STRINGSTRING
CDKN2C CDKN2C AHR AHR CCNE1 CCNE1 CCNE2 CCNE2 PLCB4 PLCB4 PLCB1 PLCB1 MAP2K1 MAP2K1 DVL2 DVL2 LOC103009357 LOC103009357 ADCY7 ADCY7 GNAI2 GNAI2 CREB3L3 CREB3L3 LOC103015346 LOC103015346 MAP2K2 MAP2K2 RAP1A RAP1A GNAI3 GNAI3 WNT2B WNT2B WNT3A WNT3A WNT9A WNT9A USP8 USP8 CCND1 CCND1 AIP AIP WNT8A WNT8A TCF7L2 TCF7L2 PRKACB PRKACB FZD6 FZD6 AGT AGT MEN1 MEN1 PLCB3 PLCB3 RASD1 RASD1 CACNA1D CACNA1D LOC103018737 LOC103018737 WNT4 WNT4 CRHR2 CRHR2 TCF7L1 TCF7L1 KCNK2 KCNK2 ADCY5 ADCY5 WNT9B WNT9B WDR5B WDR5B WNT3 WNT3 PDE8B PDE8B CACNA1G CACNA1G GNA11 GNA11 CDKN2B CDKN2B LOC103012968 LOC103012968 WNT16 WNT16 CREB3L2 CREB3L2 AIPL1 AIPL1 ARNT ARNT ASH2L ASH2L STAR STAR CREB3L4 CREB3L4 ADCY6 ADCY6 WNT10B WNT10B WNT1 WNT1 SP1 SP1 CDK2 CDK2 NR4A1 NR4A1 CDK4 CDK4 FZD2 FZD2 ADCY4 ADCY4 PLCB2 PLCB2 CREB3L1 CREB3L1 KCNA4 KCNA4 ADCY9 ADCY9 GSK3B GSK3B PRKACA PRKACA CACNA1H CACNA1H LOC103018216 LOC103018216 FH FH CACNA1F CACNA1F RBBP5 RBBP5 MRAP MRAP CRH CRH LOC103004158 LOC103004158 AXIN2 AXIN2 MAPK3 MAPK3 RB1 RB1 ITPR3 ITPR3 FZD9 FZD9 GNAI1 GNAI1 LOC103007900 LOC103007900 WNT8B WNT8B ADCY1 ADCY1 EGFR EGFR WNT10A WNT10A AGTR1 AGTR1 CAMK2A CAMK2A ADCY8 ADCY8 ATF4 ATF4 WNT7B WNT7B ORAI1 ORAI1 SCARB1 SCARB1 PDE11A PDE11A ATF2 ATF2 FZD7 FZD7 LEF1 LEF1 PBX1 PBX1 ADCY3 ADCY3 KCNK3 KCNK3 ADCY2 ADCY2 APC APC ITPR1 ITPR1 LOC103001360 LOC103001360 FZD3 FZD3 E2F1 E2F1 CTNNB1 CTNNB1 CREB5 CREB5 WNT11 WNT11 ATF6B ATF6B PDE8A PDE8A NR5A1 NR5A1 WDR5 WDR5 RAP1B RAP1B WNT2 WNT2 ITPR2 ITPR2 DVL3 DVL3 FZD1 FZD1 CDK6 CDK6 CDKN1B CDKN1B MAPK1 MAPK1 MC2R MC2R KMT2A KMT2A CREB3 CREB3 E2F3 E2F3 LOC103011342 LOC103011342 NCEH1 NCEH1 CDKN1A CDKN1A APC2 APC2 FZD10 FZD10 CREB1 CREB1 CACNA1S CACNA1S FZD4 FZD4 LDLR LDLR E2F2 E2F2 CRHR1 CRHR1 CACNA1C CACNA1C KMT2D KMT2D LOC103016619 LOC103016619 GNAS GNAS ARMC5 ARMC5 DVL1 DVL1 CAMK2B CAMK2B CACNA1I CACNA1I
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CDKN2CCyclin-dependent kinase 4 inhibitor C. (168 aa)
AHRLOW QUALITY PROTEIN: aryl hydrocarbon receptor. (857 aa)
CCNE1LOW QUALITY PROTEIN: G1/S-specific cyclin-E1; Belongs to the cyclin family. (416 aa)
CCNE2G1/S-specific cyclin-E2; Belongs to the cyclin family. (405 aa)
PLCB41-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1258 aa)
PLCB11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1115 aa)
MAP2K1Dual specificity mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
DVL2Segment polarity protein dishevelled homolog DVL-2. (734 aa)
LOC103009357Cytochrome P450 11B1, mitochondrial; Belongs to the cytochrome P450 family. (412 aa)
ADCY7Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1078 aa)
GNAI2Guanine nucleotide-binding protein G(I) subunit alpha-2. (303 aa)
CREB3L3Cyclic AMP-responsive element-binding protein 3-like protein 3. (457 aa)
LOC1030153463 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase; Belongs to the 3-beta-HSD family. (373 aa)
MAP2K2Dual specificity mitogen-activated protein kinase kinase 2. (303 aa)
RAP1ARas-related protein Rap-1A. (184 aa)
GNAI3Guanine nucleotide-binding protein G(K) subunit alpha. (354 aa)
WNT2BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (394 aa)
WNT3AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (352 aa)
WNT9AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (455 aa)
USP8Ubiquitin carboxyl-terminal hydrolase 8; Belongs to the peptidase C19 family. (1087 aa)
CCND1G1/S-specific cyclin-D1 isoform X1; Belongs to the cyclin family. (214 aa)
AIPPeptidylprolyl isomerase. (330 aa)
WNT8AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (352 aa)
TCF7L2Transcription factor 7-like 2 isoform X1. (515 aa)
PRKACBcAMP-dependent protein kinase catalytic subunit beta isoform X1; Belongs to the protein kinase superfamily. (397 aa)
FZD6Frizzled-6 isoform X1; Belongs to the G-protein coupled receptor Fz/Smo family. (712 aa)
AGTAngiotensinogen; Belongs to the serpin family. (477 aa)
MEN1Menin. (517 aa)
PLCB31-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1230 aa)
RASD1Dexamethasone-induced Ras-related protein 1. (189 aa)
CACNA1DVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2183 aa)
LOC103018737Ras-related protein Rap-1b-like isoform X1. (142 aa)
WNT4Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (296 aa)
CRHR2Corticotropin-releasing factor receptor 2 isoform X1; Belongs to the G-protein coupled receptor 2 family. (437 aa)
TCF7L1Transcription factor 7-like 1 isoform X1. (439 aa)
KCNK2Potassium channel subfamily K member 2 isoform X2; Belongs to the two pore domain potassium channel (TC 1.A.1.8) family. (427 aa)
ADCY5Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1018 aa)
WNT9BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (358 aa)
WDR5BWD repeat-containing protein 5B isoform X1. (329 aa)
WNT3Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (355 aa)
PDE8BPhosphodiesterase. (779 aa)
CACNA1GVoltage-dependent T-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. This channel gives rise to T-type calcium currents. T-type calcium channels belong to the "low-voltage activated (LVA)" group and are strongly blocked by nickel and mibefradil. A particularity of this type of channels is an opening at quite ne [...] (2389 aa)
GNA11Guanine nucleotide-binding protein subunit alpha-11. (301 aa)
CDKN2BCyclin-dependent kinase 4 inhibitor B isoform X1. (131 aa)
LOC103012968Cyclin-dependent kinase inhibitor 2A. (109 aa)
WNT16Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (361 aa)
CREB3L2Cyclic AMP-responsive element-binding protein 3-like protein 2. (520 aa)
AIPL1Aryl-hydrocarbon-interacting protein-like 1. (328 aa)
ARNTAryl hydrocarbon receptor nuclear translocator isoform X1. (790 aa)
ASH2Lset1/Ash2 histone methyltransferase complex subunit ASH2 isoform X1. (630 aa)
STARSteroidogenic acute regulatory protein, mitochondrial; Plays a key role in steroid hormone synthesis by enhancing the metabolism of cholesterol into pregnenolone. Mediates the transfer of cholesterol from the outer mitochondrial membrane to the inner mitochondrial membrane where it is cleaved to pregnenolone. (285 aa)
CREB3L4Cyclic AMP-responsive element-binding protein 3-like protein 4 isoform X1. (395 aa)
ADCY6Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1220 aa)
WNT10BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (389 aa)
WNT1Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa)
SP1Transcription factor Sp1. (787 aa)
CDK2Cyclin-dependent kinase 2 isoform X1; Belongs to the protein kinase superfamily. (346 aa)
NR4A1Nuclear receptor subfamily 4 group A member 1. (598 aa)
CDK4Cyclin-dependent kinase 4 isoform X1; Belongs to the protein kinase superfamily. (303 aa)
FZD2Frizzled-2; Belongs to the G-protein coupled receptor Fz/Smo family. (565 aa)
ADCY4Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1109 aa)
PLCB21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1131 aa)
CREB3L1Cyclic AMP-responsive element-binding protein 3-like protein 1. (520 aa)
KCNA4Potassium voltage-gated channel subfamily A member 4; Belongs to the potassium channel family. (661 aa)
ADCY9Adenylate cyclase type 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1353 aa)
GSK3BGlycogen synthase kinase-3 beta isoform X1; Belongs to the protein kinase superfamily. (433 aa)
PRKACAcAMP-dependent protein kinase catalytic subunit alpha. (293 aa)
CACNA1HLOW QUALITY PROTEIN: voltage-dependent T-type calcium channel subunit alpha-1H. (2326 aa)
LOC103018216Guanine nucleotide-binding protein G(Q) subunit alpha. (301 aa)
FHFumarate hydratase, mitochondrial. (510 aa)
CACNA1FVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (1975 aa)
RBBP5Retinoblastoma-binding protein 5 isoform X1. (538 aa)
MRAPLOW QUALITY PROTEIN: melanocortin-2 receptor accessory protein. (188 aa)
CRHCorticoliberin. (193 aa)
LOC103004158Neuroendocrine secretory protein 55-like. (244 aa)
AXIN2Axin-2. (543 aa)
MAPK3Mitogen-activated protein kinase 3. (265 aa)
RB1Retinoblastoma-associated protein. (816 aa)
ITPR3LOW QUALITY PROTEIN: inositol 1,4,5-trisphosphate receptor type 3. (2666 aa)
FZD9Frizzled-9; Belongs to the G-protein coupled receptor Fz/Smo family. (408 aa)
GNAI1Guanine nucleotide-binding protein G(I) subunit alpha-1. (354 aa)
LOC103007900Steroid 17-alpha-hydroxylase/17,20 lyase isoform X1; Belongs to the cytochrome P450 family. (509 aa)
WNT8BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (336 aa)
ADCY1Adenylate cyclase type 1 isoform X1. (907 aa)
EGFRReceptor protein-tyrosine kinase. (1156 aa)
WNT10AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (417 aa)
AGTR1Type-1 angiotensin II receptor; Belongs to the G-protein coupled receptor 1 family. (359 aa)
CAMK2ACalcium/calmodulin-dependent protein kinase type II subunit alpha isoform X1; Belongs to the protein kinase superfamily. (489 aa)
ADCY8Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1248 aa)
ATF4Cyclic AMP-dependent transcription factor ATF-4. (352 aa)
WNT7BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (535 aa)
ORAI1Calcium release-activated calcium channel protein 1. (303 aa)
SCARB1Scavenger receptor class B member 1; Belongs to the CD36 family. (487 aa)
PDE11APhosphodiesterase. (934 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2 isoform X1. (505 aa)
FZD7Frizzled-7; Belongs to the G-protein coupled receptor Fz/Smo family. (570 aa)
LEF1Lymphoid enhancer-binding factor 1 isoform X1. (399 aa)
PBX1pre-B-cell leukemia transcription factor 1 isoform X1. (451 aa)
ADCY3Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1200 aa)
KCNK3Potassium channel subfamily K member 3; Belongs to the two pore domain potassium channel (TC 1.A.1.8) family. (285 aa)
ADCY2Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (972 aa)
APCAdenomatous polyposis coli protein isoform X1. (2865 aa)
ITPR1Inositol 1,4,5-trisphosphate receptor type 1 isoform X1. (2749 aa)
LOC103001360Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (204 aa)
FZD3Frizzled-3; Belongs to the G-protein coupled receptor Fz/Smo family. (666 aa)
E2F1Transcription factor E2F1. (361 aa)
CTNNB1Catenin beta-1. (767 aa)
CREB5Cyclic AMP-responsive element-binding protein 5 isoform X1. (502 aa)
WNT11Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
ATF6BLOW QUALITY PROTEIN: cyclic AMP-dependent transcription factor ATF-6 beta. (700 aa)
PDE8APhosphodiesterase. (757 aa)
NR5A1Steroidogenic factor 1. (461 aa)
WDR5WD repeat-containing protein 5. (334 aa)
RAP1BRas-related protein Rap-1b. (184 aa)
WNT2Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (360 aa)
ITPR2Inositol 1,4,5-trisphosphate receptor type 2 isoform X1. (2701 aa)
DVL3Segment polarity protein dishevelled homolog DVL-3. (719 aa)
FZD1Frizzled-1; Belongs to the G-protein coupled receptor Fz/Smo family. (565 aa)
CDK6Cyclin-dependent kinase 6; Belongs to the protein kinase superfamily. (326 aa)
CDKN1BCyclin-dependent kinase inhibitor 1B. (198 aa)
MAPK1Mitogen-activated protein kinase 1. (263 aa)
MC2RAdrenocorticotropic hormone receptor. (297 aa)
KMT2AHistone-lysine N-methyltransferase; Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. TRX/MLL subfamily. (3905 aa)
CREB3Cyclic AMP-responsive element-binding protein 3 isoform X1. (371 aa)
E2F3Transcription factor E2F3. (340 aa)
LOC103011342Cholesterol side-chain cleavage enzyme, mitochondrial; A cytochrome P450 monooxygenase that catalyzes the side-chain hydroxylation and cleavage of cholesterol to pregnenolone, the precursor of most steroid hormones. Catalyzes three sequential oxidation reactions of cholesterol, namely the hydroxylation at C22 followed with the hydroxylation at C20 to yield 20R,22R- hydroxycholesterol that is further cleaved between C20 and C22 to yield the C21-steroid pregnenolone and 4-methylpentanal. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the se [...] (520 aa)
NCEH1Neutral cholesterol ester hydrolase 1. (412 aa)
CDKN1ACyclin-dependent kinase inhibitor 1. (164 aa)
APC2LOW QUALITY PROTEIN: adenomatous polyposis coli protein 2. (1582 aa)
FZD10LOW QUALITY PROTEIN: frizzled-10; Belongs to the G-protein coupled receptor Fz/Smo family. (578 aa)
CREB1Cyclic AMP-responsive element-binding protein 1 isoform X1. (341 aa)
CACNA1SVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (1864 aa)
FZD4LOW QUALITY PROTEIN: frizzled-4; Belongs to the G-protein coupled receptor Fz/Smo family. (548 aa)
LDLRLow-density lipoprotein receptor. (842 aa)
E2F2Transcription factor E2F2. (414 aa)
CRHR1Corticotropin-releasing factor receptor 1 isoform X1; Belongs to the G-protein coupled receptor 2 family. (432 aa)
CACNA1CVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2273 aa)
KMT2DLOW QUALITY PROTEIN: histone-lysine N-methyltransferase 2D. (5534 aa)
LOC103016619Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (253 aa)
GNASGuanine nucleotide-binding protein G(S) subunit alpha isoforms XLas isoform X1. (1007 aa)
ARMC5LOW QUALITY PROTEIN: armadillo repeat-containing protein 5. (847 aa)
DVL1LOW QUALITY PROTEIN: segment polarity protein dishevelled homolog DVL-1. (681 aa)
CAMK2BCalcium/calmodulin-dependent protein kinase type II subunit beta isoform X1. (501 aa)
CACNA1IVoltage-dependent T-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. This channel gives rise to T-type calcium currents. T-type calcium channels belong to the "low-voltage activated (LVA)" group and are strongly blocked by nickel and mibefradil. A particularity of this type of channels is an opening at quite ne [...] (2076 aa)
Your Current Organism:
Balaenoptera acutorostrata
NCBI taxonomy Id: 310752
Other names: B. acutorostrata scammoni, Balaenoptera acutorostrata scammoni
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