STRINGSTRING
SCAP SCAP LOC103014598 LOC103014598 LOC102998844 LOC102998844 LOC103020549 LOC103020549 SRD5A3 SRD5A3 HSD17B14 HSD17B14 LOC103002595 LOC103002595 LOC103003050 LOC103003050 LOC103002145 LOC103002145 LBR LBR LOC103009357 LOC103009357 DHRS7C DHRS7C SLC51B SLC51B NFYB NFYB NR1H4 NR1H4 FAXDC2 FAXDC2 INSIG1 INSIG1 NFYC NFYC DHCR24 DHCR24 OSBPL9 OSBPL9 SCP2 SCP2 HSD11B1 HSD11B1 RIMBP2 RIMBP2 LOC103015911 LOC103015911 SREBF2 SREBF2 LOC103005435 LOC103005435 MBTPS2 MBTPS2 LSS LSS CDCP2 CDCP2 LOC102999763 LOC102999763 OSBPL1A OSBPL1A LOC103014627 LOC103014627 LOC103003841 LOC103003841 LOC103007308 LOC103007308 HSD11B2 HSD11B2 NFYA NFYA TSPO2 TSPO2 LOC103011342 LOC103011342 SLC10A2 SLC10A2 SC5D SC5D OSBP OSBP CUBN CUBN LOC103020030 LOC103020030 LOC103016126 LOC103016126 HMGCS1 HMGCS1 LOC103016503 LOC103016503 LOC103005519 LOC103005519 PLPP7 PLPP7 SLCO1A2 SLCO1A2 RXRA RXRA LOC103013794 LOC103013794 STARD5 STARD5 EBPL EBPL LOC103015178 LOC103015178 GC GC LOC103000983 LOC103000983 FDFT1 FDFT1 ACOX2 ACOX2 AMACR AMACR STARD4 STARD4 LOC103016570 LOC103016570 STARD6 STARD6 SCP2D1 SCP2D1 SRD5A1 SRD5A1 POMC POMC LOC103005044 LOC103005044 NCOA1 NCOA1 HSD17B7 HSD17B7 LOC103000968 LOC103000968 OSBPL6 OSBPL6 RAN RAN ADGRD1 ADGRD1 TSPO TSPO SQLE SQLE LOC102999025 LOC102999025 STARD3NL STARD3NL SUGCT SUGCT LOC103007900 LOC103007900 HSD3B7 HSD3B7 ACAT2 ACAT2 FADS6 FADS6 FDXR FDXR ACOT8 ACOT8 LOC103015403 LOC103015403 OSBPL2 OSBPL2 NCOA2 NCOA2 SLC10A1 SLC10A1 NSDHL NSDHL ABCB11 ABCB11 LRP2 LRP2 LOC103017184 LOC103017184 HSD17B2 HSD17B2 SDR42E1 SDR42E1 MBTPS1 MBTPS1 HSDL1 HSDL1 MTF1 MTF1 PLPP6 PLPP6 UBE2I UBE2I HSD17B12 HSD17B12 LOC103020890 LOC103020890 EBP EBP MVK MVK LOC103001013 LOC103001013 VDR VDR CH25H CH25H SERPINA6 SERPINA6 LOC103014370 LOC103014370 PMVK PMVK STAR STAR HSDL2 HSDL2 LOC103019221 LOC103019221 KPNB1 KPNB1 STARD3 STARD3 OSBPL7 OSBPL7 AKR1B1 AKR1B1 AKR1D1 AKR1D1 HSD17B3 HSD17B3 MSMO1 MSMO1 ABCC3 ABCC3 HMGCR HMGCR TSPOAP1 TSPOAP1 SLC27A5 SLC27A5 LOC103007249 LOC103007249 CCDC160 CCDC160 TM7SF2 TM7SF2 SREBF1 SREBF1 ARV1 ARV1 FDX1 FDX1 MVD MVD RUSC1 RUSC1 FDPS FDPS OSBPL3 OSBPL3 SLC51A SLC51A FABP6 FABP6 DHCR7 DHCR7 GGPS1 GGPS1 OSBP2 OSBP2 LOC103011787 LOC103011787 SLC27A2 SLC27A2 LOC103012080 LOC103012080 LOC103006926 LOC103006926 LOC103015346 LOC103015346 INSIG2 INSIG2 FDX2 FDX2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SCAPSterol regulatory element-binding protein cleavage-activating protein isoform X1. (1280 aa)
LOC10301459825-hydroxycholesterol 7-alpha-hydroxylase; Belongs to the cytochrome P450 family. (468 aa)
LOC102998844Cholesterol 7-alpha-monooxygenase; Belongs to the cytochrome P450 family. (501 aa)
LOC103020549Lutropin subunit beta. (253 aa)
SRD5A3Polyprenol reductase. (289 aa)
HSD17B1417-beta-hydroxysteroid dehydrogenase 14. (270 aa)
LOC1030025951,5-anhydro-D-fructose reductase-like. (189 aa)
LOC103003050Aldo-keto reductase family 1 member C3 homolog isoform X1. (324 aa)
LOC103002145Dihydrodiol dehydrogenase 3 isoform X1. (323 aa)
LBRlamin-B receptor isoform X1. (630 aa)
LOC103009357Cytochrome P450 11B1, mitochondrial; Belongs to the cytochrome P450 family. (412 aa)
DHRS7CDehydrogenase/reductase SDR family member 7C isoform X1; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (312 aa)
SLC51BOrganic solute transporter subunit beta. (130 aa)
NFYBNuclear transcription factor Y subunit beta. (207 aa)
NR1H4Bile acid receptor isoform X1. (486 aa)
FAXDC2Fatty acid hydroxylase domain-containing protein 2 isoform X1; Belongs to the sterol desaturase family. (343 aa)
INSIG1Insulin-induced gene protein; Mediates feedback control of cholesterol synthesis. Belongs to the INSIG family. (276 aa)
NFYCNuclear transcription factor Y subunit gamma isoform X1. (439 aa)
DHCR24Delta(24)-sterol reductase. (516 aa)
OSBPL9Oxysterol-binding protein; Belongs to the OSBP family. (760 aa)
SCP2Non-specific lipid-transfer protein isoform X1; Belongs to the thiolase-like superfamily. Thiolase family. (547 aa)
HSD11B1Corticosteroid 11-beta-dehydrogenase isozyme 1. (294 aa)
RIMBP2RIMS-binding protein 2. (1122 aa)
LOC103015911LOW QUALITY PROTEIN: oxysterol-binding protein-related protein 9-like. (515 aa)
SREBF2Sterol regulatory element-binding protein 2. (1110 aa)
LOC103005435Aldo-keto reductase family 1 member B10. (291 aa)
MBTPS2Membrane-bound transcription factor site-2 protease. (506 aa)
LSSTerpene cyclase/mutase family member; Belongs to the terpene cyclase/mutase family. (655 aa)
CDCP2CUB domain-containing protein 2. (540 aa)
LOC102999763LOW QUALITY PROTEIN: very-long-chain 3-oxoacyl-CoA reductase-B-like. (339 aa)
OSBPL1AOxysterol-binding protein; Belongs to the OSBP family. (966 aa)
LOC103014627Uncharacterized protein LOC103014627 isoform X1. (142 aa)
LOC103003841Steroid 21-hydroxylase isoform X1; Belongs to the cytochrome P450 family. (529 aa)
LOC103007308Isopentenyl-diphosphate Delta-isomerase 1. (195 aa)
HSD11B2Corticosteroid 11-beta-dehydrogenase isozyme 2. (509 aa)
NFYANuclear transcription factor Y subunit alpha isoform X1. (347 aa)
TSPO2Translocator protein 2 isoform X1. (240 aa)
LOC103011342Cholesterol side-chain cleavage enzyme, mitochondrial; A cytochrome P450 monooxygenase that catalyzes the side-chain hydroxylation and cleavage of cholesterol to pregnenolone, the precursor of most steroid hormones. Catalyzes three sequential oxidation reactions of cholesterol, namely the hydroxylation at C22 followed with the hydroxylation at C20 to yield 20R,22R- hydroxycholesterol that is further cleaved between C20 and C22 to yield the C21-steroid pregnenolone and 4-methylpentanal. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the se [...] (520 aa)
SLC10A2Ileal sodium/bile acid cotransporter. (358 aa)
SC5DLathosterol oxidase; Belongs to the sterol desaturase family. (299 aa)
OSBPOxysterol-binding protein; Belongs to the OSBP family. (682 aa)
CUBNCubilin isoform X1. (3619 aa)
LOC103020030RIMS-binding protein 3C-like. (1526 aa)
LOC103016126Peroxisomal multifunctional enzyme type 2-like. (145 aa)
HMGCS13-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase. (520 aa)
LOC103016503Lanosterol 14-alpha demethylase; Belongs to the cytochrome P450 family. (503 aa)
LOC103005519Solute carrier organic anion transporter family member. (686 aa)
PLPP7Inactive phospholipid phosphatase 7. (271 aa)
SLCO1A2Solute carrier organic anion transporter family member. (668 aa)
RXRARetinoic acid receptor RXR-alpha. (439 aa)
LOC103013794Peroxisomal multifunctional enzyme type 2-like. (190 aa)
STARD5stAR-related lipid transfer protein 5. (213 aa)
EBPLEmopamil-binding protein-like. (189 aa)
LOC10301517824-hydroxycholesterol 7-alpha-hydroxylase isoform X1; Belongs to the cytochrome P450 family. (469 aa)
GCVitamin D-binding protein. (475 aa)
LOC1030009835-beta-cholestane-3-alpha,7-alpha-diol 12-alpha-hydroxylase; Belongs to the cytochrome P450 family. (511 aa)
FDFT1Squalene synthase isoform X1. (417 aa)
ACOX2Acyl-coenzyme A oxidase; Belongs to the acyl-CoA oxidase family. (678 aa)
AMACRalpha-methylacyl-CoA racemase. (386 aa)
STARD4stAR-related lipid transfer protein 4 isoform X1. (224 aa)
LOC103016570Peroxisomal multifunctional enzyme type 2-like. (121 aa)
STARD6stAR-related lipid transfer protein 6 isoform X1. (185 aa)
SCP2D1SCP2 sterol-binding domain-containing protein 1. (156 aa)
SRD5A13-oxo-5-alpha-steroid 4-dehydrogenase (NADP(+)). (255 aa)
POMCPro-opiomelanocortin. (121 aa)
LOC1030050443-oxo-5-alpha-steroid 4-dehydrogenase (NADP(+)). (254 aa)
NCOA1Nuclear receptor coactivator. (1441 aa)
HSD17B73-keto-steroid reductase isoform X1. (334 aa)
LOC1030009683-hydroxy-3-methylglutaryl-coenzyme A reductase-like. (498 aa)
OSBPL6Oxysterol-binding protein; Belongs to the OSBP family. (959 aa)
RANGTP-binding nuclear protein Ran; GTP-binding protein involved in nucleocytoplasmic transport. Required for the import of protein into the nucleus and also for RNA export. Involved in chromatin condensation and control of cell cycle. Belongs to the small GTPase superfamily. Ran family. (290 aa)
ADGRD1Adhesion G-protein coupled receptor D1 isoform X1; Belongs to the G-protein coupled receptor 2 family. (906 aa)
TSPOTranslocator protein. (169 aa)
SQLESqualene monooxygenase. (574 aa)
LOC102999025Sterol 26-hydroxylase, mitochondrial; Belongs to the cytochrome P450 family. (537 aa)
STARD3NLSTARD3 N-terminal-like protein. (235 aa)
SUGCTSuccinate--hydroxymethylglutarate CoA-transferase isoform X1. (446 aa)
LOC103007900Steroid 17-alpha-hydroxylase/17,20 lyase isoform X1; Belongs to the cytochrome P450 family. (509 aa)
HSD3B73 beta-hydroxysteroid dehydrogenase type 7 isoform X1; Belongs to the 3-beta-HSD family. (369 aa)
ACAT2acetyl-CoA acetyltransferase, cytosolic; Belongs to the thiolase-like superfamily. Thiolase family. (397 aa)
FADS6Fatty acid desaturase 6. (323 aa)
FDXRNADPH:adrenodoxin oxidoreductase, mitochondrial. (523 aa)
ACOT8Acyl-coenzyme A thioesterase 8 isoform X1. (317 aa)
LOC1030154031,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial; Belongs to the cytochrome P450 family. (514 aa)
OSBPL2Oxysterol-binding protein; Belongs to the OSBP family. (481 aa)
NCOA2Nuclear receptor coactivator. (1459 aa)
SLC10A1Sodium/bile acid cotransporter. (349 aa)
NSDHLSterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating; Belongs to the 3-beta-HSD family. (361 aa)
ABCB11Bile salt export pump isoform X1. (1326 aa)
LRP2Low-density lipoprotein receptor-related protein 2. (4651 aa)
LOC103017184Cytochrome P450 27C1; Belongs to the cytochrome P450 family. (466 aa)
HSD17B2Estradiol 17-beta-dehydrogenase 2; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (388 aa)
SDR42E1Short-chain dehydrogenase/reductase family 42E member 1; Belongs to the 3-beta-HSD family. (393 aa)
MBTPS1Membrane-bound transcription factor site-1 protease isoform X1. (1055 aa)
HSDL1Inactive hydroxysteroid dehydrogenase-like protein 1 isoform X1; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (330 aa)
MTF1Metal regulatory transcription factor 1 isoform X1. (752 aa)
PLPP6Phospholipid phosphatase 6. (278 aa)
UBE2ISUMO-conjugating enzyme UBC9; Belongs to the ubiquitin-conjugating enzyme family. (158 aa)
HSD17B12Very-long-chain 3-oxoacyl-CoA reductase isoform X1; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (332 aa)
LOC1030208903-hydroxy-3-methylglutaryl-coenzyme A reductase-like. (194 aa)
EBPLOW QUALITY PROTEIN: 3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase. (233 aa)
MVKMevalonate kinase; Catalyzes the phosphorylation of mevalonate to mevalonate 5- phosphate, a key step in isoprenoid and cholesterol biosynthesis. Belongs to the GHMP kinase family. Mevalonate kinase subfamily. (396 aa)
LOC10300101325-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial isoform X1; Belongs to the cytochrome P450 family. (508 aa)
VDRVitamin D3 receptor. (427 aa)
CH25HCholesterol 25-hydroxylase; Belongs to the sterol desaturase family. (270 aa)
SERPINA6Corticosteroid-binding globulin isoform X1; Belongs to the serpin family. (404 aa)
LOC103014370Cholesterol 24-hydroxylase isoform X1; Belongs to the cytochrome P450 family. (501 aa)
PMVKPhosphomevalonate kinase. (192 aa)
STARSteroidogenic acute regulatory protein, mitochondrial; Plays a key role in steroid hormone synthesis by enhancing the metabolism of cholesterol into pregnenolone. Mediates the transfer of cholesterol from the outer mitochondrial membrane to the inner mitochondrial membrane where it is cleaved to pregnenolone. (285 aa)
HSDL2Hydroxysteroid dehydrogenase-like protein 2 isoform X1. (418 aa)
LOC103019221Estradiol 17-beta-dehydrogenase 1-like; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (318 aa)
KPNB1Importin subunit beta-1. (731 aa)
STARD3stAR-related lipid transfer protein 3 isoform X1. (513 aa)
OSBPL7Oxysterol-binding protein; Belongs to the OSBP family. (880 aa)
AKR1B1Aldose reductase. (316 aa)
AKR1D13-oxo-5-beta-steroid 4-dehydrogenase isoform X1. (326 aa)
HSD17B3Testosterone 17-beta-dehydrogenase 3; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (314 aa)
MSMO1Methylsterol monooxygenase 1 isoform X1; Belongs to the sterol desaturase family. (293 aa)
ABCC3LOW QUALITY PROTEIN: canalicular multispecific organic anion transporter 2. (1592 aa)
HMGCR3-hydroxy-3-methylglutaryl coenzyme A reductase. (884 aa)
TSPOAP1Peripheral-type benzodiazepine receptor-associated protein 1 isoform X1. (1903 aa)
SLC27A5LOW QUALITY PROTEIN: bile acyl-CoA synthetase. (690 aa)
LOC103007249Vitamin D 25-hydroxylase isoform X1; Belongs to the cytochrome P450 family. (501 aa)
CCDC160Coiled-coil domain-containing protein 160. (325 aa)
TM7SF2Delta(14)-sterol reductase. (399 aa)
SREBF1LOW QUALITY PROTEIN: sterol regulatory element-binding protein 1. (1119 aa)
ARV1Protein ARV1. (284 aa)
FDX1Adrenodoxin, mitochondrial. (134 aa)
MVDDiphosphomevalonate decarboxylase; Performs the first committed step in the biosynthesis of isoprenes. (400 aa)
RUSC1RUN and SH3 domain-containing protein 1 isoform X3. (905 aa)
FDPSFarnesyl pyrophosphate synthase isoform X1; Belongs to the FPP/GGPP synthase family. (421 aa)
OSBPL3Oxysterol-binding protein; Belongs to the OSBP family. (887 aa)
SLC51AOrganic solute transporter subunit alpha. (347 aa)
FABP6Gastrotropin. (128 aa)
DHCR77-dehydrocholesterol reductase. (475 aa)
GGPS1Geranylgeranyl pyrophosphate synthase isoform X1; Belongs to the FPP/GGPP synthase family. (300 aa)
OSBP2Oxysterol-binding protein; Belongs to the OSBP family. (905 aa)
LOC103011787Aromatase-like; Belongs to the cytochrome P450 family. (503 aa)
SLC27A2Very long-chain acyl-CoA synthetase. (620 aa)
LOC103012080Aromatase; Belongs to the cytochrome P450 family. (503 aa)
LOC103006926Bile acid receptor-like. (493 aa)
LOC1030153463 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase; Belongs to the 3-beta-HSD family. (373 aa)
INSIG2Insulin-induced gene protein; Mediates feedback control of cholesterol synthesis. Belongs to the INSIG family. (225 aa)
FDX2Ferredoxin-2, mitochondrial isoform X1. (251 aa)
Your Current Organism:
Balaenoptera acutorostrata
NCBI taxonomy Id: 310752
Other names: B. acutorostrata scammoni, Balaenoptera acutorostrata scammoni
Server load: low (16%) [HD]