STRINGSTRING
KCNQ4 KCNQ4 PLCB4 PLCB4 PLCB1 PLCB1 MAP2K1 MAP2K1 GNB1 GNB1 PIK3R6 PIK3R6 PIK3R5 PIK3R5 KCNQ5 KCNQ5 GNAO1 GNAO1 ADCY7 ADCY7 KCNJ14 KCNJ14 GNG8 GNG8 GNAI2 GNAI2 CREB3L3 CREB3L3 NRAS NRAS GNAI3 GNAI3 PIK3CD PIK3CD GNB3 GNB3 PIK3CB PIK3CB CHRM3 CHRM3 GNG4 GNG4 HRAS HRAS KCNQ1 KCNQ1 PRKACB PRKACB CHRNA7 CHRNA7 PLCB3 PLCB3 CHRM1 CHRM1 KCNJ12 KCNJ12 CACNA1D CACNA1D ADCY5 ADCY5 PIK3R1 PIK3R1 AKT1 AKT1 GNG7 GNG7 GNA11 GNA11 CHRM2 CHRM2 CREB3L2 CREB3L2 CHRNB2 CHRNB2 CREB3L4 CREB3L4 CHAT CHAT ADCY6 ADCY6 AKT2 AKT2 CHRM5 CHRM5 ADCY4 ADCY4 PLCB2 PLCB2 PIK3CG PIK3CG CREB3L1 CREB3L1 CHRM4 CHRM4 PRKCG PRKCG ADCY9 ADCY9 GNG13 GNG13 PRKACA PRKACA JAK2 JAK2 LOC103018216 LOC103018216 CACNA1F CACNA1F AKT3 AKT3 KCNJ3 KCNJ3 KCNJ6 KCNJ6 FOS FOS KCNQ2 KCNQ2 PRKCA PRKCA KCNJ2 KCNJ2 PRKCB PRKCB MAPK3 MAPK3 GNB2 GNB2 ACHE ACHE ITPR3 ITPR3 GNAI1 GNAI1 SLC5A7 SLC5A7 ADCY1 ADCY1 CAMK2A CAMK2A ADCY8 ADCY8 KCNJ4 KCNJ4 ATF4 ATF4 KCNQ3 KCNQ3 FYN FYN ADCY3 ADCY3 ADCY2 ADCY2 BCL2 BCL2 CAMK4 CAMK4 ITPR1 ITPR1 GNG2 GNG2 CREB5 CREB5 KRAS KRAS ITPR2 ITPR2 GNB5 GNB5 GNB4 GNB4 PIK3R2 PIK3R2 GNGT1 GNGT1 GNG11 GNG11 MAPK1 MAPK1 CREB3 CREB3 CHRNA6 CHRNA6 SLC18A3 SLC18A3 PIK3CA PIK3CA CREB1 CREB1 CACNA1S CACNA1S LOC103008077 LOC103008077 CHRNA3 CHRNA3 CACNA1C CACNA1C CACNA1A CACNA1A CACNA1B CACNA1B CAMK2B CAMK2B
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
KCNQ4Potassium voltage-gated channel subfamily KQT member 4; Belongs to the potassium channel family. (636 aa)
PLCB41-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1258 aa)
PLCB11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1115 aa)
MAP2K1Dual specificity mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
GNB1Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1. (296 aa)
PIK3R6Phosphoinositide 3-kinase regulatory subunit 6. (754 aa)
PIK3R5Phosphoinositide 3-kinase regulatory subunit 5. (882 aa)
KCNQ5Potassium voltage-gated channel subfamily KQT member 5; Belongs to the potassium channel family. (675 aa)
GNAO1Guanine nucleotide-binding protein G(O) subunit alpha. (302 aa)
ADCY7Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1078 aa)
KCNJ14ATP-sensitive inward rectifier potassium channel 14. (434 aa)
GNG8Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (80 aa)
GNAI2Guanine nucleotide-binding protein G(I) subunit alpha-2. (303 aa)
CREB3L3Cyclic AMP-responsive element-binding protein 3-like protein 3. (457 aa)
NRASGTPase NRas. (189 aa)
GNAI3Guanine nucleotide-binding protein G(K) subunit alpha. (354 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1042 aa)
GNB3Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 isoform X1. (340 aa)
PIK3CBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform; Belongs to the PI3/PI4-kinase family. (1070 aa)
CHRM3Muscarinic acetylcholine receptor; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. (590 aa)
GNG4Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (75 aa)
HRASGTPase HRas isoform X1. (196 aa)
KCNQ1Potassium voltage-gated channel subfamily KQT member 1; Belongs to the potassium channel family. (599 aa)
PRKACBcAMP-dependent protein kinase catalytic subunit beta isoform X1; Belongs to the protein kinase superfamily. (397 aa)
CHRNA7Neuronal acetylcholine receptor subunit alpha-7. (424 aa)
PLCB31-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1230 aa)
CHRM1Muscarinic acetylcholine receptor; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. (460 aa)
KCNJ12ATP-sensitive inward rectifier potassium channel 12. (427 aa)
CACNA1DVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2183 aa)
ADCY5Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1018 aa)
PIK3R1Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1. (724 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (476 aa)
GNG7Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa)
GNA11Guanine nucleotide-binding protein subunit alpha-11. (301 aa)
CHRM2Muscarinic acetylcholine receptor; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. (466 aa)
CREB3L2Cyclic AMP-responsive element-binding protein 3-like protein 2. (520 aa)
CHRNB2Neuronal acetylcholine receptor subunit beta-2. (446 aa)
CREB3L4Cyclic AMP-responsive element-binding protein 3-like protein 4 isoform X1. (395 aa)
CHATCholine O-acetyltransferase; Belongs to the carnitine/choline acetyltransferase family. (641 aa)
ADCY6Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1220 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
CHRM5Muscarinic acetylcholine receptor; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. (532 aa)
ADCY4Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1109 aa)
PLCB21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1131 aa)
PIK3CGLOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform; Belongs to the PI3/PI4-kinase family. (1101 aa)
CREB3L1Cyclic AMP-responsive element-binding protein 3-like protein 1. (520 aa)
CHRM4Muscarinic acetylcholine receptor; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. (478 aa)
PRKCGProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (697 aa)
ADCY9Adenylate cyclase type 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1353 aa)
GNG13Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13. (67 aa)
PRKACAcAMP-dependent protein kinase catalytic subunit alpha. (293 aa)
JAK2Tyrosine-protein kinase. (1132 aa)
LOC103018216Guanine nucleotide-binding protein G(Q) subunit alpha. (301 aa)
CACNA1FVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (1975 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (431 aa)
KCNJ3G protein-activated inward rectifier potassium channel 1 isoform X1. (501 aa)
KCNJ6G protein-activated inward rectifier potassium channel 2. (502 aa)
FOSProto-oncogene c-Fos. (380 aa)
KCNQ2Potassium voltage-gated channel subfamily KQT member 2; Belongs to the potassium channel family. (898 aa)
PRKCANon-specific serine/threonine protein kinase. (559 aa)
KCNJ2Inward rectifier potassium channel 2. (427 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (671 aa)
MAPK3Mitogen-activated protein kinase 3. (265 aa)
GNB2Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2. (340 aa)
ACHECarboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family. (615 aa)
ITPR3LOW QUALITY PROTEIN: inositol 1,4,5-trisphosphate receptor type 3. (2666 aa)
GNAI1Guanine nucleotide-binding protein G(I) subunit alpha-1. (354 aa)
SLC5A7High affinity choline transporter 1; Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family. (593 aa)
ADCY1Adenylate cyclase type 1 isoform X1. (907 aa)
CAMK2ACalcium/calmodulin-dependent protein kinase type II subunit alpha isoform X1; Belongs to the protein kinase superfamily. (489 aa)
ADCY8Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1248 aa)
KCNJ4Inward rectifier potassium channel 4. (445 aa)
ATF4Cyclic AMP-dependent transcription factor ATF-4. (352 aa)
KCNQ3Potassium voltage-gated channel subfamily KQT member 3; Belongs to the potassium channel family. (673 aa)
FYNTyrosine-protein kinase. (537 aa)
ADCY3Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1200 aa)
ADCY2Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (972 aa)
BCL2Apoptosis regulator Bcl-2 isoform X1. (233 aa)
CAMK4Calcium/calmodulin-dependent protein kinase type IV isoform X1; Belongs to the protein kinase superfamily. (473 aa)
ITPR1Inositol 1,4,5-trisphosphate receptor type 1 isoform X1. (2749 aa)
GNG2Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (71 aa)
CREB5Cyclic AMP-responsive element-binding protein 5 isoform X1. (502 aa)
KRASGTPase KRas isoform X3. (227 aa)
ITPR2Inositol 1,4,5-trisphosphate receptor type 2 isoform X1. (2701 aa)
GNB5Guanine nucleotide-binding protein subunit beta-5 isoform X1. (301 aa)
GNB4Guanine nucleotide-binding protein subunit beta-4. (340 aa)
PIK3R2Phosphatidylinositol 3-kinase regulatory subunit beta. (700 aa)
GNGT1Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (74 aa)
GNG11Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (73 aa)
MAPK1Mitogen-activated protein kinase 1. (263 aa)
CREB3Cyclic AMP-responsive element-binding protein 3 isoform X1. (371 aa)
CHRNA6LOW QUALITY PROTEIN: neuronal acetylcholine receptor subunit alpha-6. (494 aa)
SLC18A3LOW QUALITY PROTEIN: vesicular acetylcholine transporter. (527 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
CREB1Cyclic AMP-responsive element-binding protein 1 isoform X1. (341 aa)
CACNA1SVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (1864 aa)
LOC103008077Phosphatidylinositol 3-kinase regulatory subunit gamma. (484 aa)
CHRNA3Neuronal acetylcholine receptor subunit alpha-3. (438 aa)
CACNA1CVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2273 aa)
CACNA1AVoltage-dependent P/Q-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1A gives rise to P and/or Q- type calcium currents. (2185 aa)
CACNA1BVoltage-dependent N-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1B gives rise to N-type calcium currents. (2153 aa)
CAMK2BCalcium/calmodulin-dependent protein kinase type II subunit beta isoform X1. (501 aa)
Your Current Organism:
Balaenoptera acutorostrata
NCBI taxonomy Id: 310752
Other names: B. acutorostrata scammoni, Balaenoptera acutorostrata scammoni
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