STRINGSTRING
HMOX1 HMOX1 TP53 TP53 LOC103012822 LOC103012822 ALOX15 ALOX15 VDAC2 VDAC2 ACSL3 ACSL3 SLC39A14 SLC39A14 FTL FTL STEAP3 STEAP3 GCLM GCLM LPCAT3 LPCAT3 LOC103003168 LOC103003168 TFRC TFRC SLC7A11 SLC7A11 MAP1LC3B MAP1LC3B SLC39A8 SLC39A8 ACSL5 ACSL5 SLC3A2 SLC3A2 PCBP1 PCBP1 NCOA4 NCOA4 GPX4 GPX4 ACSL1 ACSL1 PCBP2 PCBP2 LOC103015028 LOC103015028 ACSL4 ACSL4 VDAC3 VDAC3 MAP1LC3C MAP1LC3C LOC103009523 LOC103009523 SAT1 SAT1 GCLC GCLC CP CP FTMT FTMT ACSL6 ACSL6 LOC103012727 LOC103012727 ATG5 ATG5 PRNP PRNP ATG7 ATG7 GSS GSS MAP1LC3A MAP1LC3A SLC40A1 SLC40A1 PGPEP1 PGPEP1 FTH1 FTH1 SLC11A2 SLC11A2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
HMOX1Heme oxygenase; Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. (288 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (387 aa)
LOC103012822Diamine acetyltransferase 2 isoform X1. (170 aa)
ALOX15LOW QUALITY PROTEIN: arachidonate 15-lipoxygenase. (663 aa)
VDAC2Voltage-dependent anion-selective channel protein 2 isoform X3. (309 aa)
ACSL3long-chain-fatty-acid--CoA ligase 3. (720 aa)
SLC39A14Zinc transporter ZIP14 isoform X1. (490 aa)
FTLFerritin; Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. (175 aa)
STEAP3Metalloreductase STEAP3 isoform X1. (524 aa)
GCLMGlutamate--cysteine ligase regulatory subunit. (261 aa)
LPCAT3Lysophospholipid acyltransferase 5; Belongs to the membrane-bound acyltransferase family. (487 aa)
LOC103003168Serotransferrin; Belongs to the transferrin family. (707 aa)
TFRCTransferrin receptor protein 1 isoform X1. (789 aa)
SLC7A11Cystine/glutamate transporter. (503 aa)
MAP1LC3BMicrotubule-associated proteins 1A/1B light chain 3B. (118 aa)
SLC39A8Zinc transporter ZIP8. (425 aa)
ACSL5long-chain-fatty-acid--CoA ligase 5. (682 aa)
SLC3A24F2 cell-surface antigen heavy chain. (533 aa)
PCBP1poly(RC)-binding protein 1. (356 aa)
NCOA4Nuclear receptor coactivator 4 isoform X1. (625 aa)
GPX4Glutathione peroxidase; Belongs to the glutathione peroxidase family. (196 aa)
ACSL1long-chain-fatty-acid--CoA ligase 1. (698 aa)
PCBP2poly(RC)-binding protein 2 isoform X1. (471 aa)
LOC103015028Inhibitor of carbonic anhydrase isoform X1; Belongs to the transferrin family. (702 aa)
ACSL4long-chain-fatty-acid--CoA ligase 4. (686 aa)
VDAC3Voltage-dependent anion-selective channel protein 3 isoform X1. (282 aa)
MAP1LC3CMicrotubule-associated proteins 1A/1B light chain 3C. (146 aa)
LOC103009523Cytochrome b-245 heavy chain. (570 aa)
SAT1Diamine acetyltransferase 1. (214 aa)
GCLCGlutamate--cysteine ligase catalytic subunit. (637 aa)
CPCeruloplasmin isoform X1; Belongs to the multicopper oxidase family. (1090 aa)
FTMTFerritin; Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. (242 aa)
ACSL6long-chain-fatty-acid--CoA ligase 6 isoform X1. (746 aa)
LOC103012727Voltage-dependent anion-selective channel protein 3-like. (264 aa)
ATG5Autophagy protein 5; Involved in autophagic vesicle formation. (275 aa)
PRNPMajor prion protein; Belongs to the prion family. (257 aa)
ATG7Ubiquitin-like modifier-activating enzyme ATG7; E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 as well as the ATG8 family proteins for their conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Required for autophagic death induced by caspase-8 inhibition. Required for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria [...] (707 aa)
GSSGlutathione synthetase. (474 aa)
MAP1LC3AMicrotubule-associated proteins 1A/1B light chain 3A. (142 aa)
SLC40A1Solute carrier family 40 protein; May be involved in iron transport and iron homeostasis. Belongs to the ferroportin (FP) (TC 2.A.100) family. SLC40A subfamily. (574 aa)
PGPEP1Pyroglutamyl-peptidase 1. (132 aa)
FTH1Ferritin; Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. (183 aa)
SLC11A2Natural resistance-associated macrophage protein 2 isoform X1. (581 aa)
Your Current Organism:
Balaenoptera acutorostrata
NCBI taxonomy Id: 310752
Other names: B. acutorostrata scammoni, Balaenoptera acutorostrata scammoni
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