STRINGSTRING
ZFYVE9 ZFYVE9 LOC103015222 LOC103015222 RGMA RGMA GDF6 GDF6 HAMP HAMP DCN DCN SMAD3 SMAD3 SMAD6 SMAD6 FMOD FMOD LOC103014954 LOC103014954 LOC103002500 LOC103002500 LOC103005758 LOC103005758 RHOA RHOA FBN1 FBN1 RPS6KB2 RPS6KB2 PPP2CA PPP2CA SMAD5 SMAD5 SKP1 SKP1 PPP2R1B PPP2R1B BMP6 BMP6 PPP2CB PPP2CB BMPR1A BMPR1A ID3 ID3 NBL1 NBL1 CDKN2B CDKN2B SP1 SP1 ACVR1B ACVR1B AMHR2 AMHR2 INHBE INHBE INHBC INHBC PPP2R1A PPP2R1A ZFYVE16 ZFYVE16 E2F5 E2F5 THBS1 THBS1 CREBBP CREBBP HJV HJV ACVR2A ACVR2A ACVR1 ACVR1 ACVR1C ACVR1C BMPR1B BMPR1B TGFB3 TGFB3 CUL1 CUL1 BMP7 BMP7 SMURF2 SMURF2 MAPK3 MAPK3 SMURF1 SMURF1 BMP5 BMP5 INHBA INHBA BAMBI BAMBI MYC MYC RBX1 RBX1 SMAD1 SMAD1 RPS6KB1 RPS6KB1 BMPR2 BMPR2 PITX2 PITX2 LTBP1 LTBP1 ROCK1 ROCK1 TGIF1 TGIF1 TGFBR2 TGFBR2 BMP2 BMP2 RBL1 RBL1 TGIF2 TGIF2 BMP4 BMP4 GDF5 GDF5 ID1 ID1 TNF TNF IFNG IFNG FST FST ID2 ID2 LOC103000722 LOC103000722 MAPK1 MAPK1 TGFBR1 TGFBR1 LOC103020685 LOC103020685 SMAD2 SMAD2 SMAD4 SMAD4 SMAD7 SMAD7 RGMB RGMB NEO1 NEO1 THSD4 THSD4 E2F4 E2F4 SMAD9 SMAD9 CHRD CHRD TFDP1 TFDP1 NODAL NODAL TGFB1 TGFB1 NOG NOG LOC103010763 LOC103010763 GREM1 GREM1 EP300 EP300
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ZFYVE9Zinc finger FYVE domain-containing protein. (1423 aa)
LOC103015222Bone morphogenetic protein 8B. (390 aa)
RGMARepulsive guidance molecule A isoform X2. (345 aa)
GDF6Growth/differentiation factor 6. (375 aa)
HAMPHepcidin. (82 aa)
DCNDecorin; May affect the rate of fibrils formation. (360 aa)
SMAD3Mothers against decapentaplegic homolog. (425 aa)
SMAD6Mothers against decapentaplegic homolog. (321 aa)
FMODFibromodulin. (376 aa)
LOC103014954Bone morphogenetic protein 8A-like. (279 aa)
LOC103002500Left-right determination factor. (367 aa)
LOC103005758Left-right determination factor 2. (226 aa)
RHOATransforming protein RhoA. (193 aa)
FBN1LOW QUALITY PROTEIN: fibrillin-1. (2876 aa)
RPS6KB2Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (590 aa)
PPP2CASerine/threonine-protein phosphatase. (309 aa)
SMAD5Mothers against decapentaplegic homolog. (465 aa)
SKP1S-phase kinase-associated protein 1; Belongs to the SKP1 family. (163 aa)
PPP2R1BSerine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform isoform X4. (666 aa)
BMP6Bone morphogenetic protein 6. (388 aa)
PPP2CBSerine/threonine-protein phosphatase. (244 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
ID3DNA-binding protein inhibitor ID-3. (119 aa)
NBL1Neuroblastoma suppressor of tumorigenicity 1. (176 aa)
CDKN2BCyclin-dependent kinase 4 inhibitor B isoform X1. (131 aa)
SP1Transcription factor Sp1. (787 aa)
ACVR1BReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (530 aa)
AMHR2Anti-Muellerian hormone type-2 receptor; On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for anti-Muellerian hormone. (549 aa)
INHBEInhibin beta E chain. (351 aa)
INHBCInhibin beta C chain. (352 aa)
PPP2R1ASerine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform. (589 aa)
ZFYVE16Zinc finger FYVE domain-containing protein 16 isoform X1. (1563 aa)
E2F5Transcription factor E2F5. (333 aa)
THBS1Thrombospondin-1. (1170 aa)
CREBBPCREB-binding protein isoform X1. (2444 aa)
HJVLOW QUALITY PROTEIN: hemojuvelin. (428 aa)
ACVR2ASerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (513 aa)
ACVR1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (509 aa)
ACVR1CReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (443 aa)
BMPR1BSerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (502 aa)
TGFB3Transforming growth factor beta-3 proprotein. (456 aa)
CUL1Cullin-1; Belongs to the cullin family. (776 aa)
BMP7Bone morphogenetic protein 7. (431 aa)
SMURF2E3 ubiquitin-protein ligase. (735 aa)
MAPK3Mitogen-activated protein kinase 3. (265 aa)
SMURF1E3 ubiquitin-protein ligase SMURF1. (719 aa)
BMP5Bone morphogenetic protein 5. (454 aa)
INHBAInhibin beta A chain. (425 aa)
BAMBIBMP and activin membrane-bound inhibitor homolog; Negatively regulates TGF-beta signaling. Belongs to the BAMBI family. (247 aa)
MYCMyc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (438 aa)
RBX1E3 ubiquitin-protein ligase RBX1. (108 aa)
SMAD1Mothers against decapentaplegic homolog. (465 aa)
RPS6KB1Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (525 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1038 aa)
PITX2Homeobox protein. (325 aa)
LTBP1Latent-transforming growth factor beta-binding protein 1 isoform X1. (1518 aa)
ROCK1Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1354 aa)
TGIF1Homeobox protein TGIF1 isoform X2. (272 aa)
TGFBR2Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (543 aa)
BMP2Bone morphogenetic protein 2. (395 aa)
RBL1Retinoblastoma-like protein 1. (1068 aa)
TGIF2Homeobox protein TGIF2. (237 aa)
BMP4Bone morphogenetic protein 4 isoform X1. (420 aa)
GDF5Growth/differentiation factor 5. (511 aa)
ID1DNA-binding protein inhibitor ID-1. (87 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (166 aa)
FSTFollistatin isoform X1. (344 aa)
ID2DNA-binding protein inhibitor ID-2. (134 aa)
LOC103000722Bone morphogenetic protein 8A-like. (220 aa)
MAPK1Mitogen-activated protein kinase 1. (263 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (434 aa)
LOC103020685Bone morphogenetic protein 8B-like. (201 aa)
SMAD2Mothers against decapentaplegic homolog. (467 aa)
SMAD4Mothers against decapentaplegic homolog. (553 aa)
SMAD7Mothers against decapentaplegic homolog. (426 aa)
RGMBRGM domain family member B. (409 aa)
NEO1Neogenin. (1444 aa)
THSD4Thrombospondin type-1 domain-containing protein 4. (874 aa)
E2F4Transcription factor E2F4 isoform X1. (421 aa)
SMAD9Mothers against decapentaplegic homolog. (440 aa)
CHRDChordin; Dorsalizing factor. Key developmental protein that dorsalizes early vertebrate embryonic tissues by binding to ventralizing TGF-beta family bone morphogenetic proteins (BMPs) and sequestering them in latent complexes. (943 aa)
TFDP1Transcription factor. (410 aa)
NODALNodal homolog. (280 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (407 aa)
NOGNoggin. (154 aa)
LOC103010763Splicing factor 3A subunit 2. (677 aa)
GREM1Gremlin. (184 aa)
EP300Histone acetyltransferase p300. (2445 aa)
Your Current Organism:
Balaenoptera acutorostrata
NCBI taxonomy Id: 310752
Other names: B. acutorostrata scammoni, Balaenoptera acutorostrata scammoni
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