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SCN1B SCN1B PLCB4 PLCB4 PLCB1 PLCB1 CACNG2 CACNG2 CALML4 CALML4 ATP2B1 ATP2B1 ATP2B4 ATP2B4 PIK3R6 PIK3R6 ATP1B2 ATP1B2 PIK3R5 PIK3R5 SLC8A1 SLC8A1 TNNT2 TNNT2 CREM CREM ADCY7 ADCY7 GNAI2 GNAI2 MYL3 MYL3 CACNA2D2 CACNA2D2 CREB3L3 CREB3L3 GNAI3 GNAI3 ATP1A1 ATP1A1 SLC9A1 SLC9A1 PPP2R3A PPP2R3A RYR2 RYR2 KCNQ1 KCNQ1 PPP1CA PPP1CA LOC103005600 LOC103005600 PPP2CA PPP2CA ATP1B1 ATP1B1 PPP2R1B PPP2R1B PPP2R2C PPP2R2C PPP2R2D PPP2R2D PRKACB PRKACB ADRB1 ADRB1 AGT AGT PPP2CB PPP2CB PLCB3 PLCB3 PPP2R5B PPP2R5B TNNC1 TNNC1 CACNA2D3 CACNA2D3 CACNA1D CACNA1D ADCY5 ADCY5 MYL4 MYL4 AKT1 AKT1 CREB3L2 CREB3L2 ATP2A3 ATP2A3 TPM3 TPM3 ATP1B4 ATP1B4 CACNA2D4 CACNA2D4 CREB3L4 CREB3L4 PPP2R5C PPP2R5C CACNA2D1 CACNA2D1 ADCY6 ADCY6 RAPGEF3 RAPGEF3 PPP1R1A PPP1R1A CACNB3 CACNB3 PPP2R1A PPP2R1A AKT2 AKT2 ACTC1 ACTC1 LOC103014002 LOC103014002 ADCY4 ADCY4 PLCB2 PLCB2 MYH6 MYH6 RPS6KA5 RPS6KA5 PIK3CG PIK3CG CREB3L1 CREB3L1 CACNG6 CACNG6 TNNI3 TNNI3 CACNG8 CACNG8 ADCY9 ADCY9 PRKACA PRKACA LOC103004609 LOC103004609 LOC103018216 LOC103018216 CACNA1F CACNA1F AKT3 AKT3 CACNB4 CACNB4 SCN7A SCN7A RAPGEF4 RAPGEF4 TPM4 TPM4 KCNE1 KCNE1 SLC8A3 SLC8A3 PPP2R5A PPP2R5A AGTR2 AGTR2 LOC103004158 LOC103004158 CACNG5 CACNG5 PRKCA PRKCA CACNG1 CACNG1 CACNG4 CACNG4 CACNG3 CACNG3 ATP2A1 ATP2A1 MAPK3 MAPK3 LOC103002139 LOC103002139 GNAI1 GNAI1 ADCY1 ADCY1 AGTR1 AGTR1 ADRB2 ADRB2 CAMK2A CAMK2A ADCY8 ADCY8 ATF4 ATF4 MYL2 MYL2 PPP1CC PPP1CC CALM2 CALM2 ATF2 ATF2 PLN PLN ADCY3 ADCY3 PPP1CB PPP1CB SCN5A SCN5A ADCY2 ADCY2 BCL2 BCL2 ADRA1A ADRA1A PPP2R2A PPP2R2A PPP2R5E PPP2R5E CREB5 CREB5 ATF6B ATF6B PPP2R2B PPP2R2B LOC102999798 LOC102999798 MAPK1 MAPK1 CACNB2 CACNB2 FXYD2 FXYD2 SCN4B SCN4B CREB3 CREB3 MAPK14 MAPK14 ATP1B3 ATP1B3 PPP2R3C PPP2R3C ADRA1D ADRA1D CREB1 CREB1 CACNA1S CACNA1S MAPK13 MAPK13 PPP2R5D PPP2R5D ATP1A3 ATP1A3 SLC8A2 SLC8A2 ADRA1B ADRA1B LOC103005321 LOC103005321 CACNA1C CACNA1C CACNG7 CACNG7 TPM1 TPM1 ATP2B3 ATP2B3 GNAS GNAS CAMK2B CAMK2B ATP2A2 ATP2A2
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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co-expression
protein homology
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SCN1BSodium channel subunit beta-1 isoform X1. (205 aa)
PLCB41-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1258 aa)
PLCB11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1115 aa)
CACNG2Voltage-dependent calcium channel gamma-2 subunit; Regulates the trafficking and gating properties of AMPA- selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Thought to stabilize the calcium channel in an inactivated (closed) state; Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (323 aa)
CALML4Calmodulin-like protein 4. (153 aa)
ATP2B1Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1249 aa)
ATP2B4Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1243 aa)
PIK3R6Phosphoinositide 3-kinase regulatory subunit 6. (754 aa)
ATP1B2Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (290 aa)
PIK3R5Phosphoinositide 3-kinase regulatory subunit 5. (882 aa)
SLC8A1Sodium/calcium exchanger 1 isoform X1; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (991 aa)
TNNT2Troponin T, cardiac muscle isoform X1. (280 aa)
CREMcAMP-responsive element modulator isoform X2. (360 aa)
ADCY7Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1078 aa)
GNAI2Guanine nucleotide-binding protein G(I) subunit alpha-2. (303 aa)
MYL3Myosin light chain 3. (199 aa)
CACNA2D2Voltage-dependent calcium channel subunit alpha-2/delta-2 isoform X1. (1075 aa)
CREB3L3Cyclic AMP-responsive element-binding protein 3-like protein 3. (457 aa)
GNAI3Guanine nucleotide-binding protein G(K) subunit alpha. (354 aa)
ATP1A1Sodium/potassium-transporting ATPase subunit alpha. (1021 aa)
SLC9A1Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. (815 aa)
PPP2R3ASerine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha isoform X1. (1151 aa)
RYR2Ryanodine receptor 2 isoform X1. (4884 aa)
KCNQ1Potassium voltage-gated channel subfamily KQT member 1; Belongs to the potassium channel family. (599 aa)
PPP1CASerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (363 aa)
LOC103005600Sodium/potassium-transporting ATPase subunit alpha. (1020 aa)
PPP2CASerine/threonine-protein phosphatase. (309 aa)
ATP1B1Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (303 aa)
PPP2R1BSerine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform isoform X4. (666 aa)
PPP2R2CSerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (447 aa)
PPP2R2DSerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (288 aa)
PRKACBcAMP-dependent protein kinase catalytic subunit beta isoform X1; Belongs to the protein kinase superfamily. (397 aa)
ADRB1Beta-1 adrenergic receptor; Belongs to the G-protein coupled receptor 1 family. (526 aa)
AGTAngiotensinogen; Belongs to the serpin family. (477 aa)
PPP2CBSerine/threonine-protein phosphatase. (244 aa)
PLCB31-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1230 aa)
PPP2R5BSerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (522 aa)
TNNC1Troponin C, slow skeletal and cardiac muscles. (161 aa)
CACNA2D3Voltage-dependent calcium channel subunit alpha-2/delta-3. (1091 aa)
CACNA1DVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2183 aa)
ADCY5Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1018 aa)
MYL4Myosin light chain 4 isoform X1. (209 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (476 aa)
CREB3L2Cyclic AMP-responsive element-binding protein 3-like protein 2. (520 aa)
ATP2A3Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (934 aa)
TPM3Tropomyosin alpha-3 chain isoform X6; Belongs to the tropomyosin family. (284 aa)
ATP1B4Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (357 aa)
CACNA2D4Voltage-dependent calcium channel subunit alpha-2/delta-4. (1108 aa)
CREB3L4Cyclic AMP-responsive element-binding protein 3-like protein 4 isoform X1. (395 aa)
PPP2R5CSerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (571 aa)
CACNA2D1Voltage-dependent calcium channel subunit alpha-2/delta-1 isoform X1. (1110 aa)
ADCY6Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1220 aa)
RAPGEF3Rap guanine nucleotide exchange factor 3 isoform X1. (936 aa)
PPP1R1AProtein phosphatase 1 regulatory subunit 1A isoform X1. (171 aa)
CACNB3Voltage-dependent L-type calcium channel subunit beta-3. (539 aa)
PPP2R1ASerine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform. (589 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
ACTC1Actin, alpha cardiac muscle 1. (383 aa)
LOC103014002Myosin-7; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1934 aa)
ADCY4Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1109 aa)
PLCB21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1131 aa)
MYH6Myosin-6; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1850 aa)
RPS6KA5Ribosomal protein S6 kinase. (800 aa)
PIK3CGLOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform; Belongs to the PI3/PI4-kinase family. (1101 aa)
CREB3L1Cyclic AMP-responsive element-binding protein 3-like protein 1. (520 aa)
CACNG6Voltage-dependent calcium channel gamma-6 subunit; Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit. Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (261 aa)
TNNI3Troponin I, cardiac muscle. (211 aa)
CACNG8Voltage-dependent calcium channel gamma-8 subunit. (228 aa)
ADCY9Adenylate cyclase type 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1353 aa)
PRKACAcAMP-dependent protein kinase catalytic subunit alpha. (293 aa)
LOC103004609Tropomyosin alpha-3 chain-like isoform X1; Belongs to the tropomyosin family. (248 aa)
LOC103018216Guanine nucleotide-binding protein G(Q) subunit alpha. (301 aa)
CACNA1FVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (1975 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (431 aa)
CACNB4Voltage-dependent L-type calcium channel subunit beta-4 isoform X1. (502 aa)
SCN7ASodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (1684 aa)
RAPGEF4Rap guanine nucleotide exchange factor 4. (858 aa)
TPM4Tropomyosin alpha-4 chain isoform X1; Belongs to the tropomyosin family. (284 aa)
KCNE1Potassium voltage-gated channel subfamily E member 1. (129 aa)
SLC8A3Sodium/calcium exchanger 3 isoform X1; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (927 aa)
PPP2R5ASerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (487 aa)
AGTR2Type-2 angiotensin II receptor; Belongs to the G-protein coupled receptor 1 family. (362 aa)
LOC103004158Neuroendocrine secretory protein 55-like. (244 aa)
CACNG5Voltage-dependent calcium channel gamma-5 subunit. (275 aa)
PRKCANon-specific serine/threonine protein kinase. (559 aa)
CACNG1Voltage-dependent calcium channel gamma-1 subunit; Regulatory subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents in skeletal muscle. Regulates channel inactivation kinetics. (224 aa)
CACNG4Voltage-dependent calcium channel gamma-4 subunit. (549 aa)
CACNG3Voltage-dependent calcium channel gamma-3 subunit. (315 aa)
ATP2A1Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1000 aa)
MAPK3Mitogen-activated protein kinase 3. (265 aa)
LOC103002139Tropomyosin alpha-3 chain-like isoform X1; Belongs to the tropomyosin family. (261 aa)
GNAI1Guanine nucleotide-binding protein G(I) subunit alpha-1. (354 aa)
ADCY1Adenylate cyclase type 1 isoform X1. (907 aa)
AGTR1Type-1 angiotensin II receptor; Belongs to the G-protein coupled receptor 1 family. (359 aa)
ADRB2Beta-2 adrenergic receptor isoform X1. (449 aa)
CAMK2ACalcium/calmodulin-dependent protein kinase type II subunit alpha isoform X1; Belongs to the protein kinase superfamily. (489 aa)
ADCY8Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1248 aa)
ATF4Cyclic AMP-dependent transcription factor ATF-4. (352 aa)
MYL2Myosin regulatory light chain 2, ventricular/cardiac muscle isoform. (166 aa)
PPP1CCSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (337 aa)
CALM2Calmodulin-1; Belongs to the calmodulin family. (149 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2 isoform X1. (505 aa)
PLNCardiac phospholamban; Reversibly inhibits the activity of ATP2A2 in cardiac sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca(2+). Modulates the contractility of the heart muscle in response to physiological stimuli via its effects on ATP2A2. Modulates calcium re-uptake during muscle relaxation and plays an important role in calcium homeostasis in the heart muscle. The degree of ATP2A2 inhibition depends on the oligomeric state of PLN. (52 aa)
ADCY3Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1200 aa)
PPP1CBSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (327 aa)
SCN5ASodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (1992 aa)
ADCY2Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (972 aa)
BCL2Apoptosis regulator Bcl-2 isoform X1. (233 aa)
ADRA1Aalpha-1A adrenergic receptor isoform X1. (466 aa)
PPP2R2ASerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (447 aa)
PPP2R5ESerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (467 aa)
CREB5Cyclic AMP-responsive element-binding protein 5 isoform X1. (502 aa)
ATF6BLOW QUALITY PROTEIN: cyclic AMP-dependent transcription factor ATF-6 beta. (700 aa)
PPP2R2BSerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (501 aa)
LOC102999798Mitogen-activated protein kinase. (203 aa)
MAPK1Mitogen-activated protein kinase 1. (263 aa)
CACNB2Voltage-dependent L-type calcium channel subunit beta-2 isoform X1. (604 aa)
FXYD2FXYD domain-containing ion transport regulator; Belongs to the FXYD family. (102 aa)
SCN4BSodium channel subunit beta-4. (228 aa)
CREB3Cyclic AMP-responsive element-binding protein 3 isoform X1. (371 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
ATP1B3Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (266 aa)
PPP2R3CLOW QUALITY PROTEIN: serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma. (453 aa)
ADRA1Dalpha-1D adrenergic receptor. (459 aa)
CREB1Cyclic AMP-responsive element-binding protein 1 isoform X1. (341 aa)
CACNA1SVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (1864 aa)
MAPK13Mitogen-activated protein kinase. (288 aa)
PPP2R5DSerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (601 aa)
ATP1A3Sodium/potassium-transporting ATPase subunit alpha. (1014 aa)
SLC8A2Sodium/calcium exchanger 2 isoform X1; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (922 aa)
ADRA1Balpha-1B adrenergic receptor. (326 aa)
LOC103005321Sodium/potassium-transporting ATPase subunit alpha. (1028 aa)
CACNA1CVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2273 aa)
CACNG7Voltage-dependent calcium channel gamma-7 subunit; Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit (By similarity). Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization. Shows specificity only for GRIA1 and GRIA2. Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (282 aa)
TPM1Tropomyosin alpha-1 chain isoform X3; Belongs to the tropomyosin family. (286 aa)
ATP2B3Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1168 aa)
GNASGuanine nucleotide-binding protein G(S) subunit alpha isoforms XLas isoform X1. (1007 aa)
CAMK2BCalcium/calmodulin-dependent protein kinase type II subunit beta isoform X1. (501 aa)
ATP2A2Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1008 aa)
Your Current Organism:
Balaenoptera acutorostrata
NCBI taxonomy Id: 310752
Other names: B. acutorostrata scammoni, Balaenoptera acutorostrata scammoni
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