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PLCB4 PLCB4 PLCB1 PLCB1 NOS3 NOS3 PRKG2 PRKG2 CALML4 CALML4 ATP2B1 ATP2B1 MAP2K1 MAP2K1 ATP2B4 ATP2B4 PIK3R6 PIK3R6 ATP1B2 ATP1B2 PIK3R5 PIK3R5 KCNMA1 KCNMA1 VDAC2 VDAC2 PPP3CB PPP3CB IRS1 IRS1 SLC8A1 SLC8A1 ADCY7 ADCY7 MYLK3 MYLK3 PPP3CC PPP3CC VASP VASP GNAI2 GNAI2 RHOA RHOA INSR INSR CREB3L3 CREB3L3 MAP2K2 MAP2K2 ADORA3 ADORA3 GNAI3 GNAI3 ATP1A1 ATP1A1 NPPB NPPB KCNU1 KCNU1 NPPA NPPA OPRD1 OPRD1 INS INS KCNMB1 KCNMB1 PPP1CA PPP1CA MEF2D MEF2D LOC103005600 LOC103005600 VDAC1 VDAC1 ADRA2C ADRA2C ATP1B1 ATP1B1 SLC25A31 SLC25A31 PDE5A PDE5A NFATC1 NFATC1 PPP3CA PPP3CA ADRB1 ADRB1 SLC25A6 SLC25A6 PDE2A PDE2A BAD BAD PLCB3 PLCB3 CACNA1D CACNA1D MRVI1 MRVI1 PDE3B PDE3B ADCY5 ADCY5 MYLK MYLK AKT1 AKT1 GNA11 GNA11 CREB3L2 CREB3L2 ATP2A3 ATP2A3 SLC25A4 SLC25A4 SLC25A5 SLC25A5 NPR1 NPR1 ATP1B4 ATP1B4 CREB3L4 CREB3L4 BDKRB2 BDKRB2 ADCY6 ADCY6 AKT2 AKT2 LOC103014002 LOC103014002 NFATC4 NFATC4 ADCY4 ADCY4 CNGA1 CNGA1 PLCB2 PLCB2 MYH6 MYH6 PIK3CG PIK3CG CREB3L1 CREB3L1 ADCY9 ADCY9 VDAC3 VDAC3 KCNMB2 KCNMB2 LOC103018216 LOC103018216 CACNA1F CACNA1F AKT3 AKT3 GUCY1A2 GUCY1A2 PRKG1 PRKG1 GUCY1A1 GUCY1A1 GUCY1B1 GUCY1B1 PPIF PPIF SLC8A3 SLC8A3 GNA13 GNA13 ADORA1 ADORA1 EDNRB EDNRB ATP2A1 ATP2A1 MAPK3 MAPK3 GTF2I GTF2I GTF2IRD1 GTF2IRD1 LOC103005013 LOC103005013 ITPR3 ITPR3 GNAI1 GNAI1 ADCY1 ADCY1 AGTR1 AGTR1 ADRB2 ADRB2 ADCY8 ADCY8 LOC103012727 LOC103012727 ATF4 ATF4 EDNRA EDNRA PPP1CC PPP1CC CALM2 CALM2 PRKCE PRKCE ATF2 ATF2 PLN PLN RGS2 RGS2 MEF2A MEF2A ADCY3 ADCY3 TRPC6 TRPC6 PPP1CB PPP1CB ROCK1 ROCK1 ADCY2 ADCY2 RAF1 RAF1 ITPR1 ITPR1 ADRA1A ADRA1A GATA4 GATA4 MYL9 MYL9 MYLK2 MYLK2 CREB5 CREB5 ATF6B ATF6B KCNJ8 KCNJ8 PPP1R12A PPP1R12A KNG1 KNG1 ITPR2 ITPR2 KCNMB4 KCNMB4 ROCK2 ROCK2 MEF2B MEF2B MAPK1 MAPK1 FXYD2 FXYD2 IRS2 IRS2 NPR2 NPR2 CREB3 CREB3 ADRA2B ADRA2B NFATC3 NFATC3 IRS4 IRS4 ATP1B3 ATP1B3 KCNMB3 KCNMB3 PPP3R2 PPP3R2 PDE3A PDE3A ADRA1D ADRA1D CREB1 CREB1 CACNA1S CACNA1S SRF SRF CNGB1 CNGB1 ATP1A3 ATP1A3 SLC8A2 SLC8A2 ADRB3 ADRB3 ADRA1B ADRA1B LOC103005321 LOC103005321 MYLK4 MYLK4 GNA12 GNA12 CACNA1C CACNA1C ATP2B3 ATP2B3 NFATC2 NFATC2 ATP2A2 ATP2A2
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
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a 3D structure is known or predicted
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gene neighborhood
gene fusions
gene co-occurrence
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PLCB41-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1258 aa)
PLCB11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1115 aa)
NOS3Nitric oxide synthase; Produces nitric oxide (NO). (1206 aa)
PRKG2cGMP-dependent protein kinase. (762 aa)
CALML4Calmodulin-like protein 4. (153 aa)
ATP2B1Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1249 aa)
MAP2K1Dual specificity mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
ATP2B4Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1243 aa)
PIK3R6Phosphoinositide 3-kinase regulatory subunit 6. (754 aa)
ATP1B2Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (290 aa)
PIK3R5Phosphoinositide 3-kinase regulatory subunit 5. (882 aa)
KCNMA1Calcium-activated potassium channel subunit alpha-1 isoform X11. (1230 aa)
VDAC2Voltage-dependent anion-selective channel protein 2 isoform X3. (309 aa)
PPP3CBSerine/threonine-protein phosphatase. (528 aa)
IRS1Insulin receptor substrate 1. (1244 aa)
SLC8A1Sodium/calcium exchanger 1 isoform X1; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (991 aa)
ADCY7Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1078 aa)
MYLK3Myosin light chain kinase 3 isoform X1. (800 aa)
PPP3CCSerine/threonine-protein phosphatase. (583 aa)
VASPVasodilator-stimulated phosphoprotein isoform X1; Ena/VASP proteins are actin-associated proteins involved in a range of processes dependent on cytoskeleton remodeling and cell polarity such as axon guidance, lamellipodial and filopodial dynamics, platelet activation and cell migration. Belongs to the Ena/VASP family. (385 aa)
GNAI2Guanine nucleotide-binding protein G(I) subunit alpha-2. (303 aa)
RHOATransforming protein RhoA. (193 aa)
INSRTyrosine-protein kinase receptor. (1343 aa)
CREB3L3Cyclic AMP-responsive element-binding protein 3-like protein 3. (457 aa)
MAP2K2Dual specificity mitogen-activated protein kinase kinase 2. (303 aa)
ADORA3Adenosine receptor A3; Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family. (329 aa)
GNAI3Guanine nucleotide-binding protein G(K) subunit alpha. (354 aa)
ATP1A1Sodium/potassium-transporting ATPase subunit alpha. (1021 aa)
NPPBNatriuretic peptides B. (132 aa)
KCNU1Potassium channel subfamily U member 1. (1147 aa)
NPPANatriuretic peptides A. (152 aa)
OPRD1Delta-type opioid receptor; Belongs to the G-protein coupled receptor 1 family. (355 aa)
INSInsulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (112 aa)
KCNMB1Calcium-activated potassium channel subunit beta-1. (197 aa)
PPP1CASerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (363 aa)
MEF2DLOW QUALITY PROTEIN: myocyte-specific enhancer factor 2D. (512 aa)
LOC103005600Sodium/potassium-transporting ATPase subunit alpha. (1020 aa)
VDAC1Voltage-dependent anion-selective channel protein 1. (283 aa)
ADRA2Calpha-2C adrenergic receptor. (422 aa)
ATP1B1Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (303 aa)
SLC25A31ADP/ATP translocase 4; Belongs to the mitochondrial carrier (TC 2.A.29) family. (323 aa)
PDE5APhosphodiesterase. (865 aa)
NFATC1Nuclear factor of activated T-cells, cytoplasmic 1. (901 aa)
PPP3CASerine/threonine-protein phosphatase. (521 aa)
ADRB1Beta-1 adrenergic receptor; Belongs to the G-protein coupled receptor 1 family. (526 aa)
SLC25A6ADP/ATP translocase 3; Belongs to the mitochondrial carrier (TC 2.A.29) family. (317 aa)
PDE2APhosphodiesterase. (934 aa)
BADBcl2-associated agonist of cell death. (168 aa)
PLCB31-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1230 aa)
CACNA1DVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2183 aa)
MRVI1Protein MRVI1. (875 aa)
PDE3BPhosphodiesterase. (1085 aa)
ADCY5Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1018 aa)
MYLKMyosin light chain kinase, smooth muscle isoform X1. (2025 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (476 aa)
GNA11Guanine nucleotide-binding protein subunit alpha-11. (301 aa)
CREB3L2Cyclic AMP-responsive element-binding protein 3-like protein 2. (520 aa)
ATP2A3Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (934 aa)
SLC25A4ADP/ATP translocase 1; Belongs to the mitochondrial carrier (TC 2.A.29) family. (298 aa)
SLC25A5ADP/ATP translocase 2; Belongs to the mitochondrial carrier (TC 2.A.29) family. (283 aa)
NPR1Guanylate cyclase. (1059 aa)
ATP1B4Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (357 aa)
CREB3L4Cyclic AMP-responsive element-binding protein 3-like protein 4 isoform X1. (395 aa)
BDKRB2B2 bradykinin receptor; Belongs to the G-protein coupled receptor 1 family. (379 aa)
ADCY6Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1220 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
LOC103014002Myosin-7; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1934 aa)
NFATC4Nuclear factor of activated T-cells, cytoplasmic 4 isoform X1. (901 aa)
ADCY4Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1109 aa)
CNGA1cGMP-gated cation channel alpha-1. (689 aa)
PLCB21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1131 aa)
MYH6Myosin-6; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1850 aa)
PIK3CGLOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform; Belongs to the PI3/PI4-kinase family. (1101 aa)
CREB3L1Cyclic AMP-responsive element-binding protein 3-like protein 1. (520 aa)
ADCY9Adenylate cyclase type 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1353 aa)
VDAC3Voltage-dependent anion-selective channel protein 3 isoform X1. (282 aa)
KCNMB2Calcium-activated potassium channel subunit beta-2. (235 aa)
LOC103018216Guanine nucleotide-binding protein G(Q) subunit alpha. (301 aa)
CACNA1FVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (1975 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (431 aa)
GUCY1A2Guanylate cyclase soluble subunit alpha-2; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (329 aa)
PRKG1cGMP-dependent protein kinase. (686 aa)
GUCY1A1Guanylate cyclase soluble subunit alpha-1; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (691 aa)
GUCY1B1Guanylate cyclase soluble subunit beta-1; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (550 aa)
PPIFPeptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family. (205 aa)
SLC8A3Sodium/calcium exchanger 3 isoform X1; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (927 aa)
GNA13Guanine nucleotide-binding protein subunit alpha-13. (282 aa)
ADORA1Adenosine receptor A1; Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family. (326 aa)
EDNRBEndothelin receptor type B; Belongs to the G-protein coupled receptor 1 family. (443 aa)
ATP2A1Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1000 aa)
MAPK3Mitogen-activated protein kinase 3. (265 aa)
GTF2IGeneral transcription factor II-I isoform X1. (999 aa)
GTF2IRD1General transcription factor II-I repeat domain-containing protein 1 isoform X1. (938 aa)
LOC103005013Insulin receptor substrate 1-like. (572 aa)
ITPR3LOW QUALITY PROTEIN: inositol 1,4,5-trisphosphate receptor type 3. (2666 aa)
GNAI1Guanine nucleotide-binding protein G(I) subunit alpha-1. (354 aa)
ADCY1Adenylate cyclase type 1 isoform X1. (907 aa)
AGTR1Type-1 angiotensin II receptor; Belongs to the G-protein coupled receptor 1 family. (359 aa)
ADRB2Beta-2 adrenergic receptor isoform X1. (449 aa)
ADCY8Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1248 aa)
LOC103012727Voltage-dependent anion-selective channel protein 3-like. (264 aa)
ATF4Cyclic AMP-dependent transcription factor ATF-4. (352 aa)
EDNRAEndothelin-1 receptor; Belongs to the G-protein coupled receptor 1 family. (427 aa)
PPP1CCSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (337 aa)
CALM2Calmodulin-1; Belongs to the calmodulin family. (149 aa)
PRKCEProtein kinase C epsilon type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays essential roles in the regulation of multiple cellular processes linked to cytoskeletal proteins, such as cell adhesion, motility, migration and cell cycle, functions in neuron growth and ion channel regulation, and is involved in immune response, cancer cell invasion and regulation of apoptosis. Mediates cell adhesion to the extracellular matrix via integrin- dependent signaling, by mediating angiotensin-2-induced activation of integrin beta- [...] (737 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2 isoform X1. (505 aa)
PLNCardiac phospholamban; Reversibly inhibits the activity of ATP2A2 in cardiac sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca(2+). Modulates the contractility of the heart muscle in response to physiological stimuli via its effects on ATP2A2. Modulates calcium re-uptake during muscle relaxation and plays an important role in calcium homeostasis in the heart muscle. The degree of ATP2A2 inhibition depends on the oligomeric state of PLN. (52 aa)
RGS2Regulator of G-protein signaling 2. (185 aa)
MEF2AMyocyte-specific enhancer factor 2A isoform X1. (503 aa)
ADCY3Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1200 aa)
TRPC6Short transient receptor potential channel 6 isoform X1; Belongs to the transient receptor (TC 1.A.4) family. (932 aa)
PPP1CBSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (327 aa)
ROCK1Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1354 aa)
ADCY2Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (972 aa)
RAF1RAF proto-oncogene serine/threonine-protein kinase isoform X1. (668 aa)
ITPR1Inositol 1,4,5-trisphosphate receptor type 1 isoform X1. (2749 aa)
ADRA1Aalpha-1A adrenergic receptor isoform X1. (466 aa)
GATA4Transcription factor GATA-4. (229 aa)
MYL9Myosin regulatory light polypeptide 9. (172 aa)
MYLK2Myosin light chain kinase 2, skeletal/cardiac muscle. (615 aa)
CREB5Cyclic AMP-responsive element-binding protein 5 isoform X1. (502 aa)
ATF6BLOW QUALITY PROTEIN: cyclic AMP-dependent transcription factor ATF-6 beta. (700 aa)
KCNJ8ATP-sensitive inward rectifier potassium channel 8. (424 aa)
PPP1R12AProtein phosphatase 1 regulatory subunit. (1085 aa)
KNG1Kininogen-1. (426 aa)
ITPR2Inositol 1,4,5-trisphosphate receptor type 2 isoform X1. (2701 aa)
KCNMB4Calcium-activated potassium channel subunit beta-4. (210 aa)
ROCK2Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1388 aa)
MEF2BMyocyte-specific enhancer factor 2B. (420 aa)
MAPK1Mitogen-activated protein kinase 1. (263 aa)
FXYD2FXYD domain-containing ion transport regulator; Belongs to the FXYD family. (102 aa)
IRS2Insulin receptor substrate 2. (507 aa)
NPR2Guanylate cyclase. (1047 aa)
CREB3Cyclic AMP-responsive element-binding protein 3 isoform X1. (371 aa)
ADRA2Balpha-2B adrenergic receptor. (448 aa)
NFATC3Nuclear factor of activated T-cells, cytoplasmic 3. (998 aa)
IRS4LOW QUALITY PROTEIN: insulin receptor substrate 4. (1043 aa)
ATP1B3Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (266 aa)
KCNMB3LOW QUALITY PROTEIN: calcium-activated potassium channel subunit beta-3. (188 aa)
PPP3R2LOW QUALITY PROTEIN: calcineurin subunit B type 2. (170 aa)
PDE3APhosphodiesterase. (993 aa)
ADRA1Dalpha-1D adrenergic receptor. (459 aa)
CREB1Cyclic AMP-responsive element-binding protein 1 isoform X1. (341 aa)
CACNA1SVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (1864 aa)
SRFSerum response factor. (464 aa)
CNGB1Cyclic nucleotide-gated cation channel beta-1. (1322 aa)
ATP1A3Sodium/potassium-transporting ATPase subunit alpha. (1014 aa)
SLC8A2Sodium/calcium exchanger 2 isoform X1; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (922 aa)
ADRB3LOW QUALITY PROTEIN: beta-3 adrenergic receptor. (423 aa)
ADRA1Balpha-1B adrenergic receptor. (326 aa)
LOC103005321Sodium/potassium-transporting ATPase subunit alpha. (1028 aa)
MYLK4Myosin light chain kinase family member 4 isoform X1; Belongs to the protein kinase superfamily. (444 aa)
GNA12Guanine nucleotide-binding protein subunit alpha-12. (253 aa)
CACNA1CVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2273 aa)
ATP2B3Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1168 aa)
NFATC2Nuclear factor of activated T-cells, cytoplasmic 2 isoform X3. (818 aa)
ATP2A2Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1008 aa)
Your Current Organism:
Balaenoptera acutorostrata
NCBI taxonomy Id: 310752
Other names: B. acutorostrata scammoni, Balaenoptera acutorostrata scammoni
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