform X2. (303 aa)
TCF7L2Transcription factor 7-like 2 isoform X1. (515 aa)
PSMA4Proteasome subunit alpha type. (261 aa)
UBBpolyubiquitin-B. (305 aa)
PSMA1Proteasome subunit alpha type. (263 aa)
TEAD1Transcriptional enhancer factor TEF-1. (509 aa)
TCF7L1Transcription factor 7-like 1 isoform X1. (439 aa)
PSMC526S proteasome regulatory subunit 8; Belongs to the AAA ATPase family. (406 aa)
PSMC226S proteasome regulatory subunit 7; Belongs to the AAA ATPase family. (433 aa)
PSMB3Proteasome subunit beta. (205 aa)
PSMD326S proteasome non-ATPase regulatory subunit 3. (534 aa)
LOC103001388Proteasome activator complex subunit 3. (254 aa)
PSMB4Proteasome subunit beta; Belongs to the peptidase T1B family. (264 aa)
PSMD426S proteasome non-ATPase regulatory subunit 4 isoform X1. (380 aa)
PSMD526S proteasome non-ATPase regulatory subunit 5. (504 aa)
LOC103010956Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. (361 aa)
MAMLD1Mastermind-like domain-containing protein 1 isoform X1. (1038 aa)
PSMC426S proteasome regulatory subunit 6B; Belongs to the AAA ATPase family. (418 aa)
PSMD826S proteasome non-ATPase regulatory subunit 8. (351 aa)
ZFHX2LOW QUALITY PROTEIN: zinc finger homeobox protein 2. (2572 aa)
PSMB5Proteasome subunit beta. (263 aa)
PSME2Proteasome activator complex subunit 2. (239 aa)
PSME1Proteasome activator complex subunit 1. (249 aa)
PSMA6Proteasome subunit alpha type. (246 aa)
PSMC126S proteasome regulatory subunit 4; Belongs to the AAA ATPase family. (440 aa)
PSMC326S proteasome regulatory subunit 6A; Belongs to the AAA ATPase family. (423 aa)
CREBBPCREB-binding protein isoform X1. (2444 aa)
PSMB2Proteasome subunit beta. (201 aa)
KAT2BHistone acetyltransferase KAT2B. (703 aa)
PSMD1426S proteasome non-ATPase regulatory subunit 14 isoform X1. (310 aa)
SNW1SNW domain-containing protein 1 isoform X1. (536 aa)
PSMD126S proteasome non-ATPase regulatory subunit 1; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S1 family. (953 aa)
HDAC4Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1149 aa)
PSMA7Proteasome endopeptidase complex. (220 aa)
SMURF2E3 ubiquitin-protein ligase. (735 aa)
PSMD1226S proteasome non-ATPase regulatory subunit 12. (434 aa)
PSMB1Proteasome subunit beta. (241 aa)
SMURF1E3 ubiquitin-protein ligase SMURF1. (719 aa)
BRD2Bromodomain-containing protein 2 isoform X1. (803 aa)
PSMB8Proteasome subunit beta. (276 aa)
FNDC3AFibronectin type-III domain-containing protein 3A isoform X1. (1198 aa)
EP300Histone acetyltransferase p300. (2445 aa)
PSMB9Proteasome subunit beta type-9. (322 aa)
PSMA2Proteasome subunit alpha type. (234 aa)
PSMD926S proteasome non-ATPase regulatory subunit 9. (223 aa)
UBCpolyubiquitin-C. (609 aa)
RPS27Aubiquitin-40S ribosomal protein S27a. (156 aa)
PSMD1126S proteasome non-ATPase regulatory subunit 11 isoform X1. (429 aa)
LEF1Lymphoid enhancer-binding factor 1 isoform X1. (399 aa)
CCN2Connective tissue growth factor. (268 aa)
MAML2Mastermind-like protein 2. (1115 aa)
PSMD626S proteasome non-ATPase regulatory subunit 6. (389 aa)
PSMC626S proteasome regulatory subunit 10B; Belongs to the AAA ATPase family. (403 aa)
PSMA3Proteasome subunit alpha type. (255 aa)
SRCTyrosine-protein kinase. (557 aa)
RBPJLRecombining binding protein suppressor of hairless-like protein. (489 aa)
CTNNB1Catenin beta-1. (767 aa)
PSMF1Proteasome inhibitor PI31 subunit. (270 aa)
PSMB7Proteasome subunit beta. (277 aa)
MDM2E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family. (491 aa)
HES1Transcription factor HES-1. (280 aa)
UBA52ubiquitin-60S ribosomal protein L40. (128 aa)
PSMD1026S proteasome non-ATPase regulatory subunit 10 isoform X1. (226 aa)
SMAD2Mothers against decapentaplegic homolog. (467 aa)
SMAD4Mothers against decapentaplegic homolog. (553 aa)
FNDC3BFibronectin type III domain-containing protein 3B isoform X1. (1206 aa)
PSMB10Proteasome subunit beta. (273 aa)
TEAD3Transcriptional enhancer factor TEF-5; Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. (497 aa)
ZFHX3Zinc finger homeobox protein 3. (3687 aa)
CBFBCore-binding factor subunit beta. (151 aa)
PSMD7LOW QUALITY PROTEIN: 26S proteasome non-ATPase regulatory subunit 7. (326 aa)
LOC103008006Recombining binding protein suppressor of hairless isoform X1. (491 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (407 aa)
MAML3LOW QUALITY PROTEIN: mastermind-like protein 3. (1110 aa)
KAT2ALOW QUALITY PROTEIN: histone acetyltransferase KAT2A. (839 aa)
LOC103012500LOW QUALITY PROTEIN: histone acetyltransferase KAT2A-like. (732 aa)
LOC103013996Proteasome subunit alpha type. (284 aa)
LOC103011160Ubiquitin-like. (144 aa)
ZFHX4LOW QUALITY PROTEIN: zinc finger homeobox protein 4. (3612 aa)
Your Current Organism:
Balaenoptera acutorostrata
NCBI taxonomy Id: 310752
Other names: B. acutorostrata scammoni, Balaenoptera acutorostrata scammoni
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