STRINGSTRING
PRKAA2 PRKAA2 MKNK1 MKNK1 PTPRF PTPRF RHEB RHEB PRKAG2 PRKAG2 SOCS2 SOCS2 CALML4 CALML4 MAP2K1 MAP2K1 SLC2A4 SLC2A4 IRS1 IRS1 SOS1 SOS1 PHKB PHKB HKDC1 HKDC1 GYS1 GYS1 PRKAR2A PRKAR2A INSR INSR TRIP10 TRIP10 NRAS NRAS MAP2K2 MAP2K2 EIF4E1B EIF4E1B PIK3CD PIK3CD EIF4EBP1 EIF4EBP1 MTOR MTOR PIK3CB PIK3CB SHC4 SHC4 INS INS HRAS HRAS RPS6KB2 RPS6KB2 PPP1CA PPP1CA PKLR PKLR PRKACB PRKACB INPP5A INPP5A PPP1R3B PPP1R3B BAD BAD SREBF1 SREBF1 PYGM PYGM PHKA2 PHKA2 PDE3B PDE3B PIK3R1 PIK3R1 AKT1 AKT1 MKNK2 MKNK2 SHC2 SHC2 FBP1 FBP1 RPS6 RPS6 FBP2 FBP2 MAPK10 MAPK10 LOC103002194 LOC103002194 LOC103010774 LOC103010774 SHC1 SHC1 MAPK8 MAPK8 PRKAG1 PRKAG1 AKT2 AKT2 LOC103020229 LOC103020229 G6PC3 G6PC3 ARAF ARAF ELK1 ELK1 PCK2 PCK2 PRKAR2B PRKAR2B PDPK1 PDPK1 GSK3B GSK3B PRKACA PRKACA PRKAB2 PRKAB2 AKT3 AKT3 PPP1R3F PPP1R3F G6PC2 G6PC2 CRK CRK FLOT2 FLOT2 EIF4E EIF4E HK2 HK2 EIF4E2 EIF4E2 PTPN1 PTPN1 PPP1R3D PPP1R3D PRKAR1A PRKAR1A EXOC7 EXOC7 GRB2 GRB2 SOCS3 SOCS3 RPTOR RPTOR LOC103017465 LOC103017465 PHKG2 PHKG2 MAPK3 MAPK3 PHKG1 PHKG1 LOC103005013 LOC103005013 CBLB CBLB PHKA1 PHKA1 SORBS1 SORBS1 PPP1R3C PPP1R3C PPARGC1A PPARGC1A GCK GCK SOCS1 SOCS1 PRKAB1 PRKAB1 PPP1CC PPP1CC CALM2 CALM2 RHOQ RHOQ ACACA ACACA RPS6KB1 RPS6KB1 PPP1CB PPP1CB PYGB PYGB PRKAA1 PRKAA1 RAF1 RAF1 SOS2 SOS2 PYGL PYGL SOCS4 SOCS4 FOXO1 FOXO1 FLOT1 FLOT1 TSC1 TSC1 KRAS KRAS GYS2 GYS2 PPP1R3A PPP1R3A PIK3R2 PIK3R2 CRKL CRKL MAPK1 MAPK1 IRS2 IRS2 PRKCI PRKCI IRS4 IRS4 INPPL1 INPPL1 PIK3CA PIK3CA SHC3 SHC3 RAPGEF1 RAPGEF1 CBL CBL HK1 HK1 LOC103008077 LOC103008077 LIPE LIPE PRKAR1B PRKAR1B TSC2 TSC2 PCK1 PCK1 PRKCZ PRKCZ PRKAG3 PRKAG3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PRKAA2Non-specific serine/threonine protein kinase. (524 aa)
MKNK1MAP kinase-interacting serine/threonine-protein kinase 1 isoform X1; Belongs to the protein kinase superfamily. (459 aa)
PTPRFReceptor-type tyrosine-protein phosphatase F. (1906 aa)
RHEBGTP-binding protein Rheb. (179 aa)
PRKAG25'-AMP-activated protein kinase subunit gamma-2 isoform X1. (566 aa)
SOCS2Suppressor of cytokine signaling 2. (198 aa)
CALML4Calmodulin-like protein 4. (153 aa)
MAP2K1Dual specificity mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
SLC2A4Solute carrier family 2, facilitated glucose transporter member 4 isoform X1; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (550 aa)
IRS1Insulin receptor substrate 1. (1244 aa)
SOS1Son of sevenless homolog 1 isoform X1. (1001 aa)
PHKBPhosphorylase b kinase regulatory subunit; Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I. Belongs to the phosphorylase b kinase regulatory chain family. (1090 aa)
HKDC1Putative hexokinase HKDC1 isoform X1. (918 aa)
GYS1Glycogen [starch] synthase; Transfers the glycosyl residue from UDP-Glc to the non- reducing end of alpha-1,4-glucan. (737 aa)
PRKAR2AcAMP-dependent protein kinase type II-alpha regulatory subunit. (365 aa)
INSRTyrosine-protein kinase receptor. (1343 aa)
TRIP10Cdc42-interacting protein 4 isoform X1. (603 aa)
NRASGTPase NRas. (189 aa)
MAP2K2Dual specificity mitogen-activated protein kinase kinase 2. (303 aa)
EIF4E1BEukaryotic translation initiation factor 4E type 1B; Belongs to the eukaryotic initiation factor 4E family. (238 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1042 aa)
EIF4EBP1Eukaryotic translation initiation factor 4E-binding protein 1. (118 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2546 aa)
PIK3CBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform; Belongs to the PI3/PI4-kinase family. (1070 aa)
SHC4SHC-transforming protein 4 isoform X1. (630 aa)
INSInsulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (112 aa)
HRASGTPase HRas isoform X1. (196 aa)
RPS6KB2Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (590 aa)
PPP1CASerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (363 aa)
PKLRPyruvate kinase; Belongs to the pyruvate kinase family. (543 aa)
PRKACBcAMP-dependent protein kinase catalytic subunit beta isoform X1; Belongs to the protein kinase superfamily. (397 aa)
INPP5AType I inositol 1,4,5-trisphosphate 5-phosphatase isoform X3. (412 aa)
PPP1R3BProtein phosphatase 1 regulatory subunit. (297 aa)
BADBcl2-associated agonist of cell death. (168 aa)
SREBF1LOW QUALITY PROTEIN: sterol regulatory element-binding protein 1. (1119 aa)
PYGMAlpha-1,4 glucan phosphorylase; Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties. (842 aa)
PHKA2Phosphorylase b kinase regulatory subunit; Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I. (1236 aa)
PDE3BPhosphodiesterase. (1085 aa)
PIK3R1Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1. (724 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (476 aa)
MKNK2MAP kinase-interacting serine/threonine-protein kinase 2 isoform X1; Belongs to the protein kinase superfamily. (463 aa)
SHC2SHC-transforming protein 2. (426 aa)
FBP1Fructose-1,6-bisphosphatase 1; Belongs to the FBPase class 1 family. (338 aa)
RPS640S ribosomal protein S6; Belongs to the eukaryotic ribosomal protein eS6 family. (247 aa)
FBP2Fructose-1,6-bisphosphatase isozyme 2; Belongs to the FBPase class 1 family. (340 aa)
MAPK10Mitogen-activated protein kinase. (464 aa)
LOC103002194Glucose-6-phosphatase-like. (366 aa)
LOC103010774Glucose-6-phosphatase; Belongs to the glucose-6-phosphatase family. (357 aa)
SHC1SHC-transforming protein 1 isoform X1. (584 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
PRKAG15'-AMP-activated protein kinase subunit gamma-1 isoform X1. (336 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
LOC103020229acetyl-CoA carboxylase 2 isoform X1. (2648 aa)
G6PC3Glucose-6-phosphatase; Belongs to the glucose-6-phosphatase family. (346 aa)
ARAFSerine/threonine-protein kinase A-Raf isoform X1. (611 aa)
ELK1ETS domain-containing protein Elk-1. (437 aa)
PCK2Phosphoenolpyruvate carboxykinase [GTP], mitochondrial. (640 aa)
PRKAR2BcAMP-dependent protein kinase type II-beta regulatory subunit. (431 aa)
PDPK13-phosphoinositide-dependent protein kinase 1 isoform X1. (531 aa)
GSK3BGlycogen synthase kinase-3 beta isoform X1; Belongs to the protein kinase superfamily. (433 aa)
PRKACAcAMP-dependent protein kinase catalytic subunit alpha. (293 aa)
PRKAB25'-AMP-activated protein kinase subunit beta-2. (272 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (431 aa)
PPP1R3FProtein phosphatase 1 regulatory subunit 3F isoform X1. (484 aa)
G6PC2Glucose-6-phosphatase; Belongs to the glucose-6-phosphatase family. (355 aa)
CRKAdapter molecule crk isoform X1. (304 aa)
FLOT2Flotillin; Belongs to the band 7/mec-2 family. Flotillin subfamily. (379 aa)
EIF4EEukaryotic translation initiation factor 4E; Belongs to the eukaryotic initiation factor 4E family. (217 aa)
HK2Hexokinase-2 isoform X1. (1002 aa)
EIF4E2Eukaryotic translation initiation factor 4E type 2 isoform X1; Belongs to the eukaryotic initiation factor 4E family. (240 aa)
PTPN1Tyrosine-protein phosphatase non-receptor type. (424 aa)
PPP1R3DProtein phosphatase 1 regulatory subunit 3D. (195 aa)
PRKAR1AcAMP-dependent protein kinase type I-alpha regulatory subunit. (380 aa)
EXOC7Exocyst complex component 7; Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. (707 aa)
GRB2Growth factor receptor-bound protein 2. (217 aa)
SOCS3Suppressor of cytokine signaling 3. (238 aa)
RPTORRegulatory-associated protein of mTOR isoform X1. (1351 aa)
LOC103017465Fatty acid synthase-like isoform X1. (3457 aa)
PHKG2Phosphorylase b kinase gamma catalytic chain, liver/testis isoform isoform X1; Belongs to the protein kinase superfamily. (406 aa)
MAPK3Mitogen-activated protein kinase 3. (265 aa)
PHKG1Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform; Belongs to the protein kinase superfamily. (387 aa)
LOC103005013Insulin receptor substrate 1-like. (572 aa)
CBLBE3 ubiquitin-protein ligase CBL-B isoform X1. (983 aa)
PHKA1Phosphorylase b kinase regulatory subunit; Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I. (1223 aa)
SORBS1Sorbin and SH3 domain-containing protein 1 isoform X1. (1551 aa)
PPP1R3CProtein phosphatase 1 regulatory subunit 3C; Acts as a glycogen-targeting subunit for PP1 and regulates its activity. Activates glycogen synthase, reduces glycogen phosphorylase activity and limits glycogen breakdown. (317 aa)
PPARGC1APeroxisome proliferator-activated receptor gamma coactivator 1-alpha isoform X1. (803 aa)
GCKPhosphotransferase. (482 aa)
SOCS1Suppressor of cytokine signaling 1. (215 aa)
PRKAB15'-AMP-activated protein kinase subunit beta-1. (270 aa)
PPP1CCSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (337 aa)
CALM2Calmodulin-1; Belongs to the calmodulin family. (149 aa)
RHOQRho-related GTP-binding protein RhoQ. (205 aa)
ACACAacetyl-CoA carboxylase 1 isoform X1. (2383 aa)
RPS6KB1Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (525 aa)
PPP1CBSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (327 aa)
PYGBAlpha-1,4 glucan phosphorylase; Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties. (842 aa)
PRKAA1Non-specific serine/threonine protein kinase. (458 aa)
RAF1RAF proto-oncogene serine/threonine-protein kinase isoform X1. (668 aa)
SOS2Son of sevenless homolog 2 isoform X1. (1272 aa)
PYGLAlpha-1,4 glucan phosphorylase; Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties. (854 aa)
SOCS4Suppressor of cytokine signaling 4. (440 aa)
FOXO1Forkhead box protein O1. (518 aa)
FLOT1Flotillin; Belongs to the band 7/mec-2 family. Flotillin subfamily. (427 aa)
TSC1Hamartin. (1155 aa)
KRASGTPase KRas isoform X3. (227 aa)
GYS2Glycogen [starch] synthase; Transfers the glycosyl residue from UDP-Glc to the non- reducing end of alpha-1,4-glucan. (700 aa)
PPP1R3AProtein phosphatase 1 regulatory subunit 3A. (1117 aa)
PIK3R2Phosphatidylinositol 3-kinase regulatory subunit beta. (700 aa)
CRKLCrk-like protein. (303 aa)
MAPK1Mitogen-activated protein kinase 1. (263 aa)
IRS2Insulin receptor substrate 2. (507 aa)
PRKCIProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (597 aa)
IRS4LOW QUALITY PROTEIN: insulin receptor substrate 4. (1043 aa)
INPPL1LOW QUALITY PROTEIN: phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2. (1174 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
SHC3SHC-transforming protein 3 isoform X1. (430 aa)
RAPGEF1Rap guanine nucleotide exchange factor 1 isoform X1. (1238 aa)
CBLE3 ubiquitin-protein ligase CBL. (898 aa)
HK1Hexokinase-1 isoform X1. (889 aa)
LOC103008077Phosphatidylinositol 3-kinase regulatory subunit gamma. (484 aa)
LIPELOW QUALITY PROTEIN: hormone-sensitive lipase. (1040 aa)
PRKAR1BcAMP-dependent protein kinase type I-beta regulatory subunit. (390 aa)
TSC2LOW QUALITY PROTEIN: tuberin. (1815 aa)
PCK1Phosphoenolpyruvate carboxykinase, cytosolic [GTP]. (622 aa)
PRKCZProtein kinase C zeta type isoform X1; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (518 aa)
PRKAG35'-AMP-activated protein kinase subunit gamma-3 isoform X1. (478 aa)
Your Current Organism:
Balaenoptera acutorostrata
NCBI taxonomy Id: 310752
Other names: B. acutorostrata scammoni, Balaenoptera acutorostrata scammoni
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