STRINGSTRING
CCNE1 CCNE1 CCNE2 CCNE2 LIN37 LIN37 RHEB RHEB CCNB2 CCNB2 SMAD3 SMAD3 CALML4 CALML4 MAP2K1 MAP2K1 TP53 TP53 VDAC2 VDAC2 PPP3CB PPP3CB HIPK4 HIPK4 ZFP36L2 ZFP36L2 RBL2 RBL2 MCU MCU PPP3CC PPP3CC LIN54 LIN54 SIRT1 SIRT1 CDC25A CDC25A NRAS NRAS MAP2K2 MAP2K2 HIPK1 HIPK1 SQSTM1 SQSTM1 PIK3CD PIK3CD EIF4EBP1 EIF4EBP1 CCND2 CCND2 FOXM1 FOXM1 MTOR MTOR MRAS MRAS TRPM7 TRPM7 PIK3CB PIK3CB CDK1 CDK1 CHEK2 CHEK2 CCND1 CCND1 RELA RELA HRAS HRAS FBXW11 FBXW11 PPP1CA PPP1CA MAPKAPK2 MAPKAPK2 GADD45A GADD45A VDAC1 VDAC1 CCNA2 CCNA2 SLC25A31 SLC25A31 NFATC1 NFATC1 PPP3CA PPP3CA ATM ATM NFKB1 NFKB1 LOC103007740 LOC103007740 SLC25A6 SLC25A6 MAP2K3 MAP2K3 CACNA1D CACNA1D RRAS2 RRAS2 CCNB1 CCNB1 PIK3R1 PIK3R1 AKT1 AKT1 GADD45B GADD45B CDKN2B CDKN2B LOC103012968 LOC103012968 HIPK2 HIPK2 SLC25A4 SLC25A4 HUS1 HUS1 SLC25A5 SLC25A5 PTEN PTEN CDK2 CDK2 CDK4 CDK4 CXCL8 CXCL8 AKT2 AKT2 TRPV4 TRPV4 E2F5 E2F5 NFATC4 NFATC4 HIPK3 HIPK3 VDAC3 VDAC3 NBN NBN RBBP4 RBBP4 AKT3 AKT3 ETS1 ETS1 CHEK1 CHEK1 IL6 IL6 PPID PPID ZFP36L1 ZFP36L1 LIN52 LIN52 TGFB3 TGFB3 MAP2K6 MAP2K6 MAPK3 MAPK3 SERPINE1 SERPINE1 RB1 RB1 ITPR3 ITPR3 BTRC BTRC IGFBP3 IGFBP3 ATR ATR RAD50 RAD50 MYC MYC LOC103012727 LOC103012727 PPP1CC PPP1CC MRE11 MRE11 CALM2 CALM2 TRAF3IP2 TRAF3IP2 PPP1CB PPP1CB TGFBR2 TGFBR2 RAD1 RAD1 RAF1 RAF1 ITPR1 ITPR1 GATA4 GATA4 RBL1 RBL1 MYBL2 MYBL2 E2F1 E2F1 GADD45G GADD45G FOXO1 FOXO1 CCNA1 CCNA1 TSC1 TSC1 KRAS KRAS LOC102999798 LOC102999798 MDM2 MDM2 ITPR2 ITPR2 RASSF5 RASSF5 PIK3R2 PIK3R2 CDK6 CDK6 MAPK1 MAPK1 TGFBR1 TGFBR1 E2F3 E2F3 SMAD2 SMAD2 IL1A IL1A LOC103019749 LOC103019749 MAPK14 MAPK14 NFATC3 NFATC3 CCND3 CCND3 CDKN1A CDKN1A E2F4 E2F4 CAPN2 CAPN2 PPP3R2 PPP3R2 PIK3CA PIK3CA LOC103008230 LOC103008230 LIN9 LIN9 MAPK13 MAPK13 TGFB1 TGFB1 LOC103008077 LOC103008077 CAPN1 CAPN1 E2F2 E2F2 TSC2 TSC2 CCNB3 CCNB3 NFATC2 NFATC2 RAD9B RAD9B FOXO3 FOXO3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CCNE1LOW QUALITY PROTEIN: G1/S-specific cyclin-E1; Belongs to the cyclin family. (416 aa)
CCNE2G1/S-specific cyclin-E2; Belongs to the cyclin family. (405 aa)
LIN37Protein lin-37 homolog isoform X1. (246 aa)
RHEBGTP-binding protein Rheb. (179 aa)
CCNB2G2/mitotic-specific cyclin-B2; Belongs to the cyclin family. (398 aa)
SMAD3Mothers against decapentaplegic homolog. (425 aa)
CALML4Calmodulin-like protein 4. (153 aa)
MAP2K1Dual specificity mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (387 aa)
VDAC2Voltage-dependent anion-selective channel protein 2 isoform X3. (309 aa)
PPP3CBSerine/threonine-protein phosphatase. (528 aa)
HIPK4Homeodomain-interacting protein kinase 4. (612 aa)
ZFP36L2mRNA decay activator protein ZFP36L2. (376 aa)
RBL2Retinoblastoma-like protein 2. (1160 aa)
MCUCalcium uniporter protein, mitochondrial. (348 aa)
PPP3CCSerine/threonine-protein phosphatase. (583 aa)
LIN54Protein lin-54 homolog isoform X1. (748 aa)
SIRT1NAD-dependent protein deacetylase sirtuin-1 isoform X1. (557 aa)
CDC25AM-phase inducer phosphatase 1 isoform X1. (524 aa)
NRASGTPase NRas. (189 aa)
MAP2K2Dual specificity mitogen-activated protein kinase kinase 2. (303 aa)
HIPK1Homeodomain-interacting protein kinase 1. (1211 aa)
SQSTM1Sequestosome-1. (440 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1042 aa)
EIF4EBP1Eukaryotic translation initiation factor 4E-binding protein 1. (118 aa)
CCND2G1/S-specific cyclin-D2; Belongs to the cyclin family. (289 aa)
FOXM1Forkhead box protein M1 isoform X2. (758 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2546 aa)
MRASRas-related protein M-Ras isoform X1. (208 aa)
TRPM7Transient receptor potential cation channel subfamily M member 7 isoform X1. (1867 aa)
PIK3CBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform; Belongs to the PI3/PI4-kinase family. (1070 aa)
CDK1Cyclin-dependent kinase 1; Belongs to the protein kinase superfamily. (297 aa)
CHEK2Serine/threonine-protein kinase Chk2. (544 aa)
CCND1G1/S-specific cyclin-D1 isoform X1; Belongs to the cyclin family. (214 aa)
RELATranscription factor p65 isoform X1. (520 aa)
HRASGTPase HRas isoform X1. (196 aa)
FBXW11F-box/WD repeat-containing protein 11 isoform X1. (563 aa)
PPP1CASerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (363 aa)
MAPKAPK2MAP kinase-activated protein kinase 2; Belongs to the protein kinase superfamily. (388 aa)
GADD45AGrowth arrest and DNA damage-inducible protein GADD45 alpha isoform X1. (171 aa)
VDAC1Voltage-dependent anion-selective channel protein 1. (283 aa)
CCNA2cyclin-A2; Belongs to the cyclin family. (435 aa)
SLC25A31ADP/ATP translocase 4; Belongs to the mitochondrial carrier (TC 2.A.29) family. (323 aa)
NFATC1Nuclear factor of activated T-cells, cytoplasmic 1. (901 aa)
PPP3CASerine/threonine-protein phosphatase. (521 aa)
ATMSerine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3057 aa)
NFKB1Nuclear factor NF-kappa-B p105 subunit isoform X1. (974 aa)
LOC103007740H-2 class I histocompatibility antigen, Q10 alpha chain-like isoform X1; Belongs to the MHC class I family. (349 aa)
SLC25A6ADP/ATP translocase 3; Belongs to the mitochondrial carrier (TC 2.A.29) family. (317 aa)
MAP2K3Dual specificity mitogen-activated protein kinase kinase 3; Belongs to the protein kinase superfamily. (347 aa)
CACNA1DVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2183 aa)
RRAS2Ras-related protein R-Ras2. (169 aa)
CCNB1G2/mitotic-specific cyclin-B1 isoform X1; Belongs to the cyclin family. (433 aa)
PIK3R1Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1. (724 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (476 aa)
GADD45BGrowth arrest and DNA damage-inducible protein GADD45 beta. (160 aa)
CDKN2BCyclin-dependent kinase 4 inhibitor B isoform X1. (131 aa)
LOC103012968Cyclin-dependent kinase inhibitor 2A. (109 aa)
HIPK2Homeodomain-interacting protein kinase 2 isoform X1. (1207 aa)
SLC25A4ADP/ATP translocase 1; Belongs to the mitochondrial carrier (TC 2.A.29) family. (298 aa)
HUS1Checkpoint protein; Belongs to the HUS1 family. (259 aa)
SLC25A5ADP/ATP translocase 2; Belongs to the mitochondrial carrier (TC 2.A.29) family. (283 aa)
PTENPhosphatase and tensin homolog. (612 aa)
CDK2Cyclin-dependent kinase 2 isoform X1; Belongs to the protein kinase superfamily. (346 aa)
CDK4Cyclin-dependent kinase 4 isoform X1; Belongs to the protein kinase superfamily. (303 aa)
CXCL8Multifunctional fusion protein; Belongs to the intercrine alpha (chemokine CxC) family. (101 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
TRPV4Transient receptor potential cation channel subfamily V member 4; Belongs to the transient receptor (TC 1.A.4) family. (871 aa)
E2F5Transcription factor E2F5. (333 aa)
NFATC4Nuclear factor of activated T-cells, cytoplasmic 4 isoform X1. (901 aa)
HIPK3Homeodomain-interacting protein kinase 3 isoform X1. (1214 aa)
VDAC3Voltage-dependent anion-selective channel protein 3 isoform X1. (282 aa)
NBNNibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. (727 aa)
RBBP4Histone-binding protein RBBP4. (425 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (431 aa)
ETS1Protein C-ets-1 isoform X1. (485 aa)
CHEK1Serine/threonine-protein kinase Chk1; Belongs to the protein kinase superfamily. (476 aa)
IL6Interleukin-6. (208 aa)
PPIDPeptidyl-prolyl cis-trans isomerase D. (370 aa)
ZFP36L1mRNA decay activator protein ZFP36L1. (323 aa)
LIN52Protein lin-52 homolog isoform X1. (116 aa)
TGFB3Transforming growth factor beta-3 proprotein. (456 aa)
MAP2K6Dual specificity mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily. (368 aa)
MAPK3Mitogen-activated protein kinase 3. (265 aa)
SERPINE1Plasminogen activator inhibitor 1; Belongs to the serpin family. (402 aa)
RB1Retinoblastoma-associated protein. (816 aa)
ITPR3LOW QUALITY PROTEIN: inositol 1,4,5-trisphosphate receptor type 3. (2666 aa)
BTRCF-box/WD repeat-containing protein 1A isoform X1. (611 aa)
IGFBP3Insulin-like growth factor-binding protein 3. (146 aa)
ATRSerine/threonine-protein kinase ATR; Belongs to the PI3/PI4-kinase family. (2645 aa)
RAD50DNA repair protein RAD50 isoform X1. (1312 aa)
MYCMyc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (438 aa)
LOC103012727Voltage-dependent anion-selective channel protein 3-like. (264 aa)
PPP1CCSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (337 aa)
MRE11Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (707 aa)
CALM2Calmodulin-1; Belongs to the calmodulin family. (149 aa)
TRAF3IP2Adapter protein CIKS isoform X1. (565 aa)
PPP1CBSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (327 aa)
TGFBR2Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (543 aa)
RAD1Cell cycle checkpoint protein RAD1 isoform X1. (279 aa)
RAF1RAF proto-oncogene serine/threonine-protein kinase isoform X1. (668 aa)
ITPR1Inositol 1,4,5-trisphosphate receptor type 1 isoform X1. (2749 aa)
GATA4Transcription factor GATA-4. (229 aa)
RBL1Retinoblastoma-like protein 1. (1068 aa)
MYBL2Myb-related protein B. (803 aa)
E2F1Transcription factor E2F1. (361 aa)
GADD45GGrowth arrest and DNA damage-inducible protein GADD45 gamma. (159 aa)
FOXO1Forkhead box protein O1. (518 aa)
CCNA1cyclin-A1; Belongs to the cyclin family. (421 aa)
TSC1Hamartin. (1155 aa)
KRASGTPase KRas isoform X3. (227 aa)
LOC102999798Mitogen-activated protein kinase. (203 aa)
MDM2E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family. (491 aa)
ITPR2Inositol 1,4,5-trisphosphate receptor type 2 isoform X1. (2701 aa)
RASSF5Ras association domain-containing protein 5 isoform X1. (421 aa)
PIK3R2Phosphatidylinositol 3-kinase regulatory subunit beta. (700 aa)
CDK6Cyclin-dependent kinase 6; Belongs to the protein kinase superfamily. (326 aa)
MAPK1Mitogen-activated protein kinase 1. (263 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (434 aa)
E2F3Transcription factor E2F3. (340 aa)
SMAD2Mothers against decapentaplegic homolog. (467 aa)
IL1AInterleukin-1; Belongs to the IL-1 family. (270 aa)
LOC103019749Calpain-2 catalytic subunit-like; Belongs to the peptidase C2 family. (445 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
NFATC3Nuclear factor of activated T-cells, cytoplasmic 3. (998 aa)
CCND3G1/S-specific cyclin-D3 isoform X1; Belongs to the cyclin family. (292 aa)
CDKN1ACyclin-dependent kinase inhibitor 1. (164 aa)
E2F4Transcription factor E2F4 isoform X1. (421 aa)
CAPN2LOW QUALITY PROTEIN: calpain-2 catalytic subunit; Belongs to the peptidase C2 family. (585 aa)
PPP3R2LOW QUALITY PROTEIN: calcineurin subunit B type 2. (170 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
LOC103008230BOLA class I histocompatibility antigen, alpha chain BL3-7-like isoform X1; Belongs to the MHC class I family. (388 aa)
LIN9Protein lin-9 homolog. (490 aa)
MAPK13Mitogen-activated protein kinase. (288 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (407 aa)
LOC103008077Phosphatidylinositol 3-kinase regulatory subunit gamma. (484 aa)
CAPN1Calpain-1 catalytic subunit isoform X2; Belongs to the peptidase C2 family. (959 aa)
E2F2Transcription factor E2F2. (414 aa)
TSC2LOW QUALITY PROTEIN: tuberin. (1815 aa)
CCNB3LOW QUALITY PROTEIN: G2/mitotic-specific cyclin-B3; Belongs to the cyclin family. (1428 aa)
NFATC2Nuclear factor of activated T-cells, cytoplasmic 2 isoform X3. (818 aa)
RAD9BCell cycle checkpoint control protein; Belongs to the rad9 family. (413 aa)
FOXO3LOW QUALITY PROTEIN: forkhead box protein O3. (467 aa)
Your Current Organism:
Balaenoptera acutorostrata
NCBI taxonomy Id: 310752
Other names: B. acutorostrata scammoni, Balaenoptera acutorostrata scammoni
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