STRINGSTRING
PTCH2 PTCH2 CSNK1G1 CSNK1G1 CUL3 CUL3 CCND2 CCND2 CCND1 CCND1 GRK2 GRK2 FBXW11 FBXW11 GPR161 GPR161 PRKACB PRKACB ARRB1 ARRB1 SPOP SPOP GLI1 GLI1 DHH DHH GLI2 GLI2 GSK3B GSK3B MGRN1 MGRN1 PRKACA PRKACA SPOPL SPOPL LRP2 LRP2 CDON CDON CUL1 CUL1 CSNK1D CSNK1D SMURF2 SMURF2 SMURF1 SMURF1 SUFU SUFU BTRC BTRC GLI3 GLI3 IHH IHH CSNK1G3 CSNK1G3 KIF3A KIF3A CSNK1A1 CSNK1A1 LOC103005963 LOC103005963 HHIP HHIP MOSMO MOSMO EVC EVC BCL2 BCL2 KIF7 KIF7 MEGF8 MEGF8 PTCH1 PTCH1 SMO SMO SHH SHH GRK3 GRK3 BOC BOC EVC2 EVC2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PTCH2Protein patched homolog 2 isoform X1. (1213 aa)
CSNK1G1Casein kinase I; Belongs to the protein kinase superfamily. (466 aa)
CUL3Cullin-3; Belongs to the cullin family. (746 aa)
CCND2G1/S-specific cyclin-D2; Belongs to the cyclin family. (289 aa)
CCND1G1/S-specific cyclin-D1 isoform X1; Belongs to the cyclin family. (214 aa)
GRK2G protein-coupled receptor kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. (647 aa)
FBXW11F-box/WD repeat-containing protein 11 isoform X1. (563 aa)
GPR161G-protein coupled receptor 161; Belongs to the G-protein coupled receptor 1 family. (528 aa)
PRKACBcAMP-dependent protein kinase catalytic subunit beta isoform X1; Belongs to the protein kinase superfamily. (397 aa)
ARRB1Beta-arrestin-1 isoform X1. (413 aa)
SPOPSpeckle-type POZ protein. (374 aa)
GLI1Zinc finger protein GLI1. (1106 aa)
DHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (396 aa)
GLI2Zinc finger protein GLI2. (1411 aa)
GSK3BGlycogen synthase kinase-3 beta isoform X1; Belongs to the protein kinase superfamily. (433 aa)
MGRN1E3 ubiquitin-protein ligase MGRN1. (539 aa)
PRKACAcAMP-dependent protein kinase catalytic subunit alpha. (293 aa)
SPOPLSpeckle-type POZ protein-like isoform X1. (424 aa)
LRP2Low-density lipoprotein receptor-related protein 2. (4651 aa)
CDONCell adhesion molecule-related/down-regulated by oncogenes. (1251 aa)
CUL1Cullin-1; Belongs to the cullin family. (776 aa)
CSNK1DCasein kinase I isoform X1. (371 aa)
SMURF2E3 ubiquitin-protein ligase. (735 aa)
SMURF1E3 ubiquitin-protein ligase SMURF1. (719 aa)
SUFUSuppressor of fused homolog; Negative regulator in the hedgehog signaling pathway. Down- regulates GLI1-mediated transactivation of target genes. Part of a corepressor complex that acts on DNA-bound GLI1. May also act by linking GLI1 to BTRC and thereby targeting GLI1 to degradation by the proteasome. Sequesters GLI1, GLI2 and GLI3 in the cytoplasm, this effect is overcome by binding of STK36 to both SUFU and a GLI protein. Negative regulator of beta-catenin signaling. Regulates the formation of either the repressor form (GLI3R) or the activator form (GLI3A) of the full-length form of [...] (485 aa)
BTRCF-box/WD repeat-containing protein 1A isoform X1. (611 aa)
GLI3Transcriptional activator GLI3 isoform X1. (1591 aa)
IHHIndian hedgehog protein. (309 aa)
CSNK1G3Casein kinase I isoform X1; Belongs to the protein kinase superfamily. (456 aa)
KIF3AKinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (726 aa)
CSNK1A1Casein kinase I isoform X1; Belongs to the protein kinase superfamily. (368 aa)
LOC103005963Casein kinase I isoform X3; Belongs to the protein kinase superfamily. (416 aa)
HHIPHedgehog-interacting protein isoform X1. (700 aa)
MOSMOModulator of smoothened protein. (167 aa)
EVCEllis-van Creveld syndrome protein. (1044 aa)
BCL2Apoptosis regulator Bcl-2 isoform X1. (233 aa)
KIF7Kinesin-like protein KIF7; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1247 aa)
MEGF8Multiple epidermal growth factor-like domains protein 8. (2787 aa)
PTCH1LOW QUALITY PROTEIN: protein patched homolog 1. (1304 aa)
SMOSmoothened homolog; Belongs to the G-protein coupled receptor Fz/Smo family. (837 aa)
SHHLOW QUALITY PROTEIN: sonic hedgehog protein. (271 aa)
GRK3G protein-coupled receptor kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. (646 aa)
BOCBrother of CDO isoform X1. (1138 aa)
EVC2LOW QUALITY PROTEIN: limbin. (1210 aa)
Your Current Organism:
Balaenoptera acutorostrata
NCBI taxonomy Id: 310752
Other names: B. acutorostrata scammoni, Balaenoptera acutorostrata scammoni
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