STRINGSTRING
LOC103014668 LOC103014668 LOC103001311 LOC103001311 CALML4 CALML4 IRAK4 IRAK4 GNAI2 GNAI2 RHOA RHOA TICAM1 TICAM1 C3 C3 GNAI3 GNAI3 C1S C1S C1R C1R RELA RELA CFL1 CFL1 C4BPA C4BPA IL10 IL10 IL12B IL12B ITGB2 ITGB2 NFKB1 NFKB1 CASP7 CASP7 C1QA C1QA C1QC C1QC C1QB C1QB MAPK10 MAPK10 CASP3 CASP3 LOC103013544 LOC103013544 C5 C5 TLR4 TLR4 MAPK8 MAPK8 IL23A IL23A CXCL8 CXCL8 LOC103010959 LOC103010959 ITGA5 ITGA5 CFL2 CFL2 TRAF6 TRAF6 TIRAP TIRAP IL6 IL6 NOS2 NOS2 FOS FOS IRF3 IRF3 LY96 LY96 IRAK1 IRAK1 MAPK3 MAPK3 ITGAM ITGAM LOC103004444 LOC103004444 IL12A IL12A GNAI1 GNAI1 IRF1 IRF1 ITGB1 ITGB1 CALM2 CALM2 MYD88 MYD88 CASP1 CASP1 TICAM2 TICAM2 LOC103015179 LOC103015179 C2 C2 TNF TNF CD14 CD14 LOC102999798 LOC102999798 MAPK1 MAPK1 IL1B IL1B IL1A IL1A MAPK14 MAPK14 SERPING1 SERPING1 MAPK13 MAPK13 C4BPB C4BPB NLRP3 NLRP3 NOD1 NOD1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
LOC103014668Transcription factor AP-1; Belongs to the bZIP family. (253 aa)
LOC103001311Transcription factor AP-1-like. (199 aa)
CALML4Calmodulin-like protein 4. (153 aa)
IRAK4Interleukin-1 receptor-associated kinase 4 isoform X1. (460 aa)
GNAI2Guanine nucleotide-binding protein G(I) subunit alpha-2. (303 aa)
RHOATransforming protein RhoA. (193 aa)
TICAM1TIR domain-containing adapter molecule 1; Involved in innate immunity against invading pathogens. Component of a multi-helicase-TICAM1 complex that acts as a cytoplasmic sensor of viral double-stranded RNA (dsRNA) and plays a role in the activation of a cascade of antiviral responses including the induction of proinflammatory cytokines. (705 aa)
C3Complement C3. (1609 aa)
GNAI3Guanine nucleotide-binding protein G(K) subunit alpha. (354 aa)
C1SComplement C1s subcomponent isoform X1; Belongs to the peptidase S1 family. (784 aa)
C1RLOW QUALITY PROTEIN: complement C1r subcomponent; Belongs to the peptidase S1 family. (788 aa)
RELATranscription factor p65 isoform X1. (520 aa)
CFL1Cofilin-1; Belongs to the actin-binding proteins ADF family. (243 aa)
C4BPAC4b-binding protein alpha chain isoform X1. (663 aa)
IL10Interleukin-10. (178 aa)
IL12BInterleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. (329 aa)
ITGB2Integrin beta. (718 aa)
NFKB1Nuclear factor NF-kappa-B p105 subunit isoform X1. (974 aa)
CASP7Caspase-7; Belongs to the peptidase C14A family. (301 aa)
C1QAComplement C1q subcomponent subunit A. (245 aa)
C1QCComplement C1q subcomponent subunit C. (245 aa)
C1QBComplement C1q subcomponent subunit B. (251 aa)
MAPK10Mitogen-activated protein kinase. (464 aa)
CASP3Caspase-3; Belongs to the peptidase C14A family. (275 aa)
LOC103013544Pulmonary surfactant-associated protein A. (248 aa)
C5Complement C5 isoform X1. (1677 aa)
TLR4Toll-like receptor 4; Belongs to the Toll-like receptor family. (841 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
IL23AInterleukin-23 subunit alpha. (190 aa)
CXCL8Multifunctional fusion protein; Belongs to the intercrine alpha (chemokine CxC) family. (101 aa)
LOC103010959C-X-C motif chemokine. (137 aa)
ITGA5Integrin alpha-5; Belongs to the integrin alpha chain family. (1108 aa)
CFL2Cofilin-2; Belongs to the actin-binding proteins ADF family. (149 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (561 aa)
TIRAPToll/interleukin-1 receptor domain-containing adapter protein. (226 aa)
IL6Interleukin-6. (208 aa)
NOS2Nitric oxide synthase; Produces nitric oxide (NO). (1157 aa)
FOSProto-oncogene c-Fos. (380 aa)
IRF3Interferon regulatory factor 3 isoform X1. (434 aa)
LY96Lymphocyte antigen 96. (160 aa)
IRAK1Interleukin-1 receptor-associated kinase 1. (340 aa)
MAPK3Mitogen-activated protein kinase 3. (265 aa)
ITGAMIntegrin alpha-M; Belongs to the integrin alpha chain family. (1152 aa)
LOC103004444Apoptosis-associated speck-like protein containing a CARD. (195 aa)
IL12AInterleukin-12 subunit alpha; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated Killer cells, and stimulate the production of IFN-gamma by resting PBMC. (222 aa)
GNAI1Guanine nucleotide-binding protein G(I) subunit alpha-1. (354 aa)
IRF1Interferon regulatory factor. (322 aa)
ITGB1Integrin beta; Belongs to the integrin beta chain family. (801 aa)
CALM2Calmodulin-1; Belongs to the calmodulin family. (149 aa)
MYD88Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (296 aa)
CASP1Caspase-1; Belongs to the peptidase C14A family. (404 aa)
TICAM2TIR domain-containing adapter molecule 2. (235 aa)
LOC103015179Complement C4. (1737 aa)
C2Complement C2; Belongs to the peptidase S1 family. (751 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)
CD14Monocyte differentiation antigen CD14; Coreceptor for bacterial lipopolysaccharide. In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Acts as a coreceptor for TLR2:TLR6 heterodimer in response to diacylated lipopeptides and for TLR2:TLR1 heterodimer in response to triacylated lipopeptides, these clusters trigger signaling from the cell su [...] (372 aa)
LOC102999798Mitogen-activated protein kinase. (203 aa)
MAPK1Mitogen-activated protein kinase 1. (263 aa)
IL1BMultifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (266 aa)
IL1AInterleukin-1; Belongs to the IL-1 family. (270 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
SERPING1Plasma protease C1 inhibitor; Belongs to the serpin family. (481 aa)
MAPK13Mitogen-activated protein kinase. (288 aa)
C4BPBC4b-binding protein beta chain isoform X1. (263 aa)
NLRP3NACHT, LRR and PYD domains-containing protein 3 isoform X1. (1056 aa)
NOD1Nucleotide-binding oligomerization domain-containing protein 1. (818 aa)
Your Current Organism:
Balaenoptera acutorostrata
NCBI taxonomy Id: 310752
Other names: B. acutorostrata scammoni, Balaenoptera acutorostrata scammoni
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