STRINGSTRING
TRAF5 TRAF5 LOC103014668 LOC103014668 LOC103001311 LOC103001311 SCIN SCIN CCNE1 CCNE1 CCNE2 CCNE2 LOC103019413 LOC103019413 GTF2A2 GTF2A2 TP53 TP53 SCRIB SCRIB EIF2AK2 EIF2AK2 RBL2 RBL2 EGR3 EGR3 BAX BAX LYN LYN RHOA RHOA CCR3 CCR3 LOC103002871 LOC103002871 C3 C3 CREB3L3 CREB3L3 NRAS NRAS PIK3CD PIK3CD LOC103000493 LOC103000493 CCND2 CCND2 LTBR LTBR PIK3CB PIK3CB CHD4 CHD4 YWHAH YWHAH CDK1 CDK1 EGR2 EGR2 HDAC1 HDAC1 CCND1 CCND1 RELA RELA HRAS HRAS PXN PXN IRF7 IRF7 MAPKAPK2 MAPKAPK2 CCNA2 CCNA2 NFKB1 NFKB1 PRKACB PRKACB YWHAZ YWHAZ LOC103007740 LOC103007740 BAD BAD GTF2E2 GTF2E2 DDB1 DDB1 MAD1L1 MAD1L1 GTF2H1 GTF2H1 CDC42 CDC42 LOC103000259 LOC103000259 ATP6V0D2 ATP6V0D2 TRAF3 TRAF3 PIK3R1 PIK3R1 GTF2B GTF2B CDKN2B CDKN2B LOC103012968 LOC103012968 HNRNPK HNRNPK SND1 SND1 CREB3L2 CREB3L2 LOC103018003 LOC103018003 LOC103016424 LOC103016424 LOC103018292 LOC103018292 LOC103015570 LOC103015570 LOC103019568 LOC103019568 LOC103016974 LOC103016974 LOC103019838 LOC103019838 LOC103020607 LOC103020607 LOC102997405 LOC102997405 CASP3 CASP3 LOC103018297 LOC103018297 GSN GSN TRAF1 TRAF1 LOC103017256 LOC103017256 CREB3L4 CREB3L4 LOC102998884 LOC102998884 LOC103010190 LOC103010190 LOC103010782 LOC103010782 LOC103003205 LOC103003205 UBE3A UBE3A CDK2 CDK2 CDK4 CDK4 ACTN4 ACTN4 HDAC5 HDAC5 IRF9 IRF9 NFKBIA NFKBIA PSMC1 PSMC1 CREB3L1 CREB3L1 CREBBP CREBBP DNAJA3 DNAJA3 GTF2E1 GTF2E1 PRKACA PRKACA POLB POLB VDAC3 VDAC3 LOC103003603 LOC103003603 HDAC11 HDAC11 KAT2B KAT2B CHEK1 CHEK1 YWHAE YWHAE ACTN1 ACTN1 SNW1 SNW1 HDAC4 HDAC4 IRF3 IRF3 GRB2 GRB2 LOC103005469 LOC103005469 TBP TBP LOC103002676 LOC103002676 LOC103002948 LOC103002948 MAPK3 MAPK3 RAC1 RAC1 RB1 RB1 BAK1 BAK1 YWHAG YWHAG LOC103017578 LOC103017578 LOC102997446 LOC102997446 NFKB2 NFKB2 USP7 USP7 LOC103010322 LOC103010322 GTF2A1 GTF2A1 LOC103012727 LOC103012727 ATF4 ATF4 HDAC10 HDAC10 GTF2H3 GTF2H3 REL REL GTF2A1L GTF2A1L ATF2 ATF2 CASP8 CASP8 HDAC2 HDAC2 TBPL1 TBPL1 CCR8 CCR8 CCR4 CCR4 PMAIP1 PMAIP1 SKP2 SKP2 TBPL2 TBPL2 YWHAB YWHAB SRC SRC RBL1 RBL1 SYK SYK CCNA1 CCNA1 CREB5 CREB5 MRPS18B MRPS18B ATF6B ATF6B GTF2H4 GTF2H4 HDAC3 HDAC3 TRAF2 TRAF2 KRAS KRAS MDM2 MDM2 JAK3 JAK3 PIK3R2 PIK3R2 IL6ST IL6ST YWHAQ YWHAQ CDK6 CDK6 CDKN1B CDKN1B RANBP1 RANBP1 MAPK1 MAPK1 CREB3 CREB3 PKM PKM CCND3 CCND3 TRADD TRADD CDKN1A CDKN1A ATP6V0D1 ATP6V0D1 VAC14 VAC14 PIK3CA PIK3CA LOC103008230 LOC103008230 CREB1 CREB1 SRF SRF JAK1 JAK1 LOC103008077 LOC103008077 CDC20 CDC20 DLG1 DLG1 HDAC9 HDAC9 UBR4 UBR4 HPN HPN LOC103008157 LOC103008157 LOC103019119 LOC103019119 HDAC6 HDAC6 LOC103011078 LOC103011078 LOC103005377 LOC103005377 RASA2 RASA2 EP300 EP300
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
TRAF5TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (558 aa)
LOC103014668Transcription factor AP-1; Belongs to the bZIP family. (253 aa)
LOC103001311Transcription factor AP-1-like. (199 aa)
SCINAdseverin. (715 aa)
CCNE1LOW QUALITY PROTEIN: G1/S-specific cyclin-E1; Belongs to the cyclin family. (416 aa)
CCNE2G1/S-specific cyclin-E2; Belongs to the cyclin family. (405 aa)
LOC103019413Histone H2B; Belongs to the histone H2B family. (122 aa)
GTF2A2Transcription initiation factor IIA subunit 2; TFIIA is a component of the transcription machinery of RNA polymerase II and plays an important role in transcriptional activation; Belongs to the TFIIA subunit 2 family. (109 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (387 aa)
SCRIBLOW QUALITY PROTEIN: protein scribble homolog. (1610 aa)
EIF2AK2Interferon-induced, double-stranded RNA-activated protein kinase. (539 aa)
RBL2Retinoblastoma-like protein 2. (1160 aa)
EGR3Early growth response protein 3. (387 aa)
BAXApoptosis regulator BAX. (192 aa)
LYNTyrosine-protein kinase. (512 aa)
RHOATransforming protein RhoA. (193 aa)
CCR3C-C chemokine receptor type 3; Belongs to the G-protein coupled receptor 1 family. (358 aa)
LOC103002871C-C chemokine receptor type 5; Belongs to the G-protein coupled receptor 1 family. (352 aa)
C3Complement C3. (1609 aa)
CREB3L3Cyclic AMP-responsive element-binding protein 3-like protein 3. (457 aa)
NRASGTPase NRas. (189 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1042 aa)
LOC103000493Histone H2B; Belongs to the histone H2B family. (126 aa)
CCND2G1/S-specific cyclin-D2; Belongs to the cyclin family. (289 aa)
LTBRTumor necrosis factor receptor superfamily member 3. (421 aa)
PIK3CBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform; Belongs to the PI3/PI4-kinase family. (1070 aa)
CHD4chromodomain-helicase-DNA-binding protein 4 isoform X1. (1940 aa)
YWHAH14-3-3 protein eta; Belongs to the 14-3-3 family. (218 aa)
CDK1Cyclin-dependent kinase 1; Belongs to the protein kinase superfamily. (297 aa)
EGR2E3 SUMO-protein ligase EGR2. (472 aa)
HDAC1Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. (482 aa)
CCND1G1/S-specific cyclin-D1 isoform X1; Belongs to the cyclin family. (214 aa)
RELATranscription factor p65 isoform X1. (520 aa)
HRASGTPase HRas isoform X1. (196 aa)
PXNPaxillin; Belongs to the paxillin family. (599 aa)
IRF7Interferon regulatory factor 7. (463 aa)
MAPKAPK2MAP kinase-activated protein kinase 2; Belongs to the protein kinase superfamily. (388 aa)
CCNA2cyclin-A2; Belongs to the cyclin family. (435 aa)
NFKB1Nuclear factor NF-kappa-B p105 subunit isoform X1. (974 aa)
PRKACBcAMP-dependent protein kinase catalytic subunit beta isoform X1; Belongs to the protein kinase superfamily. (397 aa)
YWHAZ14-3-3 protein zeta/delta; Belongs to the 14-3-3 family. (245 aa)
LOC103007740H-2 class I histocompatibility antigen, Q10 alpha chain-like isoform X1; Belongs to the MHC class I family. (349 aa)
BADBcl2-associated agonist of cell death. (168 aa)
GTF2E2Transcription initiation factor IIE subunit beta; Recruits TFIIH to the initiation complex and stimulates the RNA polymerase II C-terminal domain kinase and DNA-dependent ATPase activities of TFIIH. Both TFIIH and TFIIE are required for promoter clearance by RNA polymerase. (306 aa)
DDB1DNA damage-binding protein 1. (1140 aa)
MAD1L1LOW QUALITY PROTEIN: mitotic spindle assembly checkpoint protein MAD1. (719 aa)
GTF2H1General transcription factor IIH subunit 1 isoform X1. (548 aa)
CDC42Cell division control protein 42 homolog isoform X2. (191 aa)
LOC103000259General transcription factor IIH subunit. (395 aa)
ATP6V0D2V-type proton ATPase subunit; Subunit of the integral membrane V0 complex of vacuolar ATPase. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. Belongs to the V-ATPase V0D/AC39 subunit family. (351 aa)
TRAF3TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (572 aa)
PIK3R1Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1. (724 aa)
GTF2BTranscription initiation factor IIB. (316 aa)
CDKN2BCyclin-dependent kinase 4 inhibitor B isoform X1. (131 aa)
LOC103012968Cyclin-dependent kinase inhibitor 2A. (109 aa)
HNRNPKHeterogeneous nuclear ribonucleoprotein K isoform X1. (464 aa)
SND1Staphylococcal nuclease domain-containing protein; Endonuclease that mediates miRNA decay of both protein-free and AGO2-loaded miRNAs. (910 aa)
CREB3L2Cyclic AMP-responsive element-binding protein 3-like protein 2. (520 aa)
LOC103018003Histone H2B; Belongs to the histone H2B family. (150 aa)
LOC103016424Uncharacterized protein LOC103016424 isoform X1; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (329 aa)
LOC103018292Histone H2B type 1-L-like; Belongs to the histone H2B family. (154 aa)
LOC103015570Histone H2B; Belongs to the histone H2B family. (126 aa)
LOC103019568Histone H2B; Belongs to the histone H2B family. (126 aa)
LOC103016974Histone H2B; Belongs to the histone H2B family. (126 aa)
LOC103019838Histone H2B; Belongs to the histone H2B family. (126 aa)
LOC103020607Signal transducer and activator of transcription. (794 aa)
LOC102997405Signal transducer and activator of transcription. (783 aa)
CASP3Caspase-3; Belongs to the peptidase C14A family. (275 aa)
LOC103018297Histone H2B; Belongs to the histone H2B family. (126 aa)
GSNGelsolin isoform X1. (780 aa)
TRAF1TNF receptor-associated factor. (415 aa)
LOC103017256Histone H2B; Belongs to the histone H2B family. (143 aa)
CREB3L4Cyclic AMP-responsive element-binding protein 3-like protein 4 isoform X1. (395 aa)
LOC102998884Histone H2B; Belongs to the histone H2B family. (126 aa)
LOC103010190Histone H2B; Belongs to the histone H2B family. (126 aa)
LOC103010782Histone H2B; Belongs to the histone H2B family. (126 aa)
LOC103003205Histone H2B; Belongs to the histone H2B family. (126 aa)
UBE3AUbiquitin-protein ligase E3A; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and transfers it to its substrates. (875 aa)
CDK2Cyclin-dependent kinase 2 isoform X1; Belongs to the protein kinase superfamily. (346 aa)
CDK4Cyclin-dependent kinase 4 isoform X1; Belongs to the protein kinase superfamily. (303 aa)
ACTN4Alpha-actinin-4. (881 aa)
HDAC5Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1138 aa)
IRF9Interferon regulatory factor 9 isoform X1. (411 aa)
NFKBIANF-kappa-B inhibitor alpha. (280 aa)
PSMC126S proteasome regulatory subunit 4; Belongs to the AAA ATPase family. (440 aa)
CREB3L1Cyclic AMP-responsive element-binding protein 3-like protein 1. (520 aa)
CREBBPCREB-binding protein isoform X1. (2444 aa)
DNAJA3dnaJ homolog subfamily A member 3, mitochondrial isoform X1. (480 aa)
GTF2E1General transcription factor IIE subunit 1 isoform X1. (439 aa)
PRKACAcAMP-dependent protein kinase catalytic subunit alpha. (293 aa)
POLBDNA polymerase; DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template- independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity. (335 aa)
VDAC3Voltage-dependent anion-selective channel protein 3 isoform X1. (282 aa)
LOC103003603ATP-dependent RNA helicase DDX3X isoform X1; Belongs to the DEAD box helicase family. (672 aa)
HDAC11Histone deacetylase 11 isoform X1. (347 aa)
KAT2BHistone acetyltransferase KAT2B. (703 aa)
CHEK1Serine/threonine-protein kinase Chk1; Belongs to the protein kinase superfamily. (476 aa)
YWHAE14-3-3 protein epsilon isoform X1; Belongs to the 14-3-3 family. (255 aa)
ACTN1Alpha-actinin-1 isoform X1. (914 aa)
SNW1SNW domain-containing protein 1 isoform X1. (536 aa)
HDAC4Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1149 aa)
IRF3Interferon regulatory factor 3 isoform X1. (434 aa)
GRB2Growth factor receptor-bound protein 2. (217 aa)
LOC103005469Late histone H2B.L4-like; Belongs to the histone H2B family. (140 aa)
TBPTATA-box-binding protein isoform X1. (317 aa)
LOC103002676Histone H2B type 1-A-like; Belongs to the histone H2B family. (126 aa)
LOC103002948Histone H2B; Belongs to the histone H2B family. (127 aa)
MAPK3Mitogen-activated protein kinase 3. (265 aa)
RAC1Ras-related C3 botulinum toxin substrate 1. (194 aa)
RB1Retinoblastoma-associated protein. (816 aa)
BAK1Bcl-2 homologous antagonist/killer. (211 aa)
YWHAG14-3-3 protein gamma; Belongs to the 14-3-3 family. (225 aa)
LOC103017578Histone deacetylase 8-like. (194 aa)
LOC102997446ATP-dependent RNA helicase DDX3X isoform X1; Belongs to the DEAD box helicase family. (662 aa)
NFKB2Nuclear factor NF-kappa-B p100 subunit isoform X2. (901 aa)
USP7Ubiquitin carboxyl-terminal hydrolase 7; Belongs to the peptidase C19 family. (1055 aa)
LOC10301032214-3-3 protein beta/alpha-like isoform X1; Belongs to the 14-3-3 family. (250 aa)
GTF2A1Transcription initiation factor IIA subunit 1. (336 aa)
LOC103012727Voltage-dependent anion-selective channel protein 3-like. (264 aa)
ATF4Cyclic AMP-dependent transcription factor ATF-4. (352 aa)
HDAC10Polyamine deacetylase HDAC10 isoform X1. (715 aa)
GTF2H3General transcription factor IIH subunit 3. (309 aa)
RELProto-oncogene c-Rel. (594 aa)
GTF2A1LTFIIA-alpha and beta-like factor. (477 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2 isoform X1. (505 aa)
CASP8Caspase-8; Belongs to the peptidase C14A family. (486 aa)
HDAC2Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. (492 aa)
TBPL1TATA box-binding protein-like protein 1. (186 aa)
CCR8C-C chemokine receptor type 8; Belongs to the G-protein coupled receptor 1 family. (353 aa)
CCR4C-C chemokine receptor type 4; Belongs to the G-protein coupled receptor 1 family. (364 aa)
PMAIP1Phorbol-12-myristate-13-acetate-induced protein 1. (74 aa)
SKP2S-phase kinase-associated protein 2. (436 aa)
TBPL2TATA box-binding protein-like protein 2. (449 aa)
YWHAB14-3-3 protein beta/alpha isoform X1; Belongs to the 14-3-3 family. (246 aa)
SRCTyrosine-protein kinase. (557 aa)
RBL1Retinoblastoma-like protein 1. (1068 aa)
SYKTyrosine-protein kinase. (626 aa)
CCNA1cyclin-A1; Belongs to the cyclin family. (421 aa)
CREB5Cyclic AMP-responsive element-binding protein 5 isoform X1. (502 aa)
MRPS18B28S ribosomal protein S18b, mitochondrial. (292 aa)
ATF6BLOW QUALITY PROTEIN: cyclic AMP-dependent transcription factor ATF-6 beta. (700 aa)
GTF2H4General transcription factor IIH subunit 4; Component of the general transcription and DNA repair factor IIH (TFIIH) core complex which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA. Belongs to the TFB2 family. (463 aa)
HDAC3Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. (428 aa)
TRAF2TNF receptor-associated factor. (412 aa)
KRASGTPase KRas isoform X3. (227 aa)
MDM2E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family. (491 aa)
JAK3Tyrosine-protein kinase. (1104 aa)
PIK3R2Phosphatidylinositol 3-kinase regulatory subunit beta. (700 aa)
IL6STInterleukin-6 receptor subunit beta. (918 aa)
YWHAQ14-3-3 protein theta; Belongs to the 14-3-3 family. (245 aa)
CDK6Cyclin-dependent kinase 6; Belongs to the protein kinase superfamily. (326 aa)
CDKN1BCyclin-dependent kinase inhibitor 1B. (198 aa)
RANBP1Ran-specific GTPase-activating protein. (257 aa)
MAPK1Mitogen-activated protein kinase 1. (263 aa)
CREB3Cyclic AMP-responsive element-binding protein 3 isoform X1. (371 aa)
PKMPyruvate kinase; Belongs to the pyruvate kinase family. (531 aa)
CCND3G1/S-specific cyclin-D3 isoform X1; Belongs to the cyclin family. (292 aa)
TRADDTumor necrosis factor receptor type 1-associated DEATH domain protein isoform X1. (343 aa)
CDKN1ACyclin-dependent kinase inhibitor 1. (164 aa)
ATP6V0D1V-type proton ATPase subunit; Subunit of the integral membrane V0 complex of vacuolar ATPase. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. Belongs to the V-ATPase V0D/AC39 subunit family. (351 aa)
VAC14LOW QUALITY PROTEIN: protein VAC14 homolog. (783 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
LOC103008230BOLA class I histocompatibility antigen, alpha chain BL3-7-like isoform X1; Belongs to the MHC class I family. (388 aa)
CREB1Cyclic AMP-responsive element-binding protein 1 isoform X1. (341 aa)
SRFSerum response factor. (464 aa)
JAK1Tyrosine-protein kinase. (1155 aa)
LOC103008077Phosphatidylinositol 3-kinase regulatory subunit gamma. (484 aa)
CDC20LOW QUALITY PROTEIN: cell division cycle protein 20 homolog. (499 aa)
DLG1Disks large homolog 1 isoform X8; Belongs to the MAGUK family. (927 aa)
HDAC9Histone deacetylase 9 isoform X1. (666 aa)
UBR4E3 ubiquitin-protein ligase UBR4 isoform X1. (5237 aa)
HPNSerine protease hepsin; Belongs to the peptidase S1 family. (382 aa)
LOC103008157Signal transducer and activator of transcription. (793 aa)
LOC103019119Histone H2B; Belongs to the histone H2B family. (126 aa)
HDAC6Histone deacetylase 6. (1143 aa)
LOC10301107814-3-3 protein gamma-A-like; Belongs to the 14-3-3 family. (149 aa)
LOC103005377Histone deacetylase 8. (340 aa)
RASA2Ras GTPase-activating protein 2 isoform X2. (795 aa)
EP300Histone acetyltransferase p300. (2445 aa)
Your Current Organism:
Balaenoptera acutorostrata
NCBI taxonomy Id: 310752
Other names: B. acutorostrata scammoni, Balaenoptera acutorostrata scammoni
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