STRINGSTRING
PDX1 PDX1 SLC2A1 SLC2A1 FFAR1 FFAR1 PLCB4 PLCB4 PLCB1 PLCB1 ATP1B2 ATP1B2 KCNMA1 KCNMA1 VAMP2 VAMP2 ADCY7 ADCY7 KCNN4 KCNN4 TRPM4 TRPM4 CCKAR CCKAR CREB3L3 CREB3L3 ATP1A1 ATP1A1 KCNU1 KCNU1 CHRM3 CHRM3 RYR2 RYR2 INS INS KCNMB1 KCNMB1 LOC103005600 LOC103005600 ATP1B1 ATP1B1 PRKACB PRKACB PLCB3 PLCB3 CACNA1D CACNA1D KCNJ11 KCNJ11 ABCC8 ABCC8 ADCY5 ADCY5 GIP GIP GNA11 GNA11 CREB3L2 CREB3L2 KCNN3 KCNN3 ATP1B4 ATP1B4 CREB3L4 CREB3L4 ADCY6 ADCY6 ADCY4 ADCY4 PLCB2 PLCB2 CREB3L1 CREB3L1 PRKCG PRKCG ADCY9 ADCY9 PRKACA PRKACA KCNMB2 KCNMB2 LOC103018216 LOC103018216 CACNA1F CACNA1F GCG GCG RAPGEF4 RAPGEF4 LOC103004158 LOC103004158 PRKCA PRKCA PRKCB PRKCB STX1A STX1A ITPR3 ITPR3 GCK GCK ADCY1 ADCY1 GPR119 GPR119 CAMK2A CAMK2A ADCY8 ADCY8 ATF4 ATF4 ATF2 ATF2 ADCY3 ADCY3 ADCYAP1 ADCYAP1 ADCY2 ADCY2 KCNN2 KCNN2 CCK CCK CREB5 CREB5 ATF6B ATF6B KCNMB4 KCNMB4 KCNN1 KCNN1 RAB3A RAB3A FXYD2 FXYD2 CREB3 CREB3 SLC2A2 SLC2A2 GLP1R GLP1R ATP1B3 ATP1B3 KCNMB3 KCNMB3 CREB1 CREB1 CACNA1S CACNA1S ATP1A3 ATP1A3 PCLO PCLO LOC103005321 LOC103005321 RIMS2 RIMS2 ADCYAP1R1 ADCYAP1R1 CACNA1C CACNA1C GNAS GNAS CAMK2B CAMK2B
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
Your Input:
PDX1LOW QUALITY PROTEIN: pancreas/duodenum homeobox protein 1. (280 aa)
SLC2A1Solute carrier family 2, facilitated glucose transporter member 1; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (480 aa)
FFAR1Free fatty acid receptor 1. (300 aa)
PLCB41-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1258 aa)
PLCB11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1115 aa)
ATP1B2Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (290 aa)
KCNMA1Calcium-activated potassium channel subunit alpha-1 isoform X11. (1230 aa)
VAMP2Vesicle-associated membrane protein 2. (164 aa)
ADCY7Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1078 aa)
KCNN4Intermediate conductance calcium-activated potassium channel protein 4. (428 aa)
TRPM4Transient receptor potential cation channel subfamily M member 4 isoform X1. (1206 aa)
CCKARCholecystokinin receptor type A; Belongs to the G-protein coupled receptor 1 family. (427 aa)
CREB3L3Cyclic AMP-responsive element-binding protein 3-like protein 3. (457 aa)
ATP1A1Sodium/potassium-transporting ATPase subunit alpha. (1021 aa)
KCNU1Potassium channel subfamily U member 1. (1147 aa)
CHRM3Muscarinic acetylcholine receptor; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. (590 aa)
RYR2Ryanodine receptor 2 isoform X1. (4884 aa)
INSInsulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (112 aa)
KCNMB1Calcium-activated potassium channel subunit beta-1. (197 aa)
LOC103005600Sodium/potassium-transporting ATPase subunit alpha. (1020 aa)
ATP1B1Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (303 aa)
PRKACBcAMP-dependent protein kinase catalytic subunit beta isoform X1; Belongs to the protein kinase superfamily. (397 aa)
PLCB31-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1230 aa)
CACNA1DVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2183 aa)
KCNJ11ATP-sensitive inward rectifier potassium channel 11. (396 aa)
ABCC8ATP-binding cassette sub-family C member 8 isoform X1. (1584 aa)
ADCY5Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1018 aa)
GIPGastric inhibitory polypeptide. (144 aa)
GNA11Guanine nucleotide-binding protein subunit alpha-11. (301 aa)
CREB3L2Cyclic AMP-responsive element-binding protein 3-like protein 2. (520 aa)
KCNN3Small conductance calcium-activated potassium channel protein 3 isoform X1. (726 aa)
ATP1B4Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (357 aa)
CREB3L4Cyclic AMP-responsive element-binding protein 3-like protein 4 isoform X1. (395 aa)
ADCY6Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1220 aa)
ADCY4Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1109 aa)
PLCB21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1131 aa)
CREB3L1Cyclic AMP-responsive element-binding protein 3-like protein 1. (520 aa)
PRKCGProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (697 aa)
ADCY9Adenylate cyclase type 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1353 aa)
PRKACAcAMP-dependent protein kinase catalytic subunit alpha. (293 aa)
KCNMB2Calcium-activated potassium channel subunit beta-2. (235 aa)
LOC103018216Guanine nucleotide-binding protein G(Q) subunit alpha. (301 aa)
CACNA1FVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (1975 aa)
GCGGlucagon isoform X1. (180 aa)
RAPGEF4Rap guanine nucleotide exchange factor 4. (858 aa)
LOC103004158Neuroendocrine secretory protein 55-like. (244 aa)
PRKCANon-specific serine/threonine protein kinase. (559 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (671 aa)
STX1Asyntaxin-1A; Belongs to the syntaxin family. (259 aa)
ITPR3LOW QUALITY PROTEIN: inositol 1,4,5-trisphosphate receptor type 3. (2666 aa)
GCKPhosphotransferase. (482 aa)
ADCY1Adenylate cyclase type 1 isoform X1. (907 aa)
GPR119Glucose-dependent insulinotropic receptor; Belongs to the G-protein coupled receptor 1 family. (335 aa)
CAMK2ACalcium/calmodulin-dependent protein kinase type II subunit alpha isoform X1; Belongs to the protein kinase superfamily. (489 aa)
ADCY8Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1248 aa)
ATF4Cyclic AMP-dependent transcription factor ATF-4. (352 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2 isoform X1. (505 aa)
ADCY3Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1200 aa)
ADCYAP1Pituitary adenylate cyclase-activating polypeptide. (176 aa)
ADCY2Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (972 aa)
KCNN2LOW QUALITY PROTEIN: small conductance calcium-activated potassium channel protein 2. (856 aa)
CCKCholecystokinin. (115 aa)
CREB5Cyclic AMP-responsive element-binding protein 5 isoform X1. (502 aa)
ATF6BLOW QUALITY PROTEIN: cyclic AMP-dependent transcription factor ATF-6 beta. (700 aa)
KCNMB4Calcium-activated potassium channel subunit beta-4. (210 aa)
KCNN1Small conductance calcium-activated potassium channel protein 1 isoform X3. (546 aa)
RAB3ARas-related protein Rab-3A. (220 aa)
FXYD2FXYD domain-containing ion transport regulator; Belongs to the FXYD family. (102 aa)
CREB3Cyclic AMP-responsive element-binding protein 3 isoform X1. (371 aa)
SLC2A2Solute carrier family 2, facilitated glucose transporter member 2 isoform X1; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (524 aa)
GLP1RGlucagon-like peptide 1 receptor; Belongs to the G-protein coupled receptor 2 family. (446 aa)
ATP1B3Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (266 aa)
KCNMB3LOW QUALITY PROTEIN: calcium-activated potassium channel subunit beta-3. (188 aa)
CREB1Cyclic AMP-responsive element-binding protein 1 isoform X1. (341 aa)
CACNA1SVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (1864 aa)
ATP1A3Sodium/potassium-transporting ATPase subunit alpha. (1014 aa)
PCLOProtein piccolo. (4698 aa)
LOC103005321Sodium/potassium-transporting ATPase subunit alpha. (1028 aa)
RIMS2Regulating synaptic membrane exocytosis protein 2 isoform X1. (1406 aa)
ADCYAP1R1Pituitary adenylate cyclase-activating polypeptide type I receptor isoform X1; Belongs to the G-protein coupled receptor 2 family. (513 aa)
CACNA1CVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2273 aa)
GNASGuanine nucleotide-binding protein G(S) subunit alpha isoforms XLas isoform X1. (1007 aa)
CAMK2BCalcium/calmodulin-dependent protein kinase type II subunit beta isoform X1. (501 aa)
Your Current Organism:
Balaenoptera acutorostrata
NCBI taxonomy Id: 310752
Other names: B. acutorostrata scammoni, Balaenoptera acutorostrata scammoni
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