STRINGSTRING
LATS2 LATS2 PATJ PATJ LOC103015222 LOC103015222 WTIP WTIP GDF6 GDF6 STK3 STK3 SMAD3 SMAD3 TP73 TP73 DLG4 DLG4 DLG5 DLG5 DVL2 DVL2 LOC103014954 LOC103014954 SCRIB SCRIB TP53BP2 TP53BP2 CRB1 CRB1 NKD1 NKD1 CTNNA3 CTNNA3 TEAD2 TEAD2 SNAI2 SNAI2 BBC3 BBC3 DLG2 DLG2 LIMD1 LIMD1 RASSF1 RASSF1 WNT2B WNT2B WNT3A WNT3A CCND2 CCND2 WNT9A WNT9A TEAD4 TEAD4 YWHAH YWHAH CCND1 CCND1 FBXW11 FBXW11 WWC1 WWC1 PPP1CA PPP1CA PPP2CA PPP2CA CTNNA1 CTNNA1 WNT8A WNT8A ITGB2 ITGB2 PPP2R1B PPP2R1B PARD6G PARD6G PPP2R2C PPP2R2C TCF7L2 TCF7L2 PPP2R2D PPP2R2D FZD6 FZD6 YWHAZ YWHAZ BMP6 BMP6 LLGL1 LLGL1 PPP2CB PPP2CB BMPR1A BMPR1A WNT4 WNT4 TEAD1 TEAD1 TCF7L1 TCF7L1 WNT9B WNT9B WNT3 WNT3 WNT16 WNT16 WNT10B WNT10B WNT1 WNT1 RASSF6 RASSF6 PPP2R1A PPP2R1A AREG AREG LOC103009326 LOC103009326 FZD2 FZD2 AJUBA AJUBA GLI2 GLI2 GSK3B GSK3B AMOT AMOT YWHAE YWHAE BMPR1B BMPR1B MPP5 MPP5 TGFB3 TGFB3 BMP7 BMP7 PARD6B PARD6B BIRC5 BIRC5 ACTG1 ACTG1 CSNK1D CSNK1D AXIN2 AXIN2 SERPINE1 SERPINE1 ACTB ACTB FZD9 FZD9 BMP5 BMP5 YWHAG YWHAG BTRC BTRC WNT8B WNT8B WWTR1 WWTR1 WNT10A WNT10A LOC103010322 LOC103010322 MYC MYC MOB1A MOB1A LOC103005963 LOC103005963 WNT7B WNT7B SMAD1 SMAD1 PPP1CC PPP1CC BMPR2 BMPR2 FZD7 FZD7 LEF1 LEF1 CCN2 CCN2 BIRC2 BIRC2 YAP1 YAP1 PPP1CB PPP1CB BIRC3 BIRC3 TGFBR2 TGFBR2 NKD2 NKD2 BMP2 BMP2 APC APC PPP2R2A PPP2R2A SAV1 SAV1 FRMD6 FRMD6 LOC103001360 LOC103001360 CTNNA2 CTNNA2 YWHAB YWHAB FZD3 FZD3 BMP4 BMP4 GDF5 GDF5 ID1 ID1 CTNNB1 CTNNB1 MOB1B MOB1B WNT11 WNT11 PPP2R2B PPP2R2B FGF1 FGF1 CRB2 CRB2 WNT2 WNT2 SOX2 SOX2 DVL3 DVL3 YWHAQ YWHAQ ID2 ID2 LOC103000722 LOC103000722 FZD1 FZD1 TGFBR1 TGFBR1 LATS1 LATS1 LOC103020685 LOC103020685 SMAD2 SMAD2 SMAD4 SMAD4 SMAD7 SMAD7 PRKCI PRKCI LOC102999370 LOC102999370 CCND3 CCND3 PARD6A PARD6A APC2 APC2 FZD10 FZD10 FZD4 FZD4 TGFB1 TGFB1 NF2 NF2 DLG1 DLG1 LOC103010763 LOC103010763 LOC103016619 LOC103016619 LOC103011078 LOC103011078 DLG3 DLG3 LLGL2 LLGL2 DVL1 DVL1 PRKCZ PRKCZ PARD3 PARD3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
LATS2Serine/threonine-protein kinase LATS2. (795 aa)
PATJinaD-like protein isoform X1. (1903 aa)
LOC103015222Bone morphogenetic protein 8B. (390 aa)
WTIPWilms tumor protein 1-interacting protein isoform X1. (189 aa)
GDF6Growth/differentiation factor 6. (375 aa)
STK3Serine/threonine-protein kinase 3. (487 aa)
SMAD3Mothers against decapentaplegic homolog. (425 aa)
TP73Tumor protein p73; Participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73 isoforms. May be a tumor suppressor protein. (640 aa)
DLG4Disks large homolog 4 isoform X1; Belongs to the MAGUK family. (754 aa)
DLG5Disks large homolog 5; Belongs to the MAGUK family. (1902 aa)
DVL2Segment polarity protein dishevelled homolog DVL-2. (734 aa)
LOC103014954Bone morphogenetic protein 8A-like. (279 aa)
SCRIBLOW QUALITY PROTEIN: protein scribble homolog. (1610 aa)
TP53BP2Apoptosis-stimulating of p53 protein 2. (1136 aa)
CRB1Protein crumbs homolog 1 isoform X1. (1417 aa)
NKD1Protein naked cuticle homolog 1. (623 aa)
CTNNA3Catenin alpha-3 isoform X1. (944 aa)
TEAD2Transcriptional enhancer factor TEF-4 isoform X1. (451 aa)
SNAI2Zinc finger protein SNAI2. (268 aa)
BBC3Bcl-2-binding component 3. (140 aa)
DLG2Disks large homolog 2 isoform X8. (957 aa)
LIMD1LIM domain-containing protein 1. (188 aa)
RASSF1Ras association domain-containing protein 1. (295 aa)
WNT2BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (394 aa)
WNT3AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (352 aa)
CCND2G1/S-specific cyclin-D2; Belongs to the cyclin family. (289 aa)
WNT9AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (455 aa)
TEAD4Transcriptional enhancer factor TEF-3. (580 aa)
YWHAH14-3-3 protein eta; Belongs to the 14-3-3 family. (218 aa)
CCND1G1/S-specific cyclin-D1 isoform X1; Belongs to the cyclin family. (214 aa)
FBXW11F-box/WD repeat-containing protein 11 isoform X1. (563 aa)
WWC1Protein KIBRA. (1020 aa)
PPP1CASerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (363 aa)
PPP2CASerine/threonine-protein phosphatase. (309 aa)
CTNNA1Catenin alpha-1. (906 aa)
WNT8AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (352 aa)
ITGB2Integrin beta. (718 aa)
PPP2R1BSerine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform isoform X4. (666 aa)
PARD6GPartitioning defective 6 homolog gamma. (371 aa)
PPP2R2CSerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (447 aa)
TCF7L2Transcription factor 7-like 2 isoform X1. (515 aa)
PPP2R2DSerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (288 aa)
FZD6Frizzled-6 isoform X1; Belongs to the G-protein coupled receptor Fz/Smo family. (712 aa)
YWHAZ14-3-3 protein zeta/delta; Belongs to the 14-3-3 family. (245 aa)
BMP6Bone morphogenetic protein 6. (388 aa)
LLGL1Lethal(2) giant larvae protein homolog 1. (1107 aa)
PPP2CBSerine/threonine-protein phosphatase. (244 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
WNT4Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (296 aa)
TEAD1Transcriptional enhancer factor TEF-1. (509 aa)
TCF7L1Transcription factor 7-like 1 isoform X1. (439 aa)
WNT9BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (358 aa)
WNT3Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (355 aa)
WNT16Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (361 aa)
WNT10BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (389 aa)
WNT1Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa)
RASSF6Ras association domain-containing protein 6. (337 aa)
PPP2R1ASerine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform. (589 aa)
AREGAmphiregulin isoform X1. (254 aa)
LOC103009326Alpha-fetoprotein. (610 aa)
FZD2Frizzled-2; Belongs to the G-protein coupled receptor Fz/Smo family. (565 aa)
AJUBALIM domain-containing protein ajuba isoform X1. (557 aa)
GLI2Zinc finger protein GLI2. (1411 aa)
GSK3BGlycogen synthase kinase-3 beta isoform X1; Belongs to the protein kinase superfamily. (433 aa)
AMOTAngiomotin. (951 aa)
YWHAE14-3-3 protein epsilon isoform X1; Belongs to the 14-3-3 family. (255 aa)
BMPR1BSerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (502 aa)
MPP5MAGUK p55 subfamily member 5 isoform X1; Belongs to the MAGUK family. (675 aa)
TGFB3Transforming growth factor beta-3 proprotein. (456 aa)
BMP7Bone morphogenetic protein 7. (431 aa)
PARD6BPartitioning defective 6 homolog beta. (372 aa)
BIRC5Baculoviral IAP repeat-containing protein 5. (143 aa)
ACTG1Actin, cytoplasmic 2. (375 aa)
CSNK1DCasein kinase I isoform X1. (371 aa)
AXIN2Axin-2. (543 aa)
SERPINE1Plasminogen activator inhibitor 1; Belongs to the serpin family. (402 aa)
ACTBActin, cytoplasmic 1. (375 aa)
FZD9Frizzled-9; Belongs to the G-protein coupled receptor Fz/Smo family. (408 aa)
BMP5Bone morphogenetic protein 5. (454 aa)
YWHAG14-3-3 protein gamma; Belongs to the 14-3-3 family. (225 aa)
BTRCF-box/WD repeat-containing protein 1A isoform X1. (611 aa)
WNT8BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (336 aa)
WWTR1WW domain-containing transcription regulator protein 1. (400 aa)
WNT10AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (417 aa)
LOC10301032214-3-3 protein beta/alpha-like isoform X1; Belongs to the 14-3-3 family. (250 aa)
MYCMyc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (438 aa)
MOB1AMOB kinase activator 1A. (216 aa)
LOC103005963Casein kinase I isoform X3; Belongs to the protein kinase superfamily. (416 aa)
WNT7BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (535 aa)
SMAD1Mothers against decapentaplegic homolog. (465 aa)
PPP1CCSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (337 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1038 aa)
FZD7Frizzled-7; Belongs to the G-protein coupled receptor Fz/Smo family. (570 aa)
LEF1Lymphoid enhancer-binding factor 1 isoform X1. (399 aa)
CCN2Connective tissue growth factor. (268 aa)
BIRC2Baculoviral IAP repeat-containing protein 2. (620 aa)
YAP1Transcriptional coactivator YAP1. (332 aa)
PPP1CBSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (327 aa)
BIRC3Baculoviral IAP repeat-containing protein 3. (604 aa)
TGFBR2Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (543 aa)
NKD2Protein naked cuticle homolog 2. (542 aa)
BMP2Bone morphogenetic protein 2. (395 aa)
APCAdenomatous polyposis coli protein isoform X1. (2865 aa)
PPP2R2ASerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (447 aa)
SAV1Protein salvador homolog 1. (351 aa)
FRMD6FERM domain-containing protein 6 isoform X1. (622 aa)
LOC103001360Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (204 aa)
CTNNA2Catenin alpha-2 isoform X1. (969 aa)
YWHAB14-3-3 protein beta/alpha isoform X1; Belongs to the 14-3-3 family. (246 aa)
FZD3Frizzled-3; Belongs to the G-protein coupled receptor Fz/Smo family. (666 aa)
BMP4Bone morphogenetic protein 4 isoform X1. (420 aa)
GDF5Growth/differentiation factor 5. (511 aa)
ID1DNA-binding protein inhibitor ID-1. (87 aa)
CTNNB1Catenin beta-1. (767 aa)
MOB1BMOB kinase activator 1B. (216 aa)
WNT11Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
PPP2R2BSerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (501 aa)
FGF1Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (189 aa)
CRB2Protein crumbs homolog 2. (1075 aa)
WNT2Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (360 aa)
SOX2Transcription factor SOX-2. (273 aa)
DVL3Segment polarity protein dishevelled homolog DVL-3. (719 aa)
YWHAQ14-3-3 protein theta; Belongs to the 14-3-3 family. (245 aa)
ID2DNA-binding protein inhibitor ID-2. (134 aa)
LOC103000722Bone morphogenetic protein 8A-like. (220 aa)
FZD1Frizzled-1; Belongs to the G-protein coupled receptor Fz/Smo family. (565 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (434 aa)
LATS1Serine/threonine-protein kinase LATS1. (1127 aa)
LOC103020685Bone morphogenetic protein 8B-like. (201 aa)
SMAD2Mothers against decapentaplegic homolog. (467 aa)
SMAD4Mothers against decapentaplegic homolog. (553 aa)
SMAD7Mothers against decapentaplegic homolog. (426 aa)
PRKCIProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (597 aa)
LOC102999370Cadherin-1; Cadherins are calcium-dependent cell adhesion proteins. (887 aa)
CCND3G1/S-specific cyclin-D3 isoform X1; Belongs to the cyclin family. (292 aa)
PARD6APartitioning defective 6 homolog alpha. (345 aa)
APC2LOW QUALITY PROTEIN: adenomatous polyposis coli protein 2. (1582 aa)
FZD10LOW QUALITY PROTEIN: frizzled-10; Belongs to the G-protein coupled receptor Fz/Smo family. (578 aa)
FZD4LOW QUALITY PROTEIN: frizzled-4; Belongs to the G-protein coupled receptor Fz/Smo family. (548 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (407 aa)
NF2Merlin isoform X4. (619 aa)
DLG1Disks large homolog 1 isoform X8; Belongs to the MAGUK family. (927 aa)
LOC103010763Splicing factor 3A subunit 2. (677 aa)
LOC103016619Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (253 aa)
LOC10301107814-3-3 protein gamma-A-like; Belongs to the 14-3-3 family. (149 aa)
DLG3Disks large homolog 3 isoform X1; Belongs to the MAGUK family. (625 aa)
LLGL2Lethal(2) giant larvae protein homolog 2 isoform X1. (1049 aa)
DVL1LOW QUALITY PROTEIN: segment polarity protein dishevelled homolog DVL-1. (681 aa)
PRKCZProtein kinase C zeta type isoform X1; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (518 aa)
PARD3Partitioning defective 3 homolog isoform X9. (1221 aa)
Your Current Organism:
Balaenoptera acutorostrata
NCBI taxonomy Id: 310752
Other names: B. acutorostrata scammoni, Balaenoptera acutorostrata scammoni
Server load: low (24%) [HD]