STRINGSTRING
PDX1 PDX1 SOCS2 SOCS2 SLC2A4 SLC2A4 IRS1 IRS1 HKDC1 HKDC1 INSR INSR PIK3CD PIK3CD MTOR MTOR PIK3CB PIK3CB INS INS PKLR PKLR PRKCD PRKCD CACNA1D CACNA1D KCNJ11 KCNJ11 ABCC8 ABCC8 PIK3R1 PIK3R1 CACNA1G CACNA1G MAPK10 MAPK10 MAPK8 MAPK8 HK2 HK2 SOCS3 SOCS3 MAPK3 MAPK3 LOC103005013 LOC103005013 GCK GCK SOCS1 SOCS1 PRKCE PRKCE SOCS4 SOCS4 TNF TNF ADIPOQ ADIPOQ PIK3R2 PIK3R2 MAPK1 MAPK1 IRS2 IRS2 SLC2A2 SLC2A2 PKM PKM IRS4 IRS4 PIK3CA PIK3CA HK1 HK1 LOC103008077 LOC103008077 CACNA1C CACNA1C CACNA1A CACNA1A CACNA1B CACNA1B PRKCZ PRKCZ CACNA1E CACNA1E
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PDX1LOW QUALITY PROTEIN: pancreas/duodenum homeobox protein 1. (280 aa)
SOCS2Suppressor of cytokine signaling 2. (198 aa)
SLC2A4Solute carrier family 2, facilitated glucose transporter member 4 isoform X1; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (550 aa)
IRS1Insulin receptor substrate 1. (1244 aa)
HKDC1Putative hexokinase HKDC1 isoform X1. (918 aa)
INSRTyrosine-protein kinase receptor. (1343 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1042 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2546 aa)
PIK3CBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform; Belongs to the PI3/PI4-kinase family. (1070 aa)
INSInsulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (112 aa)
PKLRPyruvate kinase; Belongs to the pyruvate kinase family. (543 aa)
PRKCDProtein kinase C delta type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti- apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (675 aa)
CACNA1DVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2183 aa)
KCNJ11ATP-sensitive inward rectifier potassium channel 11. (396 aa)
ABCC8ATP-binding cassette sub-family C member 8 isoform X1. (1584 aa)
PIK3R1Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1. (724 aa)
CACNA1GVoltage-dependent T-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. This channel gives rise to T-type calcium currents. T-type calcium channels belong to the "low-voltage activated (LVA)" group and are strongly blocked by nickel and mibefradil. A particularity of this type of channels is an opening at quite ne [...] (2389 aa)
MAPK10Mitogen-activated protein kinase. (464 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
HK2Hexokinase-2 isoform X1. (1002 aa)
SOCS3Suppressor of cytokine signaling 3. (238 aa)
MAPK3Mitogen-activated protein kinase 3. (265 aa)
LOC103005013Insulin receptor substrate 1-like. (572 aa)
GCKPhosphotransferase. (482 aa)
SOCS1Suppressor of cytokine signaling 1. (215 aa)
PRKCEProtein kinase C epsilon type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays essential roles in the regulation of multiple cellular processes linked to cytoskeletal proteins, such as cell adhesion, motility, migration and cell cycle, functions in neuron growth and ion channel regulation, and is involved in immune response, cancer cell invasion and regulation of apoptosis. Mediates cell adhesion to the extracellular matrix via integrin- dependent signaling, by mediating angiotensin-2-induced activation of integrin beta- [...] (737 aa)
SOCS4Suppressor of cytokine signaling 4. (440 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)
ADIPOQAdiponectin. (243 aa)
PIK3R2Phosphatidylinositol 3-kinase regulatory subunit beta. (700 aa)
MAPK1Mitogen-activated protein kinase 1. (263 aa)
IRS2Insulin receptor substrate 2. (507 aa)
SLC2A2Solute carrier family 2, facilitated glucose transporter member 2 isoform X1; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (524 aa)
PKMPyruvate kinase; Belongs to the pyruvate kinase family. (531 aa)
IRS4LOW QUALITY PROTEIN: insulin receptor substrate 4. (1043 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
HK1Hexokinase-1 isoform X1. (889 aa)
LOC103008077Phosphatidylinositol 3-kinase regulatory subunit gamma. (484 aa)
CACNA1CVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2273 aa)
CACNA1AVoltage-dependent P/Q-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1A gives rise to P and/or Q- type calcium currents. (2185 aa)
CACNA1BVoltage-dependent N-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1B gives rise to N-type calcium currents. (2153 aa)
PRKCZProtein kinase C zeta type isoform X1; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (518 aa)
CACNA1EVoltage-dependent R-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1E gives rise to R-type calcium currents. (2331 aa)
Your Current Organism:
Balaenoptera acutorostrata
NCBI taxonomy Id: 310752
Other names: B. acutorostrata scammoni, Balaenoptera acutorostrata scammoni
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