STRINGSTRING
CR1 CR1 PLK3 PLK3 ATP6V0B ATP6V0B NFYC NFYC CEBPG CEBPG APAF1 APAF1 NFYB NFYB CALML4 CALML4 EEA1 EEA1 PPP3CB PPP3CB NOD2 NOD2 PPP3CC PPP3CC SPHK2 SPHK2 BAX BAX IRAK4 IRAK4 ATP6V1H ATP6V1H RHOA RHOA LOC103016277 LOC103016277 CD209 CD209 C3 C3 LOC103000222 LOC103000222 TNFRSF1A TNFRSF1A FADD FADD RELA RELA LSP1 LSP1 TCIRG1 TCIRG1 STAT1 STAT1 FCGR2A FCGR2A IL10 IL10 IL12B IL12B LOC103003361 LOC103003361 LOC103008795 LOC103008795 FCER1G FCER1G HSPA9 HSPA9 ITGB2 ITGB2 PIK3C3 PIK3C3 PPP3CA PPP3CA IL18 IL18 BCL10 BCL10 NFKB1 NFKB1 BAD BAD LOC103010163 LOC103010163 CASP9 CASP9 ATP6V0D2 ATP6V0D2 AKT1 AKT1 LOC103010469 LOC103010469 LOC103008826 LOC103008826 LOC103010766 LOC103010766 ATP6V0A4 ATP6V0A4 IFNB1 IFNB1 MAPK10 MAPK10 LOC103013898 LOC103013898 LOC103019480 LOC103019480 CASP3 CASP3 LOC103009700 LOC103009700 RFX5 RFX5 TLR4 TLR4 CTSS CTSS MAPK8 MAPK8 TLR1 TLR1 TLR6 TLR6 RAB7A RAB7A VDR VDR RAB5B RAB5B LOC103001013 LOC103001013 IL23A IL23A AKT2 AKT2 TRAF6 TRAF6 CREBBP CREBBP ATP6V0C ATP6V0C JAK2 JAK2 RIPK2 RIPK2 AKT3 AKT3 RAB5A RAB5A PLA2R1 PLA2R1 TIRAP TIRAP IL10RB IL10RB IFNGR2 IFNGR2 IL6 IL6 NOS2 NOS2 TGFB3 TGFB3 ATP6AP1 ATP6AP1 IRAK1 IRAK1 SPHK1 SPHK1 CORO1A CORO1A ITGAX ITGAX MAPK3 MAPK3 ITGAM ITGAM LOC103009822 LOC103009822 LOC103010705 LOC103010705 LOC103008197 LOC103008197 LOC103012629 LOC103012629 IL12A IL12A CIITA CIITA CD74 CD74 CAMK2A CAMK2A TLR2 TLR2 ATP6V0A2 ATP6V0A2 CALM2 CALM2 LOC103017780 LOC103017780 HSPD1 HSPD1 CASP10 CASP10 CASP8 CASP8 LOC102999215 LOC102999215 IFNGR1 IFNGR1 MYD88 MYD88 BCL2 BCL2 MALT1 MALT1 LOC103007035 LOC103007035 RAF1 RAF1 IRAK2 IRAK2 LBP LBP SRC SRC SYK SYK LOC103007833 LOC103007833 TNF TNF LOC103007535 LOC103007535 CD14 CD14 LOC102999798 LOC102999798 IFNG IFNG RFXANK RFXANK CLEC7A CLEC7A MAPK1 MAPK1 IL10RA IL10RA MRC1 MRC1 LAMP1 LAMP1 ARHGEF12 ARHGEF12 IL1B IL1B IL1A IL1A NFYA NFYA MAPK14 MAPK14 LOC103007162 LOC103007162 TRADD TRADD LOC103009695 LOC103009695 ATP6V0D1 ATP6V0D1 RFXAP RFXAP PPP3R2 PPP3R2 CARD9 CARD9 CREB1 CREB1 MAPK13 MAPK13 LOC103016278 LOC103016278 TGFB1 TGFB1 JAK1 JAK1 CTSD CTSD MRC2 MRC2 KSR1 KSR1 CAMK2B CAMK2B EP300 EP300
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CR1Complement receptor type 1. (1331 aa)
PLK3Serine/threonine-protein kinase PLK. (647 aa)
ATP6V0BV-type proton ATPase 21 kDa proteolipid subunit; Belongs to the V-ATPase proteolipid subunit family. (205 aa)
NFYCNuclear transcription factor Y subunit gamma isoform X1. (439 aa)
CEBPGCCAAT/enhancer-binding protein gamma. (187 aa)
APAF1Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. (1253 aa)
NFYBNuclear transcription factor Y subunit beta. (207 aa)
CALML4Calmodulin-like protein 4. (153 aa)
EEA1Early endosome antigen 1. (1437 aa)
PPP3CBSerine/threonine-protein phosphatase. (528 aa)
NOD2Nucleotide-binding oligomerization domain-containing protein 2 isoform X2. (1013 aa)
PPP3CCSerine/threonine-protein phosphatase. (583 aa)
SPHK2Sphingosine kinase 2 isoform X1. (665 aa)
BAXApoptosis regulator BAX. (192 aa)
IRAK4Interleukin-1 receptor-associated kinase 4 isoform X1. (460 aa)
ATP6V1HV-type proton ATPase subunit H; Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit H activates ATPase activity of the enzyme and couples ATPase activity to proton flow. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. (483 aa)
RHOATransforming protein RhoA. (193 aa)
LOC103016277Cathelicidin-3-like. (162 aa)
CD209CD209 antigen. (278 aa)
C3Complement C3. (1609 aa)
LOC103000222C-type lectin domain family 4 member E. (212 aa)
TNFRSF1ATumor necrosis factor receptor superfamily member 1A. (343 aa)
FADDFAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (210 aa)
RELATranscription factor p65 isoform X1. (520 aa)
LSP1Lymphocyte-specific protein 1. (392 aa)
TCIRG1V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (745 aa)
STAT1Signal transducer and activator of transcription. (749 aa)
FCGR2ALow affinity immunoglobulin gamma Fc region receptor II-a isoform X1. (322 aa)
IL10Interleukin-10. (178 aa)
IL12BInterleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. (329 aa)
LOC103003361Cytochrome c; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
LOC103008795Low affinity immunoglobulin gamma Fc region receptor III-like. (253 aa)
FCER1GHigh affinity immunoglobulin epsilon receptor subunit gamma isoform X1. (174 aa)
HSPA9Stress-70 protein, mitochondrial; Belongs to the heat shock protein 70 family. (679 aa)
ITGB2Integrin beta. (718 aa)
PIK3C3Phosphatidylinositol 3-kinase catalytic subunit type 3. (887 aa)
PPP3CASerine/threonine-protein phosphatase. (521 aa)
IL18Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family. (175 aa)
BCL10B-cell lymphoma/leukemia 10. (233 aa)
NFKB1Nuclear factor NF-kappa-B p105 subunit isoform X1. (974 aa)
BADBcl2-associated agonist of cell death. (168 aa)
LOC103010163Toll-like receptor 9 isoform X1. (1323 aa)
CASP9Caspase-9 isoform X1; Belongs to the peptidase C14A family. (414 aa)
ATP6V0D2V-type proton ATPase subunit; Subunit of the integral membrane V0 complex of vacuolar ATPase. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. Belongs to the V-ATPase V0D/AC39 subunit family. (351 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (476 aa)
LOC103010469Interferon alpha-1-like. (189 aa)
LOC103008826Interferon alpha-1-like. (189 aa)
LOC103010766Interferon alpha-1-like. (189 aa)
ATP6V0A4V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (879 aa)
IFNB1Interferon beta. (186 aa)
MAPK10Mitogen-activated protein kinase. (464 aa)
LOC103013898Ras-related protein Rab-5C. (216 aa)
LOC103019480V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (845 aa)
CASP3Caspase-3; Belongs to the peptidase C14A family. (275 aa)
LOC103009700Protegrin-5-like. (140 aa)
RFX5DNA-binding protein RFX5. (607 aa)
TLR4Toll-like receptor 4; Belongs to the Toll-like receptor family. (841 aa)
CTSSCathepsin S; Belongs to the peptidase C1 family. (340 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
TLR1Toll-like receptor 1; Belongs to the Toll-like receptor family. (796 aa)
TLR6Toll-like receptor 6; Belongs to the Toll-like receptor family. (797 aa)
RAB7ARas-related protein Rab-7a. (207 aa)
VDRVitamin D3 receptor. (427 aa)
RAB5BRas-related protein Rab-5B. (215 aa)
LOC10300101325-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial isoform X1; Belongs to the cytochrome P450 family. (508 aa)
IL23AInterleukin-23 subunit alpha. (190 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (561 aa)
CREBBPCREB-binding protein isoform X1. (2444 aa)
ATP6V0CV-type proton ATPase proteolipid subunit; Proton-conducting pore forming subunit of the membrane integral V0 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (155 aa)
JAK2Tyrosine-protein kinase. (1132 aa)
RIPK2Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. (536 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (431 aa)
RAB5ARas-related protein Rab-5A isoform X1. (215 aa)
PLA2R1Secretory phospholipase A2 receptor isoform X1. (1454 aa)
TIRAPToll/interleukin-1 receptor domain-containing adapter protein. (226 aa)
IL10RBInterleukin-10 receptor subunit beta. (383 aa)
IFNGR2Interferon gamma receptor 2. (351 aa)
IL6Interleukin-6. (208 aa)
NOS2Nitric oxide synthase; Produces nitric oxide (NO). (1157 aa)
TGFB3Transforming growth factor beta-3 proprotein. (456 aa)
ATP6AP1V-type proton ATPase subunit S1. (468 aa)
IRAK1Interleukin-1 receptor-associated kinase 1. (340 aa)
SPHK1Sphingosine kinase 1. (476 aa)
CORO1ACoronin; Belongs to the WD repeat coronin family. (461 aa)
ITGAXIntegrin alpha-X isoform X1; Belongs to the integrin alpha chain family. (1173 aa)
MAPK3Mitogen-activated protein kinase 3. (265 aa)
ITGAMIntegrin alpha-M; Belongs to the integrin alpha chain family. (1152 aa)
LOC103009822HLA class II histocompatibility antigen, DM alpha chain isoform X1; Belongs to the MHC class II family. (261 aa)
LOC103010705HLA class II histocompatibility antigen, DM beta chain isoform X1. (273 aa)
LOC103008197HLA class II histocompatibility antigen, DO alpha chain. (250 aa)
LOC103012629HLA class II histocompatibility antigen, DO beta chain-like. (270 aa)
IL12AInterleukin-12 subunit alpha; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated Killer cells, and stimulate the production of IFN-gamma by resting PBMC. (222 aa)
CIITAMHC class II transactivator isoform X1. (1159 aa)
CD74HLA class II histocompatibility antigen gamma chain isoform X1. (278 aa)
CAMK2ACalcium/calmodulin-dependent protein kinase type II subunit alpha isoform X1; Belongs to the protein kinase superfamily. (489 aa)
TLR2Toll-like receptor 2; Belongs to the Toll-like receptor family. (785 aa)
ATP6V0A2V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (854 aa)
CALM2Calmodulin-1; Belongs to the calmodulin family. (149 aa)
LOC103017780Cytochrome c 2; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
HSPD160 kDa heat shock protein, mitochondrial isoform X1; Belongs to the chaperonin (HSP60) family. (575 aa)
CASP10Caspase-10 isoform X1; Belongs to the peptidase C14A family. (525 aa)
CASP8Caspase-8; Belongs to the peptidase C14A family. (486 aa)
LOC102999215Cytochrome c-like; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
IFNGR1Interferon gamma receptor 1. (502 aa)
MYD88Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (296 aa)
BCL2Apoptosis regulator Bcl-2 isoform X1. (233 aa)
MALT1Mucosa-associated lymphoid tissue lymphoma translocation protein 1. (803 aa)
LOC103007035DLA class II histocompatibility antigen, DR-1 beta chain-like. (176 aa)
RAF1RAF proto-oncogene serine/threonine-protein kinase isoform X1. (668 aa)
IRAK2Interleukin-1 receptor-associated kinase-like 2 isoform X1. (623 aa)
LBPLipopolysaccharide-binding protein. (481 aa)
SRCTyrosine-protein kinase. (557 aa)
SYKTyrosine-protein kinase. (626 aa)
LOC103007833HLA class II histocompatibility antigen, DR alpha chain; Belongs to the MHC class II family. (253 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)
LOC103007535DLA class II histocompatibility antigen, DR-1 beta chain-like. (265 aa)
CD14Monocyte differentiation antigen CD14; Coreceptor for bacterial lipopolysaccharide. In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Acts as a coreceptor for TLR2:TLR6 heterodimer in response to diacylated lipopeptides and for TLR2:TLR1 heterodimer in response to triacylated lipopeptides, these clusters trigger signaling from the cell su [...] (372 aa)
LOC102999798Mitogen-activated protein kinase. (203 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (166 aa)
RFXANKDNA-binding protein RFXANK isoform X1. (260 aa)
CLEC7AC-type lectin domain family 7 member A isoform X1. (246 aa)
MAPK1Mitogen-activated protein kinase 1. (263 aa)
IL10RAInterleukin-10 receptor subunit alpha. (579 aa)
MRC1Macrophage mannose receptor 1 isoform X1. (1503 aa)
LAMP1Lysosome-associated membrane glycoprotein 1. (438 aa)
ARHGEF12Rho guanine nucleotide exchange factor 12 isoform X1. (1545 aa)
IL1BMultifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (266 aa)
IL1AInterleukin-1; Belongs to the IL-1 family. (270 aa)
NFYANuclear transcription factor Y subunit alpha isoform X1. (347 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
LOC103007162Interferon alpha-1-like. (104 aa)
TRADDTumor necrosis factor receptor type 1-associated DEATH domain protein isoform X1. (343 aa)
LOC103009695LOW QUALITY PROTEIN: interferon alpha-7. (169 aa)
ATP6V0D1V-type proton ATPase subunit; Subunit of the integral membrane V0 complex of vacuolar ATPase. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. Belongs to the V-ATPase V0D/AC39 subunit family. (351 aa)
RFXAPLOW QUALITY PROTEIN: regulatory factor X-associated protein. (440 aa)
PPP3R2LOW QUALITY PROTEIN: calcineurin subunit B type 2. (170 aa)
CARD9Caspase recruitment domain-containing protein 9. (529 aa)
CREB1Cyclic AMP-responsive element-binding protein 1 isoform X1. (341 aa)
MAPK13Mitogen-activated protein kinase. (288 aa)
LOC103016278Cathelicidin-6-like. (173 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (407 aa)
JAK1Tyrosine-protein kinase. (1155 aa)
CTSDCathepsin D; Belongs to the peptidase A1 family. (482 aa)
MRC2C-type mannose receptor 2. (1389 aa)
KSR1Kinase suppressor of Ras 1 isoform X1. (842 aa)
CAMK2BCalcium/calmodulin-dependent protein kinase type II subunit beta isoform X1. (501 aa)
EP300Histone acetyltransferase p300. (2445 aa)
Your Current Organism:
Balaenoptera acutorostrata
NCBI taxonomy Id: 310752
Other names: B. acutorostrata scammoni, Balaenoptera acutorostrata scammoni
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