STRINGSTRING
LOC103014668 LOC103014668 LOC103001311 LOC103001311 CALML4 CALML4 MAP2K1 MAP2K1 GNB1 GNB1 PIK3R6 PIK3R6 TP53 TP53 GABARAP GABARAP PIK3R5 PIK3R5 PPP3CB PPP3CB EIF2AK2 EIF2AK2 PTGS2 PTGS2 PPP3CC PPP3CC GNG8 GNG8 BAX BAX LYN LYN LOC103004076 LOC103004076 CCR3 CCR3 LOC103002871 LOC103002871 MAP2K7 MAP2K7 TICAM1 TICAM1 C3 C3 ICAM1 ICAM1 TYK2 TYK2 NRAS NRAS MAP2K2 MAP2K2 PIK3CD PIK3CD GNB3 GNB3 MTOR MTOR TNFRSF1A TNFRSF1A PIK3CB PIK3CB GNG4 GNG4 CCND1 CCND1 FADD FADD RELA RELA HRAS HRAS STAT1 STAT1 IRF7 IRF7 MAPKAPK2 MAPKAPK2 LOC103003361 LOC103003361 PIK3C3 PIK3C3 NFATC1 NFATC1 PPP3CA PPP3CA NFKB1 NFKB1 TCF7L2 TCF7L2 LOC103007740 LOC103007740 TLR3 TLR3 UBB UBB CASP9 CASP9 MAP2K4 MAP2K4 TCF7L1 TCF7L1 CD86 CD86 TRAF3 TRAF3 PIK3R1 PIK3R1 AKT1 AKT1 GNG7 GNG7 LOC103010469 LOC103010469 LOC103008826 LOC103008826 LOC103010766 LOC103010766 IFNB1 IFNB1 MAPK10 MAPK10 LOC103012872 LOC103012872 LOC102997405 LOC102997405 CASP3 CASP3 MAPK8 MAPK8 FAS FAS STAT2 STAT2 TBK1 TBK1 CDK4 CDK4 LOC103005920 LOC103005920 LOC103006206 LOC103006206 CXCL8 CXCL8 LOC103005635 LOC103005635 AKT2 AKT2 ZFP36 ZFP36 IRF9 IRF9 NFATC4 NFATC4 NFKBIA NFKBIA PIK3CG PIK3CG CREBBP CREBBP GNG13 GNG13 GSK3B GSK3B CD200R1 CD200R1 ATG3 ATG3 JAK2 JAK2 BECN2 BECN2 PLCG2 PLCG2 GABARAPL2 GABARAPL2 AKT3 AKT3 IFNAR2 IFNAR2 IFNAR1 IFNAR1 RCAN1 RCAN1 IL6 IL6 FOS FOS IRF3 IRF3 PREX1 PREX1 MAP2K6 MAP2K6 MAPK3 MAPK3 GNB2 GNB2 RAC1 RAC1 RB1 RB1 ITPR3 ITPR3 BAK1 BAK1 CHUK CHUK CSF2 CSF2 MYC MYC ANGPT2 ANGPT2 PDGFB PDGFB UBC UBC RPS27A RPS27A CALM2 CALM2 LOC103017780 LOC103017780 CASP8 CASP8 LOC102999215 LOC102999215 LEF1 LEF1 IFNGR1 IFNGR1 CCR8 CCR8 CCR4 CCR4 RAF1 RAF1 ITPR1 ITPR1 ATG14 ATG14 GNG2 GNG2 HIF1A HIF1A SRC SRC PLCG1 PLCG1 E2F1 E2F1 SYK SYK HCK HCK CTNNB1 CTNNB1 TRAF2 TRAF2 KRAS KRAS LOC102999798 LOC102999798 IKBKE IKBKE ITPR2 ITPR2 GNB5 GNB5 GNB4 GNB4 PIK3R2 PIK3R2 GNGT1 GNGT1 IL6ST IL6ST GNG11 GNG11 UBA52 UBA52 CDK6 CDK6 CLEC2B CLEC2B MAPK1 MAPK1 GABARAPL1 GABARAPL1 E2F3 E2F3 MAPK14 MAPK14 LOC103007162 LOC103007162 NFATC3 NFATC3 TRADD TRADD LOC103009695 LOC103009695 CDKN1A CDKN1A PPP3R2 PPP3R2 PIK3CA PIK3CA LOC103008230 LOC103008230 VEGFA VEGFA LOC103005235 LOC103005235 CREB1 CREB1 MAPK13 MAPK13 JAK1 JAK1 LOC103008077 LOC103008077 FGF2 FGF2 E2F2 E2F2 LOC103008157 LOC103008157 NFATC2 NFATC2 EP300 EP300
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
LOC103014668Transcription factor AP-1; Belongs to the bZIP family. (253 aa)
LOC103001311Transcription factor AP-1-like. (199 aa)
CALML4Calmodulin-like protein 4. (153 aa)
MAP2K1Dual specificity mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
GNB1Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1. (296 aa)
PIK3R6Phosphoinositide 3-kinase regulatory subunit 6. (754 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (387 aa)
GABARAPGamma-aminobutyric acid receptor-associated protein. (117 aa)
PIK3R5Phosphoinositide 3-kinase regulatory subunit 5. (882 aa)
PPP3CBSerine/threonine-protein phosphatase. (528 aa)
EIF2AK2Interferon-induced, double-stranded RNA-activated protein kinase. (539 aa)
PTGS2Prostaglandin G/H synthase 2. (604 aa)
PPP3CCSerine/threonine-protein phosphatase. (583 aa)
GNG8Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (80 aa)
BAXApoptosis regulator BAX. (192 aa)
LYNTyrosine-protein kinase. (512 aa)
LOC103004076C-C chemokine receptor type 1; Belongs to the G-protein coupled receptor 1 family. (355 aa)
CCR3C-C chemokine receptor type 3; Belongs to the G-protein coupled receptor 1 family. (358 aa)
LOC103002871C-C chemokine receptor type 5; Belongs to the G-protein coupled receptor 1 family. (352 aa)
MAP2K7Dual specificity mitogen-activated protein kinase kinase 7 isoform X2. (435 aa)
TICAM1TIR domain-containing adapter molecule 1; Involved in innate immunity against invading pathogens. Component of a multi-helicase-TICAM1 complex that acts as a cytoplasmic sensor of viral double-stranded RNA (dsRNA) and plays a role in the activation of a cascade of antiviral responses including the induction of proinflammatory cytokines. (705 aa)
C3Complement C3. (1609 aa)
ICAM1Intercellular adhesion molecule 1. (536 aa)
TYK2Tyrosine-protein kinase. (1161 aa)
NRASGTPase NRas. (189 aa)
MAP2K2Dual specificity mitogen-activated protein kinase kinase 2. (303 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1042 aa)
GNB3Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 isoform X1. (340 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2546 aa)
TNFRSF1ATumor necrosis factor receptor superfamily member 1A. (343 aa)
PIK3CBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform; Belongs to the PI3/PI4-kinase family. (1070 aa)
GNG4Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (75 aa)
CCND1G1/S-specific cyclin-D1 isoform X1; Belongs to the cyclin family. (214 aa)
FADDFAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (210 aa)
RELATranscription factor p65 isoform X1. (520 aa)
HRASGTPase HRas isoform X1. (196 aa)
STAT1Signal transducer and activator of transcription. (749 aa)
IRF7Interferon regulatory factor 7. (463 aa)
MAPKAPK2MAP kinase-activated protein kinase 2; Belongs to the protein kinase superfamily. (388 aa)
LOC103003361Cytochrome c; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
PIK3C3Phosphatidylinositol 3-kinase catalytic subunit type 3. (887 aa)
NFATC1Nuclear factor of activated T-cells, cytoplasmic 1. (901 aa)
PPP3CASerine/threonine-protein phosphatase. (521 aa)
NFKB1Nuclear factor NF-kappa-B p105 subunit isoform X1. (974 aa)
TCF7L2Transcription factor 7-like 2 isoform X1. (515 aa)
LOC103007740H-2 class I histocompatibility antigen, Q10 alpha chain-like isoform X1; Belongs to the MHC class I family. (349 aa)
TLR3Toll-like receptor 3 isoform X1; Belongs to the Toll-like receptor family. (957 aa)
UBBpolyubiquitin-B. (305 aa)
CASP9Caspase-9 isoform X1; Belongs to the peptidase C14A family. (414 aa)
MAP2K4Dual specificity mitogen-activated protein kinase kinase 4 isoform X1; Belongs to the protein kinase superfamily. (338 aa)
TCF7L1Transcription factor 7-like 1 isoform X1. (439 aa)
CD86T-lymphocyte activation antigen CD86 isoform X1. (334 aa)
TRAF3TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (572 aa)
PIK3R1Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1. (724 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (476 aa)
GNG7Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa)
LOC103010469Interferon alpha-1-like. (189 aa)
LOC103008826Interferon alpha-1-like. (189 aa)
LOC103010766Interferon alpha-1-like. (189 aa)
IFNB1Interferon beta. (186 aa)
MAPK10Mitogen-activated protein kinase. (464 aa)
LOC103012872Beclin-1 isoform X1. (473 aa)
LOC102997405Signal transducer and activator of transcription. (783 aa)
CASP3Caspase-3; Belongs to the peptidase C14A family. (275 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
FASTumor necrosis factor receptor superfamily member 6 isoform X1. (334 aa)
STAT2Signal transducer and activator of transcription. (879 aa)
TBK1Serine/threonine-protein kinase TBK1. (753 aa)
CDK4Cyclin-dependent kinase 4 isoform X1; Belongs to the protein kinase superfamily. (303 aa)
LOC103005920C-X-C motif chemokine. (104 aa)
LOC103006206C-X-C motif chemokine. (104 aa)
CXCL8Multifunctional fusion protein; Belongs to the intercrine alpha (chemokine CxC) family. (101 aa)
LOC103005635C-X-C motif chemokine. (104 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
ZFP36LOW QUALITY PROTEIN: mRNA decay activator protein ZFP36. (325 aa)
IRF9Interferon regulatory factor 9 isoform X1. (411 aa)
NFATC4Nuclear factor of activated T-cells, cytoplasmic 4 isoform X1. (901 aa)
NFKBIANF-kappa-B inhibitor alpha. (280 aa)
PIK3CGLOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform; Belongs to the PI3/PI4-kinase family. (1101 aa)
CREBBPCREB-binding protein isoform X1. (2444 aa)
GNG13Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13. (67 aa)
GSK3BGlycogen synthase kinase-3 beta isoform X1; Belongs to the protein kinase superfamily. (433 aa)
CD200R1Cell surface glycoprotein CD200 receptor 1. (357 aa)
ATG3Autophagy-related protein 3. (314 aa)
JAK2Tyrosine-protein kinase. (1132 aa)
BECN2Beclin-2. (432 aa)
PLCG21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1265 aa)
GABARAPL2Gamma-aminobutyric acid receptor-associated protein-like 2. (117 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (431 aa)
IFNAR2Interferon alpha/beta receptor 2 isoform X1. (477 aa)
IFNAR1Interferon alpha/beta receptor 1 isoform X1. (562 aa)
RCAN1Calcipressin-1. (197 aa)
IL6Interleukin-6. (208 aa)
FOSProto-oncogene c-Fos. (380 aa)
IRF3Interferon regulatory factor 3 isoform X1. (434 aa)
PREX1Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein. (1480 aa)
MAP2K6Dual specificity mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily. (368 aa)
MAPK3Mitogen-activated protein kinase 3. (265 aa)
GNB2Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2. (340 aa)
RAC1Ras-related C3 botulinum toxin substrate 1. (194 aa)
RB1Retinoblastoma-associated protein. (816 aa)
ITPR3LOW QUALITY PROTEIN: inositol 1,4,5-trisphosphate receptor type 3. (2666 aa)
BAK1Bcl-2 homologous antagonist/killer. (211 aa)
CHUKInhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1. (744 aa)
CSF2Granulocyte-macrophage colony-stimulating factor. (144 aa)
MYCMyc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (438 aa)
ANGPT2Angiopoietin-2 isoform X1. (496 aa)
PDGFBPlatelet-derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (240 aa)
UBCpolyubiquitin-C. (609 aa)
RPS27Aubiquitin-40S ribosomal protein S27a. (156 aa)
CALM2Calmodulin-1; Belongs to the calmodulin family. (149 aa)
LOC103017780Cytochrome c 2; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
CASP8Caspase-8; Belongs to the peptidase C14A family. (486 aa)
LOC102999215Cytochrome c-like; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
LEF1Lymphoid enhancer-binding factor 1 isoform X1. (399 aa)
IFNGR1Interferon gamma receptor 1. (502 aa)
CCR8C-C chemokine receptor type 8; Belongs to the G-protein coupled receptor 1 family. (353 aa)
CCR4C-C chemokine receptor type 4; Belongs to the G-protein coupled receptor 1 family. (364 aa)
RAF1RAF proto-oncogene serine/threonine-protein kinase isoform X1. (668 aa)
ITPR1Inositol 1,4,5-trisphosphate receptor type 1 isoform X1. (2749 aa)
ATG14Beclin 1-associated autophagy-related key regulator. (492 aa)
GNG2Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (71 aa)
HIF1AHypoxia-inducible factor 1-alpha isoform X1. (823 aa)
SRCTyrosine-protein kinase. (557 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1257 aa)
E2F1Transcription factor E2F1. (361 aa)
SYKTyrosine-protein kinase. (626 aa)
HCKTyrosine-protein kinase. (504 aa)
CTNNB1Catenin beta-1. (767 aa)
TRAF2TNF receptor-associated factor. (412 aa)
KRASGTPase KRas isoform X3. (227 aa)
LOC102999798Mitogen-activated protein kinase. (203 aa)
IKBKEInhibitor of nuclear factor kappa-B kinase subunit epsilon isoform X1. (752 aa)
ITPR2Inositol 1,4,5-trisphosphate receptor type 2 isoform X1. (2701 aa)
GNB5Guanine nucleotide-binding protein subunit beta-5 isoform X1. (301 aa)
GNB4Guanine nucleotide-binding protein subunit beta-4. (340 aa)
PIK3R2Phosphatidylinositol 3-kinase regulatory subunit beta. (700 aa)
GNGT1Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (74 aa)
IL6STInterleukin-6 receptor subunit beta. (918 aa)
GNG11Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (73 aa)
UBA52ubiquitin-60S ribosomal protein L40. (128 aa)
CDK6Cyclin-dependent kinase 6; Belongs to the protein kinase superfamily. (326 aa)
CLEC2BC-type lectin domain family 2 member B isoform X1. (187 aa)
MAPK1Mitogen-activated protein kinase 1. (263 aa)
GABARAPL1Gamma-aminobutyric acid receptor-associated protein-like 1. (117 aa)
E2F3Transcription factor E2F3. (340 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
LOC103007162Interferon alpha-1-like. (104 aa)
NFATC3Nuclear factor of activated T-cells, cytoplasmic 3. (998 aa)
TRADDTumor necrosis factor receptor type 1-associated DEATH domain protein isoform X1. (343 aa)
LOC103009695LOW QUALITY PROTEIN: interferon alpha-7. (169 aa)
CDKN1ACyclin-dependent kinase inhibitor 1. (164 aa)
PPP3R2LOW QUALITY PROTEIN: calcineurin subunit B type 2. (170 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
LOC103008230BOLA class I histocompatibility antigen, alpha chain BL3-7-like isoform X1; Belongs to the MHC class I family. (388 aa)
VEGFAVascular endothelial growth factor A isoform X2; Belongs to the PDGF/VEGF growth factor family. (186 aa)
LOC103005235LOW QUALITY PROTEIN: MHC class I polypeptide-related sequence B. (341 aa)
CREB1Cyclic AMP-responsive element-binding protein 1 isoform X1. (341 aa)
MAPK13Mitogen-activated protein kinase. (288 aa)
JAK1Tyrosine-protein kinase. (1155 aa)
LOC103008077Phosphatidylinositol 3-kinase regulatory subunit gamma. (484 aa)
FGF2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (155 aa)
E2F2Transcription factor E2F2. (414 aa)
LOC103008157Signal transducer and activator of transcription. (793 aa)
NFATC2Nuclear factor of activated T-cells, cytoplasmic 2 isoform X3. (818 aa)
EP300Histone acetyltransferase p300. (2445 aa)
Your Current Organism:
Balaenoptera acutorostrata
NCBI taxonomy Id: 310752
Other names: B. acutorostrata scammoni, Balaenoptera acutorostrata scammoni
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